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UniProtKB - P60660 (MYL6_HUMAN)

Entry version 158 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Myosin light polypeptide 6

Gene

MYL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory light chain of myosin. Does not bind calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-445355 Smooth Muscle Contraction
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
17 kDa myosin light chain
Short name:
LC17
Myosin light chain 3
Short name:
MLC-3
Myosin light chain alkali 3
Short name:
Myosin light chain A3
Smooth muscle and nonmuscle myosin light chain alkali 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYL6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000092841.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:7587 MYL6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609931 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P60660

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4637

Open Targets

More...OpenTargetsi		ENSG00000092841

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31384

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYL6

Domain mapping of disease mutations (DMDM)

More...DMDMi		47606436

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001986902 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylcysteineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Isoform Smooth muscle (identifier: P60660-2)
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P60660

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P60660

MaxQB - The MaxQuant DataBase

More...MaxQBi		P60660

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P60660

PeptideAtlas

More...PeptideAtlasi		P60660

PRoteomics IDEntifications database

More...PRIDEi		P60660

ProteomicsDB human proteome resource

More...ProteomicsDBi		57221
57222 [P60660-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P60660-1 [P60660-1]
P60660-2 [P60660-2]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P60660

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P60660

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P60660

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P60660

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P60660

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092841 Expressed in 233 organ(s), highest expression level in left uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P60660 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P60660 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA046859
HPA063034

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110721, 94 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P60660

Protein interaction database and analysis system

More...IntActi		P60660, 49 interactors

Molecular INTeraction database

More...MINTi		P60660

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000446714

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P60660

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P60660

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0030 Eukaryota
COG5126 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154128

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG012180

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P60660

KEGG Orthology (KO)

More...KOi		K12751

Database of Orthologous Groups

More...OrthoDBi		1470794at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P60660

TreeFam database of animal gene trees

More...TreeFami		TF351553

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13405 EF-hand_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform Non-muscle (identifier: P60660-1) [UniParc]FASTAAdd to basket
Also known as: MLC3nm, LC17A, LC17-nm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK 
        60         70         80         90        100
VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG 
       110        120        130        140        150
NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS 

G
Length:151
Mass (Da):16,930
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2B7B4F41179523D
GO
Isoform Smooth muscle (identifier: P60660-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: MLC3sm, LC17B, LC17-sm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: AFVRHILSG → ELVRMVLNG

Show »
Length:151
Mass (Da):16,961
Checksum:i25B244E686095233
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z6Z4B7Z6Z4_HUMAN
cDNA FLJ56329, highly similar to My...
MYL6
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLA2G8JLA2_HUMAN
Myosin light polypeptide 6
MYL6
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1V0G3V1V0_HUMAN
Myosin light polypeptide 6
MYL6 hCG_2039617
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KND3J3KND3_HUMAN
Myosin light polypeptide 6
MYL6
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1R7F8W1R7_HUMAN
Myosin light polypeptide 6
MYL6
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W180F8W180_HUMAN
Myosin light polypeptide 6
MYL6
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZU9F8VZU9_HUMAN
Myosin light polypeptide 6
MYL6
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI43H0YI43_HUMAN
Myosin light polypeptide 6
MYL6
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1Y7G3V1Y7_HUMAN
Myosin light polypeptide 6
MYL6 hCG_2039617
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPF3F8VPF3_HUMAN
Myosin light polypeptide 6
MYL6
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → ADLIPST in AAA20643 (PubMed:8188229).Curated1
Sequence conflicti45N → D in AAA59853 (PubMed:2304459).Curated1
Sequence conflicti76T → R in AAA20643 (PubMed:8188229).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05045785T → I. Corresponds to variant dbSNP:rs11553509Ensembl.1
Natural variantiVAR_034118103T → P. Corresponds to variant dbSNP:rs1050470Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009735143 – 151AFVRHILSG → ELVRMVLNG in isoform Smooth muscle. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M22918 mRNA Translation: AAA36347.1
M22919 Genomic DNA Translation: AAA59892.1
M22919 Genomic DNA Translation: AAA59893.1
M22920 mRNA Translation: AAA36348.1
M31212 mRNA Translation: AAA59853.1
U02629 mRNA Translation: AAA20643.1
AB046613 mRNA Translation: BAB62402.1
CR457014 mRNA Translation: CAG33295.1
BC006781 mRNA Translation: AAH06781.2
BC017455 mRNA Translation: AAH17455.1
BC071661 mRNA Translation: AAH71661.1
BC093066 mRNA Translation: AAH93066.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31834.1 [P60660-2]
CCDS8906.1

Protein sequence database of the Protein Information Resource

More...PIRi		A33709 MOHU6N
A49620 MOHU6E
B33709 MOHU6M

NCBI Reference Sequences

More...RefSeqi		NP_066299.2, NM_021019.4 [P60660-1]
NP_524147.2, NM_079423.3 [P60660-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.632717

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000547649; ENSP00000446714; ENSG00000092841 [P60660-2]
ENST00000548293; ENSP00000448101; ENSG00000092841 [P60660-1]
ENST00000550697; ENSP00000446955; ENSG00000092841 [P60660-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4637

UCSC genome browser

More...UCSCi		uc001sjw.3 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22918 mRNA Translation: AAA36347.1
M22919 Genomic DNA Translation: AAA59892.1
M22919 Genomic DNA Translation: AAA59893.1
M22920 mRNA Translation: AAA36348.1
M31212 mRNA Translation: AAA59853.1
U02629 mRNA Translation: AAA20643.1
AB046613 mRNA Translation: BAB62402.1
CR457014 mRNA Translation: CAG33295.1
BC006781 mRNA Translation: AAH06781.2
BC017455 mRNA Translation: AAH17455.1
BC071661 mRNA Translation: AAH71661.1
BC093066 mRNA Translation: AAH93066.1
CCDSiCCDS31834.1 [P60660-2]
CCDS8906.1
PIRiA33709 MOHU6N
A49620 MOHU6E
B33709 MOHU6M
RefSeqiNP_066299.2, NM_021019.4 [P60660-1]
NP_524147.2, NM_079423.3 [P60660-2]
UniGeneiHs.632717

3D structure databases

ProteinModelPortaliP60660
SMRiP60660
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110721, 94 interactors
CORUMiP60660
IntActiP60660, 49 interactors
MINTiP60660
STRINGi9606.ENSP00000446714

PTM databases

iPTMnetiP60660
PhosphoSitePlusiP60660
SwissPalmiP60660

Polymorphism and mutation databases

BioMutaiMYL6
DMDMi47606436

2D gel databases

DOSAC-COBS-2DPAGEiP60660
SWISS-2DPAGEiP60660

Proteomic databases

EPDiP60660
jPOSTiP60660
MaxQBiP60660
PaxDbiP60660
PeptideAtlasiP60660
PRIDEiP60660
ProteomicsDBi57221
57222 [P60660-2]
TopDownProteomicsiP60660-1 [P60660-1]
P60660-2 [P60660-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4637
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000547649; ENSP00000446714; ENSG00000092841 [P60660-2]
ENST00000548293; ENSP00000448101; ENSG00000092841 [P60660-1]
ENST00000550697; ENSP00000446955; ENSG00000092841 [P60660-1]
GeneIDi4637
KEGGihsa:4637
UCSCiuc001sjw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4637
DisGeNETi4637
EuPathDBiHostDB:ENSG00000092841.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYL6
HGNCiHGNC:7587 MYL6
HPAiHPA046859
HPA063034
MIMi609931 gene
neXtProtiNX_P60660
OpenTargetsiENSG00000092841
PharmGKBiPA31384

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00940000154128
HOVERGENiHBG012180
InParanoidiP60660
KOiK12751
OrthoDBi1470794at2759
PhylomeDBiP60660
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-445355 Smooth Muscle Contraction
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYL6 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYL6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4637

Protein Ontology

More...PROi		PR:P60660

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000092841 Expressed in 233 organ(s), highest expression level in left uterine tube
ExpressionAtlasiP60660 baseline and differential
GenevisibleiP60660 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYL6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60660
Secondary accession number(s): P16475
, P24572, P24573, Q12790, Q561V9, Q6IAZ0, Q6IPY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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