UniProtKB - P60807 (HIS1_METMP)
Protein
ATP phosphoribosyltransferase
Gene
hisG
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Functioni
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation
Catalytic activityi
- 1-(5-phospho-β-D-ribosyl)-ATP + diphosphate = 5-phospho-α-D-ribose 1-diphosphate + ATPUniRule annotationEC:2.4.2.17UniRule annotation
Cofactori
Mg2+UniRule annotation
Activity regulationi
Feedback inhibited by histidine.UniRule annotation
: L-histidine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationProteins known to be involved in the 9 steps of the subpathway in this organism are:
- ATP phosphoribosyltransferase (hisG)
- Phosphoribosyl-ATP pyrophosphatase (hisE)
- Phosphoribosyl-AMP cyclohydrolase (hisI)
- 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
- Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol-phosphate synthase (MMP1083), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1)
- Imidazoleglycerol-phosphate dehydratase (hisB)
- Histidinol-phosphate aminotransferase (hisC)
- no protein annotated in this organism
- Histidinol dehydrogenase (hisD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP phosphoribosyltransferase activity Source: UniProtKB-UniRule
- magnesium ion binding Source: UniProtKB-UniRule
GO - Biological processi
- histidine biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Amino-acid biosynthesis, Histidine biosynthesis |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MMAR267377:MMP_RS04910-MONOMER |
UniPathwayi | UPA00031;UER00006 |
Names & Taxonomyi
Protein namesi | Recommended name: ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)Short name: ATP-PRTUniRule annotation Short name: ATP-PRTaseUniRule annotation |
Gene namesi | Name:hisGUniRule annotation Ordered Locus Names:MMP0947 |
Organismi | Methanococcus maripaludis (strain S2 / LL) |
Taxonomic identifieri | 267377 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Methanomada group › Methanococci › Methanococcales › Methanococcaceae › Methanococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000151885 | 1 – 288 | ATP phosphoribosyltransferaseAdd BLAST | 288 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | arCOG02208, Archaea |
HOGENOMi | CLU_038115_1_0_2 |
OMAi | YVMMDYD |
OrthoDBi | 56745at2157 |
Family and domain databases
Gene3Di | 3.30.70.120, 1 hit |
HAMAPi | MF_00079, HisG_Long, 1 hit |
InterProi | View protein in InterPro IPR013820, ATP_PRibTrfase_cat IPR018198, ATP_PRibTrfase_CS IPR001348, ATP_PRibTrfase_HisG IPR020621, ATP_PRibTrfase_HisG_long IPR013115, HisG_C IPR011322, N-reg_PII-like_a/b IPR015867, N-reg_PII/ATP_PRibTrfase_C |
PANTHERi | PTHR21403, PTHR21403, 1 hit |
Pfami | View protein in Pfam PF01634, HisG, 1 hit PF08029, HisG_C, 1 hit |
SUPFAMi | SSF54913, SSF54913, 1 hit |
TIGRFAMsi | TIGR00070, hisG, 1 hit TIGR03455, HisG_C-term, 1 hit |
PROSITEi | View protein in PROSITE PS01316, ATP_P_PHORIBOSYLTR, 1 hit |
i Sequence
Sequence statusi: Complete.
P60807-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILLALPNKG RISKPVNEIL EKSGLKISVH GRSLFAKTVD PEIKVMFARA
60 70 80 90 100
KDIPEFVRDG VADVGVTGYD LMLERDTEEE LEMLLDFKFG NARLVLAAPE
110 120 130 140 150
NSDVNSIEDV KNGMKIATEF PGLTKRYLEK KGLNLEIIEL SGATEIAPFI
160 170 180 190 200
GVSDLICDLT STGTTLQLNR LKEIENVVSS STRLVANKKS MEDPEKSAKI
210 220 230 240 250
NQVLSGIKSV MYAQSKRLIM MNAPKDKVSE ITSVIPGMGG PTVSEILSNC
260 270 280
NMLAINAVID ENKVFETVSN LEKLGARDIL VVPIERIL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30503.1 |
RefSeqi | WP_011170891.1, NC_005791.1 |
Genome annotation databases
EnsemblBacteriai | CAF30503; CAF30503; MMP0947 |
GeneIDi | 41279457 |
KEGGi | mmp:MMP0947 |
PATRICi | fig|267377.15.peg.975 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX950229 Genomic DNA Translation: CAF30503.1 |
RefSeqi | WP_011170891.1, NC_005791.1 |
3D structure databases
SMRi | P60807 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 267377.MMP0947 |
Genome annotation databases
EnsemblBacteriai | CAF30503; CAF30503; MMP0947 |
GeneIDi | 41279457 |
KEGGi | mmp:MMP0947 |
PATRICi | fig|267377.15.peg.975 |
Phylogenomic databases
eggNOGi | arCOG02208, Archaea |
HOGENOMi | CLU_038115_1_0_2 |
OMAi | YVMMDYD |
OrthoDBi | 56745at2157 |
Enzyme and pathway databases
UniPathwayi | UPA00031;UER00006 |
BioCyci | MMAR267377:MMP_RS04910-MONOMER |
Family and domain databases
Gene3Di | 3.30.70.120, 1 hit |
HAMAPi | MF_00079, HisG_Long, 1 hit |
InterProi | View protein in InterPro IPR013820, ATP_PRibTrfase_cat IPR018198, ATP_PRibTrfase_CS IPR001348, ATP_PRibTrfase_HisG IPR020621, ATP_PRibTrfase_HisG_long IPR013115, HisG_C IPR011322, N-reg_PII-like_a/b IPR015867, N-reg_PII/ATP_PRibTrfase_C |
PANTHERi | PTHR21403, PTHR21403, 1 hit |
Pfami | View protein in Pfam PF01634, HisG, 1 hit PF08029, HisG_C, 1 hit |
SUPFAMi | SSF54913, SSF54913, 1 hit |
TIGRFAMsi | TIGR00070, hisG, 1 hit TIGR03455, HisG_C-term, 1 hit |
PROSITEi | View protein in PROSITE PS01316, ATP_P_PHORIBOSYLTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HIS1_METMP | |
Accessioni | P60807Primary (citable) accession number: P60807 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families