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Protein

DnaJ homolog subfamily C member 5

Gene

Dnajc5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calcium-mediated control of a late stage of exocytosis (By similarity). May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity).By similarity

GO - Molecular functioni

  • ATP-dependent protein binding Source: RGD

GO - Biological processi

  • chemical synaptic transmission Source: RGD
  • negative regulation of neuron apoptotic process Source: Ensembl

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation
R-RNO-888590 GABA synthesis, release, reuptake and degradation

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 5Curated
Alternative name(s):
Cysteine string protein1 Publication
Short name:
CSP1 Publication
Gene namesi
Name:Dnajc5Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620516 Dnajc5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000710541 – 198DnaJ homolog subfamily C member 5Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1 Publication1
Modified residuei12PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphotyrosineBy similarity1
Modified residuei56N6-acetyllysineBy similarity1
Modified residuei151PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated (PubMed:11931641). Phosphorylation results in a profound decrease in the affinity for syntaxin but has no effect on the affinity for HSC70 (PubMed:11604405, PubMed:11931641). Ser-10 phosphorylation induces an order-to-disorder transition triggering the interaction with Lys-58 (By similarity). This conformational switch modulates DNAJC5's cellular functions by reducing binding to syntaxin and synaptogamin without altering HSC70 interactions (By similarity).By similarity2 Publications
Fatty acylated. Heavily palmitoylated in the cysteine string motif.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP60905
PRIDEiP60905

PTM databases

iPTMnetiP60905
PhosphoSitePlusiP60905
SwissPalmiP60905

Expressioni

Tissue specificityi

Brain. Predominantly associated with nerve endings and synaptic vesicles.

Gene expression databases

BgeeiENSRNOG00000015202 Expressed in 10 organ(s), highest expression level in brain
ExpressionAtlasiP60905 baseline and differential
GenevisibleiP60905 RN

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with the chaperone complex consisting of HSC70 and SGTA (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:25253725). Interacts with SYT1, SYT5 and SYT7, and with SYT9, forming a complex with SNAP25 (By similarity). Interacts with SYT1 in a phosphorylation-dependent manner (PubMed:11931641).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249414, 1 interactor
CORUMiP60905
STRINGi10116.ENSRNOP00000020581

Structurei

3D structure databases

ProteinModelPortaliP60905
SMRiP60905
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 82JPROSITE-ProRule annotationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 128Poly-CysAdd BLAST11

Phylogenomic databases

eggNOGiKOG0716 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00920000148989
HOGENOMiHOG000231969
HOVERGENiHBG005414
InParanoidiP60905
KOiK09525
OMAiGHYSYHT
OrthoDBiEOG091G0QJP
PhylomeDBiP60905
TreeFamiTF105164

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P60905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN
60 70 80 90 100
PEAADKFKEI NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV
110 120 130 140 150
LSSWWAKALF VVCGLLTCCY CCCCLCCCFN CCCGKCKPKA PEGEETEFYV
160 170 180 190
SPEDLEAQLQ SDEREATDTP IVIQPASATE TTQLTADSHP SYHTDGFN
Length:198
Mass (Da):22,101
Last modified:April 13, 2004 - v1
Checksum:i52F98261FBAD978F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JX56A0A0G2JX56_RAT
DnaJ (Hsp40) homolog, subfamily C, ...
Dnajc5 rCG_38517
167Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39320 mRNA Translation: AAA81372.1
S81917 mRNA Translation: AAB36303.1
AF323955 mRNA Translation: AAL04453.1
PIRiI52655
RefSeqiNP_077075.1, NM_024161.2
XP_008760766.1, XM_008762544.2
XP_008760767.1, XM_008762545.2
UniGeneiRn.100120

Genome annotation databases

EnsembliENSRNOT00000020581; ENSRNOP00000020581; ENSRNOG00000015202
GeneIDi79130
KEGGirno:79130
UCSCiRGD:620516 rat

Similar proteinsi

Entry informationi

Entry nameiDNJC5_RAT
AccessioniPrimary (citable) accession number: P60905
Secondary accession number(s): P54101
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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