UniProtKB - P60660 (MYL6_HUMAN)
Myosin light polypeptide 6
MYL6
Functioni
GO - Molecular functioni
- actin-dependent ATPase activity Source: HGNC-UCL
- calcium ion binding Source: InterPro
- motor activity Source: HGNC-UCL
- structural constituent of muscle Source: HGNC-UCL
GO - Biological processi
- muscle contraction Source: HGNC-UCL
- muscle filament sliding Source: HGNC-UCL
- skeletal muscle tissue development Source: UniProtKB
Keywordsi
Molecular function | Motor protein, Muscle protein, Myosin |
Enzyme and pathway databases
PathwayCommonsi | P60660 |
Reactomei | R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-445355, Smooth Muscle Contraction R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin light polypeptide 6Alternative name(s): 17 kDa myosin light chain Short name: LC17 Myosin light chain 3 Short name: MLC-3 Myosin light chain alkali 3 Short name: Myosin light chain A3 Smooth muscle and nonmuscle myosin light chain alkali 6 |
Gene namesi | Name:MYL6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000092841.18 |
HGNCi | HGNC:7587, MYL6 |
MIMi | 609931, gene |
neXtProti | NX_P60660 |
Subcellular locationi
Cytoskeleton
- myosin complex Source: HGNC-UCL
- unconventional myosin complex Source: BHF-UCL
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- brush border Source: UniProtKB
- membrane Source: UniProtKB
- vesicle Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000092841 |
PharmGKBi | PA31384 |
Miscellaneous databases
Pharosi | P60660, Tbio |
Polymorphism and mutation databases
BioMutai | MYL6 |
DMDMi | 47606436 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000198690 | 2 – 151 | Myosin light polypeptide 6Add BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylcysteineCombined sources | 1 | ||
Modified residuei | 57 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 81 | N6-acetyllysineCombined sources | 1 | ||
Isoform Smooth muscle (identifier: P60660-2) | |||||
Modified residuei | 135 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P60660 |
jPOSTi | P60660 |
MassIVEi | P60660 |
MaxQBi | P60660 |
PaxDbi | P60660 |
PeptideAtlasi | P60660 |
PRIDEi | P60660 |
ProteomicsDBi | 57221 57222 [P60660-2] |
TopDownProteomicsi | P60660-1 [P60660-1] P60660-2 [P60660-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P60660 |
SWISS-2DPAGEi | P60660 |
PTM databases
iPTMneti | P60660 |
MetOSitei | P60660 |
PhosphoSitePlusi | P60660 |
SwissPalmi | P60660 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092841, Expressed in left uterine tube and 241 other tissues |
ExpressionAtlasi | P60660, baseline and differential |
Genevisiblei | P60660, HS |
Organism-specific databases
HPAi | ENSG00000092841, Low tissue specificity |
Interactioni
Subunit structurei
Myosin is a hexamer of 2 heavy chains and 4 light chains.
Interacts with SPATA6.
By similarityBinary interactionsi
Hide detailsP60660
Protein-protein interaction databases
BioGRIDi | 110721, 135 interactors |
CORUMi | P60660 |
IntActi | P60660, 69 interactors |
MINTi | P60660 |
STRINGi | 9606.ENSP00000446955 |
Miscellaneous databases
RNActi | P60660, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 42 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 84 – 119 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 119 – 151 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 33 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0030, Eukaryota |
GeneTreei | ENSGT01000000214455 |
InParanoidi | P60660 |
OrthoDBi | 1470794at2759 |
PhylomeDBi | P60660 |
TreeFami | TF351553 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK
60 70 80 90 100
VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS
G
The sequence of this isoform differs from the canonical sequence as follows:
143-151: AFVRHILSG → ELVRMVLNG
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z6Z4 | B7Z6Z4_HUMAN | Myosin light polypeptide 6 | MYL6 | 238 | Annotation score: | ||
F8W180 | F8W180_HUMAN | Myosin light polypeptide 6 | MYL6 | 196 | Annotation score: | ||
F8VZU9 | F8VZU9_HUMAN | Myosin light polypeptide 6 | MYL6 | 103 | Annotation score: | ||
F8W1R7 | F8W1R7_HUMAN | Myosin light polypeptide 6 | MYL6 | 145 | Annotation score: | ||
G8JLA2 | G8JLA2_HUMAN | Myosin light polypeptide 6 | MYL6 | 152 | Annotation score: | ||
G3V1V0 | G3V1V0_HUMAN | Myosin light polypeptide 6 | MYL6 hCG_2039617 | 161 | Annotation score: | ||
J3KND3 | J3KND3_HUMAN | Myosin light polypeptide 6 | MYL6 | 152 | Annotation score: | ||
F8VPF3 | F8VPF3_HUMAN | Myosin light polypeptide 6 | MYL6 | 130 | Annotation score: | ||
G3V1Y7 | G3V1Y7_HUMAN | Myosin light polypeptide 6 | MYL6 hCG_2039617 | 115 | Annotation score: | ||
H0YI43 | H0YI43_HUMAN | Myosin light polypeptide 6 | MYL6 | 83 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | A → ADLIPST in AAA20643 (PubMed:8188229).Curated | 1 | |
Sequence conflicti | 45 | N → D in AAA59853 (PubMed:2304459).Curated | 1 | |
Sequence conflicti | 76 | T → R in AAA20643 (PubMed:8188229).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050457 | 85 | T → I. Corresponds to variant dbSNP:rs11553509Ensembl. | 1 | |
Natural variantiVAR_034118 | 103 | T → P. Corresponds to variant dbSNP:rs1050470Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009735 | 143 – 151 | AFVRHILSG → ELVRMVLNG in isoform Smooth muscle. 2 Publications | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22918 mRNA Translation: AAA36347.1 M22919 Genomic DNA Translation: AAA59892.1 M22919 Genomic DNA Translation: AAA59893.1 M22920 mRNA Translation: AAA36348.1 M31212 mRNA Translation: AAA59853.1 U02629 mRNA Translation: AAA20643.1 AB046613 mRNA Translation: BAB62402.1 CR457014 mRNA Translation: CAG33295.1 BC006781 mRNA Translation: AAH06781.2 BC017455 mRNA Translation: AAH17455.1 BC071661 mRNA Translation: AAH71661.1 BC093066 mRNA Translation: AAH93066.1 |
CCDSi | CCDS31834.1 [P60660-2] CCDS8906.1 |
PIRi | A33709, MOHU6N A49620, MOHU6E B33709, MOHU6M |
RefSeqi | NP_066299.2, NM_021019.4 [P60660-1] NP_524147.2, NM_079423.3 [P60660-2] |
Genome annotation databases
Ensembli | ENST00000547649; ENSP00000446714; ENSG00000092841 [P60660-2] ENST00000548293; ENSP00000448101; ENSG00000092841 [P60660-1] ENST00000550697; ENSP00000446955; ENSG00000092841 [P60660-1] |
GeneIDi | 4637 |
KEGGi | hsa:4637 |
UCSCi | uc001sjw.3, human |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22918 mRNA Translation: AAA36347.1 M22919 Genomic DNA Translation: AAA59892.1 M22919 Genomic DNA Translation: AAA59893.1 M22920 mRNA Translation: AAA36348.1 M31212 mRNA Translation: AAA59853.1 U02629 mRNA Translation: AAA20643.1 AB046613 mRNA Translation: BAB62402.1 CR457014 mRNA Translation: CAG33295.1 BC006781 mRNA Translation: AAH06781.2 BC017455 mRNA Translation: AAH17455.1 BC071661 mRNA Translation: AAH71661.1 BC093066 mRNA Translation: AAH93066.1 |
CCDSi | CCDS31834.1 [P60660-2] CCDS8906.1 |
PIRi | A33709, MOHU6N A49620, MOHU6E B33709, MOHU6M |
RefSeqi | NP_066299.2, NM_021019.4 [P60660-1] NP_524147.2, NM_079423.3 [P60660-2] |
3D structure databases
SMRi | P60660 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110721, 135 interactors |
CORUMi | P60660 |
IntActi | P60660, 69 interactors |
MINTi | P60660 |
STRINGi | 9606.ENSP00000446955 |
PTM databases
iPTMneti | P60660 |
MetOSitei | P60660 |
PhosphoSitePlusi | P60660 |
SwissPalmi | P60660 |
Polymorphism and mutation databases
BioMutai | MYL6 |
DMDMi | 47606436 |
2D gel databases
DOSAC-COBS-2DPAGEi | P60660 |
SWISS-2DPAGEi | P60660 |
Proteomic databases
EPDi | P60660 |
jPOSTi | P60660 |
MassIVEi | P60660 |
MaxQBi | P60660 |
PaxDbi | P60660 |
PeptideAtlasi | P60660 |
PRIDEi | P60660 |
ProteomicsDBi | 57221 57222 [P60660-2] |
TopDownProteomicsi | P60660-1 [P60660-1] P60660-2 [P60660-2] |
Protocols and materials databases
Antibodypediai | 27997, 333 antibodies |
DNASUi | 4637 |
Genome annotation databases
Ensembli | ENST00000547649; ENSP00000446714; ENSG00000092841 [P60660-2] ENST00000548293; ENSP00000448101; ENSG00000092841 [P60660-1] ENST00000550697; ENSP00000446955; ENSG00000092841 [P60660-1] |
GeneIDi | 4637 |
KEGGi | hsa:4637 |
UCSCi | uc001sjw.3, human |
Organism-specific databases
CTDi | 4637 |
EuPathDBi | HostDB:ENSG00000092841.18 |
GeneCardsi | MYL6 |
HGNCi | HGNC:7587, MYL6 |
HPAi | ENSG00000092841, Low tissue specificity |
MIMi | 609931, gene |
neXtProti | NX_P60660 |
OpenTargetsi | ENSG00000092841 |
PharmGKBi | PA31384 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0030, Eukaryota |
GeneTreei | ENSGT01000000214455 |
InParanoidi | P60660 |
OrthoDBi | 1470794at2759 |
PhylomeDBi | P60660 |
TreeFami | TF351553 |
Enzyme and pathway databases
PathwayCommonsi | P60660 |
Reactomei | R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-445355, Smooth Muscle Contraction R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs |
Miscellaneous databases
BioGRID-ORCSi | 4637, 19 hits in 841 CRISPR screens |
ChiTaRSi | MYL6, human |
GeneWikii | MYL6 |
GenomeRNAii | 4637 |
Pharosi | P60660, Tbio |
PROi | PR:P60660 |
RNActi | P60660, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000092841, Expressed in left uterine tube and 241 other tissues |
ExpressionAtlasi | P60660, baseline and differential |
Genevisiblei | P60660, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR002048, EF_hand_dom |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYL6_HUMAN | |
Accessioni | P60660Primary (citable) accession number: P60660 Secondary accession number(s): P16475 Q6IPY5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations