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Protein

Myosin light polypeptide 6

Gene

MYL6

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • calcium ion binding Source: InterPro
  • microfilament motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-SSC-445355 Smooth Muscle Contraction
R-SSC-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
17 kDa myosin light chain
Short name:
LC17
Myosin light chain 3
Short name:
MLC-3
Myosin light chain alkali 3
Short name:
Myosin light chain A3
Smooth muscle and nonmuscle myosin light chain alkali 6
Gene namesi
Name:MYL6
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001986922 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP60662
PeptideAtlasiP60662
PRIDEiP60662

Expressioni

Gene expression databases

BgeeiENSSSCG00000025467 Expressed in 6 organ(s), highest expression level in lung
ExpressionAtlasiP60662 differential
GenevisibleiP60662 SS

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000411

Structurei

3D structure databases

ProteinModelPortaliP60662
SMRiP60662
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP60662
KOiK12751
OMAiXEKMTEE
OrthoDBiEOG091G0TQL
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Non-muscle (identifier: P60662-1) [UniParc]FASTAAdd to basket
Also known as: MLC3nm, LC17A, LC17-nm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK
60 70 80 90 100
VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS

G
Length:151
Mass (Da):16,930
Last modified:January 23, 2007 - v2
Checksum:iA2B7B4F41179523D
GO
Isoform Smooth muscle (identifier: P60662-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: MLC3sm, LC17B, LC17-sm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: AFVRHILSG → ELVRMVLNG

Show »
Length:151
Mass (Da):16,961
Checksum:i25B244E686095233
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9F331A0A2C9F331_PIG
Myosin light polypeptide 6
MYL6
160Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009737143 – 151AFVRHILSG → ELVRMVLNG in isoform Smooth muscle. 1 Publication9

Sequence databases

PIRiJX0214
JX0215
RefSeqiNP_001157469.1, NM_001163997.1 [P60662-1]
XP_005655646.1, XM_005655589.2 [P60662-2]
XP_005655689.1, XM_005655632.2
XP_013843762.1, XM_013988308.1
UniGeneiSsc.42598

Genome annotation databases

EnsembliENSSSCT00000000408; ENSSSCP00000000402; ENSSSCG00000039795 [P60662-1]
GeneIDi396807
KEGGissc:396807

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiJX0214
JX0215
RefSeqiNP_001157469.1, NM_001163997.1 [P60662-1]
XP_005655646.1, XM_005655589.2 [P60662-2]
XP_005655689.1, XM_005655632.2
XP_013843762.1, XM_013988308.1
UniGeneiSsc.42598

3D structure databases

ProteinModelPortaliP60662
SMRiP60662
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000000411

Proteomic databases

PaxDbiP60662
PeptideAtlasiP60662
PRIDEiP60662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000000408; ENSSSCP00000000402; ENSSSCG00000039795 [P60662-1]
GeneIDi396807
KEGGissc:396807

Organism-specific databases

CTDi4637

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP60662
KOiK12751
OMAiXEKMTEE
OrthoDBiEOG091G0TQL
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-SSC-445355 Smooth Muscle Contraction
R-SSC-5627123 RHO GTPases activate PAKs

Gene expression databases

BgeeiENSSSCG00000025467 Expressed in 6 organ(s), highest expression level in lung
ExpressionAtlasiP60662 differential
GenevisibleiP60662 SS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6_PIG
AccessioniPrimary (citable) accession number: P60662
Secondary accession number(s): P16475
, P24572, P24573, Q12790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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