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Protein

Kappa-theraphotoxin-Sc1a

Gene
N/A
Organism
Stromatopelma calceatum (Featherleg baboon tarantula) (Scodra calceata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC50 is 12.7 nM), Kv2.1/Kv9.3 (IC50 is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC50 is 21.4 nM), and transient Kv4.2/KCND2 (IC50 is 1.2 nM) channels.1 Publication

Miscellaneous

This toxin does not have effect on Kv4.1/KCND1 and Kv4.3/KCND3. Intracerebroventricular injection into mice does not induce observable neurotoxicity symptoms (PubMed:12065754).1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-theraphotoxin-Sc1a
Short name:
Kappa-TRTX-Sc1a
Alternative name(s):
Stromatoxin-11 Publication
Short name:
ScTx11 Publication
OrganismiStromatopelma calceatum (Featherleg baboon tarantula) (Scodra calceata)
Taxonomic identifieri269628 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeTheraphosidaeStromatopelma

Organism-specific databases

ArachnoServeriAS000228 kappa-theraphotoxin-Sc1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000450251 – 34Kappa-theraphotoxin-Sc1aAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 16By similarity
Disulfide bondi9 ↔ 21By similarity
Disulfide bondi15 ↔ 28By similarity
Modified residuei34Isoleucine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP60991
SMRiP60991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR011696 Huwentoxin-1
PfamiView protein in Pfam
PF07740 Toxin_12, 1 hit

Sequencei

Sequence statusi: Complete.

P60991-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
DCTRMFGACR RDSDCCPHLG CKPTSKYCAW DGTI
Length:34
Mass (Da):3,798
Last modified:April 26, 2004 - v1
Checksum:i20C682CC0CDA14CE
GO

Mass spectrometryi

Molecular mass is 3788.62 Da from positions 1 - 34. Determined by MALDI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ProteinModelPortaliP60991
SMRiP60991
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000228 kappa-theraphotoxin-Sc1a

Family and domain databases

InterProiView protein in InterPro
IPR011696 Huwentoxin-1
PfamiView protein in Pfam
PF07740 Toxin_12, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTX1_STRCF
AccessioniPrimary (citable) accession number: P60991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: June 20, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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