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Protein

Leucine zipper putative tumor suppressor 1

Gene

Lzts1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 1
Alternative name(s):
F37/Esophageal cancer-related gene-coding leucine-zipper motif
Fez1
Gene namesi
Name:Lzts1
Synonyms:Fez1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2684762 Lzts1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001829722 – 599Leucine zipper putative tumor suppressor 1Add BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiP60853
MaxQBiP60853
PaxDbiP60853
PRIDEiP60853

PTM databases

iPTMnetiP60853
PhosphoSitePlusiP60853

Expressioni

Gene expression databases

BgeeiENSMUSG00000036306 Expressed in 177 organ(s), highest expression level in olfactory tubercle
CleanExiMM_LZTS1
GenevisibleiP60853 MM

Interactioni

Subunit structurei

Binds EEF1G, TLK2 and CDK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229205, 1 interactor
IntActiP60853, 1 interactor
STRINGi10090.ENSMUSP00000039397

Structurei

3D structure databases

ProteinModelPortaliP60853
SMRiP60853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili256 – 572Sequence analysisAdd BLAST317

Sequence similaritiesi

Belongs to the LZTS family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE Eukaryota
ENOG4111JZA LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiP60853
OMAiGMELKTQ
OrthoDBiEOG091G03L2
TreeFamiTF331420

Family and domain databases

InterProiView protein in InterPro
IPR033293 LZTS1
PANTHERiPTHR19354:SF5 PTHR19354:SF5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60853-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS
60 70 80 90 100
GRGKSSSKMG KSEDFFYIKV SQKARGSHRP DYTALSSGDI GGQTGVDFDP
110 120 130 140 150
ATPPKLMPFS NQLEMSSDKG AVRPTAFKPV LPRSGAILHS SPESTSHQLH
160 170 180 190 200
PMPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTTSS YQLDPLVTPV
210 220 230 240 250
GPTSRFGGSA HNITQGIILQ DSNMMSLKAL SFSDGGSKLA HPGKADKGAS
260 270 280 290 300
CVRSPLSTDE CTIQELEQKL LQRETALQKL QRSFDEKEFA SGQTFEERPR
310 320 330 340 350
RTRDELECLE PKSKLKPPSQ KSQRTQQVLQ LQVLQLQQEK RQLRQELESL
360 370 380 390 400
MKEQDLLETK LRSYEREKTN FAPALEETQW EVCQKSGEIS LLKQQLKESQ
410 420 430 440 450
LEVNTKASEI LSLKAQLKDT RGKLDGMELK TQDLESALRT KGLELEVCEN
460 470 480 490 500
ELQRKKNEAE LLREKVNLLE QELMELRAQA ALHPAPLGPP GVGLTFSEDI
510 520 530 540 550
PALQRELDRL RAELKEERQG HDQMSSGFQH ERLVWKEEKE KVIQYQRQLQ
560 570 580 590
QSYLAMYQRN QRLEKALQQL ARGDGPGEPF EIDLEGADIP YEDIIATEI
Length:599
Mass (Da):67,290
Last modified:July 27, 2011 - v3
Checksum:i7B77A3BCF249E817
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90I → M in AAQ14349 (PubMed:10097140).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288601 mRNA Translation: AAQ14349.1
BC139350 mRNA Translation: AAI39351.1
BC139352 mRNA Translation: AAI39353.1
CCDSiCCDS22345.1
RefSeqiNP_955396.2, NM_199364.2
XP_006509669.1, XM_006509606.1
XP_006509670.1, XM_006509607.3
XP_006509671.1, XM_006509608.3
UniGeneiMm.409446
Mm.479807

Genome annotation databases

EnsembliENSMUST00000037049; ENSMUSP00000039397; ENSMUSG00000036306
ENSMUST00000185176; ENSMUSP00000139117; ENSMUSG00000036306
GeneIDi211134
KEGGimmu:211134
UCSCiuc009lxa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288601 mRNA Translation: AAQ14349.1
BC139350 mRNA Translation: AAI39351.1
BC139352 mRNA Translation: AAI39353.1
CCDSiCCDS22345.1
RefSeqiNP_955396.2, NM_199364.2
XP_006509669.1, XM_006509606.1
XP_006509670.1, XM_006509607.3
XP_006509671.1, XM_006509608.3
UniGeneiMm.409446
Mm.479807

3D structure databases

ProteinModelPortaliP60853
SMRiP60853
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229205, 1 interactor
IntActiP60853, 1 interactor
STRINGi10090.ENSMUSP00000039397

PTM databases

iPTMnetiP60853
PhosphoSitePlusiP60853

Proteomic databases

EPDiP60853
MaxQBiP60853
PaxDbiP60853
PRIDEiP60853

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037049; ENSMUSP00000039397; ENSMUSG00000036306
ENSMUST00000185176; ENSMUSP00000139117; ENSMUSG00000036306
GeneIDi211134
KEGGimmu:211134
UCSCiuc009lxa.1 mouse

Organism-specific databases

CTDi11178
MGIiMGI:2684762 Lzts1

Phylogenomic databases

eggNOGiENOG410IGJE Eukaryota
ENOG4111JZA LUCA
GeneTreeiENSGT00510000046769
HOGENOMiHOG000230889
HOVERGENiHBG052381
InParanoidiP60853
OMAiGMELKTQ
OrthoDBiEOG091G03L2
TreeFamiTF331420

Miscellaneous databases

PROiPR:P60853
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036306 Expressed in 177 organ(s), highest expression level in olfactory tubercle
CleanExiMM_LZTS1
GenevisibleiP60853 MM

Family and domain databases

InterProiView protein in InterPro
IPR033293 LZTS1
PANTHERiPTHR19354:SF5 PTHR19354:SF5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLZTS1_MOUSE
AccessioniPrimary (citable) accession number: P60853
Secondary accession number(s): B2RTI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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