UniProtKB - P61019 (RAB2A_HUMAN)
Protein
Ras-related protein Rab-2A
Gene
RAB2A
Organism
Homo sapiens (Human)
Status
Functioni
Required for protein transport from the endoplasmic reticulum to the Golgi complex.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 13 – 21 | GTPCombined sources | 9 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 119 – 122 | GTPCombined sources | 4 | |
Nucleotide bindingi | 149 – 151 | GTPCombined sources | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: ProtInc
- Golgi organization Source: UniProtKB
- post-translational protein modification Source: Reactome
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P61019 |
Reactomei | R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-8873719, RAB geranylgeranylation |
SIGNORi | P61019 |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-2A |
Gene namesi | Name:RAB2A Synonyms:RAB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9763, RAB2A |
MIMi | 179509, gene |
neXtProti | NX_P61019 |
VEuPathDBi | HostDB:ENSG00000104388.14 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Lipid-anchor Curated
Golgi apparatus
- Golgi apparatus membrane Curated; Lipid-anchor Curated
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication; Lipid-anchor 1 Publication
- Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: GO_Central
Lysosome
- lysosomal membrane Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5862 |
OpenTargetsi | ENSG00000104388 |
PharmGKBi | PA162400618 |
Miscellaneous databases
Pharosi | P61019, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4105893 |
Genetic variation databases
BioMutai | RAB2A |
DMDMi | 46577636 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000121066 | 2 – 212 | Ras-related protein Rab-2AAdd BLAST | 211 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Lipidationi | 211 | S-geranylgeranyl cysteine1 Publication | 1 | |
Lipidationi | 212 | S-geranylgeranyl cysteine1 Publication | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, PrenylationProteomic databases
EPDi | P61019 |
jPOSTi | P61019 |
MassIVEi | P61019 |
MaxQBi | P61019 |
PaxDbi | P61019 |
PeptideAtlasi | P61019 |
PRIDEi | P61019 |
ProteomicsDBi | 57251 [P61019-1] 57252 [P61019-2] |
TopDownProteomicsi | P61019-1 [P61019-1] P61019-2 [P61019-2] |
PTM databases
iPTMneti | P61019 |
PhosphoSitePlusi | P61019 |
SwissPalmi | P61019 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104388, Expressed in frontal cortex and 252 other tissues |
ExpressionAtlasi | P61019, baseline and differential |
Genevisiblei | P61019, HS |
Organism-specific databases
HPAi | ENSG00000104388, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP61019
Protein-protein interaction databases
BioGRIDi | 111800, 182 interactors |
DIPi | DIP-316N |
IntActi | P61019, 75 interactors |
MINTi | P61019 |
STRINGi | 9606.ENSP00000262646 |
Miscellaneous databases
RNActi | P61019, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P61019 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61019 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 19 | Required for interaction with PRKCI1 PublicationAdd BLAST | 18 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 43 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | P61019 |
OMAi | HADPHLT |
PhylomeDBi | P61019 |
TreeFami | TF300032 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P61019-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNATHAG
210
NQGGQQAGGG CC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PKL7 | E9PKL7_HUMAN | Ras-related protein Rab-2A | RAB2A | 181 | Annotation score: | ||
H7C125 | H7C125_HUMAN | Ras-related protein Rab-2A | RAB2A | 104 | Annotation score: | ||
H0YD31 | H0YD31_HUMAN | Ras-related protein Rab-2A | RAB2A | 135 | Annotation score: | ||
H0YDL5 | H0YDL5_HUMAN | Ras-related protein Rab-2A | RAB2A | 69 | Annotation score: | ||
A0A1D5RMT4 | A0A1D5RMT4_HUMAN | Ras-related protein Rab-2A | RAB2A | 10 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | I → M in AAA60241 (PubMed:2501306).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042917 | 16 – 39 | Missing in isoform 2. 1 PublicationAdd BLAST | 24 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12953 mRNA Translation: CAA31411.1 M28213 mRNA Translation: AAA60241.1 AF498930 mRNA Translation: AAM21078.1 BT019695 mRNA Translation: AAV38501.1 AK297576 mRNA Translation: BAG59967.1 AK312344 mRNA Translation: BAG35265.1 AC068389 Genomic DNA No translation available. AC079065 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW86827.1 BC008929 mRNA Translation: AAH08929.1 |
CCDSi | CCDS56537.1 [P61019-2] CCDS6175.1 [P61019-1] |
PIRi | B34323 |
RefSeqi | NP_001229573.1, NM_001242644.1 [P61019-2] NP_002856.1, NM_002865.2 [P61019-1] |
Genome annotation databases
Ensembli | ENST00000262646; ENSP00000262646; ENSG00000104388 [P61019-1] ENST00000531289; ENSP00000431846; ENSG00000104388 [P61019-2] |
GeneIDi | 5862 |
KEGGi | hsa:5862 |
UCSCi | uc003xud.3, human [P61019-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X12953 mRNA Translation: CAA31411.1 M28213 mRNA Translation: AAA60241.1 AF498930 mRNA Translation: AAM21078.1 BT019695 mRNA Translation: AAV38501.1 AK297576 mRNA Translation: BAG59967.1 AK312344 mRNA Translation: BAG35265.1 AC068389 Genomic DNA No translation available. AC079065 Genomic DNA No translation available. CH471068 Genomic DNA Translation: EAW86827.1 BC008929 mRNA Translation: AAH08929.1 |
CCDSi | CCDS56537.1 [P61019-2] CCDS6175.1 [P61019-1] |
PIRi | B34323 |
RefSeqi | NP_001229573.1, NM_001242644.1 [P61019-2] NP_002856.1, NM_002865.2 [P61019-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z0A | X-ray | 2.12 | A/B/C/D | 2-170 | [»] | |
SMRi | P61019 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111800, 182 interactors |
DIPi | DIP-316N |
IntActi | P61019, 75 interactors |
MINTi | P61019 |
STRINGi | 9606.ENSP00000262646 |
Chemistry databases
ChEMBLi | CHEMBL4105893 |
PTM databases
iPTMneti | P61019 |
PhosphoSitePlusi | P61019 |
SwissPalmi | P61019 |
Genetic variation databases
BioMutai | RAB2A |
DMDMi | 46577636 |
Proteomic databases
EPDi | P61019 |
jPOSTi | P61019 |
MassIVEi | P61019 |
MaxQBi | P61019 |
PaxDbi | P61019 |
PeptideAtlasi | P61019 |
PRIDEi | P61019 |
ProteomicsDBi | 57251 [P61019-1] 57252 [P61019-2] |
TopDownProteomicsi | P61019-1 [P61019-1] P61019-2 [P61019-2] |
Protocols and materials databases
Antibodypediai | 4367, 311 antibodies |
DNASUi | 5862 |
Genome annotation databases
Ensembli | ENST00000262646; ENSP00000262646; ENSG00000104388 [P61019-1] ENST00000531289; ENSP00000431846; ENSG00000104388 [P61019-2] |
GeneIDi | 5862 |
KEGGi | hsa:5862 |
UCSCi | uc003xud.3, human [P61019-1] |
Organism-specific databases
CTDi | 5862 |
DisGeNETi | 5862 |
GeneCardsi | RAB2A |
HGNCi | HGNC:9763, RAB2A |
HPAi | ENSG00000104388, Low tissue specificity |
MIMi | 179509, gene |
neXtProti | NX_P61019 |
OpenTargetsi | ENSG00000104388 |
PharmGKBi | PA162400618 |
VEuPathDBi | HostDB:ENSG00000104388.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0098, Eukaryota |
GeneTreei | ENSGT00940000153886 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | P61019 |
OMAi | HADPHLT |
PhylomeDBi | P61019 |
TreeFami | TF300032 |
Enzyme and pathway databases
PathwayCommonsi | P61019 |
Reactomei | R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-8873719, RAB geranylgeranylation |
SIGNORi | P61019 |
Miscellaneous databases
BioGRID-ORCSi | 5862, 14 hits in 877 CRISPR screens |
ChiTaRSi | RAB2A, human |
EvolutionaryTracei | P61019 |
GeneWikii | RAB2A |
GenomeRNAii | 5862 |
Pharosi | P61019, Tbio |
PROi | PR:P61019 |
RNActi | P61019, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104388, Expressed in frontal cortex and 252 other tissues |
ExpressionAtlasi | P61019, baseline and differential |
Genevisiblei | P61019, HS |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB2A_HUMAN | |
Accessioni | P61019Primary (citable) accession number: P61019 Secondary accession number(s): B2R5W8, B4DMQ5, P08886 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM