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Protein

50S ribosomal protein L24

Gene

rplX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. It is not thought to be involved in the functions of the mature 50S subunit in vitro.3 Publications
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.2 Publications

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10884-MONOMER
MetaCyc:EG10884-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L24
Alternative name(s):
Large ribosomal subunit protein uL241 Publication
Gene namesi
Name:rplX
Ordered Locus Names:b3309, JW3271
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10884 rplX

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001306542 – 10450S ribosomal protein L24Add BLAST103

Proteomic databases

EPDiP60624
PaxDbiP60624
PRIDEiP60624

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit (PubMed:391595, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:25310980, PubMed:24844575, PubMed:27934701, PubMed:27906160, PubMed:27906161). Might contact the SecYEG translocation complex when it is docked with the ribosome.1 Publication9 Publications

Protein-protein interaction databases

DIPiDIP-47846N
IntActiP60624, 61 interactors
STRINGi316385.ECDH10B_3484

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60624
SMRiP60624
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60624

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105KAR Bacteria
COG0198 LUCA
HOGENOMiHOG000039892
InParanoidiP60624
KOiK02895
OMAiPQGGIVE
PhylomeDBiP60624

Family and domain databases

Gene3Di2.30.30.30, 1 hit
HAMAPiMF_01326_B Ribosomal_L24_B, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR003256 Ribosomal_L24
IPR005825 Ribosomal_L24/26_CS
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR12903 PTHR12903, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF17136 ribosomal_L24, 1 hit
SMARTiView protein in SMART
SM00739 KOW, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01079 rplX_bact, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60624-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAKIRRDDE VIVLTGKDKG KRGKVKNVLS SGKVIVEGIN LVKKHQKPVP
60 70 80 90 100
ALNQPGGIVE KEAAIQVSNV AIFNAATGKA DRVGFRFEDG KKVRFFKSNS

ETIK
Length:104
Mass (Da):11,316
Last modified:January 23, 2007 - v2
Checksum:i0ABF7DD305FA07F5
GO

Mass spectrometryi

Molecular mass is 11186.5 Da from positions 2 - 104. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01563 Genomic DNA Translation: CAA25716.1
U18997 Genomic DNA Translation: AAA58106.1
U00096 Genomic DNA Translation: AAC76334.1
AP009048 Genomic DNA Translation: BAE77982.1
M10195 Genomic DNA Translation: AAA24050.1
PIRiH65123 R5EC24
RefSeqiNP_417768.1, NC_000913.3
WP_000729185.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76334; AAC76334; b3309
BAE77982; BAE77982; BAE77982
GeneIDi29456670
947810
KEGGiecj:JW3271
eco:b3309
PATRICifig|1411691.4.peg.3422

Similar proteinsi

Entry informationi

Entry nameiRL24_ECOLI
AccessioniPrimary (citable) accession number: P60624
Secondary accession number(s): P02425, P37438, Q2M6X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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