UniProtKB - P61015 (PPLA_RABIT)
Protein
Cardiac phospholamban
Gene
PLN
Organism
Oryctolagus cuniculus (Rabbit)
Status
Functioni
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity).By similarity
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
- ATPase inhibitor activity Source: BHF-UCL
- enzyme inhibitor activity Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Source: Ensembl
- cardiac muscle tissue development Source: Ensembl
- cellular calcium ion homeostasis Source: Ensembl
- negative regulation of ATPase activity Source: Ensembl
- negative regulation of ATPase-coupled calcium transmembrane transporter activity Source: UniProtKB
- negative regulation of calcium ion binding Source: BHF-UCL
- negative regulation of calcium ion import Source: BHF-UCL
- negative regulation of calcium ion import into sarcoplasmic reticulum Source: UniProtKB
- negative regulation of calcium ion transmembrane transporter activity Source: BHF-UCL
- negative regulation of catalytic activity Source: BHF-UCL
- negative regulation of heart rate Source: Ensembl
- Notch signaling pathway Source: Ensembl
- regulation of calcium ion transport Source: UniProtKB
- regulation of cardiac muscle cell contraction Source: Ensembl
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: Ensembl
- regulation of relaxation of muscle Source: Ensembl
- regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
- regulation of the force of heart contraction by cardiac conduction Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Cardiac phospholambanShort name: PLB |
Gene namesi | Name:PLN |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Mitochondrion
- Mitochondrion membrane By similarity; Single-pass membrane protein Sequence analysis
Other locations
- Sarcoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
- Membrane By similarity; Single-pass membrane protein Sequence analysis
Note: Colocalizes with HAX1 at the endoplasmic reticulum. Colocalizes with DMPK a the sarcoplasmic reticulum.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: BHF-UCL
- sarcoplasmic reticulum membrane Source: UniProtKB
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- calcium ion-transporting ATPase complex Source: Ensembl
- perinuclear region of cytoplasm Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, Mitochondrion, Sarcoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191247 | 1 – 52 | Cardiac phospholambanAdd BLAST | 52 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 16 | Phosphoserine; by PKA and DMPKBy similarity | 1 | |
Modified residuei | 17 | Phosphothreonine; by CaMK2By similarity | 1 | |
Lipidationi | 36 | S-palmitoyl cysteineBy similarity | 1 |
Post-translational modificationi
Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes (By similarity).By similarity
Palmitoylated by ZDHHC16, promoting formation of the homopentamer.By similarity
Keywords - PTMi
Acetylation, Lipoprotein, Palmitate, PhosphoproteinPTM databases
iPTMneti | P61015 |
Expressioni
Tissue specificityi
Heart.1 Publication
Gene expression databases
ExpressionAtlasi | P61015, baseline |
Interactioni
Subunit structurei
Homopentamer (By similarity).
Interacts with HAX1 and ATP2A2 (By similarity).
By similarityBinary interactionsi
P61015
With | #Exp. | IntAct |
---|---|---|
itself | 8 | EBI-79236,EBI-79236 |
GO - Molecular functioni
- ATPase binding Source: BHF-UCL
- identical protein binding Source: IntAct
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
DIPi | DIP-31022N |
IntActi | P61015, 6 interactors |
STRINGi | 9986.ENSOCUP00000011917 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P61015 |
SMRi | P61015 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P61015 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phospholamban family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S97F, Eukaryota |
GeneTreei | ENSGT00390000002403 |
InParanoidi | P61015 |
OMAi | MEVPQQA |
Family and domain databases
InterProi | View protein in InterPro IPR005984, PLB |
PANTHERi | PTHR21194, PTHR21194, 1 hit |
Pfami | View protein in Pfam PF04272, Phospholamban, 1 hit |
PIRSFi | PIRSF001665, PLB, 1 hit |
TIGRFAMsi | TIGR01294, P_lamban, 1 hit |
i Sequence
Sequence statusi: Complete.
P61015-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKVQYLTRS AIRRASTIEM PQQARQNLQN LFINFCLILI CLLLICIIVM
LL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63600 Genomic DNA No translation available. M63601 Genomic DNA Translation: AAA31445.1 Y00761 mRNA Translation: CAA68730.1 |
PIRi | B40424 |
RefSeqi | NP_001076090.1, NM_001082621.2 |
Genome annotation databases
Ensembli | ENSOCUT00000013855; ENSOCUP00000011917; ENSOCUG00000013865 |
GeneIDi | 100009299 |
KEGGi | ocu:100009299 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63600 Genomic DNA No translation available. M63601 Genomic DNA Translation: AAA31445.1 Y00761 mRNA Translation: CAA68730.1 |
PIRi | B40424 |
RefSeqi | NP_001076090.1, NM_001082621.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1N7L | NMR | - | A | 1-52 | [»] | |
1XNU | model | - | A/B/C/D/E | 1-52 | [»] | |
2KB7 | Other | - | P | 1-52 | [»] | |
2KYV | Other | - | A/B/C/D/E | 1-52 | [»] | |
2LPF | NMR | - | A | 1-52 | [»] | |
2M3B | Other | - | A/B/C/D/E | 1-52 | [»] | |
BMRBi | P61015 | |||||
SMRi | P61015 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-31022N |
IntActi | P61015, 6 interactors |
STRINGi | 9986.ENSOCUP00000011917 |
PTM databases
iPTMneti | P61015 |
Genome annotation databases
Ensembli | ENSOCUT00000013855; ENSOCUP00000011917; ENSOCUG00000013865 |
GeneIDi | 100009299 |
KEGGi | ocu:100009299 |
Organism-specific databases
CTDi | 5350 |
Phylogenomic databases
eggNOGi | ENOG502S97F, Eukaryota |
GeneTreei | ENSGT00390000002403 |
InParanoidi | P61015 |
OMAi | MEVPQQA |
Miscellaneous databases
EvolutionaryTracei | P61015 |
Gene expression databases
ExpressionAtlasi | P61015, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR005984, PLB |
PANTHERi | PTHR21194, PTHR21194, 1 hit |
Pfami | View protein in Pfam PF04272, Phospholamban, 1 hit |
PIRSFi | PIRSF001665, PLB, 1 hit |
TIGRFAMsi | TIGR01294, P_lamban, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPLA_RABIT | |
Accessioni | P61015Primary (citable) accession number: P61015 Secondary accession number(s): P20006 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | April 26, 2004 | |
Last modified: | February 10, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families