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Protein

Keratinocyte differentiation-associated protein

Gene

KRTDAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • epidermis development Source: GO_Central

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte differentiation-associated protein
Gene namesi
Name:KRTDAP
Synonyms:KDAP
ORF Names:UNQ467/PRO826
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188508.10
HGNCiHGNC:16313 KRTDAP
neXtProtiNX_P60985

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188508
PharmGKBiPA30236

Polymorphism and mutation databases

BioMutaiKRTDAP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002260923 – 99Keratinocyte differentiation-associated proteinAdd BLAST77

Proteomic databases

PaxDbiP60985
PeptideAtlasiP60985
PRIDEiP60985
ProteomicsDBi57243
57244 [P60985-2]

PTM databases

iPTMnetiP60985
PhosphoSitePlusiP60985

Expressioni

Tissue specificityi

Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected in gastrointestinal mucosa.1 Publication

Inductioni

Up-regulated in situ in psoriatic skin (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000188508 Expressed in 102 organ(s), highest expression level in mammalian vulva
CleanExiHS_KRTDAP
GenevisibleiP60985 HS

Organism-specific databases

HPAiHPA063474

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000339251

Structurei

3D structure databases

ProteinModelPortaliP60985
SMRiP60985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2MA Eukaryota
ENOG41118KR LUCA
GeneTreeiENSGT00390000009097
HOGENOMiHOG000113266
HOVERGENiHBG108078
InParanoidiP60985
OMAiEEFLNWH
OrthoDBiEOG091G17JA
PhylomeDBiP60985
TreeFamiTF341267

Family and domain databases

InterProiView protein in InterPro
IPR028196 KRTDAP
PANTHERiPTHR36463 PTHR36463, 1 hit
PfamiView protein in Pfam
PF15200 KRTDAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P60985-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKIPVLPAVV LLSLLVLHSA QGATLGGPEE ESTIENYASR PEAFNTPFLN
60 70 80 90
IDKLRSAFKA DEFLNWHALF ESIKRKLPFL NWDAFPKLKG LRSATPDAQ
Length:99
Mass (Da):11,050
Last modified:April 26, 2004 - v1
Checksum:i0F966EC142C89838
GO
Isoform 2 (identifier: P60985-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-58: Missing.

Show »
Length:85
Mass (Da):9,432
Checksum:iF392074ED0B9773E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03085645 – 58Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359007 mRNA Translation: AAQ89366.1
BC130501 mRNA Translation: AAI30502.1
CCDSiCCDS12462.1 [P60985-1]
CCDS59377.1 [P60985-2]
RefSeqiNP_001231776.1, NM_001244847.1 [P60985-2]
NP_997275.1, NM_207392.2 [P60985-1]
UniGeneiHs.112457

Genome annotation databases

EnsembliENST00000338897; ENSP00000339251; ENSG00000188508 [P60985-1]
ENST00000484218; ENSP00000470713; ENSG00000188508 [P60985-2]
GeneIDi388533
KEGGihsa:388533
UCSCiuc002nzh.4 human [P60985-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359007 mRNA Translation: AAQ89366.1
BC130501 mRNA Translation: AAI30502.1
CCDSiCCDS12462.1 [P60985-1]
CCDS59377.1 [P60985-2]
RefSeqiNP_001231776.1, NM_001244847.1 [P60985-2]
NP_997275.1, NM_207392.2 [P60985-1]
UniGeneiHs.112457

3D structure databases

ProteinModelPortaliP60985
SMRiP60985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000339251

PTM databases

iPTMnetiP60985
PhosphoSitePlusiP60985

Polymorphism and mutation databases

BioMutaiKRTDAP

Proteomic databases

PaxDbiP60985
PeptideAtlasiP60985
PRIDEiP60985
ProteomicsDBi57243
57244 [P60985-2]

Protocols and materials databases

DNASUi388533
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338897; ENSP00000339251; ENSG00000188508 [P60985-1]
ENST00000484218; ENSP00000470713; ENSG00000188508 [P60985-2]
GeneIDi388533
KEGGihsa:388533
UCSCiuc002nzh.4 human [P60985-1]

Organism-specific databases

CTDi388533
EuPathDBiHostDB:ENSG00000188508.10
GeneCardsiKRTDAP
HGNCiHGNC:16313 KRTDAP
HPAiHPA063474
neXtProtiNX_P60985
OpenTargetsiENSG00000188508
PharmGKBiPA30236
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2MA Eukaryota
ENOG41118KR LUCA
GeneTreeiENSGT00390000009097
HOGENOMiHOG000113266
HOVERGENiHBG108078
InParanoidiP60985
OMAiEEFLNWH
OrthoDBiEOG091G17JA
PhylomeDBiP60985
TreeFamiTF341267

Miscellaneous databases

ChiTaRSiKRTDAP human
GeneWikiiKRTDAP
GenomeRNAii388533
PROiPR:P60985

Gene expression databases

BgeeiENSG00000188508 Expressed in 102 organ(s), highest expression level in mammalian vulva
CleanExiHS_KRTDAP
GenevisibleiP60985 HS

Family and domain databases

InterProiView protein in InterPro
IPR028196 KRTDAP
PANTHERiPTHR36463 PTHR36463, 1 hit
PfamiView protein in Pfam
PF15200 KRTDAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKTDAP_HUMAN
AccessioniPrimary (citable) accession number: P60985
Secondary accession number(s): A1L4D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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