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Protein

Neurogranin

Gene

Nrgn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38Crucial for interaction with calmodulin1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neurogranin
Short name:
Ng
Alternative name(s):
RC3
Cleaved into the following chain:
Gene namesi
Name:Nrgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1927184 Nrgn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38R → A: Abolishes calmodulin binding, unable to potentiate synaptic transmission. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595921 – 78NeurograninAdd BLAST78
PeptideiPRO_000037770255 – 78NEUG(55-78)By similarityAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Disulfide bondi3 ↔ 51Or C-51 with C-4 or C-9
Modified residuei36Phosphoserine; by PHK and PKC1 Publication1
Modified residuei68Citrulline; partialBy similarity1
Modified residuei68Omega-N-methylarginineCombined sources1

Post-translational modificationi

Disulfide bond formation is redox-sensitive. The cysteine residues are readily oxidized by several nitric acid (NO) donors and other oxidants to form intramolecular disulfide. Cys-51 can form a disulfide with any other of the cysteine residues with an order of reactivity Cys-9 > Cys-4 > Cys-3 (By similarity).By similarity
Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP60761
PaxDbiP60761
PeptideAtlasiP60761
PRIDEiP60761

PTM databases

iPTMnetiP60761
PhosphoSitePlusiP60761

Expressioni

Gene expression databases

BgeeiENSMUSG00000053310 Expressed in 94 organ(s), highest expression level in primary motor cortex
CleanExiMM_NRGN
GenevisibleiP60761 MM

Interactioni

Subunit structurei

Interacts with apo-calmodulin; this interaction decreases the affinity of calmodulin for calcium ions.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211017, 1 interactor
IntActiP60761, 2 interactors
STRINGi10090.ENSMUSP00000070113

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP60761
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 47IQPROSITE-ProRule annotationAdd BLAST22
Domaini48 – 78Collagen-likeAdd BLAST31

Domaini

Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.

Sequence similaritiesi

Belongs to the neurogranin family.Curated

Phylogenomic databases

eggNOGiENOG410JNUP Eukaryota
ENOG41118RJ LUCA
GeneTreeiENSGT00440000039324
HOGENOMiHOG000113769
HOVERGENiHBG000470
InParanoidiP60761
OMAiPQESACS
PhylomeDBiP60761
TreeFamiTF342962

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60761-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDCCTESACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE
60 70
CGRKGPGPGG PGGAGGARGG AGGGPSGD
Length:78
Mass (Da):7,496
Last modified:April 13, 2004 - v1
Checksum:i8E47CDB38E095794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230869 Genomic DNA Translation: AAG27519.1
AK002933 mRNA Translation: BAB22466.1
AK158630 mRNA Translation: BAE34589.1
BC061102 mRNA Translation: AAH61102.1
BC138511 mRNA Translation: AAI38512.1
BC138513 mRNA Translation: AAI38514.1
CCDSiCCDS40585.1
RefSeqiNP_071312.1, NM_022029.2
UniGeneiMm.335065

Genome annotation databases

EnsembliENSMUST00000065668; ENSMUSP00000070113; ENSMUSG00000053310
GeneIDi64011
KEGGimmu:64011
UCSCiuc009ovc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNEUG_MOUSE
AccessioniPrimary (citable) accession number: P60761
Secondary accession number(s): B2RRN7, Q3TYH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: September 12, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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