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Protein

Actin, cytoplasmic 1

Gene

Actb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:23558171, PubMed:25759381).By similarity2 Publications

Miscellaneous

In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-418990 Adherens junctions interactions
R-MMU-437239 Recycling pathway of L1
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-446353 Cell-extracellular matrix interactions
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, cytoplasmic 1
Alternative name(s):
Beta-actin
Cleaved into the following chain:
Gene namesi
Name:Actb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:87904 Actb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003670761 – 375Actin, cytoplasmic 1Add BLAST375
Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00000007752 – 375Actin, cytoplasmic 1, N-terminally processedAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed1 Publication1
Modified residuei44Methionine (R)-sulfoxide1 Publication1
Modified residuei47Methionine (R)-sulfoxide1 Publication1
Modified residuei73Tele-methylhistidine1 Publication1
Modified residuei84N6-methyllysineBy similarity1

Post-translational modificationi

ISGylated.1 Publication
Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization (PubMed:23911929). MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (PubMed:23911929).1 Publication
Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.By similarity
Actin, cytoplasmic 1, N-terminally processed: N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. In contrast, filament nucleation by the Arp2/3 complex is not affected.By similarity

Keywords - PTMi

Acetylation, Methylation, Oxidation, Ubl conjugation

Proteomic databases

EPDiP60710
MaxQBiP60710
PaxDbiP60710
PeptideAtlasiP60710
PRIDEiP60710
TopDownProteomicsiP60710

2D gel databases

COMPLUYEAST-2DPAGEiP60710
REPRODUCTION-2DPAGEiP60710
SWISS-2DPAGEiP99041
UCD-2DPAGEiP60710

PTM databases

CarbonylDBiP60710
iPTMnetiP60710
PhosphoSitePlusiP60710
SwissPalmiP60710

Expressioni

Gene expression databases

BgeeiENSMUSG00000029580 Expressed in 312 organ(s), highest expression level in male reproductive system
CleanExiMM_ACTB
ExpressionAtlasiP60710 baseline and differential
GenevisibleiP60710 MM

Interactioni

Subunit structurei

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:25759381). Each actin can bind to 4 others (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity). Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, MARCB1/BAF47, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3 (By similarity). Found in a complex with XPO6, Ran, ACTB and PFN1 (By similarity). Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM (By similarity). Interacts with XPO6 and EMD (By similarity). Interacts with ERBB2 (By similarity). Interacts with GCSAM (By similarity). Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145). Interacts with TBC1D21 (PubMed:21128978). Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (By similarity). Interacts with FAM107A (PubMed:21969592).By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197944, 216 interactors
ComplexPortaliCPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-990 NuA4 histone acetyltransferase complex
CORUMiP60710
DIPiDIP-31574N
IntActiP60710, 227 interactors
MINTiP60710
STRINGi10090.ENSMUSP00000098066

Structurei

3D structure databases

ProteinModelPortaliP60710
SMRiP60710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOVERGENiHBG003771
InParanoidiP60710
KOiK05692
OMAiYKCDLDI
OrthoDBiEOG091G08LD
PhylomeDBiP60710
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P60710-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Length:375
Mass (Da):41,737
Last modified:April 1, 1988 - v1
Checksum:i6AFD05CA94E360E2
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q5F4E9Q5F4_MOUSE
Actin, cytoplasmic 1
Actb
265Annotation score:
E9Q1F2E9Q1F2_MOUSE
Actin, cytoplasmic 1
Actb
295Annotation score:
E9Q606E9Q606_MOUSE
Actin, cytoplasmic 1
Actb
150Annotation score:
E9Q2D1E9Q2D1_MOUSE
Actin, cytoplasmic 1
Actb
108Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38P → S in CAA27396 (PubMed:3084797).Curated1
Sequence conflicti38P → S in AAA37144 (PubMed:3084797).Curated1
Sequence conflicti52S → F in BAE39957 (PubMed:16141072).Curated1
Sequence conflicti80D → E in BAE35572 (PubMed:16141072).Curated1
Sequence conflicti109P → T in BAE39957 (PubMed:16141072).Curated1
Sequence conflicti156G → R in BAE39957 (PubMed:16141072).Curated1
Sequence conflicti178L → V in BAE39957 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03672 mRNA Translation: CAA27307.1
AK088691 mRNA Translation: BAC40507.1
AK145191 mRNA Translation: BAE26283.1
AK145196 mRNA Translation: BAE26288.1
AK145308 mRNA Translation: BAE26359.1
AK150711 mRNA Translation: BAE29789.1
AK150879 mRNA Translation: BAE29928.1
AK151010 mRNA Translation: BAE30031.1
AK151136 mRNA Translation: BAE30144.1
AK151145 mRNA Translation: BAE30152.1
AK151159 mRNA Translation: BAE30164.1
AK151166 mRNA Translation: BAE30169.1
AK151190 mRNA Translation: BAE30187.1
AK151202 mRNA Translation: BAE30199.1
AK151226 mRNA Translation: BAE30218.1
AK151277 mRNA Translation: BAE30264.1
AK151350 mRNA Translation: BAE30326.1
AK151398 mRNA Translation: BAE30366.1
AK151995 mRNA Translation: BAE30859.1
AK151999 mRNA Translation: BAE30863.1
AK152615 mRNA Translation: BAE31359.1
AK152651 mRNA Translation: BAE31388.1
AK152844 mRNA Translation: BAE31537.1
AK159759 mRNA Translation: BAE35350.1
AK159834 mRNA Translation: BAE35412.1
AK160029 mRNA Translation: BAE35572.1
AK166349 mRNA Translation: BAE38723.1
AK166498 mRNA Translation: BAE38810.1
AK167117 mRNA Translation: BAE39265.1
AK167960 mRNA Translation: BAE39957.1
X03765 mRNA Translation: CAA27396.1
M12481 mRNA Translation: AAA37144.1
CCDSiCCDS19833.1
PIRiA39104 ATMSB
RefSeqiNP_031419.1, NM_007393.5
UniGeneiMm.328431
Mm.391967
Mm.469717

Genome annotation databases

EnsembliENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580
GeneIDi11461
KEGGimmu:11461
UCSCiuc009ajk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03672 mRNA Translation: CAA27307.1
AK088691 mRNA Translation: BAC40507.1
AK145191 mRNA Translation: BAE26283.1
AK145196 mRNA Translation: BAE26288.1
AK145308 mRNA Translation: BAE26359.1
AK150711 mRNA Translation: BAE29789.1
AK150879 mRNA Translation: BAE29928.1
AK151010 mRNA Translation: BAE30031.1
AK151136 mRNA Translation: BAE30144.1
AK151145 mRNA Translation: BAE30152.1
AK151159 mRNA Translation: BAE30164.1
AK151166 mRNA Translation: BAE30169.1
AK151190 mRNA Translation: BAE30187.1
AK151202 mRNA Translation: BAE30199.1
AK151226 mRNA Translation: BAE30218.1
AK151277 mRNA Translation: BAE30264.1
AK151350 mRNA Translation: BAE30326.1
AK151398 mRNA Translation: BAE30366.1
AK151995 mRNA Translation: BAE30859.1
AK151999 mRNA Translation: BAE30863.1
AK152615 mRNA Translation: BAE31359.1
AK152651 mRNA Translation: BAE31388.1
AK152844 mRNA Translation: BAE31537.1
AK159759 mRNA Translation: BAE35350.1
AK159834 mRNA Translation: BAE35412.1
AK160029 mRNA Translation: BAE35572.1
AK166349 mRNA Translation: BAE38723.1
AK166498 mRNA Translation: BAE38810.1
AK167117 mRNA Translation: BAE39265.1
AK167960 mRNA Translation: BAE39957.1
X03765 mRNA Translation: CAA27396.1
M12481 mRNA Translation: AAA37144.1
CCDSiCCDS19833.1
PIRiA39104 ATMSB
RefSeqiNP_031419.1, NM_007393.5
UniGeneiMm.328431
Mm.391967
Mm.469717

3D structure databases

ProteinModelPortaliP60710
SMRiP60710
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197944, 216 interactors
ComplexPortaliCPX-1232 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1233 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1234 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1235 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1236 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1237 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1238 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1239 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1240 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1241 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1242 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1243 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1244 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1245 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1246 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1247 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1248 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant
CPX-1250 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant
CPX-1251 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex
CPX-1252 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1253 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1254 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1255 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1256 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1257 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1258 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1259 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1261 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1262 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1263 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1264 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-990 NuA4 histone acetyltransferase complex
CORUMiP60710
DIPiDIP-31574N
IntActiP60710, 227 interactors
MINTiP60710
STRINGi10090.ENSMUSP00000098066

PTM databases

CarbonylDBiP60710
iPTMnetiP60710
PhosphoSitePlusiP60710
SwissPalmiP60710

2D gel databases

COMPLUYEAST-2DPAGEiP60710
REPRODUCTION-2DPAGEiP60710
SWISS-2DPAGEiP99041
UCD-2DPAGEiP60710

Proteomic databases

EPDiP60710
MaxQBiP60710
PaxDbiP60710
PeptideAtlasiP60710
PRIDEiP60710
TopDownProteomicsiP60710

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580
GeneIDi11461
KEGGimmu:11461
UCSCiuc009ajk.1 mouse

Organism-specific databases

CTDi60
MGIiMGI:87904 Actb

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOVERGENiHBG003771
InParanoidiP60710
KOiK05692
OMAiYKCDLDI
OrthoDBiEOG091G08LD
PhylomeDBiP60710
TreeFamiTF354237

Enzyme and pathway databases

ReactomeiR-MMU-190873 Gap junction degradation
R-MMU-196025 Formation of annular gap junctions
R-MMU-2029482 Regulation of actin dynamics for phagocytic cup formation
R-MMU-3928662 EPHB-mediated forward signaling
R-MMU-418990 Adherens junctions interactions
R-MMU-437239 Recycling pathway of L1
R-MMU-4420097 VEGFA-VEGFR2 Pathway
R-MMU-445095 Interaction between L1 and Ankyrins
R-MMU-446353 Cell-extracellular matrix interactions
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5626467 RHO GTPases activate IQGAPs
R-MMU-5663213 RHO GTPases Activate WASPs and WAVEs
R-MMU-5663220 RHO GTPases Activate Formins
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5689603 UCH proteinases
R-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiActb mouse
PROiPR:P60710
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029580 Expressed in 312 organ(s), highest expression level in male reproductive system
CleanExiMM_ACTB
ExpressionAtlasiP60710 baseline and differential
GenevisibleiP60710 MM

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACTB_MOUSE
AccessioniPrimary (citable) accession number: P60710
Secondary accession number(s): P02570
, P70514, P99021, Q11211, Q3TI89, Q3TVP6, Q64316, Q6ZWM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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