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Protein

Ribose-phosphate pyrophosphokinase 1

Gene

PRPS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Catalytic activityi

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Activity regulationi

Activated by magnesium and inorganic phosphate.

Pathwayi: 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I).
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-phosphate pyrophosphokinase 2 (PRPS2), Ribose-phosphate pyrophosphokinase 3 (PRPS1L1), Ribose-phosphate pyrophosphokinase 1 (PRPS1)
This subpathway is part of the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I), the pathway 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi128MagnesiumSequence analysis1
Metal bindingi130MagnesiumSequence analysis1
Binding sitei130ATP1
Metal bindingi139MagnesiumSequence analysis1
Metal bindingi143MagnesiumSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 101ATP6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS07410-MONOMER
BRENDAi2.7.6.1 2681
ReactomeiR-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis
UniPathwayi
UPA00087;UER00172

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-phosphate pyrophosphokinase 1 (EC:2.7.6.1)
Alternative name(s):
PPRibP
Phosphoribosyl pyrophosphate synthase I
Short name:
PRS-I
Gene namesi
Name:PRPS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147224.10
HGNCiHGNC:9462 PRPS1
MIMi311850 gene
neXtProtiNX_P60891

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Phosphoribosyl pyrophosphate synthetase I deficiency is a rare condition caused by mutations in PRPS1 that lead to variable disease phenotypes including optic atrophy, retinitis pigmentosa, ataxia, peripheral neuropathy and hearing loss.1 Publication
Phosphoribosylpyrophosphate synthetase superactivity (PRPS1 superactivity)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionFamilial disorder characterized by excessive purine production, gout and uric acid urolithiasis.
See also OMIM:300661
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01604452D → H in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852542EnsemblClinVar.1
Natural variantiVAR_004163114N → S in PRPS1 superactivity. 2 PublicationsCorresponds to variant dbSNP:rs137852540EnsemblClinVar.1
Natural variantiVAR_016045129L → I in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852543EnsemblClinVar.1
Natural variantiVAR_004164183D → H in PRPS1 superactivity. 2 PublicationsCorresponds to variant dbSNP:rs137852541EnsemblClinVar.1
Natural variantiVAR_016046190A → V in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852544EnsemblClinVar.1
Natural variantiVAR_016047193H → Q in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852545EnsemblClinVar.1
Charcot-Marie-Tooth disease, X-linked recessive, 5 (CMTX5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy.
See also OMIM:311070
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03694143E → D in CMTX5. 1 PublicationCorresponds to variant dbSNP:rs80338731EnsemblClinVar.1
Natural variantiVAR_036942115M → T in CMTX5. 1 PublicationCorresponds to variant dbSNP:rs80338732EnsemblClinVar.1
ARTS syndrome (ARTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by mental retardation, early-onset hypotonia, ataxia, delayed motor development, hearing impairment, and optic atrophy. Susceptibility to infections, especially of the upper respiratory tract, can result in early death.
See also OMIM:301835
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036943133Q → P in ARTS. 1 PublicationCorresponds to variant dbSNP:rs80338675EnsemblClinVar.1
Natural variantiVAR_036944152L → P in ARTS. 1 PublicationCorresponds to variant dbSNP:rs80338676EnsemblClinVar.1
Deafness, X-linked, 1 (DFNX1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of deafness characterized by progressive, severe-to-profound sensorineural hearing loss in males. Females manifest mild to moderate hearing loss.
See also OMIM:304500
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06352265D → N in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177151EnsemblClinVar.1
Natural variantiVAR_06352387A → T in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177152EnsemblClinVar.1
Natural variantiVAR_063524290I → T in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177153EnsemblClinVar.1
Natural variantiVAR_063525306G → R in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177154EnsemblClinVar.1
A mutation in PRPS1 has been found in a patient with a phenotype that bridges that of PRSPS1 superactivity and ARTS syndrome with uric acid overproduction without gout but with recurrent infections, sensorineural hearing loss and motor neuropathy. The intermediate phenotype may be because Leu-142 variant affects both allosteric sites that are involved in inhibition of PRPS1 and the ATP-binding site, which suggests that this substitution can result both in a gain-of-function and loss-of-function of PRPP synthetase.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi132S → A: Reduces catalytic activity. 1 Publication1
Mutagenesisi132S → F: No effect on catalytic activity. 1 Publication1
Mutagenesisi144N → H: No effect on catalytic activity. 1 Publication1
Mutagenesisi146Y → F: No effect on catalytic activity. 1 Publication1
Mutagenesisi146Y → M: Reduces catalytic activity. 1 Publication1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Deafness, Disease mutation, Gout, Mental retardation, Neurodegeneration, Neuropathy, Non-syndromic deafness, Retinitis pigmentosa

Organism-specific databases

DisGeNETi5631
GeneReviewsiPRPS1
MalaCardsiPRPS1
MIMi300661 phenotype
301835 phenotype
304500 phenotype
311070 phenotype
OpenTargetsiENSG00000147224
Orphaneti1187 Lethal ataxia with deafness and optic atrophy
411536 Mild phosphoribosylpyrophosphate synthetase superactivity
411543 Severe phosphoribosylpyrophosphate synthetase superactivity
99014 X-linked Charcot-Marie-Tooth disease type 5
423479 X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome
90625 X-linked non-syndromic sensorineural deafness type DFN
PharmGKBiPA33817

Chemistry databases

ChEMBLiCHEMBL2638

Polymorphism and mutation databases

BioMutaiPRPS1
DMDMi46397477

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001410712 – 318Ribose-phosphate pyrophosphokinase 1Add BLAST317

Proteomic databases

EPDiP60891
MaxQBiP60891
PaxDbiP60891
PeptideAtlasiP60891
PRIDEiP60891
ProteomicsDBi57233

2D gel databases

UCD-2DPAGEiP60891

PTM databases

iPTMnetiP60891
PhosphoSitePlusiP60891
SwissPalmiP60891

Expressioni

Gene expression databases

BgeeiENSG00000147224 Expressed in 232 organ(s), highest expression level in left coronary artery
CleanExiHS_PRPS1
ExpressionAtlasiP60891 baseline and differential
GenevisibleiP60891 HS

Interactioni

Subunit structurei

Homodimer. The active form is probably a hexamer composed of 3 homodimers.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111615, 58 interactors
DIPiDIP-61999N
IntActiP60891, 19 interactors
MINTiP60891
STRINGi9606.ENSP00000361512

Chemistry databases

BindingDBiP60891

Structurei

Secondary structure

1318
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60891
SMRiP60891
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60891

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 227Binding of phosphoribosylpyrophosphateSequence analysisAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1448 Eukaryota
COG0462 LUCA
GeneTreeiENSGT00550000074583
HOGENOMiHOG000210451
HOVERGENiHBG001520
InParanoidiP60891
KOiK00948
OMAiFGWARQD
OrthoDBiEOG091G0ZG8
PhylomeDBiP60891
TreeFamiTF106366

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00583_B RibP_PPkinase_B, 1 hit
InterProiView protein in InterPro
IPR000842 PRib_PP_synth_CS
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
IPR037515 Rib-P_diPkinase_bac
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit
PROSITEiView protein in PROSITE
PS00114 PRPP_SYNTHASE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60891-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIGESVRG
60 70 80 90 100
EDVYIVQSGC GEINDNLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK
110 120 130 140 150
DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA
160 170 180 190 200
VLKWIRENIS EWRNCTIVSP DAGGAKRVTS IADRLNVDFA LIHKERKKAN
210 220 230 240 250
EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATRVYAILTH
260 270 280 290 300
GIFSGPAISR INNACFEAVV VTNTIPQEDK MKHCSKIQVI DISMILAEAI
310
RRTHNGESVS YLFSHVPL
Length:318
Mass (Da):34,834
Last modified:January 23, 2007 - v2
Checksum:i46D017E969908BA0
GO
Isoform 2 (identifier: P60891-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-67: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):27,526
Checksum:iA43F363C2E2ECF33
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7H4A0A2R8Y7H4_HUMAN
Ribose-phosphate pyrophosphokinase
PRPS1
321Annotation score:
B7ZB02B7ZB02_HUMAN
Ribose-phosphate pyrophosphokinase ...
PRPS1
114Annotation score:
B1ALA9B1ALA9_HUMAN
Ribose-phosphate pyrophosphokinase ...
PRPS1
285Annotation score:
B1ALA7B1ALA7_HUMAN
Ribose-phosphate pyrophosphokinase ...
PRPS1
168Annotation score:
Q15244Q15244_HUMAN
Phosphoribosylpyrophosphate synthet...
PRPS1
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82A → G in BAG35584 (PubMed:14702039).Curated1
Sequence conflicti122D → G in BAG35584 (PubMed:14702039).Curated1
Sequence conflicti278E → G in BAG35584 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07271916S → P Probable disease-associated mutation found in patients with phosphoribosyl pyrophosphate synthetase I deficiency. 1 PublicationCorresponds to variant dbSNP:rs869025594EnsemblClinVar.1
Natural variantiVAR_03694143E → D in CMTX5. 1 PublicationCorresponds to variant dbSNP:rs80338731EnsemblClinVar.1
Natural variantiVAR_01604452D → H in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852542EnsemblClinVar.1
Natural variantiVAR_06352265D → N in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177151EnsemblClinVar.1
Natural variantiVAR_06352387A → T in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177152EnsemblClinVar.1
Natural variantiVAR_004163114N → S in PRPS1 superactivity. 2 PublicationsCorresponds to variant dbSNP:rs137852540EnsemblClinVar.1
Natural variantiVAR_036942115M → T in CMTX5. 1 PublicationCorresponds to variant dbSNP:rs80338732EnsemblClinVar.1
Natural variantiVAR_016045129L → I in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852543EnsemblClinVar.1
Natural variantiVAR_036943133Q → P in ARTS. 1 PublicationCorresponds to variant dbSNP:rs80338675EnsemblClinVar.1
Natural variantiVAR_078489142V → L Probable disease-associated mutation found in a patient with an intermediate phenotype between ARTS and PRPS1 superactivity; normal PRPP synthetase activity in fibroblasts; loss of activity in erythrocytes. 1 PublicationCorresponds to variant dbSNP:rs398122855EnsemblClinVar.1
Natural variantiVAR_036944152L → P in ARTS. 1 PublicationCorresponds to variant dbSNP:rs80338676EnsemblClinVar.1
Natural variantiVAR_004164183D → H in PRPS1 superactivity. 2 PublicationsCorresponds to variant dbSNP:rs137852541EnsemblClinVar.1
Natural variantiVAR_016046190A → V in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852544EnsemblClinVar.1
Natural variantiVAR_016047193H → Q in PRPS1 superactivity. 1 PublicationCorresponds to variant dbSNP:rs137852545EnsemblClinVar.1
Natural variantiVAR_036593203D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036594219V → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036595231H → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_063524290I → T in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177153EnsemblClinVar.1
Natural variantiVAR_063525306G → R in DFNX1. 1 PublicationCorresponds to variant dbSNP:rs180177154EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560281 – 67Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15331 mRNA Translation: CAA33386.1
D00860 mRNA Translation: BAA00733.1
AK297968 mRNA Translation: BAG60278.1
AK312706 mRNA Translation: BAG35584.1
AL137787 Genomic DNA No translation available.
AL772400 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02709.1
CH471120 Genomic DNA Translation: EAX02710.1
CH471120 Genomic DNA Translation: EAX02711.1
BC001605 mRNA Translation: AAH01605.1
CCDSiCCDS14529.1 [P60891-1]
PIRiJX0159 KIHUR1
RefSeqiNP_001191331.1, NM_001204402.1
NP_002755.1, NM_002764.3 [P60891-1]
UniGeneiHs.56

Genome annotation databases

EnsembliENST00000372435; ENSP00000361512; ENSG00000147224 [P60891-1]
GeneIDi5631
KEGGihsa:5631
UCSCiuc004ene.5 human [P60891-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15331 mRNA Translation: CAA33386.1
D00860 mRNA Translation: BAA00733.1
AK297968 mRNA Translation: BAG60278.1
AK312706 mRNA Translation: BAG35584.1
AL137787 Genomic DNA No translation available.
AL772400 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02709.1
CH471120 Genomic DNA Translation: EAX02710.1
CH471120 Genomic DNA Translation: EAX02711.1
BC001605 mRNA Translation: AAH01605.1
CCDSiCCDS14529.1 [P60891-1]
PIRiJX0159 KIHUR1
RefSeqiNP_001191331.1, NM_001204402.1
NP_002755.1, NM_002764.3 [P60891-1]
UniGeneiHs.56

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H06X-ray2.20A/B1-318[»]
2H07X-ray2.20A/B1-318[»]
2H08X-ray2.50A/B1-318[»]
2HCRX-ray2.20A/B1-318[»]
3EFHX-ray2.60A/B1-318[»]
3S5JX-ray2.02A/B1-318[»]
4F8EX-ray2.27A/B1-318[»]
4LYGX-ray3.00A/B1-318[»]
4LZNX-ray2.14A/B1-318[»]
4LZOX-ray3.31A/B1-318[»]
4M0PX-ray2.11A/B1-318[»]
4M0UX-ray2.74A/B1-318[»]
ProteinModelPortaliP60891
SMRiP60891
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111615, 58 interactors
DIPiDIP-61999N
IntActiP60891, 19 interactors
MINTiP60891
STRINGi9606.ENSP00000361512

Chemistry databases

BindingDBiP60891
ChEMBLiCHEMBL2638

PTM databases

iPTMnetiP60891
PhosphoSitePlusiP60891
SwissPalmiP60891

Polymorphism and mutation databases

BioMutaiPRPS1
DMDMi46397477

2D gel databases

UCD-2DPAGEiP60891

Proteomic databases

EPDiP60891
MaxQBiP60891
PaxDbiP60891
PeptideAtlasiP60891
PRIDEiP60891
ProteomicsDBi57233

Protocols and materials databases

DNASUi5631
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372435; ENSP00000361512; ENSG00000147224 [P60891-1]
GeneIDi5631
KEGGihsa:5631
UCSCiuc004ene.5 human [P60891-1]

Organism-specific databases

CTDi5631
DisGeNETi5631
EuPathDBiHostDB:ENSG00000147224.10
GeneCardsiPRPS1
GeneReviewsiPRPS1
HGNCiHGNC:9462 PRPS1
MalaCardsiPRPS1
MIMi300661 phenotype
301835 phenotype
304500 phenotype
311070 phenotype
311850 gene
neXtProtiNX_P60891
OpenTargetsiENSG00000147224
Orphaneti1187 Lethal ataxia with deafness and optic atrophy
411536 Mild phosphoribosylpyrophosphate synthetase superactivity
411543 Severe phosphoribosylpyrophosphate synthetase superactivity
99014 X-linked Charcot-Marie-Tooth disease type 5
423479 X-linked intellectual disability-limb spasticity-retinal dystrophy-diabetes insipidus syndrome
90625 X-linked non-syndromic sensorineural deafness type DFN
PharmGKBiPA33817
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1448 Eukaryota
COG0462 LUCA
GeneTreeiENSGT00550000074583
HOGENOMiHOG000210451
HOVERGENiHBG001520
InParanoidiP60891
KOiK00948
OMAiFGWARQD
OrthoDBiEOG091G0ZG8
PhylomeDBiP60891
TreeFamiTF106366

Enzyme and pathway databases

UniPathwayi
UPA00087;UER00172

BioCyciMetaCyc:HS07410-MONOMER
BRENDAi2.7.6.1 2681
ReactomeiR-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis

Miscellaneous databases

ChiTaRSiPRPS1 human
EvolutionaryTraceiP60891
GenomeRNAii5631
PROiPR:P60891
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147224 Expressed in 232 organ(s), highest expression level in left coronary artery
CleanExiHS_PRPS1
ExpressionAtlasiP60891 baseline and differential
GenevisibleiP60891 HS

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_00583_B RibP_PPkinase_B, 1 hit
InterProiView protein in InterPro
IPR000842 PRib_PP_synth_CS
IPR029099 Pribosyltran_N
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR005946 Rib-P_diPkinase
IPR037515 Rib-P_diPkinase_bac
PANTHERiPTHR10210 PTHR10210, 1 hit
PfamiView protein in Pfam
PF14572 Pribosyl_synth, 1 hit
PF13793 Pribosyltran_N, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01251 ribP_PPkin, 1 hit
PROSITEiView protein in PROSITE
PS00114 PRPP_SYNTHASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRPS1_HUMAN
AccessioniPrimary (citable) accession number: P60891
Secondary accession number(s): B1ALA8
, B2R6T7, B4DNL6, D3DUX6, P09329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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