UniProtKB - P61018 (RAB4B_HUMAN)
Ras-related protein Rab-4B
RAB4B
Functioni
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state (By similarity).
Protein transport. Probably involved in vesicular traffic (By similarity).
Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity).
By similarityCatalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 23 | GTPCombined sources1 Publication | 9 | |
Nucleotide bindingi | 63 – 67 | GTPBy similarity | 5 | |
Nucleotide bindingi | 121 – 124 | GTPCombined sources1 Publication | 4 | |
Nucleotide bindingi | 151 – 153 | GTPCombined sources1 Publication | 3 |
GO - Molecular functioni
- G protein activity Source: UniProtKB-EC
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- glucose import Source: UniProtKB
- protein transport Source: UniProtKB-KW
- Rab protein signal transduction Source: InterPro
- regulation of endocytosis Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P61018 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8875656, MET receptor recycling |
SignaLinki | P61018 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RAB4B ORF Names:PP1596 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9782, RAB4B |
MIMi | 612945, gene |
neXtProti | NX_P61018 |
VEuPathDBi | HostDB:ENSG00000167578 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- endosome Source: GO_Central
- recycling endosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- insulin-responsive compartment Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- secretory granule membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 53916 |
OpenTargetsi | ENSG00000167578 |
PharmGKBi | PA34142 |
Miscellaneous databases
Pharosi | P61018, Tbio |
Genetic variation databases
BioMutai | RAB4B |
DMDMi | 46577635 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000121099 | 2 – 213 | Ras-related protein Rab-4BAdd BLAST | 212 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 67 | 5-glutamyl serotoninBy similarity | 1 | |
Modified residuei | 185 | PhosphoserineBy similarity | 1 | |
Modified residuei | 193 | PhosphoserineCombined sources | 1 | |
Lipidationi | 211 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 213 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 213 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, Phosphoprotein, PrenylationProteomic databases
EPDi | P61018 |
jPOSTi | P61018 |
MassIVEi | P61018 |
MaxQBi | P61018 |
PaxDbi | P61018 |
PeptideAtlasi | P61018 |
PRIDEi | P61018 |
ProteomicsDBi | 57249 [P61018-1] 57250 [P61018-2] |
PTM databases
iPTMneti | P61018 |
PhosphoSitePlusi | P61018 |
SwissPalmi | P61018 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167578, Expressed in C1 segment of cervical spinal cord and 213 other tissues |
ExpressionAtlasi | P61018, baseline and differential |
Genevisiblei | P61018, HS |
Organism-specific databases
HPAi | ENSG00000167578, Low tissue specificity |
Interactioni
Binary interactionsi
P61018
Protein-protein interaction databases
BioGRIDi | 119816, 30 interactors |
IntActi | P61018, 23 interactors |
STRINGi | 9606.ENSP00000349560 |
Miscellaneous databases
RNActi | P61018, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P61018 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61018 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 37 – 45 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0086, Eukaryota |
GeneTreei | ENSGT00940000159399 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | P61018 |
OMAi | EWAEASR |
PhylomeDBi | P61018 |
TreeFami | TF300032 |
Family and domain databases
CDDi | cd04113, Rab4, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041819, Rab4 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAETYDFLFK FLVIGSAGTG KSCLLHQFIE NKFKQDSNHT IGVEFGSRVV
60 70 80 90 100
NVGGKTVKLQ IWDTAGQERF RSVTRSYYRG AAGALLVYDI TSRETYNSLA
110 120 130 140 150
AWLTDARTLA SPNIVVILCG NKKDLDPERE VTFLEASRFA QENELMFLET
160 170 180 190 200
SALTGENVEE AFLKCARTIL NKIDSGELDP ERMGSGIQYG DASLRQLRQP
210
RSAQAVAPQP CGC
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6PIK3 | Q6PIK3_HUMAN | HCG1995540, isoform CRA_b | RAB4B hCG_1995540, hCG_2044074 | 121 | Annotation score: | ||
W4VSR3 | W4VSR3_HUMAN | HCG2044074, isoform CRA_c | MIA-RAB4B hCG_2044074 | 131 | Annotation score: | ||
M0R0X1 | M0R0X1_HUMAN | Ras-related protein Rab-4B | RAB4B | 192 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 – 6 | TYD → DRH in AAP97171 (Ref. 1) Curated | 3 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013567 | 1 – 5 | MAETY → MSVSLPLTVMVRERDWIGIH LFSLYLSLPVGIPDFGSIWS in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087861 mRNA Translation: AAP97171.1 AF165522 mRNA Translation: AAD45923.1 AF217985 mRNA Translation: AAG17228.1 AF498935 mRNA Translation: AAM21083.1 BC046927 mRNA Translation: AAH46927.1 |
CCDSi | CCDS33030.1 [P61018-1] |
RefSeqi | NP_057238.3, NM_016154.4 [P61018-1] |
Genome annotation databases
Ensembli | ENST00000357052; ENSP00000349560; ENSG00000167578 ENST00000594800; ENSP00000470246; ENSG00000167578 |
GeneIDi | 53916 |
KEGGi | hsa:53916 |
MANE-Selecti | ENST00000357052.8; ENSP00000349560.2; NM_016154.5; NP_057238.3 |
UCSCi | uc002opd.2, human [P61018-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087861 mRNA Translation: AAP97171.1 AF165522 mRNA Translation: AAD45923.1 AF217985 mRNA Translation: AAG17228.1 AF498935 mRNA Translation: AAM21083.1 BC046927 mRNA Translation: AAH46927.1 |
CCDSi | CCDS33030.1 [P61018-1] |
RefSeqi | NP_057238.3, NM_016154.4 [P61018-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2O52 | X-ray | 2.20 | A/B | 6-183 | [»] | |
SMRi | P61018 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119816, 30 interactors |
IntActi | P61018, 23 interactors |
STRINGi | 9606.ENSP00000349560 |
PTM databases
iPTMneti | P61018 |
PhosphoSitePlusi | P61018 |
SwissPalmi | P61018 |
Genetic variation databases
BioMutai | RAB4B |
DMDMi | 46577635 |
Proteomic databases
EPDi | P61018 |
jPOSTi | P61018 |
MassIVEi | P61018 |
MaxQBi | P61018 |
PaxDbi | P61018 |
PeptideAtlasi | P61018 |
PRIDEi | P61018 |
ProteomicsDBi | 57249 [P61018-1] 57250 [P61018-2] |
Protocols and materials databases
Antibodypediai | 48676, 102 antibodies from 18 providers |
DNASUi | 53916 |
Genome annotation databases
Ensembli | ENST00000357052; ENSP00000349560; ENSG00000167578 ENST00000594800; ENSP00000470246; ENSG00000167578 |
GeneIDi | 53916 |
KEGGi | hsa:53916 |
MANE-Selecti | ENST00000357052.8; ENSP00000349560.2; NM_016154.5; NP_057238.3 |
UCSCi | uc002opd.2, human [P61018-1] |
Organism-specific databases
CTDi | 53916 |
DisGeNETi | 53916 |
GeneCardsi | RAB4B |
HGNCi | HGNC:9782, RAB4B |
HPAi | ENSG00000167578, Low tissue specificity |
MIMi | 612945, gene |
neXtProti | NX_P61018 |
OpenTargetsi | ENSG00000167578 |
PharmGKBi | PA34142 |
VEuPathDBi | HostDB:ENSG00000167578 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0086, Eukaryota |
GeneTreei | ENSGT00940000159399 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | P61018 |
OMAi | EWAEASR |
PhylomeDBi | P61018 |
TreeFami | TF300032 |
Enzyme and pathway databases
PathwayCommonsi | P61018 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-8873719, RAB geranylgeranylation R-HSA-8875656, MET receptor recycling |
SignaLinki | P61018 |
Miscellaneous databases
BioGRID-ORCSi | 53916, 4 hits in 1044 CRISPR screens |
EvolutionaryTracei | P61018 |
GenomeRNAii | 53916 |
Pharosi | P61018, Tbio |
PROi | PR:P61018 |
RNActi | P61018, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167578, Expressed in C1 segment of cervical spinal cord and 213 other tissues |
ExpressionAtlasi | P61018, baseline and differential |
Genevisiblei | P61018, HS |
Family and domain databases
CDDi | cd04113, Rab4, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041819, Rab4 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB4B_HUMAN | |
Accessioni | P61018Primary (citable) accession number: P61018 Secondary accession number(s): P22750, Q7Z514, Q9HBR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families