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Protein

Protein S100-A10

Gene

S100A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • ion channel binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • membrane raft assembly Source: UniProtKB
  • positive regulation of binding Source: Ensembl
  • positive regulation of focal adhesion assembly Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • protein heterotetramerization Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • response to drug Source: Ensembl
  • vesicle budding from membrane Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-75205 Dissolution of Fibrin Clot
SIGNORiP60903

Protein family/group databases

TCDBi8.A.81.1.2 the s100 calcium-binding protein (s100) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100A10
Synonyms:ANX2LG, CAL1L, CLP11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197747.8
HGNCiHGNC:10487 S100A10
MIMi114085 gene
neXtProtiNX_P60903

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6281
OpenTargetsiENSG00000197747
PharmGKBiPA34899

Polymorphism and mutation databases

BioMutaiS100A10
DMDMi46397706

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440021 – 97Protein S100-A10Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei28N6-acetyllysineCombined sources1
Modified residuei37N6-acetyllysine; alternateCombined sources1
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei54N6-acetyllysineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP60903
MaxQBiP60903
PaxDbiP60903
PeptideAtlasiP60903
PRIDEiP60903
ProteomicsDBi57237
TopDownProteomicsiP60903

2D gel databases

SWISS-2DPAGEiP60903

PTM databases

iPTMnetiP60903
PhosphoSitePlusiP60903
SwissPalmiP60903

Expressioni

Gene expression databases

BgeeiENSG00000197747
CleanExiHS_S100A10
GenevisibleiP60903 HS

Organism-specific databases

HPAiCAB025484
HPA003340

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112189, 52 interactors
ComplexPortaliCPX-850 AHNAK - Annexin A2 - S100-A10 complex
CPX-853 Annexin A2 - S100-A10 complex
CPX-856 SMARCA3 - Annexin A2 - S100-A10 complex
IntActiP60903, 24 interactors
MINTiP60903
STRINGi9606.ENSP00000357799

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Helixi21 – 23Combined sources3
Beta strandi24 – 26Combined sources3
Helixi28 – 38Combined sources11
Helixi42 – 45Combined sources4
Helixi51 – 57Combined sources7
Beta strandi59 – 61Combined sources3
Beta strandi63 – 65Combined sources3
Helixi69 – 90Combined sources22

3D structure databases

ProteinModelPortaliP60903
SMRiP60903
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60903

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiENOG410IXW9 Eukaryota
ENOG410YSSI LUCA
GeneTreeiENSGT00760000119034
HOVERGENiHBG001479
InParanoidiP60903
KOiK17274
OMAiIACEQCY
OrthoDBiEOG091G10QT
PhylomeDBiP60903
TreeFamiTF332727

Family and domain databases

CDDicd05024 S-100A10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P60903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK
Length:97
Mass (Da):11,203
Last modified:January 23, 2007 - v2
Checksum:i3E8E03A6E7DD7A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81457 mRNA Translation: AAA58404.1
M38591 mRNA Translation: AAA58426.1
M77483 Genomic DNA No translation available.
AK291073 mRNA Translation: BAF83762.1
AL450992 Genomic DNA No translation available.
BC015973 mRNA Translation: AAH15973.1
BC105786 mRNA Translation: AAI05787.1
CCDSiCCDS1008.1
PIRiJC1139
RefSeqiNP_002957.1, NM_002966.2
UniGeneiHs.143873

Genome annotation databases

EnsembliENST00000368809; ENSP00000357799; ENSG00000197747
ENST00000368811; ENSP00000357801; ENSG00000197747
GeneIDi6281
KEGGihsa:6281
UCSCiuc001ezl.4 human

Similar proteinsi

Entry informationi

Entry nameiS10AA_HUMAN
AccessioniPrimary (citable) accession number: P60903
Secondary accession number(s): A8K4V8, P08206, Q5T1C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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