UniProtKB - P60709 (ACTB_HUMAN)
Actin, cytoplasmic 1
ACTB
Functioni
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253).
Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253).
In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947).
2 PublicationsMiscellaneous
Caution
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- kinesin binding Source: UniProtKB
- nitric-oxide synthase binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- structural constituent of cytoskeleton Source: UniProtKB
- structural constituent of postsynaptic actin cytoskeleton Source: SynGO
- Tat protein binding Source: BHF-UCL
- tau protein binding Source: ARUK-UCL
GO - Biological processi
- adherens junction assembly Source: ARUK-UCL
- apical protein localization Source: ARUK-UCL
- axonogenesis Source: GO_Central
- cell motility Source: UniProtKB
- cellular response to cytochalasin B Source: UniProtKB
- chromatin remodeling Source: GO_Central
- establishment or maintenance of cell polarity Source: ARUK-UCL
- histone H2A acetylation Source: ComplexPortal
- histone H4 acetylation Source: ComplexPortal
- maintenance of blood-brain barrier Source: ARUK-UCL
- morphogenesis of a polarized epithelium Source: ARUK-UCL
- negative regulation of protein binding Source: ARUK-UCL
- platelet aggregation Source: UniProtKB
- positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
- positive regulation of norepinephrine uptake Source: ARUK-UCL
- postsynaptic actin cytoskeleton organization Source: SynGO
- protein localization to adherens junction Source: ARUK-UCL
- regulation of cell cycle Source: ComplexPortal
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: ARUK-UCL
- regulation of norepinephrine uptake Source: ARUK-UCL
- regulation of protein localization to plasma membrane Source: ARUK-UCL
- regulation of transepithelial transport Source: ARUK-UCL
- regulation of transmembrane transporter activity Source: ARUK-UCL
- retina homeostasis Source: UniProtKB
- substantia nigra development Source: UniProtKB
- synaptic vesicle endocytosis Source: Ensembl
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P60709 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-3214847, HATs acetylate histones R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390450, Folding of actin by CCT/TriC R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-418990, Adherens junctions interactions R-HSA-437239, Recycling pathway of L1 R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-446353, Cell-extracellular matrix interactions R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5674135, MAP2K and MAPK activation R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9035034, RHOF GTPase cycle R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P60709 |
SIGNORi | P60709 |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, cytoplasmic 1Alternative name(s): Beta-actin Cleaved into the following chain: |
Gene namesi | Name:ACTB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:132, ACTB |
MIMi | 102630, gene |
neXtProti | NX_P60709 |
VEuPathDBi | HostDB:ENSG00000075624 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoskeleton
- cytoskeleton 2 Publications
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.1 Publication
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actin filament Source: GO_Central
- cortical cytoskeleton Source: Ensembl
- cytoskeleton Source: ARUK-UCL
- postsynaptic actin cytoskeleton Source: SynGO
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- adherens junction Source: ARUK-UCL
- apical junction complex Source: ARUK-UCL
- axon Source: GO_Central
- calyx of Held Source: Ensembl
- cell-cell junction Source: ARUK-UCL
- chromatin Source: UniProtKB
- cytoplasm Source: ARUK-UCL
- cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
- dense body Source: AgBase
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: SynGO
- lamellipodium Source: ARUK-UCL
- membrane Source: UniProtKB
- nucleosome Source: ComplexPortal
- presynapse Source: ARUK-UCL
- protein-containing complex Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
- Schaffer collateral - CA1 synapse Source: Ensembl
- synapse Source: GO_Central
- tight junction Source: ARUK-UCL
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
Dystonia, juvenile-onset (DJO)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030026 | 183 | R → W in DJO; modifies cell response to latrunculin A. 1 PublicationCorresponds to variant dbSNP:rs104894003EnsemblClinVar. | 1 |
Baraitser-Winter syndrome 1 (BRWS1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067810 | 12 | N → D in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875331EnsemblClinVar. | 1 | |
Natural variantiVAR_067811 | 65 | L → V in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875332EnsemblClinVar. | 1 | |
Natural variantiVAR_067812 | 196 | R → C in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875333EnsemblClinVar. | 1 | |
Natural variantiVAR_067813 | 196 | R → H in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875334EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 69 | Y → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 71 | I → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 71 | I → A: Impaired methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 73 | H → A: Abolished methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 73 | H → K: Weak methylation by a A-256 or V-256 SETD3 mutant. High methylation by a F-256 and A-274 SETD3 mutant. 2 Publications | 1 | |
Mutagenesisi | 74 | G → A: Impaired methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 79 | W → E: Does not affect methylation by SETD3. 1 Publication | 1 | |
Mutagenesisi | 80 | D → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 81 | D → A: Decreased interaction with SETD3. 1 Publication | 1 | |
Mutagenesisi | 82 | M → A: Decreased interaction with SETD3. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Disease variant, Dystonia, Mental retardationOrganism-specific databases
DisGeNETi | 60 |
GeneReviewsi | ACTB |
MalaCardsi | ACTB |
MIMi | 243310, phenotype 607371, phenotype |
OpenTargetsi | ENSG00000075624 |
Orphaneti | 2995, Baraitser-Winter cerebrofrontofacial syndrome 64755, Becker nevus syndrome 79107, Developmental malformations-deafness-dystonia syndrome |
PharmGKBi | PA24457 |
Miscellaneous databases
Pharosi | P60709, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2062353 |
DrugBanki | DB12695, Phenethyl Isothiocyanate DB04216, Quercetin |
Genetic variation databases
BioMutai | ACTB |
DMDMi | 46397333 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000367073 | 1 – 375 | Actin, cytoplasmic 1Add BLAST | 375 | |
Initiator methioninei | Removed; alternateCombined sources2 Publications | |||
ChainiPRO_0000000771 | 2 – 375 | Actin, cytoplasmic 1, N-terminally processed1 PublicationAdd BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 2 | N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processedCombined sources3 Publications | 1 | |
Modified residuei | 44 | Methionine (R)-sulfoxide1 Publication | 1 | |
Modified residuei | 47 | Methionine (R)-sulfoxide1 Publication | 1 | |
Cross-linki | 50 | (Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG11 Publication | ||
Modified residuei | 73 | Tele-methylhistidine5 Publications | 1 | |
Modified residuei | 84 | N6-methyllysine1 Publication | 1 | |
Cross-linki | 270 | (Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG11 Publication |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Oxidation, Ubl conjugationProteomic databases
EPDi | P60709 |
jPOSTi | P60709 |
MassIVEi | P60709 |
PaxDbi | P60709 |
PeptideAtlasi | P60709 |
PRIDEi | P60709 |
ProteomicsDBi | 57224 |
TopDownProteomicsi | P60709 |
2D gel databases
DOSAC-COBS-2DPAGEi | P60709 |
REPRODUCTION-2DPAGEi | P60709 |
SWISS-2DPAGEi | P60709 |
UCD-2DPAGEi | P60709 |
PTM databases
CarbonylDBi | P60709 |
GlyGeni | P60709, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | P60709 |
MetOSitei | P60709 |
PhosphoSitePlusi | P60709 |
SwissPalmi | P60709 |
Expressioni
Gene expression databases
Bgeei | ENSG00000075624, Expressed in popliteal artery and 243 other tissues |
ExpressionAtlasi | P60709, baseline and differential |
Genevisiblei | P60709, HS |
Organism-specific databases
HPAi | ENSG00000075624, Low tissue specificity |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:28604741, PubMed:16685646). Each actin can bind to 4 others (PubMed:28604741, PubMed:16685646).
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).
Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C (PubMed:18765789). In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789).
Found in a complex with XPO6, Ran, ACTB and PFN1 (PubMed:14592989).
Interacts with XPO6 and EMD (PubMed:15328537).
Interacts with ERBB2 (PubMed:21555369).
Interacts with GCSAM (PubMed:17823310).
Interacts with TBC1D21 (By similarity).
Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity).
Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes (PubMed:11687588).
Interacts with FAM107A (PubMed:21969592, PubMed:28604741).
By similarity10 PublicationsBinary interactionsi
P60709
GO - Molecular functioni
- identical protein binding Source: IntAct
- kinesin binding Source: UniProtKB
- nitric-oxide synthase binding Source: BHF-UCL
- protein kinase binding Source: ARUK-UCL
- Tat protein binding Source: BHF-UCL
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 106575, 711 interactors |
ComplexPortali | CPX-1164, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1203, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1219, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1220, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1221, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | P60709 |
DIPi | DIP-29686N |
IntActi | P60709, 337 interactors |
MINTi | P60709 |
STRINGi | 9606.ENSP00000349960 |
Miscellaneous databases
RNActi | P60709, protein |
Structurei
Secondary structure
3D structure databases
SASBDBi | P60709 |
SMRi | P60709 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P60709 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00950000182960 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P60709 |
OMAi | MIGKESE |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60709 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9R0 | G5E9R0_HUMAN | Actin, cytoplasmic 1 | ACTB hCG_15971 | 125 | Annotation score: | ||
A0A2R8Y793 | A0A2R8Y793_HUMAN | Actin, cytoplasmic 1 | ACTB | 309 | Annotation score: | ||
A0A2R8YEA7 | A0A2R8YEA7_HUMAN | Actin, cytoplasmic 1 | ACTB | 157 | Annotation score: | ||
E7EVS6 | E7EVS6_HUMAN | Actin, cytoplasmic 1 | ACTB | 334 | Annotation score: | ||
A0A2R8YGF8 | A0A2R8YGF8_HUMAN | Actin, cytoplasmic 1 | ACTB | 165 | Annotation score: | ||
A0A6Q8PFE4 | A0A6Q8PFE4_HUMAN | Actin, cytoplasmic 1 | ACTB | 332 | Annotation score: | ||
A0A6Q8PH58 | A0A6Q8PH58_HUMAN | Actin, cytoplasmic 1 | ACTB | 151 | Annotation score: | ||
C9JTX5 | C9JTX5_HUMAN | Actin, cytoplasmic 1 | ACTB | 80 | Annotation score: | ||
C9JUM1 | C9JUM1_HUMAN | Actin, cytoplasmic 1 | ACTB | 96 | Annotation score: | ||
C9JZR7 | C9JZR7_HUMAN | Actin, cytoplasmic 1 | ACTB | 102 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 97 | A → P in AAH16045 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 116 | R → L in AAH12854 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_067810 | 12 | N → D in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875331EnsemblClinVar. | 1 | |
Natural variantiVAR_067811 | 65 | L → V in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875332EnsemblClinVar. | 1 | |
Natural variantiVAR_030026 | 183 | R → W in DJO; modifies cell response to latrunculin A. 1 PublicationCorresponds to variant dbSNP:rs104894003EnsemblClinVar. | 1 | |
Natural variantiVAR_067812 | 196 | R → C in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875333EnsemblClinVar. | 1 | |
Natural variantiVAR_067813 | 196 | R → H in BRWS1. 1 PublicationCorresponds to variant dbSNP:rs281875334EnsemblClinVar. | 1 | |
Natural variantiVAR_048185 | 243 | P → L. Corresponds to variant dbSNP:rs11546899Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00351 mRNA Translation: CAA25099.1 M10277 Genomic DNA Translation: AAA51567.1 X63432 mRNA Translation: CAA45026.1 AY582799 Genomic DNA Translation: AAS79319.1 AC006483 Genomic DNA Translation: AAP22343.1 BC001301 mRNA Translation: AAH01301.1 BC002409 mRNA Translation: AAH02409.1 BC004251 mRNA Translation: AAH04251.1 BC008633 mRNA Translation: AAH08633.1 BC012854 mRNA Translation: AAH12854.1 BC013380 mRNA Translation: AAH13380.1 BC014861 mRNA Translation: AAH14861.1 BC016045 mRNA Translation: AAH16045.1 V00478 mRNA Translation: CAA23745.1 |
CCDSi | CCDS5341.1 |
PIRi | A25168, ATHUB |
RefSeqi | NP_001092.1, NM_001101.3 |
Genome annotation databases
Ensembli | ENST00000493945; ENSP00000494269; ENSG00000075624 ENST00000642480; ENSP00000495995; ENSG00000075624 ENST00000646664; ENSP00000494750; ENSG00000075624 ENST00000674681; ENSP00000502821; ENSG00000075624 ENST00000675515; ENSP00000501862; ENSG00000075624 |
GeneIDi | 60 |
KEGGi | hsa:60 |
MANE-Selecti | ENST00000646664.1; ENSP00000494750.1; NM_001101.5; NP_001092.1 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Mendelian genes actin, beta (ACTB) Leiden Open Variation Database (LOVD) |
Protein Spotlight On mar and motion - Issue 208 of November 2018 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X00351 mRNA Translation: CAA25099.1 M10277 Genomic DNA Translation: AAA51567.1 X63432 mRNA Translation: CAA45026.1 AY582799 Genomic DNA Translation: AAS79319.1 AC006483 Genomic DNA Translation: AAP22343.1 BC001301 mRNA Translation: AAH01301.1 BC002409 mRNA Translation: AAH02409.1 BC004251 mRNA Translation: AAH04251.1 BC008633 mRNA Translation: AAH08633.1 BC012854 mRNA Translation: AAH12854.1 BC013380 mRNA Translation: AAH13380.1 BC014861 mRNA Translation: AAH14861.1 BC016045 mRNA Translation: AAH16045.1 V00478 mRNA Translation: CAA23745.1 |
CCDSi | CCDS5341.1 |
PIRi | A25168, ATHUB |
RefSeqi | NP_001092.1, NM_001101.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3BYH | electron microscopy | 12.00 | A | 2-375 | [»] | |
3D2U | X-ray | 2.21 | C/G | 170-178 | [»] | |
3J82 | electron microscopy | 7.70 | B/C/D | 2-375 | [»] | |
3LUE | electron microscopy | - | A/B/C/D/E/F/G/H/I/J | 2-375 | [»] | |
6ANU | electron microscopy | 7.00 | A/B/C/D/E/F | 1-375 | [»] | |
6ICT | X-ray | 1.95 | E/G/H/I | 66-88 | [»] | |
6ICV | X-ray | 2.15 | C/D | 66-88 | [»] | |
6LTJ | electron microscopy | 3.70 | K | 1-375 | [»] | |
6MBJ | X-ray | 1.78 | Y/Z | 66-80 | [»] | |
6MBK | X-ray | 1.69 | Y/Z | 66-80 | [»] | |
6MBL | X-ray | 2.20 | Y | 66-80 | [»] | |
6NBW | X-ray | 2.50 | A | 2-375 | [»] | |
6OX0 | X-ray | 1.75 | Y/Z | 66-80 | [»] | |
6OX1 | X-ray | 1.95 | Y/Z | 66-80 | [»] | |
6OX2 | X-ray | 2.09 | Y/Z | 66-80 | [»] | |
6OX3 | X-ray | 1.78 | Y/Z | 66-84 | [»] | |
6OX4 | X-ray | 2.29 | Y/Z | 66-80 | [»] | |
6OX5 | X-ray | 2.10 | Y | 66-83 | [»] | |
6V62 | X-ray | 2.36 | Y | 66-88 | [»] | |
6V63 | X-ray | 2.02 | Y/Z | 66-88 | [»] | |
6WK1 | X-ray | 1.89 | Y/Z | 66-88 | [»] | |
6WK2 | X-ray | 1.76 | C/Y | 66-88 | [»] | |
7AS4 | electron microscopy | 4.13 | 7 | 2-375 | [»] | |
SASBDBi | P60709 | |||||
SMRi | P60709 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106575, 711 interactors |
ComplexPortali | CPX-1164, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1195, Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex CPX-1196, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant CPX-1199, Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant CPX-1201, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1203, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1219, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1220, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1221, Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-4084, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA2 variant CPX-4203, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA2 variant CPX-4206, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRA-SMARCA4 variant CPX-4207, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6A-BICRAL-SMARCA4 variant CPX-4223, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA2 variant CPX-4224, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA2 variant CPX-4225, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRA-SMARCA4 variant CPX-4226, GBAF (SWI/SNF) ATP-dependent chromatin remodeling complex, ACTL6B-BICRAL-SMARCA4 variant CPX-978, NuA4 histone acetyltransferase complex |
CORUMi | P60709 |
DIPi | DIP-29686N |
IntActi | P60709, 337 interactors |
MINTi | P60709 |
STRINGi | 9606.ENSP00000349960 |
Chemistry databases
ChEMBLi | CHEMBL2062353 |
DrugBanki | DB12695, Phenethyl Isothiocyanate DB04216, Quercetin |
PTM databases
CarbonylDBi | P60709 |
GlyGeni | P60709, 6 sites, 2 O-linked glycans (6 sites) |
iPTMneti | P60709 |
MetOSitei | P60709 |
PhosphoSitePlusi | P60709 |
SwissPalmi | P60709 |
Genetic variation databases
BioMutai | ACTB |
DMDMi | 46397333 |
2D gel databases
DOSAC-COBS-2DPAGEi | P60709 |
REPRODUCTION-2DPAGEi | P60709 |
SWISS-2DPAGEi | P60709 |
UCD-2DPAGEi | P60709 |
Proteomic databases
EPDi | P60709 |
jPOSTi | P60709 |
MassIVEi | P60709 |
PaxDbi | P60709 |
PeptideAtlasi | P60709 |
PRIDEi | P60709 |
ProteomicsDBi | 57224 |
TopDownProteomicsi | P60709 |
Protocols and materials databases
ABCDi | P60709, 4 sequenced antibodies |
Antibodypediai | 3623, 1993 antibodies from 56 providers |
DNASUi | 60 |
Genome annotation databases
Organism-specific databases
CTDi | 60 |
DisGeNETi | 60 |
GeneCardsi | ACTB |
GeneReviewsi | ACTB |
HGNCi | HGNC:132, ACTB |
HPAi | ENSG00000075624, Low tissue specificity |
MalaCardsi | ACTB |
MIMi | 102630, gene 243310, phenotype 607371, phenotype |
neXtProti | NX_P60709 |
OpenTargetsi | ENSG00000075624 |
Orphaneti | 2995, Baraitser-Winter cerebrofrontofacial syndrome 64755, Becker nevus syndrome 79107, Developmental malformations-deafness-dystonia syndrome |
PharmGKBi | PA24457 |
VEuPathDBi | HostDB:ENSG00000075624 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
GeneTreei | ENSGT00950000182960 |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | P60709 |
OMAi | MIGKESE |
OrthoDBi | 649708at2759 |
PhylomeDBi | P60709 |
TreeFami | TF354237 |
Enzyme and pathway databases
PathwayCommonsi | P60709 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-190873, Gap junction degradation R-HSA-196025, Formation of annular gap junctions R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-3214847, HATs acetylate histones R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-390450, Folding of actin by CCT/TriC R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-418990, Adherens junctions interactions R-HSA-437239, Recycling pathway of L1 R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-445095, Interaction between L1 and Ankyrins R-HSA-446353, Cell-extracellular matrix interactions R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-5674135, MAP2K and MAPK activation R-HSA-5689603, UCH proteinases R-HSA-5696394, DNA Damage Recognition in GG-NER R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9035034, RHOF GTPase cycle R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9662360, Sensory processing of sound by inner hair cells of the cochlea R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P60709 |
SIGNORi | P60709 |
Miscellaneous databases
BioGRID-ORCSi | 60, 519 hits in 1053 CRISPR screens |
ChiTaRSi | ACTB, human |
EvolutionaryTracei | P60709 |
GeneWikii | Beta-actin |
GenomeRNAii | 60 |
Pharosi | P60709, Tbio |
PROi | PR:P60709 |
RNActi | P60709, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075624, Expressed in popliteal artery and 243 other tissues |
ExpressionAtlasi | P60709, baseline and differential |
Genevisiblei | P60709, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTB_HUMAN | |
Accessioni | P60709Primary (citable) accession number: P60709 Secondary accession number(s): P02570 Q96HG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries