UniProtKB - P60670 (NPL4_MOUSE)

BLAST

>sp|P60670|NPL4_MOUSE Nuclear protein localization protein 4 homolog OS=Mus musculus OX=10090 GN=Nploc4 PE=1 SV=3
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASS
SKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPNVVEDEIDQYLSKQDGK
IYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKF
VALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDF
WRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIA
AKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPD
GHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQY
VPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLG
ETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELA
QTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHC
EMCSLPRT

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History
Entry version 131 (12 Sep 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Nuclear protein localization protein 4 homolog

Gene

Nploc4

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).By similarity

Pathwayⁱ: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	580 – 608	RanBP2-typePROSITE-ProRule annotationAdd BLAST		29

GO - Molecular functionⁱ

ATPase binding Source: MGI
metal ion binding Source: UniProtKB-KW
protein-containing complex binding Source: MGI
ubiquitin binding Source: MGI
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Golgi organization Source: HGNC
negative regulation of RIG-I signaling pathway Source: UniProtKB
negative regulation of type I interferon production Source: UniProtKB
retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
ubiquitin-dependent ERAD pathway Source: HGNC
ubiquitin-dependent protein catabolic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-110320 Translesion Synthesis by POLH
UniPathwayⁱ	UPA00144

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear protein localization protein 4 homolog Short name: Protein NPL4
Gene namesⁱ	Name:Nploc4 Synonyms:Kiaa1499, Npl4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2679787 Nploc4

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000057942	2 – 608	Nuclear protein localization protein 4 homologAdd BLAST		607

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1
Modified residueⁱ	179	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P60670
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P60670
PaxDbⁱ	P60670
PeptideAtlas More...PeptideAtlasⁱ	P60670
PRIDEⁱ	P60670

PTM databases

iPTMnetⁱ	P60670
PhosphoSitePlusⁱ	P60670

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000039703 Expressed in 271 organ(s), highest expression level in cumulus cell
Genevisibleⁱ	P60670 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer with UFD1. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817).By similarity1 Publication

GO - Molecular functionⁱ

ATPase binding Source: MGI
ubiquitin binding Source: MGI
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	229901, 4 interactors
ComplexPortalⁱ	CPX-136 Vcp-Npl4-Ufd1 AAA ATPase complex
CORUMⁱ	P60670
IntActⁱ	P60670, 3 interactors
STRINGⁱ	10090.ENSMUSP00000035851

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 10	Combined sources	3
Beta strandⁱ	12 – 17	Combined sources	6
Helixⁱ	26 – 36	Combined sources	11
Turnⁱ	41 – 43	Combined sources	3
Helixⁱ	52 – 55	Combined sources	4
Beta strandⁱ	56 – 58	Combined sources	3
Turnⁱ	63 – 67	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P60670
SMRⁱ	P60670
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P60670

EvolutionaryTraceⁱ

P60670

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	226 – 363	MPNPROSITE-ProRule annotationAdd BLAST		138

Domainⁱ

Binds ubiquitinated proteins via its RanBP2-type zinc finger.By similarity

Sequence similaritiesⁱ

Belongs to the NPL4 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	580 – 608	RanBP2-typePROSITE-ProRule annotationAdd BLAST		29

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2834 Eukaryota COG5100 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018731
HOGENOMⁱ	HOG000008139
HOVERGENⁱ	HBG052659
InParanoidⁱ	P60670
KEGG Orthology (KO) More...KOⁱ	K14015
OMAⁱ	KIKHGDM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q00
PhylomeDBⁱ	P60670
TreeFamⁱ	TF314173

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08061 MPN_NPL4, 1 hit
InterProⁱ	View protein in InterPro IPR037518 MPN IPR016563 Npl4 IPR007717 NPL4_C IPR024682 Npl4_Ub-like_dom IPR007716 NPL4_Zn-bd_put IPR029071 Ubiquitin-like_domsf IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05021 NPL4, 1 hit PF11543 UN_NPL4, 1 hit PF05020 zf-NPL4, 1 hit
PIRSFⁱ	PIRSF010052 Polyub_prc_Npl4, 1 hit
SMARTⁱ	View protein in SMART SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P60670-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR 
        60         70         80         90        100
NKTGEITASS SKSLHLLKIK HGDLLFLFPS SLAGPSSEME TSTSVGLKAF 
       110        120        130        140        150
GAPNVVEDEI DQYLSKQDGK IYRSRDPQLC RHGPLGKCVH CVPLEPFDED 
       160        170        180        190        200
YLNHLEPPVK HMSFHAYIRK LTGGADKGKF VALENISCKI KSGCEGHLPW 
       210        220        230        240        250
PNGICTKCQP SAITLNRQKY RHVDNIMFEN HTVADRFLDF WRKTGNQHFG 
       260        270        280        290        300
YLYGRYTEHK DIPLGIRAEV AAIYEPPQIG TQNSLELLED PKAEVVDEIA 
       310        320        330        340        350
AKLGLRKVGW IFTDLVSEDT RKGTVRYSRN KDTYFLSSEE CITAGDFQNK 
       360        370        380        390        400
HPNICRLSPD GHFGSKFVTA VATGGPDNQV HFEGYQVSNQ CMALVRDECL 
       410        420        430        440        450
LPCKDAPELG YAKESSSEQY VPDVFYKDID KFGNEITQLA RPLPVEYLII 
       460        470        480        490        500
DITTTFPKDP VYTFSISQNP FPIENRDVLG ETQDFHSLAT YLSQNTSSVF 
       510        520        530        540        550
LDTISDFHLL LFLVTNEVMP LQDSISLLLE AVRTRNEELA QTWKKSEQWA 
       560        570        580        590        600
TIEQLCSTVG VQLPGLHEFG AVGGSARAAT SAMWACQHCT FMNQPGTGHC 

EMCSLPRT

Length:608

Mass (Da):68,017

Last modified:January 23, 2007 - v3

Checksum:ⁱ378E31B35D559336

Isoform 2 (identifier: P60670-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
452-483: Missing.

« Hide

        10         20         30         40         50
MAESIIIRVQ SPDGVKRITA TKRETAATFL KKVAKEFGFQ NNGFSVYINR 
        60         70         80         90        100
NKTGEITASS SKSLHLLKIK HGDLLFLFPS SLAGPSSEME TSTSVGLKAF 
       110        120        130        140        150
GAPNVVEDEI DQYLSKQDGK IYRSRDPQLC RHGPLGKCVH CVPLEPFDED 
       160        170        180        190        200
YLNHLEPPVK HMSFHAYIRK LTGGADKGKF VALENISCKI KSGCEGHLPW 
       210        220        230        240        250
PNGICTKCQP SAITLNRQKY RHVDNIMFEN HTVADRFLDF WRKTGNQHFG 
       260        270        280        290        300
YLYGRYTEHK DIPLGIRAEV AAIYEPPQIG TQNSLELLED PKAEVVDEIA 
       310        320        330        340        350
AKLGLRKVGW IFTDLVSEDT RKGTVRYSRN KDTYFLSSEE CITAGDFQNK 
       360        370        380        390        400
HPNICRLSPD GHFGSKFVTA VATGGPDNQV HFEGYQVSNQ CMALVRDECL 
       410        420        430        440        450
LPCKDAPELG YAKESSSEQY VPDVFYKDID KFGNEITQLA RPLPVEYLII 
       460        470        480        490        500
DDFHSLATYL SQNTSSVFLD TISDFHLLLF LVTNEVMPLQ DSISLLLEAV 
       510        520        530        540        550
RTRNEELAQT WKKSEQWATI EQLCSTVGVQ LPGLHEFGAV GGSARAATSA 
       560        570 
MWACQHCTFM NQPGTGHCEM CSLPRT

Note: No experimental confirmation available.

Show »

Length:576

Mass (Da):64,379

Checksum:ⁱ478732FF9B936035

Sequence cautionⁱ

The sequence BAC98185 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_009790	452 – 483	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK129375 mRNA Translation: BAC98185.1 Different initiation. AL669855 Genomic DNA No translation available. BC065156 mRNA Translation: AAH65156.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25732.1 [P60670-2] CCDS56827.1 [P60670-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001181952.1, NM_001195023.1 [P60670-1] NP_955763.1, NM_199469.2 [P60670-2]
UniGeneⁱ	Mm.309520

Genome annotation databases

Ensemblⁱ	ENSMUST00000044271; ENSMUSP00000035851; ENSMUSG00000039703 [P60670-1] ENSMUST00000103017; ENSMUSP00000099306; ENSMUSG00000039703 [P60670-2]
GeneIDⁱ	217365
KEGGⁱ	mmu:217365
UCSC genome browser More...UCSCⁱ	uc007msp.2 mouse [P60670-2] uc007msq.2 mouse [P60670-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P60670	Nuclear protein localization protein 4 homolog		HUMAN		608	UniRef90_Q8TAT6
Nuclear protein localization protein 4 homolog	)	RAT		608
Uncharacterized protein		Cebus capucinus imitator		736
Uncharacterized protein		MACMU		618
Uncharacterized protein		MACFA		130
+180
P60670-2	Uncharacterized protein		CAVPO		584	UniRef90_P60670-2
nuclear protein localization protein 4 homolog isoform X3		DELLE		576
nuclear protein localization protein 4 homolog isoform X4		Yangtze finless porpoise		576
NPL4 homolog, ubiquitin recognition factor		ICTTR		571
UPI000A284636		PHACI		702
+6

Protein	Similar proteins		Species	Score	Length	Source
P60670	Nuclear protein localization protein 4 homolog		HUMAN		608	UniRef50_Q8TAT6
Nuclear protein localization protein 4 homolog	)	RAT		608
Uncharacterized protein		Cebus capucinus imitator		736
Uncharacterized protein		MACMU		618
Uncharacterized protein		MACFA		130
+285

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK129375 mRNA Translation: BAC98185.1 Different initiation. AL669855 Genomic DNA No translation available. BC065156 mRNA Translation: AAH65156.1
CCDSⁱ	CCDS25732.1 [P60670-2] CCDS56827.1 [P60670-1]
RefSeqⁱ	NP_001181952.1, NM_001195023.1 [P60670-1] NP_955763.1, NM_199469.2 [P60670-2]
UniGeneⁱ	Mm.309520

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2PJH	NMR	-	A	1-80	[»]
ProteinModelPortalⁱ	P60670
SMRⁱ	P60670
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229901, 4 interactors
ComplexPortalⁱ	CPX-136 Vcp-Npl4-Ufd1 AAA ATPase complex
CORUMⁱ	P60670
IntActⁱ	P60670, 3 interactors
STRINGⁱ	10090.ENSMUSP00000035851

PTM databases

iPTMnetⁱ	P60670
PhosphoSitePlusⁱ	P60670

Proteomic databases

EPDⁱ	P60670
MaxQBⁱ	P60670
PaxDbⁱ	P60670
PeptideAtlasⁱ	P60670
PRIDEⁱ	P60670

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000044271; ENSMUSP00000035851; ENSMUSG00000039703 [P60670-1] ENSMUST00000103017; ENSMUSP00000099306; ENSMUSG00000039703 [P60670-2]
GeneIDⁱ	217365
KEGGⁱ	mmu:217365
UCSCⁱ	uc007msp.2 mouse [P60670-2] uc007msq.2 mouse [P60670-1]

Organism-specific databases

CTDⁱ	55666
MGIⁱ	MGI:2679787 Nploc4
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2834 Eukaryota COG5100 LUCA
GeneTreeⁱ	ENSGT00390000018731
HOGENOMⁱ	HOG000008139
HOVERGENⁱ	HBG052659
InParanoidⁱ	P60670
KOⁱ	K14015
OMAⁱ	KIKHGDM
OrthoDBⁱ	EOG091G0Q00
PhylomeDBⁱ	P60670
TreeFamⁱ	TF314173

Enzyme and pathway databases

UniPathwayⁱ	UPA00144
Reactomeⁱ	R-MMU-110320 Translesion Synthesis by POLH

Miscellaneous databases

ChiTaRSⁱ	Nploc4 mouse
EvolutionaryTraceⁱ	P60670
Protein Ontology More...PROⁱ	PR:P60670
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039703 Expressed in 271 organ(s), highest expression level in cumulus cell
Genevisibleⁱ	P60670 MM

Family and domain databases

CDDⁱ	cd08061 MPN_NPL4, 1 hit
InterProⁱ	View protein in InterPro IPR037518 MPN IPR016563 Npl4 IPR007717 NPL4_C IPR024682 Npl4_Ub-like_dom IPR007716 NPL4_Zn-bd_put IPR029071 Ubiquitin-like_domsf IPR001876 Znf_RanBP2 IPR036443 Znf_RanBP2_sf
Pfamⁱ	View protein in Pfam PF05021 NPL4, 1 hit PF11543 UN_NPL4, 1 hit PF05020 zf-NPL4, 1 hit
PIRSFⁱ	PIRSF010052 Polyub_prc_Npl4, 1 hit
SMARTⁱ	View protein in SMART SM00547 ZnF_RBZ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF90209 SSF90209, 1 hit
PROSITEⁱ	View protein in PROSITE PS50249 MPN, 1 hit PS01358 ZF_RANBP2_1, 1 hit PS50199 ZF_RANBP2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NPL4_MOUSE
Accessionⁱ	P60670Primary (citable) accession number: P60670 Secondary accession number(s): B1ATY4, B1ATY5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P60670 (NPL4_MOUSE)

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Nuclear protein localization protein 4 homolog

Nploc4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: proteasomal ubiquitin-dependent pathway

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Endoplasmic reticulum

Cytosol

Cytosol

Endoplasmic reticulum

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: proteasomal ubiquitin-dependent pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ