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UniProtKB - P60903 (S10AA_HUMAN)
Protein
Protein S100-A10
Gene
S100A10
Organism
Homo sapiens (Human)
Status
Functioni
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Miscellaneous
Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
- transmembrane transporter binding Source: UniProtKB
GO - Biological processi
- membrane raft assembly Source: UniProtKB
- mRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of binding Source: Ensembl
- positive regulation of exocytosis Source: ComplexPortal
- positive regulation of focal adhesion assembly Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of plasma membrane repair Source: ComplexPortal
- positive regulation of plasminogen activation Source: ComplexPortal
- positive regulation of stress fiber assembly Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein localization to plasma membrane Source: UniProtKB
- regulation of neurogenesis Source: Ensembl
- vesicle budding from membrane Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P60903 |
Reactomei | R-HSA-75205, Dissolution of Fibrin Clot |
SignaLinki | P60903 |
SIGNORi | P60903 |
Protein family/group databases
TCDBi | 8.A.81.1.2, the s100 calcium-binding protein (s100) family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A10Alternative name(s): Calpactin I light chain Calpactin-1 light chain Cellular ligand of annexin II S100 calcium-binding protein A10 p10 protein p11 |
Gene namesi | Name:S100A10 Synonyms:ANX2LG, CAL1L, CLP11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10487, S100A10 |
MIMi | 114085, gene |
neXtProti | NX_P60903 |
VEuPathDBi | HostDB:ENSG00000197747 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
- extracellular space Source: GO_Central
Nucleus
- nuclear matrix Source: ComplexPortal
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Plasma Membrane
- extrinsic component of plasma membrane Source: Ensembl
- plasma membrane Source: ComplexPortal
- plasma membrane protein complex Source: ComplexPortal
Other locations
- AnxA2-p11 complex Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- cytoplasm Source: GO_Central
- membrane Source: ComplexPortal
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6281 |
OpenTargetsi | ENSG00000197747 |
PharmGKBi | PA34899 |
Miscellaneous databases
Pharosi | P60903, Tbio |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | S100A10 |
DMDMi | 46397706 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000144002 | 1 – 97 | Protein S100-A10Add BLAST | 97 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 23 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 28 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 37 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 37 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 54 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 57 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P60903 |
jPOSTi | P60903 |
MassIVEi | P60903 |
MaxQBi | P60903 |
PaxDbi | P60903 |
PeptideAtlasi | P60903 |
PRIDEi | P60903 |
ProteomicsDBi | 57237 |
TopDownProteomicsi | P60903 |
2D gel databases
SWISS-2DPAGEi | P60903 |
PTM databases
GlyGeni | P60903, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P60903 |
MetOSitei | P60903 |
PhosphoSitePlusi | P60903 |
SwissPalmi | P60903 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197747, Expressed in layer of synovial tissue and 248 other tissues |
Genevisiblei | P60903, HS |
Organism-specific databases
HPAi | ENSG00000197747, Tissue enhanced (esophagus) |
Interactioni
Subunit structurei
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36 (PubMed:9886297).
Interacts with SCN10A (By similarity).
Interacts with TASOR (By similarity).
By similarity1 PublicationBinary interactionsi
P60903
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
- transmembrane transporter binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112189, 103 interactors |
ComplexPortali | CPX-850, AHNAK - Annexin A2 - S100-A10 complex CPX-853, Annexin A2 - S100-A10 complex CPX-856, SMARCA3 - Annexin A2 - S100-A10 complex |
IntActi | P60903, 55 interactors |
MINTi | P60903 |
STRINGi | 9606.ENSP00000357801 |
Miscellaneous databases
RNActi | P60903, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P60903 |
SMRi | P60903 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P60903 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 60 – 71 | Ancestral calcium siteAdd BLAST | 12 |
Sequence similaritiesi
Belongs to the S-100 family.Curated
Phylogenomic databases
eggNOGi | ENOG502S6TB, Eukaryota |
GeneTreei | ENSGT00940000154197 |
HOGENOMi | CLU_138624_2_1_1 |
InParanoidi | P60903 |
OMAi | SEMEHAP |
OrthoDBi | 1508691at2759 |
PhylomeDBi | P60903 |
TreeFami | TF332727 |
Family and domain databases
CDDi | cd05024, S-100A10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR028476, S100-A10 IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub |
PANTHERi | PTHR11639:SF74, PTHR11639:SF74, 1 hit |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00303, S100_CABP, 1 hit |
i Sequence
Sequence statusi: Complete.
P60903-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81457 mRNA Translation: AAA58404.1 M38591 mRNA Translation: AAA58426.1 M77483 Genomic DNA No translation available. AK291073 mRNA Translation: BAF83762.1 AL450992 Genomic DNA No translation available. BC015973 mRNA Translation: AAH15973.1 BC105786 mRNA Translation: AAI05787.1 |
CCDSi | CCDS1008.1 |
PIRi | JC1139 |
RefSeqi | NP_002957.1, NM_002966.2 |
Genome annotation databases
Ensembli | ENST00000368809.1; ENSP00000357799.1; ENSG00000197747.9 ENST00000368811.8; ENSP00000357801.3; ENSG00000197747.9 |
GeneIDi | 6281 |
KEGGi | hsa:6281 |
MANE-Selecti | ENST00000368811.8; ENSP00000357801.3; NM_002966.3; NP_002957.1 |
UCSCi | uc001ezl.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81457 mRNA Translation: AAA58404.1 M38591 mRNA Translation: AAA58426.1 M77483 Genomic DNA No translation available. AK291073 mRNA Translation: BAF83762.1 AL450992 Genomic DNA No translation available. BC015973 mRNA Translation: AAH15973.1 BC105786 mRNA Translation: AAI05787.1 |
CCDSi | CCDS1008.1 |
PIRi | JC1139 |
RefSeqi | NP_002957.1, NM_002966.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A4P | X-ray | 2.25 | A/B | 2-97 | [»] | |
1BT6 | X-ray | 2.40 | A/B | 2-97 | [»] | |
4DRW | X-ray | 3.50 | A/B/C/D | 1-93 | [»] | |
4FTG | X-ray | 2.51 | A/B | 2-97 | [»] | |
4HRE | X-ray | 2.79 | E/F/I/J | 2-97 | [»] | |
4HRG | X-ray | 2.00 | A/B | 1-93 | [»] | |
4HRH | X-ray | 3.00 | A/B | 1-93 | [»] | |
AlphaFoldDBi | P60903 | |||||
SMRi | P60903 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112189, 103 interactors |
ComplexPortali | CPX-850, AHNAK - Annexin A2 - S100-A10 complex CPX-853, Annexin A2 - S100-A10 complex CPX-856, SMARCA3 - Annexin A2 - S100-A10 complex |
IntActi | P60903, 55 interactors |
MINTi | P60903 |
STRINGi | 9606.ENSP00000357801 |
Chemistry databases
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Protein family/group databases
TCDBi | 8.A.81.1.2, the s100 calcium-binding protein (s100) family |
PTM databases
GlyGeni | P60903, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P60903 |
MetOSitei | P60903 |
PhosphoSitePlusi | P60903 |
SwissPalmi | P60903 |
Genetic variation databases
BioMutai | S100A10 |
DMDMi | 46397706 |
2D gel databases
SWISS-2DPAGEi | P60903 |
Proteomic databases
EPDi | P60903 |
jPOSTi | P60903 |
MassIVEi | P60903 |
MaxQBi | P60903 |
PaxDbi | P60903 |
PeptideAtlasi | P60903 |
PRIDEi | P60903 |
ProteomicsDBi | 57237 |
TopDownProteomicsi | P60903 |
Protocols and materials databases
Antibodypediai | 1093, 509 antibodies from 39 providers |
DNASUi | 6281 |
Genome annotation databases
Ensembli | ENST00000368809.1; ENSP00000357799.1; ENSG00000197747.9 ENST00000368811.8; ENSP00000357801.3; ENSG00000197747.9 |
GeneIDi | 6281 |
KEGGi | hsa:6281 |
MANE-Selecti | ENST00000368811.8; ENSP00000357801.3; NM_002966.3; NP_002957.1 |
UCSCi | uc001ezl.4, human |
Organism-specific databases
CTDi | 6281 |
DisGeNETi | 6281 |
GeneCardsi | S100A10 |
HGNCi | HGNC:10487, S100A10 |
HPAi | ENSG00000197747, Tissue enhanced (esophagus) |
MIMi | 114085, gene |
neXtProti | NX_P60903 |
OpenTargetsi | ENSG00000197747 |
PharmGKBi | PA34899 |
VEuPathDBi | HostDB:ENSG00000197747 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6TB, Eukaryota |
GeneTreei | ENSGT00940000154197 |
HOGENOMi | CLU_138624_2_1_1 |
InParanoidi | P60903 |
OMAi | SEMEHAP |
OrthoDBi | 1508691at2759 |
PhylomeDBi | P60903 |
TreeFami | TF332727 |
Enzyme and pathway databases
PathwayCommonsi | P60903 |
Reactomei | R-HSA-75205, Dissolution of Fibrin Clot |
SignaLinki | P60903 |
SIGNORi | P60903 |
Miscellaneous databases
BioGRID-ORCSi | 6281, 20 hits in 1070 CRISPR screens |
ChiTaRSi | S100A10, human |
EvolutionaryTracei | P60903 |
GeneWikii | S100A10 |
GenomeRNAii | 6281 |
Pharosi | P60903, Tbio |
PROi | PR:P60903 |
RNActi | P60903, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197747, Expressed in layer of synovial tissue and 248 other tissues |
Genevisiblei | P60903, HS |
Family and domain databases
CDDi | cd05024, S-100A10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR028476, S100-A10 IPR001751, S100/CaBP7/8-like_CS IPR013787, S100_Ca-bd_sub |
PANTHERi | PTHR11639:SF74, PTHR11639:SF74, 1 hit |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00303, S100_CABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S10AA_HUMAN | |
Accessioni | P60903Primary (citable) accession number: P60903 Secondary accession number(s): A8K4V8, P08206, Q5T1C5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families