Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Profilin-3

Gene

PFN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns4P). May be involved in spermatogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-3
Alternative name(s):
Profilin III
Gene namesi
Name:PFN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000196570.2
HGNCiHGNC:18627 PFN3
MIMi612812 gene
neXtProtiNX_P60673

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196570
PharmGKBiPA142671182

Polymorphism and mutation databases

BioMutaiPFN3
DMDMi48474309

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001995791 – 137Profilin-3Add BLAST137

Proteomic databases

EPDiP60673
MaxQBiP60673
PaxDbiP60673
PeptideAtlasiP60673
PRIDEiP60673
ProteomicsDBi57223

PTM databases

iPTMnetiP60673
PhosphoSitePlusiP60673

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000196570
CleanExiHS_PFN3

Interactioni

Subunit structurei

Interacts with ACTRT3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi131350, 7 interactors
STRINGi9606.ENSP00000351379

Structurei

3D structure databases

ProteinModelPortaliP60673
SMRiP60673
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiENOG410IW5Z Eukaryota
ENOG410YRK9 LUCA
GeneTreeiENSGT00390000010143
HOGENOMiHOG000171592
HOVERGENiHBG053683
InParanoidiP60673
KOiK05759
OMAiRRCCVIR
OrthoDBiEOG091G0TWH
PhylomeDBiP60673
TreeFamiTF331744

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR029893 PFN3
IPR036140 PFN_sf
IPR005454 Profilin1/2/3_vertebrate
PANTHERiPTHR13936:SF2 PTHR13936:SF2, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR01639 PROFILINMAML
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit

Sequencei

Sequence statusi: Complete.

P60673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWKVYISA VLRDQRIDDV AIVGHADNSC VWASRPGGLL AAISPQEVGV
60 70 80 90 100
LTGPDRHTFL QAGLSVGGRR CCVIRDHLLA EGDGVLDART KGLDARAVCV
110 120 130
GRAPRALLVL MGRRGVHGGI LNKTVHELIR GLRMQGA
Length:137
Mass (Da):14,596
Last modified:March 29, 2004 - v1
Checksum:i9D1456E89AE6F1C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090063 Genomic DNA No translation available.
CH471195 Genomic DNA Translation: EAW85006.1
BC132952 mRNA Translation: AAI32953.1
BC132954 mRNA Translation: AAI32955.1
CCDSiCCDS34301.1
RefSeqiNP_001025057.1, NM_001029886.2
UniGeneiHs.130196

Genome annotation databases

EnsembliENST00000358571; ENSP00000351379; ENSG00000196570
GeneIDi345456
KEGGihsa:345456
UCSCiuc003mgl.2 human

Similar proteinsi

Entry informationi

Entry nameiPROF3_HUMAN
AccessioniPrimary (citable) accession number: P60673
Secondary accession number(s): A2RUL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health