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Entry version 162 (12 Aug 2020)
Sequence version 1 (13 Apr 2004)
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Protein

40S ribosomal protein S20

Gene

RPS20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P60866

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
40S ribosomal protein S20
Alternative name(s):
Small ribosomal subunit protein uS101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPS20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000008988.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10405, RPS20

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603682, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60866

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-8. 2 Publications1
Mutagenesisi8K → R: Enhanced readthrough on the poly(A)-stall sequences; when associated with R-4. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6224

MalaCards human disease database

More...
MalaCardsi
RPS20

Open Targets

More...
OpenTargetsi
ENSG00000008988

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
440437, Familial colorectal cancer Type X

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34807

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P60866, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RPS20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46397703

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001466832 – 11940S ribosomal protein S20Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei8N6-succinyllysine; alternateBy similarity1
Cross-linki8Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications
Modified residuei9PhosphothreonineCombined sources1
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei93PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).2 Publications
Ufmylated by UFL1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P60866

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P60866

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P60866

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P60866

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60866

PeptideAtlas

More...
PeptideAtlasi
P60866

PRoteomics IDEntifications database

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PRIDEi
P60866

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57229 [P60866-1]
57230 [P60866-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P60866-1 [P60866-1]
P60866-2 [P60866-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60866

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60866

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P60866

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000008988, Expressed in oviduct epithelium and 241 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P60866, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P60866, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000008988, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 40S small ribosomal subunit.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112138, 223 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-5223, 40S cytosolic small ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P60866

Database of interacting proteins

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DIPi
DIP-31245N

Protein interaction database and analysis system

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IntActi
P60866, 66 interactors

Molecular INTeraction database

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MINTi
P60866

STRING: functional protein association networks

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STRINGi
9606.ENSP00000429374

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60866, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P60866

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0900, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000003248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_122625_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P60866

KEGG Orthology (KO)

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KOi
K02969

Identification of Orthologs from Complete Genome Data

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OMAi
YELKIHK

Database of Orthologous Groups

More...
OrthoDBi
1454256at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60866

TreeFam database of animal gene trees

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TreeFami
TF300222

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.600, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00508, Ribosomal_S10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001848, Ribosomal_S10
IPR018268, Ribosomal_S10_CS
IPR027486, Ribosomal_S10_dom
IPR036838, Ribosomal_S10_dom_sf
IPR005729, Ribosomal_S10_euk/arc

The PANTHER Classification System

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PANTHERi
PTHR11700, PTHR11700, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00338, Ribosomal_S10, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00971, RIBOSOMALS10

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01403, Ribosomal_S10, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54999, SSF54999, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01046, uS10_euk_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00361, RIBOSOMAL_S10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFKDTGKTP VEPEVAIHRI RITLTSRNVK SLEKVCADLI RGAKEKNLKV
60 70 80 90 100
KGPVRMPTKT LRITTRKTPC GEGSKTWDRF QMRIHKRLID LHSPSEIVKQ
110
ITSISIEPGV EVEVTIADA
Length:119
Mass (Da):13,373
Last modified:April 13, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8802DF7894ADDF94
GO
Isoform 2 (identifier: P60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-119: VEVTIADA → LIESTDAEPMDTEGQQYTLRSVFESPGTCPF

Show »
Length:142
Mass (Da):16,006
Checksum:i9EB2D51538E812A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAN0G3XAN0_HUMAN
40S ribosomal protein S20
RPS20 hCG_40753
64Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJX2E5RJX2_HUMAN
40S ribosomal protein S20
RPS20
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIP1E5RIP1_HUMAN
40S ribosomal protein S20
RPS20
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042724112 – 119VEVTIADA → LIESTDAEPMDTEGQQYTLR SVFESPGTCPF in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L06498 mRNA Translation: AAA60286.1
AB061842 Genomic DNA Translation: BAB79480.1
AK301342 mRNA Translation: BAG62890.1
AK311808 mRNA Translation: BAG34751.1
AC107376 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86771.1
CH471068 Genomic DNA Translation: EAW86772.1
BC007507 mRNA Translation: AAH07507.1
BC087850 mRNA Translation: AAH87850.1
AB007156 Genomic DNA Translation: BAA25820.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55231.1 [P60866-2]
CCDS6163.1 [P60866-1]

Protein sequence database of the Protein Information Resource

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PIRi
S33710

NCBI Reference Sequences

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RefSeqi
NP_001014.1, NM_001023.3 [P60866-1]
NP_001139699.1, NM_001146227.1 [P60866-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000009589; ENSP00000009589; ENSG00000008988 [P60866-1]
ENST00000519807; ENSP00000429374; ENSG00000008988 [P60866-2]
ENST00000521262; ENSP00000427788; ENSG00000008988 [P60866-1]
ENST00000618656; ENSP00000478703; ENSG00000008988 [P60866-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6224

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6224

UCSC genome browser

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UCSCi
uc003xsm.3, human [P60866-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06498 mRNA Translation: AAA60286.1
AB061842 Genomic DNA Translation: BAB79480.1
AK301342 mRNA Translation: BAG62890.1
AK311808 mRNA Translation: BAG34751.1
AC107376 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW86771.1
CH471068 Genomic DNA Translation: EAW86772.1
BC007507 mRNA Translation: AAH07507.1
BC087850 mRNA Translation: AAH87850.1
AB007156 Genomic DNA Translation: BAA25820.1
CCDSiCCDS55231.1 [P60866-2]
CCDS6163.1 [P60866-1]
PIRiS33710
RefSeqiNP_001014.1, NM_001023.3 [P60866-1]
NP_001139699.1, NM_001146227.1 [P60866-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SU1-119[»]
4V6Xelectron microscopy5.00AU1-119[»]
5A2Qelectron microscopy3.90U1-119[»]
5AJ0electron microscopy3.50BU1-119[»]
5FLXelectron microscopy3.90U1-119[»]
5LKSelectron microscopy3.60SU1-119[»]
5OA3electron microscopy4.30U1-119[»]
5T2Celectron microscopy3.60AB1-119[»]
5VYCX-ray6.00U1/U2/U3/U4/U5/U61-119[»]
6EK0electron microscopy2.90SU1-119[»]
6FECelectron microscopy6.30h16-119[»]
6G51electron microscopy4.10U1-119[»]
6G53electron microscopy4.50U1-119[»]
6G5Helectron microscopy3.60U1-119[»]
6G5Ielectron microscopy3.50U1-119[»]
6IP5electron microscopy3.90211-119[»]
6IP6electron microscopy4.50211-119[»]
6IP8electron microscopy3.90211-119[»]
6OLEelectron microscopy3.10SU16-119[»]
6OLFelectron microscopy3.90SU16-119[»]
6OLGelectron microscopy3.40BU20-116[»]
6OLIelectron microscopy3.50SU16-119[»]
6OLZelectron microscopy3.90BU20-116[»]
6OM0electron microscopy3.10SU16-119[»]
6OM7electron microscopy3.70SU16-119[»]
6QZPelectron microscopy2.90SU17-119[»]
6Y0Gelectron microscopy3.20SU1-119[»]
6Y2Lelectron microscopy3.00SU1-119[»]
6Y57electron microscopy3.50SU1-119[»]
SMRiP60866
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112138, 223 interactors
ComplexPortaliCPX-5223, 40S cytosolic small ribosomal subunit
CORUMiP60866
DIPiDIP-31245N
IntActiP60866, 66 interactors
MINTiP60866
STRINGi9606.ENSP00000429374

PTM databases

iPTMnetiP60866
PhosphoSitePlusiP60866
SwissPalmiP60866

Polymorphism and mutation databases

BioMutaiRPS20
DMDMi46397703

Proteomic databases

EPDiP60866
jPOSTiP60866
MassIVEiP60866
MaxQBiP60866
PaxDbiP60866
PeptideAtlasiP60866
PRIDEiP60866
ProteomicsDBi57229 [P60866-1]
57230 [P60866-2]
TopDownProteomicsiP60866-1 [P60866-1]
P60866-2 [P60866-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1248, 220 antibodies

The DNASU plasmid repository

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DNASUi
6224

Genome annotation databases

EnsembliENST00000009589; ENSP00000009589; ENSG00000008988 [P60866-1]
ENST00000519807; ENSP00000429374; ENSG00000008988 [P60866-2]
ENST00000521262; ENSP00000427788; ENSG00000008988 [P60866-1]
ENST00000618656; ENSP00000478703; ENSG00000008988 [P60866-2]
GeneIDi6224
KEGGihsa:6224
UCSCiuc003xsm.3, human [P60866-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6224
DisGeNETi6224
EuPathDBiHostDB:ENSG00000008988.9

GeneCards: human genes, protein and diseases

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GeneCardsi
RPS20
HGNCiHGNC:10405, RPS20
HPAiENSG00000008988, Low tissue specificity
MalaCardsiRPS20
MIMi603682, gene
neXtProtiNX_P60866
OpenTargetsiENSG00000008988
Orphaneti440437, Familial colorectal cancer Type X
PharmGKBiPA34807

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0900, Eukaryota
GeneTreeiENSGT00390000003248
HOGENOMiCLU_122625_0_0_1
InParanoidiP60866
KOiK02969
OMAiYELKIHK
OrthoDBi1454256at2759
PhylomeDBiP60866
TreeFamiTF300222

Enzyme and pathway databases

PathwayCommonsiP60866
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649, Translation initiation complex formation
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72695, Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702, Ribosomal scanning and start codon recognition
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
6224, 746 hits in 858 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPS20, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPS20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6224
PharosiP60866, Tbio

Protein Ontology

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PROi
PR:P60866
RNActiP60866, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008988, Expressed in oviduct epithelium and 241 other tissues
ExpressionAtlasiP60866, baseline and differential
GenevisibleiP60866, HS

Family and domain databases

Gene3Di3.30.70.600, 1 hit
HAMAPiMF_00508, Ribosomal_S10, 1 hit
InterProiView protein in InterPro
IPR001848, Ribosomal_S10
IPR018268, Ribosomal_S10_CS
IPR027486, Ribosomal_S10_dom
IPR036838, Ribosomal_S10_dom_sf
IPR005729, Ribosomal_S10_euk/arc
PANTHERiPTHR11700, PTHR11700, 1 hit
PfamiView protein in Pfam
PF00338, Ribosomal_S10, 1 hit
PRINTSiPR00971, RIBOSOMALS10
SMARTiView protein in SMART
SM01403, Ribosomal_S10, 1 hit
SUPFAMiSSF54999, SSF54999, 1 hit
TIGRFAMsiTIGR01046, uS10_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00361, RIBOSOMAL_S10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRS20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60866
Secondary accession number(s): B2R4F4
, B4DW28, P17075, Q5M8S9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: August 12, 2020
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
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