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Protein

Ras-related C3 botulinum toxin substrate 3

Gene

Rac3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • calcium-dependent protein binding Source: MGI
  • GTPase activity Source: UniProtKB
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-4086400 PCP/CE pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related C3 botulinum toxin substrate 3
Alternative name(s):
p21-Rac3
Gene namesi
Name:Rac3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2180784 Rac3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988901 – 189Ras-related C3 botulinum toxin substrate 3Add BLAST189
PropeptideiPRO_0000281241190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei189Cysteine methyl esterBy similarity1
Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP60764
PeptideAtlasiP60764
PRIDEiP60764

PTM databases

iPTMnetiP60764
PhosphoSitePlusiP60764

Expressioni

Gene expression databases

BgeeiENSMUSG00000018012 Expressed in 208 organ(s), highest expression level in brain
CleanExiMM_RAC3
ExpressionAtlasiP60764 baseline and differential
GenevisibleiP60764 MM

Interactioni

Subunit structurei

Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. Interacts (via C-terminal region) with CIB1; the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ArhgdiaQ99PT13EBI-644949,EBI-494354

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228420, 2 interactors
IntActiP60764, 4 interactors
MINTiP60764
STRINGi10090.ENSMUSP00000018156

Structurei

3D structure databases

ProteinModelPortaliP60764
SMRiP60764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP60764
KOiK07861
OMAiGKKCTMF
OrthoDBiEOG091G0KCM
PhylomeDBiP60764
TreeFamiTF101109

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P60764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDGKP
60 70 80 90 100
VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASF ENVRAKWYPE
110 120 130 140 150
VRHHCPHTPI LLVGTKLDLR DDKDTIERLR DKKLAPITYP QGLAMAREIG
160 170 180 190
SVKYLECSAL TQRGLKTVFD EAIRAVLCPP PVKKPGKKCT VF
Length:192
Mass (Da):21,379
Last modified:April 13, 2004 - v1
Checksum:i560BBC26BB7CDF4A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AC13A2AC13_MOUSE
RAS-related C3 botulinum substrate ...
Rac3 mCG_2150
185Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040819 mRNA Translation: BAB40573.1
AK089930 mRNA Translation: BAC41001.1
CCDSiCCDS25754.1
RefSeqiNP_573486.1, NM_133223.4
UniGeneiMm.34008

Genome annotation databases

EnsembliENSMUST00000018156; ENSMUSP00000018156; ENSMUSG00000018012
GeneIDi170758
KEGGimmu:170758
UCSCiuc007mug.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040819 mRNA Translation: BAB40573.1
AK089930 mRNA Translation: BAC41001.1
CCDSiCCDS25754.1
RefSeqiNP_573486.1, NM_133223.4
UniGeneiMm.34008

3D structure databases

ProteinModelPortaliP60764
SMRiP60764
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228420, 2 interactors
IntActiP60764, 4 interactors
MINTiP60764
STRINGi10090.ENSMUSP00000018156

PTM databases

iPTMnetiP60764
PhosphoSitePlusiP60764

Proteomic databases

PaxDbiP60764
PeptideAtlasiP60764
PRIDEiP60764

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018156; ENSMUSP00000018156; ENSMUSG00000018012
GeneIDi170758
KEGGimmu:170758
UCSCiuc007mug.1 mouse

Organism-specific databases

CTDi5881
MGIiMGI:2180784 Rac3

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP60764
KOiK07861
OMAiGKKCTMF
OrthoDBiEOG091G0KCM
PhylomeDBiP60764
TreeFamiTF101109

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-4086400 PCP/CE pathway

Miscellaneous databases

PROiPR:P60764
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018012 Expressed in 208 organ(s), highest expression level in brain
CleanExiMM_RAC3
ExpressionAtlasiP60764 baseline and differential
GenevisibleiP60764 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAC3_MOUSE
AccessioniPrimary (citable) accession number: P60764
Secondary accession number(s): O14658
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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