S100A10

Functionⁱ

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functionⁱ

calcium ion binding Source: InterPro
ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12198146
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23091277

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

membrane raft assembly
Source: UniProtKB
Inferred from direct assayⁱ
- 23861394
positive regulation of binding Source: Ensembl
positive regulation of focal adhesion assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23129259
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23129259
positive regulation of stress fiber assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23129259
positive regulation of substrate adhesion-dependent cell spreading
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23129259
protein heterotetramerization
Source: UniProtKB
Inferred from direct assayⁱ
- 23091277
- 23861394
protein localization to plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 12198146
vesicle budding from membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 23861394

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-75205 Dissolution of Fibrin Clot
SIGNORⁱ	P60903

Protein family/group databases

TCDBⁱ	8.A.81.1.2 the s100 calcium-binding protein (s100) family

TCDBⁱ

8.A.81.1.2 the s100 calcium-binding protein (s100) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein S100-A10 Alternative name(s): Calpactin I light chain Calpactin-1 light chain Cellular ligand of annexin II S100 calcium-binding protein A10 p10 protein p11
Gene namesⁱ	Name:S100A10 Synonyms:ANX2LG, CAL1L, CLP11
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197747.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10487 S100A10
MIMⁱ	114085 gene
neXtProtⁱ	NX_P60903

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6281
Open Targets More...OpenTargetsⁱ	ENSG00000197747
PharmGKBⁱ	PA34899

Polymorphism and mutation databases

BioMutaⁱ	S100A10
DMDMⁱ	46397706

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144002	1 – 97	Protein S100-A10Add BLAST		97

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	23	N6-acetyllysineCombined sources	1
Modified residueⁱ	28	N6-acetyllysineCombined sources	1
Modified residueⁱ	37	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	37	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	54	N6-acetyllysineCombined sources	1
Modified residueⁱ	57	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P60903
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P60903
PaxDbⁱ	P60903
PeptideAtlas More...PeptideAtlasⁱ	P60903
PRIDEⁱ	P60903
ProteomicsDBⁱ	57237
TopDownProteomicsⁱ	P60903

2D gel databases

SWISS-2DPAGEⁱ	P60903

SWISS-2DPAGEⁱ

P60903

PTM databases

iPTMnetⁱ	P60903
PhosphoSitePlusⁱ	P60903
SwissPalmⁱ	P60903

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197747 Expressed in 236 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_S100A10
Genevisibleⁱ	P60903 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025484 HPA003340

HPAⁱ

CAB025484
HPA003340

Interactionⁱ

Subunit structureⁱ

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ANG	P03950	8	EBI-717048,EBI-525291
CCR10	P46092	5	EBI-717048,EBI-348022
HLTF	Q14527	2	EBI-717048,EBI-1045161
S100Z	Q8WXG8	4	EBI-717048,EBI-12198403

GO - Molecular functionⁱ

ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12198146
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23091277

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112189, 52 interactors
ComplexPortalⁱ	CPX-850 AHNAK - Annexin A2 - S100-A10 complex CPX-853 Annexin A2 - S100-A10 complex CPX-856 SMARCA3 - Annexin A2 - S100-A10 complex
IntActⁱ	P60903, 24 interactors
Molecular INTeraction database More...MINTⁱ	P60903
STRINGⁱ	9606.ENSP00000357799

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 20	Combined sources	17
Helixⁱ	21 – 23	Combined sources	3
Beta strandⁱ	24 – 26	Combined sources	3
Helixⁱ	28 – 38	Combined sources	11
Helixⁱ	42 – 45	Combined sources	4
Helixⁱ	51 – 57	Combined sources	7
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	63 – 65	Combined sources	3
Helixⁱ	69 – 90	Combined sources	22

Show more details

3D structure databases

ProteinModelPortalⁱ	P60903
SMRⁱ	P60903
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P60903

EvolutionaryTraceⁱ

P60903

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	60 – 71	Ancestral calcium siteAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IXW9 Eukaryota ENOG410YSSI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119034
HOVERGENⁱ	HBG001479
InParanoidⁱ	P60903
KEGG Orthology (KO) More...KOⁱ	K17274
OMAⁱ	AMETLMF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G10QT
PhylomeDBⁱ	P60903
TreeFamⁱ	TF332727

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd05024 S-100A10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR028476 S100-A10 IPR001751 S100/CaBP-9k_CS IPR013787 S100_Ca-bd_sub
PANTHERⁱ	PTHR11639:SF74 PTHR11639:SF74, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01023 S_100, 1 hit
SMARTⁱ	View protein in SMART SM01394 S_100, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00303 S100_CABP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P60903-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL 
        60         70         80         90 
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK

Length:97

Mass (Da):11,203

Last modified:January 23, 2007 - v2

Checksum:ⁱ3E8E03A6E7DD7A8D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81457 mRNA Translation: AAA58404.1 M38591 mRNA Translation: AAA58426.1 M77483 Genomic DNA No translation available. AK291073 mRNA Translation: BAF83762.1 AL450992 Genomic DNA No translation available. BC015973 mRNA Translation: AAH15973.1 BC105786 mRNA Translation: AAI05787.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1008.1
PIRⁱ	JC1139
NCBI Reference Sequences More...RefSeqⁱ	NP_002957.1, NM_002966.2
UniGeneⁱ	Hs.143873

Genome annotation databases

Ensemblⁱ	ENST00000368809; ENSP00000357799; ENSG00000197747 ENST00000368811; ENSP00000357801; ENSG00000197747
GeneIDⁱ	6281
KEGGⁱ	hsa:6281
UCSC genome browser More...UCSCⁱ	uc001ezl.4 human

Protein	Similar proteins		Species	Score	Length	Source
P60903	Protein S100-A10		BOVIN		97	UniRef100_P60903
Protein S100-A10		MACMU		97
Protein S100-A10		RABIT		97
Protein S100-A10		PIG		96
Uncharacterized protein		PONAB		222
+30

Protein	Similar proteins		Species	Score	Length	Source
P60903	Protein S100-A10		BOVIN		97	UniRef90_P60903
Protein S100-A10		MACMU		97
Protein S100-A10		RABIT		97
Protein S100-A10		PIG		96
Uncharacterized protein		PONAB		222
+31

Protein	Similar proteins		Species	Score	Length	Source
P60903	Protein S100-A10		BOVIN		97	UniRef50_P60903
Protein S100-A10		MACMU		97
Protein S100-A10		RABIT		97
Protein S100-A10		PIG		96
Uncharacterized protein		PONAB		222
+35

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M81457 mRNA Translation: AAA58404.1 M38591 mRNA Translation: AAA58426.1 M77483 Genomic DNA No translation available. AK291073 mRNA Translation: BAF83762.1 AL450992 Genomic DNA No translation available. BC015973 mRNA Translation: AAH15973.1 BC105786 mRNA Translation: AAI05787.1
CCDSⁱ	CCDS1008.1
PIRⁱ	JC1139
RefSeqⁱ	NP_002957.1, NM_002966.2
UniGeneⁱ	Hs.143873

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A4P	X-ray	2.25	A/B	2-97	[»]
	1BT6	X-ray	2.40	A/B	2-97	[»]
	4DRW	X-ray	3.50	A/B/C/D	1-93	[»]
	4FTG	X-ray	2.51	A/B	2-97	[»]
	4HRE	X-ray	2.79	E/F/I/J	2-97	[»]
	4HRG	X-ray	2.00	A/B	1-93	[»]
	4HRH	X-ray	3.00	A/B	1-93	[»]
ProteinModelPortalⁱ	P60903
SMRⁱ	P60903
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112189, 52 interactors
ComplexPortalⁱ	CPX-850 AHNAK - Annexin A2 - S100-A10 complex CPX-853 Annexin A2 - S100-A10 complex CPX-856 SMARCA3 - Annexin A2 - S100-A10 complex
IntActⁱ	P60903, 24 interactors
MINTⁱ	P60903
STRINGⁱ	9606.ENSP00000357799

Protein family/group databases

TCDBⁱ	8.A.81.1.2 the s100 calcium-binding protein (s100) family

TCDBⁱ

8.A.81.1.2 the s100 calcium-binding protein (s100) family

PTM databases

iPTMnetⁱ	P60903
PhosphoSitePlusⁱ	P60903
SwissPalmⁱ	P60903

Polymorphism and mutation databases

BioMutaⁱ	S100A10
DMDMⁱ	46397706

2D gel databases

SWISS-2DPAGEⁱ	P60903

SWISS-2DPAGEⁱ

P60903

Proteomic databases

EPDⁱ	P60903
MaxQBⁱ	P60903
PaxDbⁱ	P60903
PeptideAtlasⁱ	P60903
PRIDEⁱ	P60903
ProteomicsDBⁱ	57237
TopDownProteomicsⁱ	P60903

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6281
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368809; ENSP00000357799; ENSG00000197747 ENST00000368811; ENSP00000357801; ENSG00000197747
GeneIDⁱ	6281
KEGGⁱ	hsa:6281
UCSCⁱ	uc001ezl.4 human

Organism-specific databases

CTDⁱ	6281
DisGeNETⁱ	6281
EuPathDBⁱ	HostDB:ENSG00000197747.8
GeneCardsⁱ	S100A10
HGNCⁱ	HGNC:10487 S100A10
HPAⁱ	CAB025484 HPA003340
MIMⁱ	114085 gene
neXtProtⁱ	NX_P60903
OpenTargetsⁱ	ENSG00000197747
PharmGKBⁱ	PA34899
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXW9 Eukaryota ENOG410YSSI LUCA
GeneTreeⁱ	ENSGT00760000119034
HOVERGENⁱ	HBG001479
InParanoidⁱ	P60903
KOⁱ	K17274
OMAⁱ	AMETLMF
OrthoDBⁱ	EOG091G10QT
PhylomeDBⁱ	P60903
TreeFamⁱ	TF332727

Enzyme and pathway databases

Reactomeⁱ	R-HSA-75205 Dissolution of Fibrin Clot
SIGNORⁱ	P60903

Miscellaneous databases

ChiTaRSⁱ	S100A10 human
EvolutionaryTraceⁱ	P60903
GeneWikiⁱ	S100A10
GenomeRNAiⁱ	6281
Protein Ontology More...PROⁱ	PR:P60903
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197747 Expressed in 236 organ(s), highest expression level in layer of synovial tissue
CleanExⁱ	HS_S100A10
Genevisibleⁱ	P60903 HS

Family and domain databases

CDDⁱ	cd05024 S-100A10, 1 hit
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR028476 S100-A10 IPR001751 S100/CaBP-9k_CS IPR013787 S100_Ca-bd_sub
PANTHERⁱ	PTHR11639:SF74 PTHR11639:SF74, 1 hit
Pfamⁱ	View protein in Pfam PF01023 S_100, 1 hit
SMARTⁱ	View protein in SMART SM01394 S_100, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00303 S100_CABP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S10AA_HUMAN
Accessionⁱ	P60903Primary (citable) accession number: P60903 Secondary accession number(s): A8K4V8, P08206, Q5T1C5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P60903 (S10AA_HUMAN)

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Protein S100-A10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ