UniProtKB - P60893 (GPR85_HUMAN)
Protein
Probable G-protein coupled receptor 85
Gene
GPR85
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P60893 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 85Alternative name(s): Super conserved receptor expressed in brain 2 |
Gene namesi | Name:GPR85 Synonyms:SREB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164604.12 |
HGNCi | HGNC:4536, GPR85 |
MIMi | 605188, gene |
neXtProti | NX_P60893 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Plasma Membrane
- plasma membrane Source: LIFEdb
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 57 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 96 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 97 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 118 – 137 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 138 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 188 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 189 – 209 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 286 | CytoplasmicSequence analysisAdd BLAST | 77 | |
Transmembranei | 287 – 307 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 308 – 313 | ExtracellularSequence analysis | 6 | |
Transmembranei | 314 – 334 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 335 – 370 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54329 |
OpenTargetsi | ENSG00000164604 |
PharmGKBi | PA28929 |
Miscellaneous databases
Pharosi | P60893, Tbio |
Polymorphism and mutation databases
BioMutai | GPR85 |
DMDMi | 46397442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069591 | 1 – 370 | Probable G-protein coupled receptor 85Add BLAST | 370 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 94 ↔ 172 | PROSITE-ProRule annotation | ||
Glycosylationi | 182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P60893 |
PRIDEi | P60893 |
ProteomicsDBi | 57234 |
PTM databases
GlyGeni | P60893, 3 sites |
iPTMneti | P60893 |
PhosphoSitePlusi | P60893 |
Expressioni
Tissue specificityi
Highly expressed in brain and testis. Lower levels in small intestine, placenta and spleen. In brain regions, detected in all regions tested, but somewhat lower levels in the corpus callosum, medulla and spinal cord.2 Publications
Gene expression databases
Bgeei | ENSG00000164604, Expressed in cortical plate and 151 other tissues |
ExpressionAtlasi | P60893, baseline and differential |
Genevisiblei | P60893, HS |
Organism-specific databases
HPAi | ENSG00000164604, Group enriched (brain, skeletal muscle) |
Interactioni
Subunit structurei
Interacts with DLG4 AND DLG3.
1 PublicationProtein-protein interaction databases
BioGRIDi | 119932, 2 interactors |
IntActi | P60893, 1 interactor |
STRINGi | 9606.ENSP00000297146 |
Miscellaneous databases
RNActi | P60893, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00890000139436 |
HOGENOMi | CLU_055518_0_0_1 |
InParanoidi | P60893 |
OMAi | PSMANYS |
OrthoDBi | 1311948at2759 |
PhylomeDBi | P60893 |
TreeFami | TF331163 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P60893-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT
60 70 80 90 100
LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL
110 120 130 140 150
GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV
160 170 180 190 200
AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL
210 220 230 240 250
VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG
260 270 280 290 300
PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP
310 320 330 340 350
YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF
360 370
STTLLYCRKS RLPREPYCVI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JBQ9 | C9JBQ9_HUMAN | Probable G-protein-coupled receptor... | GPR85 | 121 | Annotation score: | ||
C9JDK8 | C9JDK8_HUMAN | Probable G-protein-coupled receptor... | GPR85 | 71 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074204 | 152 | M → T Found in a patient with autism spectrum disorder; unknown pathological significance; induces response to endoplasmic reticulum stress; negative regulation of dendrite morphogenesis. 1 Publication | 1 | |
Natural variantiVAR_074205 | 221 | V → L Found in a patient with autism spectrum disorder; unknown pathological significance; induces response to endoplasmic reticulum stress; negative regulation of dendrite morphogenesis. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250237 mRNA Translation: AAF79956.1 AB040800 mRNA Translation: BAA96646.1 AB065688 Genomic DNA Translation: BAC05911.1 AL161959 mRNA Translation: CAB82307.1 AC073346 Genomic DNA Translation: AAQ93365.1 |
CCDSi | CCDS5758.1 |
PIRi | T47131 |
RefSeqi | NP_001139737.1, NM_001146265.1 NP_001139738.1, NM_001146266.1 NP_001139739.1, NM_001146267.1 NP_061843.3, NM_018970.6 XP_005250508.1, XM_005250451.2 XP_016867841.1, XM_017012352.1 |
Genome annotation databases
Ensembli | ENST00000297146; ENSP00000297146; ENSG00000164604 ENST00000424100; ENSP00000396763; ENSG00000164604 ENST00000449591; ENSP00000401178; ENSG00000164604 ENST00000610164; ENSP00000476863; ENSG00000164604 |
GeneIDi | 54329 |
KEGGi | hsa:54329 |
UCSCi | uc003vgp.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF250237 mRNA Translation: AAF79956.1 AB040800 mRNA Translation: BAA96646.1 AB065688 Genomic DNA Translation: BAC05911.1 AL161959 mRNA Translation: CAB82307.1 AC073346 Genomic DNA Translation: AAQ93365.1 |
CCDSi | CCDS5758.1 |
PIRi | T47131 |
RefSeqi | NP_001139737.1, NM_001146265.1 NP_001139738.1, NM_001146266.1 NP_001139739.1, NM_001146267.1 NP_061843.3, NM_018970.6 XP_005250508.1, XM_005250451.2 XP_016867841.1, XM_017012352.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119932, 2 interactors |
IntActi | P60893, 1 interactor |
STRINGi | 9606.ENSP00000297146 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P60893, 3 sites |
iPTMneti | P60893 |
PhosphoSitePlusi | P60893 |
Polymorphism and mutation databases
BioMutai | GPR85 |
DMDMi | 46397442 |
Proteomic databases
PaxDbi | P60893 |
PRIDEi | P60893 |
ProteomicsDBi | 57234 |
Protocols and materials databases
Antibodypediai | 17381, 160 antibodies |
DNASUi | 54329 |
Genome annotation databases
Ensembli | ENST00000297146; ENSP00000297146; ENSG00000164604 ENST00000424100; ENSP00000396763; ENSG00000164604 ENST00000449591; ENSP00000401178; ENSG00000164604 ENST00000610164; ENSP00000476863; ENSG00000164604 |
GeneIDi | 54329 |
KEGGi | hsa:54329 |
UCSCi | uc003vgp.2, human |
Organism-specific databases
CTDi | 54329 |
DisGeNETi | 54329 |
EuPathDBi | HostDB:ENSG00000164604.12 |
GeneCardsi | GPR85 |
HGNCi | HGNC:4536, GPR85 |
HPAi | ENSG00000164604, Group enriched (brain, skeletal muscle) |
MIMi | 605188, gene |
neXtProti | NX_P60893 |
OpenTargetsi | ENSG00000164604 |
PharmGKBi | PA28929 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00890000139436 |
HOGENOMi | CLU_055518_0_0_1 |
InParanoidi | P60893 |
OMAi | PSMANYS |
OrthoDBi | 1311948at2759 |
PhylomeDBi | P60893 |
TreeFami | TF331163 |
Enzyme and pathway databases
PathwayCommonsi | P60893 |
Miscellaneous databases
BioGRID-ORCSi | 54329, 4 hits in 844 CRISPR screens |
GenomeRNAii | 54329 |
Pharosi | P60893, Tbio |
PROi | PR:P60893 |
RNActi | P60893, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000164604, Expressed in cortical plate and 151 other tissues |
ExpressionAtlasi | P60893, baseline and differential |
Genevisiblei | P60893, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR85_HUMAN | |
Accessioni | P60893Primary (citable) accession number: P60893 Secondary accession number(s): Q9JHI6, Q9NPD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries