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Protein

Glia maturation factor beta

Gene

GMFB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

SignaLinkiP60983
SIGNORiP60983

Names & Taxonomyi

Protein namesi
Recommended name:
Glia maturation factor beta
Short name:
GMF-beta
Gene namesi
Name:GMFB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000197045.12
HGNCiHGNC:4373 GMFB
MIMi601713 gene
neXtProtiNX_P60983

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi2764
OpenTargetsiENSG00000197045
PharmGKBiPA28758

Polymorphism and mutation databases

BioMutaiGMFB
DMDMi46577593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002149432 – 142Glia maturation factor betaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Post-translational modificationi

Phosphorylated; stimulated by phorbol ester.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP60983
MaxQBiP60983
PaxDbiP60983
PeptideAtlasiP60983
PRIDEiP60983
ProteomicsDBi57242
TopDownProteomicsiP60983

2D gel databases

OGPiP17774

PTM databases

iPTMnetiP60983
PhosphoSitePlusiP60983

Expressioni

Gene expression databases

BgeeiENSG00000197045 Expressed in 235 organ(s), highest expression level in inferior vagus X ganglion
CleanExiHS_GMFB
ExpressionAtlasiP60983 baseline and differential
GenevisibleiP60983 HS

Organism-specific databases

HPAiHPA002954

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109026, 16 interactors
IntActiP60983, 1 interactor
STRINGi9606.ENSP00000350757

Structurei

3D structure databases

ProteinModelPortaliP60983
SMRiP60983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 139ADF-HPROSITE-ProRule annotationAdd BLAST136

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1736 Eukaryota
ENOG4111RK6 LUCA
GeneTreeiENSGT00390000008920
HOGENOMiHOG000175654
HOVERGENiHBG003045
InParanoidiP60983
PhylomeDBiP60983
TreeFamiTF315147

Family and domain databases

CDDicd11283 ADF_GMF-beta_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR011171 GMF
PANTHERiPTHR11249 PTHR11249, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PIRSFiPIRSF001788 GMF-beta, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P60983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE
60 70 80 90 100
GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ
110 120 130 140
QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH
Length:142
Mass (Da):16,713
Last modified:January 23, 2007 - v2
Checksum:iCF2D4A8CB1F37B1F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4P8G3V4P8_HUMAN
Glia maturation factor beta
GMFB
150Annotation score:
G3V3X4G3V3X4_HUMAN
Glia maturation factor beta
GMFB
38Annotation score:

Sequence cautioni

The sequence AAH05359 differs from that shown. Reason: Frameshift at position 142.Curated
The sequence AAP35430 differs from that shown. Reason: Frameshift at position 142.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86492 mRNA Translation: AAA58614.1
AB001106 mRNA Translation: BAA19232.1
BT006784 mRNA Translation: AAP35430.1 Frameshift.
CR542113 mRNA Translation: CAG46910.1
AK311753 mRNA Translation: BAG34696.1
CH471061 Genomic DNA Translation: EAW80638.1
BC005359 mRNA Translation: AAH05359.1 Frameshift.
CCDSiCCDS9718.1
PIRiPT0410
RefSeqiNP_004115.1, NM_004124.2
UniGeneiHs.151413

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045
ENST00000616146; ENSP00000479543; ENSG00000197045
GeneIDi2764
KEGGihsa:2764
UCSCiuc021rtf.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86492 mRNA Translation: AAA58614.1
AB001106 mRNA Translation: BAA19232.1
BT006784 mRNA Translation: AAP35430.1 Frameshift.
CR542113 mRNA Translation: CAG46910.1
AK311753 mRNA Translation: BAG34696.1
CH471061 Genomic DNA Translation: EAW80638.1
BC005359 mRNA Translation: AAH05359.1 Frameshift.
CCDSiCCDS9718.1
PIRiPT0410
RefSeqiNP_004115.1, NM_004124.2
UniGeneiHs.151413

3D structure databases

ProteinModelPortaliP60983
SMRiP60983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109026, 16 interactors
IntActiP60983, 1 interactor
STRINGi9606.ENSP00000350757

PTM databases

iPTMnetiP60983
PhosphoSitePlusiP60983

Polymorphism and mutation databases

BioMutaiGMFB
DMDMi46577593

2D gel databases

OGPiP17774

Proteomic databases

EPDiP60983
MaxQBiP60983
PaxDbiP60983
PeptideAtlasiP60983
PRIDEiP60983
ProteomicsDBi57242
TopDownProteomicsiP60983

Protocols and materials databases

DNASUi2764
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358056; ENSP00000350757; ENSG00000197045
ENST00000616146; ENSP00000479543; ENSG00000197045
GeneIDi2764
KEGGihsa:2764
UCSCiuc021rtf.2 human

Organism-specific databases

CTDi2764
DisGeNETi2764
EuPathDBiHostDB:ENSG00000197045.12
GeneCardsiGMFB
HGNCiHGNC:4373 GMFB
HPAiHPA002954
MIMi601713 gene
neXtProtiNX_P60983
OpenTargetsiENSG00000197045
PharmGKBiPA28758
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1736 Eukaryota
ENOG4111RK6 LUCA
GeneTreeiENSGT00390000008920
HOGENOMiHOG000175654
HOVERGENiHBG003045
InParanoidiP60983
PhylomeDBiP60983
TreeFamiTF315147

Enzyme and pathway databases

SignaLinkiP60983
SIGNORiP60983

Miscellaneous databases

ChiTaRSiGMFB human
GenomeRNAii2764
PROiPR:P60983
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197045 Expressed in 235 organ(s), highest expression level in inferior vagus X ganglion
CleanExiHS_GMFB
ExpressionAtlasiP60983 baseline and differential
GenevisibleiP60983 HS

Family and domain databases

CDDicd11283 ADF_GMF-beta_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR011171 GMF
PANTHERiPTHR11249 PTHR11249, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PIRSFiPIRSF001788 GMF-beta, 1 hit
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGMFB_HUMAN
AccessioniPrimary (citable) accession number: P60983
Secondary accession number(s): B2R499, P17774, Q9BS35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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