UniProtKB - P60709 (ACTB_HUMAN)
Actin, cytoplasmic 1
ACTB
Functioni
Miscellaneous
Caution
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- kinesin binding Source: UniProtKB
- nitric-oxide synthase binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- structural constituent of cytoskeleton Source: UniProtKB
- structural constituent of postsynaptic actin cytoskeleton Source: SynGO
- Tat protein binding Source: BHF-UCL
- tau protein binding Source: ARUK-UCL
GO - Biological processi
- ATP-dependent chromatin remodeling Source: UniProtKB
- axonogenesis Source: GO_Central
- cell junction assembly Source: Reactome
- cell motility Source: UniProtKB
- cellular response to cytochalasin B Source: UniProtKB
- ephrin receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- membrane organization Source: Reactome
- negative regulation of protein binding Source: ARUK-UCL
- platelet aggregation Source: UniProtKB
- positive regulation of gene expression, epigenetic Source: Reactome
- positive regulation of norepinephrine uptake Source: ARUK-UCL
- postsynaptic actin cytoskeleton organization Source: SynGO
- protein deubiquitination Source: Reactome
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: ARUK-UCL
- regulation of norepinephrine uptake Source: ARUK-UCL
- regulation of protein localization to plasma membrane Source: ARUK-UCL
- regulation of transmembrane transporter activity Source: ARUK-UCL
- retina homeostasis Source: UniProtKB
- substantia nigra development Source: UniProtKB
- synaptic vesicle endocytosis Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-3214847 HATs acetylate histones R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390450 Folding of actin by CCT/TriC R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-418990 Adherens junctions interactions R-HSA-437239 Recycling pathway of L1 R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-446353 Cell-extracellular matrix interactions R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-5674135 MAP2K and MAPK activation R-HSA-5689603 UCH proteinases R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-9649948 Signaling downstream of RAS mutants R-HSA-983231 Factors involved in megakaryocyte development and platelet production |
SignaLinki | P60709 |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, cytoplasmic 1Alternative name(s): Beta-actin Cleaved into the following chain: |
Gene namesi | Name:ACTB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:132 ACTB |
MIMi | 102630 gene |
neXtProti | NX_P60709 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 2 Publications
Nucleus
- Nucleus 2 Publications
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.1 Publication
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actin filament Source: GO_Central
- cortical cytoskeleton Source: Ensembl
- cytoskeleton Source: ARUK-UCL
- postsynaptic actin cytoskeleton Source: SynGO
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nuclear chromatin Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- axon Source: GO_Central
- calyx of Held Source: Ensembl
- cell-cell junction Source: ARUK-UCL
- cytoplasm Source: ARUK-UCL
- cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
- dense body Source: AgBase
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: SynGO
- membrane Source: UniProtKB
- presynapse Source: ARUK-UCL
- protein-containing complex Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
- Schaffer collateral - CA1 synapse Source: Ensembl
- synapse Source: GO_Central
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Dystonia, juvenile-onset (DJO)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030026 | 183 | R → W in DJO; modifies cell response to latrunculin A. 1 PublicationCorresponds to variant dbSNP:rs104894003EnsemblClinVar. | 1 |
Baraitser-Winter syndrome 1 (BRWS1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067810 | 12 | N → D in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875331EnsemblClinVar. | 1 | |
Natural variantiVAR_067811 | 65 | L → V in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875332EnsemblClinVar. | 1 | |
Natural variantiVAR_067812 | 196 | R → C in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875333EnsemblClinVar. | 1 | |
Natural variantiVAR_067813 | 196 | R → H in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875334EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 69 | Y → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 71 | I → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 71 | I → A: Impaired methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 73 | H → A: Abolished methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 74 | G → A: Impaired methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 79 | W → E: Does not affect methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 80 | D → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 81 | D → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 82 | M → A: Decreased interaction with SETD3. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Disease mutation, Dystonia, Mental retardationOrganism-specific databases
DisGeNETi | 60 |
GeneReviewsi | ACTB |
MalaCardsi | ACTB |
MIMi | 243310 phenotype 607371 phenotype |
OpenTargetsi | ENSG00000075624 |
Orphaneti | 2995 Baraitser-Winter cerebrofrontofacial syndrome 64755 Becker nevus syndrome 79107 Developmental malformations-deafness-dystonia syndrome |
PharmGKBi | PA24457 |
Miscellaneous databases
Pharosi | P60709 |
Chemistry databases
ChEMBLi | CHEMBL2062353 |
DrugBanki | DB12695 Phenethyl Isothiocyanate DB04216 Quercetin |
Polymorphism and mutation databases
BioMutai | ACTB |
DMDMi | 46397333 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367073 | 1 – 375 | Actin, cytoplasmic 1Add BLAST | 375 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000000771 | 2 – 375 | Actin, cytoplasmic 1, N-terminally processed1 PublicationAdd BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processedCombined sources3 Publications | 1 | |
Modified residuei | 44 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 47 | Methionine (R)-sulfoxideBy similarity | 1 | |
Cross-linki | 50 | (Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG11 Publication | ||
Modified residuei | 73 | Tele-methylhistidine3 Publications | 1 | |
Modified residuei | 84 | N6-methyllysine1 Publication | 1 | |
Cross-linki | 270 | (Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG11 Publication |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Oxidation, Ubl conjugationProteomic databases
EPDi | P60709 |
jPOSTi | P60709 |
MassIVEi | P60709 |
PaxDbi | P60709 |
PeptideAtlasi | P60709 |
PRIDEi | P60709 |
ProteomicsDBi | 57224 |
TopDownProteomicsi | P60709 |
2D gel databases
DOSAC-COBS-2DPAGEi | P60709 |
REPRODUCTION-2DPAGEi | P60709 |
SWISS-2DPAGEi | P60709 |
UCD-2DPAGEi | P60709 |
PTM databases
CarbonylDBi | P60709 |
iPTMneti | P60709 |
PhosphoSitePlusi | P60709 |
SwissPalmi | P60709 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075624 Expressed in 230 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P60709 baseline and differential |
Genevisiblei | P60709 HS |
Organism-specific databases
HPAi | CAB002621 HPA041264 HPA041271 |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:28604741, PubMed:16685646). Each actin can bind to 4 others (PubMed:28604741, PubMed:16685646).
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).
Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789).
Found in a complex with XPO6, Ran, ACTB and PFN1 (PubMed:14592989).
Interacts with XPO6 and EMD (PubMed:15328537).
Interacts with ERBB2 (PubMed:21555369).
Interacts with GCSAM (PubMed:17823310).
Interacts with TBC1D21 (By similarity).
Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity).
Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (PubMed:11687588).
Interacts with FAM107A (PubMed:21969592, PubMed:28604741).
By similarity10 PublicationsBinary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
- kinesin binding Source: UniProtKB
- nitric-oxide synthase binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- Tat protein binding Source: BHF-UCL
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGridi | 106575, 355 interactors |
ComplexPortali | CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1203 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1219 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1220 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1221 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-978 NuA4 histone acetyltransferase complex |
CORUMi | P60709 |
DIPi | DIP-29686N |
IntActi | P60709, 289 interactors |
MINTi | P60709 |
STRINGi | 9606.ENSP00000349960 |
Structurei
Secondary structure
3D structure databases
SMRi | P60709 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P60709 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0676 Eukaryota COG5277 LUCA |
GeneTreei | ENSGT00950000182960 |
InParanoidi | P60709 |
KOi | K05692 |
OMAi | MIGKESE |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60709 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000 Actin IPR020902 Actin/actin-like_CS IPR004001 Actin_CS |
PANTHERi | PTHR11937 PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022 Actin, 1 hit |
PRINTSi | PR00190 ACTIN |
SMARTi | View protein in SMART SM00268 ACTIN, 1 hit |
PROSITEi | View protein in PROSITE PS00406 ACTINS_1, 1 hit PS00432 ACTINS_2, 1 hit PS01132 ACTINS_ACT_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9R0 | G5E9R0_HUMAN | Actin, cytoplasmic 1 | ACTB hCG_15971 | 125 | Annotation score: | ||
E7EVS6 | E7EVS6_HUMAN | Actin, cytoplasmic 1 | ACTB | 163 | Annotation score: | ||
A0A2R8Y793 | A0A2R8Y793_HUMAN | Actin, cytoplasmic 1 | ACTB | 309 | Annotation score: | ||
A0A2R8YGF8 | A0A2R8YGF8_HUMAN | Actin, cytoplasmic 1 | ACTB | 165 | Annotation score: | ||
A0A2R8YEA7 | A0A2R8YEA7_HUMAN | Actin, cytoplasmic 1 | ACTB | 157 | Annotation score: | ||
C9JUM1 | C9JUM1_HUMAN | Actin, cytoplasmic 1 | ACTB | 96 | Annotation score: | ||
C9JZR7 | C9JZR7_HUMAN | Actin, cytoplasmic 1 | ACTB | 102 | Annotation score: | ||
C9JTX5 | C9JTX5_HUMAN | Actin, cytoplasmic 1 | ACTB | 80 | Annotation score: | ||
A0A2R8YFE2 | A0A2R8YFE2_HUMAN | Actin, cytoplasmic 1 | ACTB | 79 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | A → P in AAH16045 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 116 | R → L in AAH12854 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067810 | 12 | N → D in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875331EnsemblClinVar. | 1 | |
Natural variantiVAR_067811 | 65 | L → V in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875332EnsemblClinVar. | 1 | |
Natural variantiVAR_030026 | 183 | R → W in DJO; modifies cell response to latrunculin A. 1 PublicationCorresponds to variant dbSNP:rs104894003EnsemblClinVar. | 1 | |
Natural variantiVAR_067812 | 196 | R → C in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875333EnsemblClinVar. | 1 | |
Natural variantiVAR_067813 | 196 | R → H in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875334EnsemblClinVar. | 1 | |
Natural variantiVAR_048185 | 243 | P → L. Corresponds to variant dbSNP:rs11546899Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00351 mRNA Translation: CAA25099.1 M10277 Genomic DNA Translation: AAA51567.1 X63432 mRNA Translation: CAA45026.1 AY582799 Genomic DNA Translation: AAS79319.1 AC006483 Genomic DNA Translation: AAP22343.1 BC001301 mRNA Translation: AAH01301.1 BC002409 mRNA Translation: AAH02409.1 BC004251 mRNA Translation: AAH04251.1 BC008633 mRNA Translation: AAH08633.1 BC012854 mRNA Translation: AAH12854.1 BC013380 mRNA Translation: AAH13380.1 BC014861 mRNA Translation: AAH14861.1 BC016045 mRNA Translation: AAH16045.1 V00478 mRNA Translation: CAA23745.1 |
CCDSi | CCDS5341.1 |
PIRi | A25168 ATHUB |
RefSeqi | NP_001092.1, NM_001101.3 |
Genome annotation databases
Ensembli | ENST00000493945; ENSP00000494269; ENSG00000075624 ENST00000646664; ENSP00000494750; ENSG00000075624 |
GeneIDi | 60 |
KEGGi | hsa:60 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Mendelian genes actin, beta (ACTB) Leiden Open Variation Database (LOVD) |
Protein Spotlight On mar and motion - Issue 208 of November 2018 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00351 mRNA Translation: CAA25099.1 M10277 Genomic DNA Translation: AAA51567.1 X63432 mRNA Translation: CAA45026.1 AY582799 Genomic DNA Translation: AAS79319.1 AC006483 Genomic DNA Translation: AAP22343.1 BC001301 mRNA Translation: AAH01301.1 BC002409 mRNA Translation: AAH02409.1 BC004251 mRNA Translation: AAH04251.1 BC008633 mRNA Translation: AAH08633.1 BC012854 mRNA Translation: AAH12854.1 BC013380 mRNA Translation: AAH13380.1 BC014861 mRNA Translation: AAH14861.1 BC016045 mRNA Translation: AAH16045.1 V00478 mRNA Translation: CAA23745.1 |
CCDSi | CCDS5341.1 |
PIRi | A25168 ATHUB |
RefSeqi | NP_001092.1, NM_001101.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BYH | electron microscopy | 12.00 | A | 2-375 | [»] | |
3D2U | X-ray | 2.21 | C/G | 170-178 | [»] | |
3J82 | electron microscopy | 7.70 | B/C/D | 2-375 | [»] | |
3LUE | electron microscopy | - | A/B/C/D/E/F/G/H/I/J | 2-375 | [»] | |
6ANU | electron microscopy | 7.00 | A/B/C/D/E/F | 1-375 | [»] | |
6ICT | X-ray | 1.95 | E/G/H/I | 66-88 | [»] | |
6ICV | X-ray | 2.15 | C/D | 66-88 | [»] | |
6MBJ | X-ray | 1.78 | Y/Z | 66-80 | [»] | |
6MBK | X-ray | 1.69 | Y/Z | 66-80 | [»] | |
6MBL | X-ray | 2.20 | Y | 66-80 | [»] | |
6OX0 | X-ray | 1.75 | Y/Z | 66-80 | [»] | |
6OX1 | X-ray | 1.95 | Y/Z | 66-80 | [»] | |
6OX2 | X-ray | 2.09 | Y/Z | 66-80 | [»] | |
6OX4 | X-ray | 2.29 | Y/Z | 66-80 | [»] | |
6OX5 | X-ray | 2.10 | Y | 66-83 | [»] | |
SMRi | P60709 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 106575, 355 interactors |
ComplexPortali | CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195 Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199 Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1203 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1219 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1220 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1221 Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226 GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-978 NuA4 histone acetyltransferase complex |
CORUMi | P60709 |
DIPi | DIP-29686N |
IntActi | P60709, 289 interactors |
MINTi | P60709 |
STRINGi | 9606.ENSP00000349960 |
Chemistry databases
ChEMBLi | CHEMBL2062353 |
DrugBanki | DB12695 Phenethyl Isothiocyanate DB04216 Quercetin |
PTM databases
CarbonylDBi | P60709 |
iPTMneti | P60709 |
PhosphoSitePlusi | P60709 |
SwissPalmi | P60709 |
Polymorphism and mutation databases
BioMutai | ACTB |
DMDMi | 46397333 |
2D gel databases
DOSAC-COBS-2DPAGEi | P60709 |
REPRODUCTION-2DPAGEi | P60709 |
SWISS-2DPAGEi | P60709 |
UCD-2DPAGEi | P60709 |
Proteomic databases
EPDi | P60709 |
jPOSTi | P60709 |
MassIVEi | P60709 |
PaxDbi | P60709 |
PeptideAtlasi | P60709 |
PRIDEi | P60709 |
ProteomicsDBi | 57224 |
TopDownProteomicsi | P60709 |
Protocols and materials databases
ABCDi | P60709 |
DNASUi | 60 |
Genome annotation databases
Ensembli | ENST00000493945; ENSP00000494269; ENSG00000075624 ENST00000646664; ENSP00000494750; ENSG00000075624 |
GeneIDi | 60 |
KEGGi | hsa:60 |
Organism-specific databases
CTDi | 60 |
DisGeNETi | 60 |
GeneCardsi | ACTB |
GeneReviewsi | ACTB |
HGNCi | HGNC:132 ACTB |
HPAi | CAB002621 HPA041264 HPA041271 |
MalaCardsi | ACTB |
MIMi | 102630 gene 243310 phenotype 607371 phenotype |
neXtProti | NX_P60709 |
OpenTargetsi | ENSG00000075624 |
Orphaneti | 2995 Baraitser-Winter cerebrofrontofacial syndrome 64755 Becker nevus syndrome 79107 Developmental malformations-deafness-dystonia syndrome |
PharmGKBi | PA24457 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0676 Eukaryota COG5277 LUCA |
GeneTreei | ENSGT00950000182960 |
InParanoidi | P60709 |
KOi | K05692 |
OMAi | MIGKESE |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60709 |
TreeFami | TF354237 |
Enzyme and pathway databases
Reactomei | R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190873 Gap junction degradation R-HSA-196025 Formation of annular gap junctions R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-3214847 HATs acetylate histones R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390450 Folding of actin by CCT/TriC R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-418990 Adherens junctions interactions R-HSA-437239 Recycling pathway of L1 R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-445095 Interaction between L1 and Ankyrins R-HSA-446353 Cell-extracellular matrix interactions R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-5674135 MAP2K and MAPK activation R-HSA-5689603 UCH proteinases R-HSA-5696394 DNA Damage Recognition in GG-NER R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-9649948 Signaling downstream of RAS mutants R-HSA-983231 Factors involved in megakaryocyte development and platelet production |
SignaLinki | P60709 |
Miscellaneous databases
ChiTaRSi | ACTB human |
EvolutionaryTracei | P60709 |
GeneWikii | Beta-actin |
GenomeRNAii | 60 |
Pharosi | P60709 |
PROi | PR:P60709 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075624 Expressed in 230 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P60709 baseline and differential |
Genevisiblei | P60709 HS |
Family and domain databases
InterProi | View protein in InterPro IPR004000 Actin IPR020902 Actin/actin-like_CS IPR004001 Actin_CS |
PANTHERi | PTHR11937 PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022 Actin, 1 hit |
PRINTSi | PR00190 ACTIN |
SMARTi | View protein in SMART SM00268 ACTIN, 1 hit |
PROSITEi | View protein in PROSITE PS00406 ACTINS_1, 1 hit PS00432 ACTINS_2, 1 hit PS01132 ACTINS_ACT_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTB_HUMAN | |
Accessioni | P60709Primary (citable) accession number: P60709 Secondary accession number(s): P02570 Q96HG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 1, 1988 | |
Last modified: | November 13, 2019 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references