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Protein

Ras-related protein Rab-2A

Gene

RAB2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPCombined sources9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPCombined sources4
Nucleotide bindingi149 – 151GTPCombined sources3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: ProtInc
  • Golgi organization Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • post-translational protein modification Source: Reactome
  • Rab protein signal transduction Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:RAB2A
Synonyms:RAB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104388.14
HGNCiHGNC:9763 RAB2A
MIMi179509 gene
neXtProtiNX_P61019

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5862
OpenTargetsiENSG00000104388
PharmGKBiPA162400618

Polymorphism and mutation databases

BioMutaiRAB2A
DMDMi46577636

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001210662 – 212Ras-related protein Rab-2AAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Lipidationi211S-geranylgeranyl cysteine1 Publication1
Lipidationi212S-geranylgeranyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

EPDiP61019
MaxQBiP61019
PaxDbiP61019
PeptideAtlasiP61019
PRIDEiP61019
ProteomicsDBi57251
57252 [P61019-2]
TopDownProteomicsiP61019-1 [P61019-1]
P61019-2 [P61019-2]

PTM databases

iPTMnetiP61019
PhosphoSitePlusiP61019
SwissPalmiP61019

Expressioni

Gene expression databases

BgeeiENSG00000104388 Expressed in 240 organ(s), highest expression level in frontal cortex
CleanExiHS_RAB2A
ExpressionAtlasiP61019 baseline and differential
GenevisibleiP61019 HS

Organism-specific databases

HPAiCAB018781

Interactioni

Subunit structurei

Interacts with PRKCI.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi111800, 111 interactors
DIPiDIP-316N
IntActiP61019, 63 interactors
MINTiP61019
STRINGi9606.ENSP00000262646

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP61019
SMRiP61019
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61019

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 19Required for interaction with PRKCI1 PublicationAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP61019
KOiK07877
OMAiHADPHLT
OrthoDBiEOG091G0QOB
PhylomeDBiP61019
TreeFamiTF300032

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P61019-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNATHAG
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,546
Last modified:April 26, 2004 - v1
Checksum:iF8731E3F8FB399A3
GO
Isoform 2 (identifier: P61019-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-39: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):20,847
Checksum:i5B13DD3486CC230F
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKL7E9PKL7_HUMAN
Ras-related protein Rab-2A
RAB2A
181Annotation score:
H0YD31H0YD31_HUMAN
Ras-related protein Rab-2A
RAB2A
135Annotation score:
H7C125H7C125_HUMAN
Ras-related protein Rab-2A
RAB2A
104Annotation score:
H0YDL5H0YDL5_HUMAN
Ras-related protein Rab-2A
RAB2A
69Annotation score: