UniProtKB - P60782 (PLSY_ECOLI)
Protein
Probable glycerol-3-phosphate acyltransferase
Gene
plsY
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO4 (Probable).1 Publication
Catalytic activityi
- EC:2.3.1.151 Publication
- a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]1 PublicationEC:2.3.1.n51 Publication
: phospholipid metabolism Pathwayi
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
GO - Molecular functioni
- acyl-phosphate glycerol-3-phosphate acyltransferase activity Source: InterPro
- glycerol-3-phosphate O-acyltransferase activity Source: UniProtKB-UniRule
- sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Source: UniProtKB-EC
GO - Biological processi
- phospholipid biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11674-MONOMER |
UniPathwayi | UPA00085 |
Protein family/group databases
TCDBi | 9.B.31.1.1, the plsy/yqih (plsy) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:plsY Synonyms:ygiH Ordered Locus Names:b3059, JW3031 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 52 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 80 | PeriplasmicSequence analysis | 7 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 111 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 112 – 132 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 133 – 137 | PeriplasmicSequence analysis | 5 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 205 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000188368 | 1 – 205 | Probable glycerol-3-phosphate acyltransferaseAdd BLAST | 205 |
Proteomic databases
jPOSTi | P60782 |
PaxDbi | P60782 |
PRIDEi | P60782 |
Interactioni
Subunit structurei
Probably interacts with PlsX.
By similarityProtein-protein interaction databases
BioGRIDi | 4259257, 299 interactors |
IntActi | P60782, 1 interactor |
STRINGi | 511145.b3059 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PlsY family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG0344, Bacteria |
HOGENOMi | CLU_081254_0_2_6 |
InParanoidi | P60782 |
PhylomeDBi | P60782 |
Family and domain databases
HAMAPi | MF_01043, PlsY, 1 hit |
InterProi | View protein in InterPro IPR003811, G3P_acylTferase_PlsY |
PANTHERi | PTHR30309, PTHR30309, 1 hit |
Pfami | View protein in Pfam PF02660, G3P_acyltransf, 1 hit |
SMARTi | View protein in SMART SM01207, G3P_acyltransf, 1 hit |
TIGRFAMsi | TIGR00023, TIGR00023, 1 hit |
i Sequence
Sequence statusi: Complete.
P60782-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAIAPGMIL IAYLCGSISS AILVCRLCGL PDPRTSGSGN PGATNVLRIG
60 70 80 90 100
GKGAAVAVLI FDVLKGMLPV WGAYELGVSP FWLGLIAIAA CLGHIWPVFF
110 120 130 140 150
GFKGGKGVAT AFGAIAPIGW DLTGVMAGTW LLTVLLSGYS SLGAIVSALI
160 170 180 190 200
APFYVWWFKP QFTFPVSMLS CLILLRHHDN IQRLWRRQET KIWTKFKRKR
EKDPE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28379 Genomic DNA Translation: AAA89139.1 U00096 Genomic DNA Translation: AAC76095.1 AP009048 Genomic DNA Translation: BAE77110.1 L12966 Genomic DNA No translation available. |
PIRi | A65094 |
RefSeqi | NP_417531.1, NC_000913.3 WP_001272796.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76095; AAC76095; b3059 BAE77110; BAE77110; BAE77110 |
GeneIDi | 58460693 947561 |
KEGGi | ecj:JW3031 eco:b3059 |
PATRICi | fig|1411691.4.peg.3672 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28379 Genomic DNA Translation: AAA89139.1 U00096 Genomic DNA Translation: AAC76095.1 AP009048 Genomic DNA Translation: BAE77110.1 L12966 Genomic DNA No translation available. |
PIRi | A65094 |
RefSeqi | NP_417531.1, NC_000913.3 WP_001272796.1, NZ_STEB01000001.1 |
3D structure databases
SMRi | P60782 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259257, 299 interactors |
IntActi | P60782, 1 interactor |
STRINGi | 511145.b3059 |
Protein family/group databases
TCDBi | 9.B.31.1.1, the plsy/yqih (plsy) family |
Proteomic databases
jPOSTi | P60782 |
PaxDbi | P60782 |
PRIDEi | P60782 |
Genome annotation databases
EnsemblBacteriai | AAC76095; AAC76095; b3059 BAE77110; BAE77110; BAE77110 |
GeneIDi | 58460693 947561 |
KEGGi | ecj:JW3031 eco:b3059 |
PATRICi | fig|1411691.4.peg.3672 |
Organism-specific databases
EchoBASEi | EB1625 |
Phylogenomic databases
eggNOGi | COG0344, Bacteria |
HOGENOMi | CLU_081254_0_2_6 |
InParanoidi | P60782 |
PhylomeDBi | P60782 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BioCyci | EcoCyc:EG11674-MONOMER |
Miscellaneous databases
PROi | PR:P60782 |
Family and domain databases
HAMAPi | MF_01043, PlsY, 1 hit |
InterProi | View protein in InterPro IPR003811, G3P_acylTferase_PlsY |
PANTHERi | PTHR30309, PTHR30309, 1 hit |
Pfami | View protein in Pfam PF02660, G3P_acyltransf, 1 hit |
SMARTi | View protein in SMART SM01207, G3P_acyltransf, 1 hit |
TIGRFAMsi | TIGR00023, TIGR00023, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLSY_ECOLI | |
Accessioni | P60782Primary (citable) accession number: P60782 Secondary accession number(s): P31056, Q2M9E6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2004 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 10, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families