Protein S100-A10

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: InterPro
• ion channel binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1."
    Girard C., Tinel N., Terrenoire C., Romey G., Lazdunski M., Borsotto M.
    EMBO J. 21:4439-4448(2002) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "N-terminal acetylation of annexin A2 is required for S100A10 binding."
    Nazmi A.R., Ozorowski G., Pejic M., Whitelegge J.P., Gerke V., Luecke H.
    Biol. Chem. 393:1141-1150(2012) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• membrane raft assembly Source: UniProtKBInferred from direct assayⁱ
  • "Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2."
    Drucker P., Pejic M., Galla H.J., Gerke V.
    J. Biol. Chem. 288:24764-24776(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of binding Source: Ensembl
• positive regulation of focal adhesion assembly Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "S100A10 is required for the organization of actin stress fibers and promotion of cell spreading."
    Sayeed S., Asano E., Ito S., Ohno K., Hamaguchi M., Senga T.
    Mol. Cell. Biochem. 374:105-111(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "S100A10 is required for the organization of actin stress fibers and promotion of cell spreading."
    Sayeed S., Asano E., Ito S., Ohno K., Hamaguchi M., Senga T.
    Mol. Cell. Biochem. 374:105-111(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stress fiber assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "S100A10 is required for the organization of actin stress fibers and promotion of cell spreading."
    Sayeed S., Asano E., Ito S., Ohno K., Hamaguchi M., Senga T.
    Mol. Cell. Biochem. 374:105-111(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKBInferred from mutant phenotypeⁱ
  • "S100A10 is required for the organization of actin stress fibers and promotion of cell spreading."
    Sayeed S., Asano E., Ito S., Ohno K., Hamaguchi M., Senga T.
    Mol. Cell. Biochem. 374:105-111(2013) [PubMed] [Europe PMC] [Abstract]
• protein localization to plasma membrane Source: UniProtKBInferred from direct assayⁱ
  • "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1."
    Girard C., Tinel N., Terrenoire C., Romey G., Lazdunski M., Borsotto M.
    EMBO J. 21:4439-4448(2002) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: Ensembl
• vesicle budding from membrane Source: UniProtKBInferred from direct assayⁱ
  • "Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2."
    Drucker P., Pejic M., Galla H.J., Gerke V.
    J. Biol. Chem. 288:24764-24776(2013) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

        10         20         30         40         50
MPSQMEHAME TMMFTFHKFA GDKGYLTKED LRVLMEKEFP GFLENQKDPL 
        60         70         80         90 
AVDKIMKDLD QCRDGKVGFQ SFFSLIAGLT IACNDYFVVH MKQKGKK