Actb

Functionⁱ

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381).By similarity2 Publications

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.Curated

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
identical protein binding Source: MGI
kinesin binding Source: MGI
nitric-oxide synthase binding Source: MGI
protein kinase binding Source: MGI
structural constituent of postsynaptic actin cytoskeleton Source: MGI
Tat protein binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axonogenesis Source: MGI
cell motility Source: MGI
cellular response to cytochalasin B Source: MGI
cellular response to electrical stimulus Source: MGI
negative regulation of cyclin-dependent protein kinase activity
Source: ARUK-UCL
Inferred by curatorⁱ
- 19118186
negative regulation of protein binding
Source: ARUK-UCL
Inferred from direct assayⁱ
- 19118186
postsynaptic actin cytoskeleton organization Source: MGI
regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
regulation of norepinephrine uptake Source: MGI
regulation of protein localization to plasma membrane Source: MGI
regulation of transmembrane transporter activity Source: MGI
synaptic vesicle endocytosis
Source: SynGO
Inferred from direct assayⁱ
- 27840001

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190873 Gap junction degradation R-MMU-196025 Formation of annular gap junctions R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-418990 Adherens junctions interactions R-MMU-437239 Recycling pathway of L1 R-MMU-4420097 VEGFA-VEGFR2 Pathway R-MMU-445095 Interaction between L1 and Ankyrins R-MMU-446353 Cell-extracellular matrix interactions R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5626467 RHO GTPases activate IQGAPs R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs R-MMU-5663220 RHO GTPases Activate Formins R-MMU-5674135 MAP2K and MAPK activation R-MMU-5689603 UCH proteinases R-MMU-5696394 DNA Damage Recognition in GG-NER R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-418990 Adherens junctions interactions
R-MMU-437239 Recycling pathway of L1
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-446353 Cell-extracellular matrix interactions
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Actin, cytoplasmic 1 Alternative name(s): Beta-actin Cleaved into the following chain: Actin, cytoplasmic 1, N-terminally processed
Gene namesⁱ	Name:Actb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:87904 Actb

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000367076	1 – 375	Actin, cytoplasmic 1Add BLAST	375
Initiator methionineⁱ		Removed; alternate1 Publication
ChainⁱPRO_0000000775	2 – 375	Actin, cytoplasmic 1, N-terminally processedAdd BLAST	374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed1 Publication	1
Modified residueⁱ	44	Methionine (R)-sulfoxide1 Publication	1
Modified residueⁱ	47	Methionine (R)-sulfoxide1 Publication	1
Modified residueⁱ	73	Tele-methylhistidine1 Publication	1
Modified residueⁱ	84	N6-methyllysineBy similarity	1

Post-translational modificationⁱ

ISGylated.1 Publication

Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization (PubMed:23911929). MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (PubMed:23911929).1 Publication

Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity

Actin, cytoplasmic 1, N-terminally processed: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.By similarity

Keywords - PTMⁱ

Acetylation, Methylation, Oxidation, Ubl conjugation

Proteomic databases

EPDⁱ	P60710
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P60710
PaxDbⁱ	P60710
PeptideAtlas More...PeptideAtlasⁱ	P60710
PRIDEⁱ	P60710
TopDownProteomicsⁱ	P60710

2D gel databases

COMPLUYEAST-2DPAGEⁱ	P60710
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	P60710
SWISS-2DPAGEⁱ	P99041
UCD-2DPAGEⁱ	P60710

PTM databases

CarbonylDBⁱ	P60710
iPTMnetⁱ	P60710
PhosphoSitePlusⁱ	P60710
SwissPalmⁱ	P60710

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029580 Expressed in 312 organ(s), highest expression level in male reproductive system
CleanExⁱ	MM_ACTB
ExpressionAtlasⁱ	P60710 baseline and differential
Genevisibleⁱ	P60710 MM

Interactionⁱ

Subunit structureⁱ

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:25759381). Each actin can bind to 4 others (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, MARCB1/BAF47, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3 (By similarity). Found in a complex with XPO6, Ran, ACTB and PFN1 (By similarity). Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM (By similarity). Interacts with XPO6 and EMD (By similarity). Interacts with ERBB2 (By similarity). Interacts with GCSAM (By similarity). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with TBC1D21 (PubMed:21128978). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (By similarity). Interacts with FAM107A (PubMed:21969592).By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Cxadr	P97792	6	EBI-353957,EBI-7429264
Trpm7	Q923J1	2	EBI-353957,EBI-8010314

GO - Molecular functionⁱ

identical protein binding Source: MGI
kinesin binding Source: MGI
nitric-oxide synthase binding Source: MGI
protein kinase binding Source: MGI
Tat protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	197944, 216 interactors
ComplexPortalⁱ	CPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-990 NuA4 histone acetyltransferase complex
CORUMⁱ	P60710
Database of interacting proteins More...DIPⁱ	DIP-31574N
IntActⁱ	P60710, 227 interactors
Molecular INTeraction database More...MINTⁱ	P60710
STRINGⁱ	10090.ENSMUSP00000098066

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P60710
SMRⁱ	P60710
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0676 Eukaryota COG5277 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118957
HOVERGENⁱ	HBG003771
InParanoidⁱ	P60710
KEGG Orthology (KO) More...KOⁱ	K05692
OMAⁱ	YKCDLDI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08LD
PhylomeDBⁱ	P60710
TreeFamⁱ	TF354237

Family and domain databases

InterProⁱ	View protein in InterPro IPR004000 Actin IPR020902 Actin/actin-like_CS IPR004001 Actin_CS
PANTHERⁱ	PTHR11937 PTHR11937, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00022 Actin, 1 hit
PRINTSⁱ	PR00190 ACTIN
SMARTⁱ	View protein in SMART SM00268 ACTIN, 1 hit
PROSITEⁱ	View protein in PROSITE PS00406 ACTINS_1, 1 hit PS00432 ACTINS_2, 1 hit PS01132 ACTINS_ACT_LIKE, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

P60710-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK 
        60         70         80         90        100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE 
       110        120        130        140        150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG 
       160        170        180        190        200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF 
       210        220        230        240        250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI 
       260        270        280        290        300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
       310        320        330        340        350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS 
       360        370 
TFQQMWISKQ EYDESGPSIV HRKCF

Length:375

Mass (Da):41,737

Last modified:April 1, 1988 - v1

Checksum:ⁱ6AFD05CA94E360E2

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9Q5F4	E9Q5F4_MOUSE	Actin, cytoplasmic 1 Actin, cytoplasmic 1	Actb	265	Annotation score:
E9Q1F2	E9Q1F2_MOUSE	Actin, cytoplasmic 1 Actin, cytoplasmic 1	Actb	295	Annotation score:
E9Q606	E9Q606_MOUSE	Actin, cytoplasmic 1 Actin, cytoplasmic 1	Actb	150	Annotation score:
E9Q2D1	E9Q2D1_MOUSE	Actin, cytoplasmic 1 Actin, cytoplasmic 1	Actb	108	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	38	P → S in CAA27396 (PubMed:3084797).Curated	1
Sequence conflictⁱ	38	P → S in AAA37144 (PubMed:3084797).Curated	1
Sequence conflictⁱ	52	S → F in BAE39957 (PubMed:16141072).Curated	1
Sequence conflictⁱ	80	D → E in BAE35572 (PubMed:16141072).Curated	1
Sequence conflictⁱ	109	P → T in BAE39957 (PubMed:16141072).Curated	1
Sequence conflictⁱ	156	G → R in BAE39957 (PubMed:16141072).Curated	1
Sequence conflictⁱ	178	L → V in BAE39957 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03672 mRNA Translation: CAA27307.1 AK088691 mRNA Translation: BAC40507.1 AK145191 mRNA Translation: BAE26283.1 AK145196 mRNA Translation: BAE26288.1 AK145308 mRNA Translation: BAE26359.1 AK150711 mRNA Translation: BAE29789.1 AK150879 mRNA Translation: BAE29928.1 AK151010 mRNA Translation: BAE30031.1 AK151136 mRNA Translation: BAE30144.1 AK151145 mRNA Translation: BAE30152.1 AK151159 mRNA Translation: BAE30164.1 AK151166 mRNA Translation: BAE30169.1 AK151190 mRNA Translation: BAE30187.1 AK151202 mRNA Translation: BAE30199.1 AK151226 mRNA Translation: BAE30218.1 AK151277 mRNA Translation: BAE30264.1 AK151350 mRNA Translation: BAE30326.1 AK151398 mRNA Translation: BAE30366.1 AK151995 mRNA Translation: BAE30859.1 AK151999 mRNA Translation: BAE30863.1 AK152615 mRNA Translation: BAE31359.1 AK152651 mRNA Translation: BAE31388.1 AK152844 mRNA Translation: BAE31537.1 AK159759 mRNA Translation: BAE35350.1 AK159834 mRNA Translation: BAE35412.1 AK160029 mRNA Translation: BAE35572.1 AK166349 mRNA Translation: BAE38723.1 AK166498 mRNA Translation: BAE38810.1 AK167117 mRNA Translation: BAE39265.1 AK167960 mRNA Translation: BAE39957.1 X03765 mRNA Translation: CAA27396.1 M12481 mRNA Translation: AAA37144.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19833.1
PIRⁱ	A39104 ATMSB
NCBI Reference Sequences More...RefSeqⁱ	NP_031419.1, NM_007393.5
UniGeneⁱ	Mm.328431 Mm.391967 Mm.469717

Genome annotation databases

Ensemblⁱ	ENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580
GeneIDⁱ	11461
KEGGⁱ	mmu:11461
UCSC genome browser More...UCSCⁱ	uc009ajk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P60710	Actin, cytoplasmic 1	)	HUMAN		375	UniRef100_P60709
Actin, cytoplasmic 1	)	BOVIN		375
Actin, cytoplasmic 1		CANLF		375
Actin, cytoplasmic 1		CAVPO		375
Actin, cytoplasmic 1	)	CHICK		375
+94

Protein	Similar proteins		Species	Score	Length	Source
P60710	Actin, cytoplasmic 1	)	HUMAN		375	UniRef90_P60709
Actin, cytoplasmic 1	)	BOVIN		375
Actin, cytoplasmic 1		CANLF		375
Actin, cytoplasmic 1		CAVPO		375
Actin, cytoplasmic 1	)	CHICK		375
+114

Protein	Similar proteins		Species	Score	Length	Source
P60710	Actin, cytoplasmic 1	)	HUMAN		375	UniRef50_P60709
Actin, cytoplasmic 1	)	BOVIN		375
Actin, cytoplasmic 1		CANLF		375
Actin, cytoplasmic 1		CAVPO		375
Actin, cytoplasmic 1	)	CHICK		375
+626

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03672 mRNA Translation: CAA27307.1 AK088691 mRNA Translation: BAC40507.1 AK145191 mRNA Translation: BAE26283.1 AK145196 mRNA Translation: BAE26288.1 AK145308 mRNA Translation: BAE26359.1 AK150711 mRNA Translation: BAE29789.1 AK150879 mRNA Translation: BAE29928.1 AK151010 mRNA Translation: BAE30031.1 AK151136 mRNA Translation: BAE30144.1 AK151145 mRNA Translation: BAE30152.1 AK151159 mRNA Translation: BAE30164.1 AK151166 mRNA Translation: BAE30169.1 AK151190 mRNA Translation: BAE30187.1 AK151202 mRNA Translation: BAE30199.1 AK151226 mRNA Translation: BAE30218.1 AK151277 mRNA Translation: BAE30264.1 AK151350 mRNA Translation: BAE30326.1 AK151398 mRNA Translation: BAE30366.1 AK151995 mRNA Translation: BAE30859.1 AK151999 mRNA Translation: BAE30863.1 AK152615 mRNA Translation: BAE31359.1 AK152651 mRNA Translation: BAE31388.1 AK152844 mRNA Translation: BAE31537.1 AK159759 mRNA Translation: BAE35350.1 AK159834 mRNA Translation: BAE35412.1 AK160029 mRNA Translation: BAE35572.1 AK166349 mRNA Translation: BAE38723.1 AK166498 mRNA Translation: BAE38810.1 AK167117 mRNA Translation: BAE39265.1 AK167960 mRNA Translation: BAE39957.1 X03765 mRNA Translation: CAA27396.1 M12481 mRNA Translation: AAA37144.1
CCDSⁱ	CCDS19833.1
PIRⁱ	A39104 ATMSB
RefSeqⁱ	NP_031419.1, NM_007393.5
UniGeneⁱ	Mm.328431 Mm.391967 Mm.469717

3D structure databases

ProteinModelPortalⁱ	P60710
SMRⁱ	P60710
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	197944, 216 interactors
ComplexPortalⁱ	CPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-990 NuA4 histone acetyltransferase complex
CORUMⁱ	P60710
DIPⁱ	DIP-31574N
IntActⁱ	P60710, 227 interactors
MINTⁱ	P60710
STRINGⁱ	10090.ENSMUSP00000098066

PTM databases

CarbonylDBⁱ	P60710
iPTMnetⁱ	P60710
PhosphoSitePlusⁱ	P60710
SwissPalmⁱ	P60710

2D gel databases

COMPLUYEAST-2DPAGEⁱ	P60710
REPRODUCTION-2DPAGEⁱ	P60710
SWISS-2DPAGEⁱ	P99041
UCD-2DPAGEⁱ	P60710

Proteomic databases

EPDⁱ	P60710
MaxQBⁱ	P60710
PaxDbⁱ	P60710
PeptideAtlasⁱ	P60710
PRIDEⁱ	P60710
TopDownProteomicsⁱ	P60710

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580
GeneIDⁱ	11461
KEGGⁱ	mmu:11461
UCSCⁱ	uc009ajk.1 mouse

Organism-specific databases

CTDⁱ	60
MGIⁱ	MGI:87904 Actb

Phylogenomic databases

eggNOGⁱ	KOG0676 Eukaryota COG5277 LUCA
GeneTreeⁱ	ENSGT00760000118957
HOVERGENⁱ	HBG003771
InParanoidⁱ	P60710
KOⁱ	K05692
OMAⁱ	YKCDLDI
OrthoDBⁱ	EOG091G08LD
PhylomeDBⁱ	P60710
TreeFamⁱ	TF354237

Enzyme and pathway databases

Reactomeⁱ	R-MMU-190873 Gap junction degradation R-MMU-196025 Formation of annular gap junctions R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662 EPHB-mediated forward signaling R-MMU-418990 Adherens junctions interactions R-MMU-437239 Recycling pathway of L1 R-MMU-4420097 VEGFA-VEGFR2 Pathway R-MMU-445095 Interaction between L1 and Ankyrins R-MMU-446353 Cell-extracellular matrix interactions R-MMU-5250924 B-WICH complex positively regulates rRNA expression R-MMU-5626467 RHO GTPases activate IQGAPs R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs R-MMU-5663220 RHO GTPases Activate Formins R-MMU-5674135 MAP2K and MAPK activation R-MMU-5689603 UCH proteinases R-MMU-5696394 DNA Damage Recognition in GG-NER R-MMU-8856828 Clathrin-mediated endocytosis

Reactomeⁱ

R-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-418990 Adherens junctions interactions
R-MMU-437239 Recycling pathway of L1
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-446353 Cell-extracellular matrix interactions
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSⁱ	Actb mouse
Protein Ontology More...PROⁱ	PR:P60710
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029580 Expressed in 312 organ(s), highest expression level in male reproductive system
CleanExⁱ	MM_ACTB
ExpressionAtlasⁱ	P60710 baseline and differential
Genevisibleⁱ	P60710 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004000 Actin IPR020902 Actin/actin-like_CS IPR004001 Actin_CS
PANTHERⁱ	PTHR11937 PTHR11937, 1 hit
Pfamⁱ	View protein in Pfam PF00022 Actin, 1 hit
PRINTSⁱ	PR00190 ACTIN
SMARTⁱ	View protein in SMART SM00268 ACTIN, 1 hit
PROSITEⁱ	View protein in PROSITE PS00406 ACTINS_1, 1 hit PS00432 ACTINS_2, 1 hit PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACTB_MOUSE
Accessionⁱ	P60710Primary (citable) accession number: P60710 Secondary accession number(s): P02570 Q6ZWM3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	April 1, 1988
	Last modified:	November 7, 2018
	This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P60710 (ACTB_MOUSE)

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Actin, cytoplasmic 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ