UniProtKB - P60710 (ACTB_MOUSE)
Actin, cytoplasmic 1
Actb
Functioni
Miscellaneous
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: MGI
- kinesin binding Source: MGI
- nitric-oxide synthase binding Source: MGI
- protein kinase binding Source: MGI
- structural constituent of postsynaptic actin cytoskeleton Source: MGI
- Tat protein binding Source: MGI
GO - Biological processi
- adherens junction assembly Source: MGI
- apical protein localization Source: MGI
- axonogenesis Source: MGI
- cell motility Source: MGI
- cellular response to cytochalasin B Source: MGI
- cellular response to electrical stimulus Source: MGI
- establishment or maintenance of cell polarity Source: MGI
- morphogenesis of a polarized epithelium Source: MGI
- negative regulation of cyclin-dependent protein kinase activity Source: ARUK-UCL
- negative regulation of protein binding Source: ARUK-UCL
- postsynaptic actin cytoskeleton organization Source: MGI
- protein localization to adherens junction Source: MGI
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- regulation of norepinephrine uptake Source: MGI
- regulation of protein localization to plasma membrane Source: MGI
- regulation of transepithelial transport Source: MGI
- regulation of transmembrane transporter activity Source: MGI
- synaptic vesicle endocytosis Source: SynGO
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-190873, Gap junction degradation R-MMU-196025, Formation of annular gap junctions R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662, EPHB-mediated forward signaling R-MMU-418990, Adherens junctions interactions R-MMU-437239, Recycling pathway of L1 R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-445095, Interaction between L1 and Ankyrins R-MMU-446353, Cell-extracellular matrix interactions R-MMU-5250924, B-WICH complex positively regulates rRNA expression R-MMU-5626467, RHO GTPases activate IQGAPs R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs R-MMU-5663220, RHO GTPases Activate Formins R-MMU-5674135, MAP2K and MAPK activation R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, cytoplasmic 1Alternative name(s): Beta-actin Cleaved into the following chain: |
Gene namesi | Name:Actb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:87904, Actb |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actin filament Source: GO_Central
- cortical cytoskeleton Source: MGI
- cytoskeleton Source: ARUK-UCL
- podosome Source: MGI
- postsynaptic actin cytoskeleton Source: MGI
- stress fiber Source: MGI
Cytosol
- cytosol Source: MGI
Nucleus
- NuA4 histone acetyltransferase complex Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- adherens junction Source: MGI
- apical junction complex Source: MGI
- axon Source: MGI
- calyx of Held Source: SynGO
- cell-cell junction Source: MGI
- cytoplasm Source: ARUK-UCL
- cytoplasmic ribonucleoprotein granule Source: MGI
- dense body Source: AgBase
- focal adhesion Source: AgBase
- glutamatergic synapse Source: MGI
- lamellipodium Source: MGI
- membrane Source: GO_Central
- membrane raft Source: MGI
- myelin sheath Source: UniProtKB
- postsynaptic density Source: MGI
- protein-containing complex Source: UniProtKB
- ribonucleoprotein complex Source: MGI
- Schaffer collateral - CA1 synapse Source: SynGO
- synapse Source: GO_Central
- tight junction Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367076 | 1 – 375 | Actin, cytoplasmic 1Add BLAST | 375 | |
Initiator methioninei | Removed; alternate1 Publication | |||
ChainiPRO_0000000775 | 2 – 375 | Actin, cytoplasmic 1, N-terminally processedAdd BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed1 Publication | 1 | |
Modified residuei | 44 | Methionine (R)-sulfoxide1 Publication | 1 | |
Modified residuei | 47 | Methionine (R)-sulfoxide1 Publication | 1 | |
Modified residuei | 73 | Tele-methylhistidine2 Publications | 1 | |
Modified residuei | 84 | N6-methyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, Oxidation, Ubl conjugationProteomic databases
CPTACi | non-CPTAC-3542 |
EPDi | P60710 |
jPOSTi | P60710 |
MaxQBi | P60710 |
PaxDbi | P60710 |
PeptideAtlasi | P60710 |
PRIDEi | P60710 |
ProteomicsDBi | 285751 |
TopDownProteomicsi | P60710 |
2D gel databases
COMPLUYEAST-2DPAGEi | P60710 |
REPRODUCTION-2DPAGEi | P60710 |
SWISS-2DPAGEi | P99041 |
UCD-2DPAGEi | P60710 |
PTM databases
CarbonylDBi | P60710 |
iPTMneti | P60710 |
PhosphoSitePlusi | P60710 |
SwissPalmi | P60710 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000029580, Expressed in lymph node and 326 other tissues |
Genevisiblei | P60710, MM |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:25759381). Each actin can bind to 4 others (By similarity).
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (By similarity).
Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, MARCB1/BAF47, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (By similarity). In muscle cells, the BAF complex also contains DPF3 (By similarity).
Found in a complex with XPO6, Ran, ACTB and PFN1 (By similarity).
Component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM (By similarity).
Interacts with XPO6 and EMD (By similarity).
Interacts with ERBB2 (By similarity).
Interacts with GCSAM (By similarity).
Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (PubMed:12522145).
Interacts with TBC1D21 (PubMed:21128978).
Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (By similarity).
Interacts with FAM107A (PubMed:21969592).
By similarity4 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- identical protein binding Source: MGI
- kinesin binding Source: MGI
- nitric-oxide synthase binding Source: MGI
- protein kinase binding Source: MGI
- Tat protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 197944, 358 interactors |
ComplexPortali | CPX-1232, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1261, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1262, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1263, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1264, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-4202, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4204, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4221, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4222, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4227, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4228, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4229, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4230, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-990, NuA4 histone acetyltransferase complex |
CORUMi | P60710 |
DIPi | DIP-31574N |
IntActi | P60710, 228 interactors |
MINTi | P60710 |
STRINGi | 10090.ENSMUSP00000098066 |
Miscellaneous databases
RNActi | P60710, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00950000182960 |
InParanoidi | P60710 |
OMAi | FHTTAER |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60710 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q5F4 | E9Q5F4_MOUSE | Actin, cytoplasmic 1 | Actb | 265 | Annotation score: | ||
E9Q606 | E9Q606_MOUSE | Actin, cytoplasmic 1 | Actb | 150 | Annotation score: | ||
E9Q1F2 | E9Q1F2_MOUSE | Actin, cytoplasmic 1 | Actb | 295 | Annotation score: | ||
E9Q2D1 | E9Q2D1_MOUSE | Actin, cytoplasmic 1 | Actb | 108 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 38 | P → S in CAA27396 (PubMed:3084797).Curated | 1 | |
Sequence conflicti | 38 | P → S in AAA37144 (PubMed:3084797).Curated | 1 | |
Sequence conflicti | 52 | S → F in BAE39957 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 80 | D → E in BAE35572 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 109 | P → T in BAE39957 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 156 | G → R in BAE39957 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 178 | L → V in BAE39957 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03672 mRNA Translation: CAA27307.1 AK088691 mRNA Translation: BAC40507.1 AK145191 mRNA Translation: BAE26283.1 AK145196 mRNA Translation: BAE26288.1 AK145308 mRNA Translation: BAE26359.1 AK150711 mRNA Translation: BAE29789.1 AK150879 mRNA Translation: BAE29928.1 AK151010 mRNA Translation: BAE30031.1 AK151136 mRNA Translation: BAE30144.1 AK151145 mRNA Translation: BAE30152.1 AK151159 mRNA Translation: BAE30164.1 AK151166 mRNA Translation: BAE30169.1 AK151190 mRNA Translation: BAE30187.1 AK151202 mRNA Translation: BAE30199.1 AK151226 mRNA Translation: BAE30218.1 AK151277 mRNA Translation: BAE30264.1 AK151350 mRNA Translation: BAE30326.1 AK151398 mRNA Translation: BAE30366.1 AK151995 mRNA Translation: BAE30859.1 AK151999 mRNA Translation: BAE30863.1 AK152615 mRNA Translation: BAE31359.1 AK152651 mRNA Translation: BAE31388.1 AK152844 mRNA Translation: BAE31537.1 AK159759 mRNA Translation: BAE35350.1 AK159834 mRNA Translation: BAE35412.1 AK160029 mRNA Translation: BAE35572.1 AK166349 mRNA Translation: BAE38723.1 AK166498 mRNA Translation: BAE38810.1 AK167117 mRNA Translation: BAE39265.1 AK167960 mRNA Translation: BAE39957.1 X03765 mRNA Translation: CAA27396.1 M12481 mRNA Translation: AAA37144.1 |
CCDSi | CCDS19833.1 |
PIRi | A39104, ATMSB |
RefSeqi | NP_031419.1, NM_007393.5 |
Genome annotation databases
Ensembli | ENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580 |
GeneIDi | 11461 |
KEGGi | mmu:11461 |
UCSCi | uc009ajk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03672 mRNA Translation: CAA27307.1 AK088691 mRNA Translation: BAC40507.1 AK145191 mRNA Translation: BAE26283.1 AK145196 mRNA Translation: BAE26288.1 AK145308 mRNA Translation: BAE26359.1 AK150711 mRNA Translation: BAE29789.1 AK150879 mRNA Translation: BAE29928.1 AK151010 mRNA Translation: BAE30031.1 AK151136 mRNA Translation: BAE30144.1 AK151145 mRNA Translation: BAE30152.1 AK151159 mRNA Translation: BAE30164.1 AK151166 mRNA Translation: BAE30169.1 AK151190 mRNA Translation: BAE30187.1 AK151202 mRNA Translation: BAE30199.1 AK151226 mRNA Translation: BAE30218.1 AK151277 mRNA Translation: BAE30264.1 AK151350 mRNA Translation: BAE30326.1 AK151398 mRNA Translation: BAE30366.1 AK151995 mRNA Translation: BAE30859.1 AK151999 mRNA Translation: BAE30863.1 AK152615 mRNA Translation: BAE31359.1 AK152651 mRNA Translation: BAE31388.1 AK152844 mRNA Translation: BAE31537.1 AK159759 mRNA Translation: BAE35350.1 AK159834 mRNA Translation: BAE35412.1 AK160029 mRNA Translation: BAE35572.1 AK166349 mRNA Translation: BAE38723.1 AK166498 mRNA Translation: BAE38810.1 AK167117 mRNA Translation: BAE39265.1 AK167960 mRNA Translation: BAE39957.1 X03765 mRNA Translation: CAA27396.1 M12481 mRNA Translation: AAA37144.1 |
CCDSi | CCDS19833.1 |
PIRi | A39104, ATMSB |
RefSeqi | NP_031419.1, NM_007393.5 |
3D structure databases
SMRi | P60710 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 197944, 358 interactors |
ComplexPortali | CPX-1232, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1233, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1234, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1235, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1236, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1237, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1238, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1239, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1240, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1241, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1242, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1243, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1244, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1245, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1246, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1247, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1248, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1250, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1251, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1252, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1253, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1254, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1255, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1256, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1257, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1258, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1259, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1261, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1262, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1263, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1264, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-4202, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4204, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4221, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4222, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4227, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4228, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4229, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4230, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-990, NuA4 histone acetyltransferase complex |
CORUMi | P60710 |
DIPi | DIP-31574N |
IntActi | P60710, 228 interactors |
MINTi | P60710 |
STRINGi | 10090.ENSMUSP00000098066 |
PTM databases
CarbonylDBi | P60710 |
iPTMneti | P60710 |
PhosphoSitePlusi | P60710 |
SwissPalmi | P60710 |
2D gel databases
COMPLUYEAST-2DPAGEi | P60710 |
REPRODUCTION-2DPAGEi | P60710 |
SWISS-2DPAGEi | P99041 |
UCD-2DPAGEi | P60710 |
Proteomic databases
CPTACi | non-CPTAC-3542 |
EPDi | P60710 |
jPOSTi | P60710 |
MaxQBi | P60710 |
PaxDbi | P60710 |
PeptideAtlasi | P60710 |
PRIDEi | P60710 |
ProteomicsDBi | 285751 |
TopDownProteomicsi | P60710 |
Protocols and materials databases
Antibodypediai | 3623, 1935 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000100497; ENSMUSP00000098066; ENSMUSG00000029580 |
GeneIDi | 11461 |
KEGGi | mmu:11461 |
UCSCi | uc009ajk.1, mouse |
Organism-specific databases
CTDi | 60 |
MGIi | MGI:87904, Actb |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00950000182960 |
InParanoidi | P60710 |
OMAi | FHTTAER |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60710 |
TreeFami | TF354237 |
Enzyme and pathway databases
Reactomei | R-MMU-190873, Gap junction degradation R-MMU-196025, Formation of annular gap junctions R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-3928662, EPHB-mediated forward signaling R-MMU-418990, Adherens junctions interactions R-MMU-437239, Recycling pathway of L1 R-MMU-4420097, VEGFA-VEGFR2 Pathway R-MMU-445095, Interaction between L1 and Ankyrins R-MMU-446353, Cell-extracellular matrix interactions R-MMU-5250924, B-WICH complex positively regulates rRNA expression R-MMU-5626467, RHO GTPases activate IQGAPs R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs R-MMU-5663220, RHO GTPases Activate Formins R-MMU-5674135, MAP2K and MAPK activation R-MMU-5689603, UCH proteinases R-MMU-5696394, DNA Damage Recognition in GG-NER R-MMU-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 11461, 24 hits in 54 CRISPR screens |
ChiTaRSi | Actb, mouse |
PROi | PR:P60710 |
RNActi | P60710, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029580, Expressed in lymph node and 326 other tissues |
Genevisiblei | P60710, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTB_MOUSE | |
Accessioni | P60710Primary (citable) accession number: P60710 Secondary accession number(s): P02570 Q6ZWM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families