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Entry version 91 (28 Feb 2018)
Sequence version 1 (15 Mar 2004)
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Protein

Alpha-bungarotoxin isoform A31

Gene
N/A
Organism
Bungarus multicinctus (Many-banded krait)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 µM).2 Publications

Caution

PubMed:9837992 indicates that a number of mRNA with sequence conflict(s) are produced by RNA editing. This seems not to be the case as discussed in PubMed:10497260.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.74.1.2 the snake cytotoxin (sct) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-bungarotoxin isoform A31
Short name:
Alpha-BTX A31
Short name:
Alpha-Bgt(A31)
Short name:
BGTX A31
Alternative name(s):
Long neurotoxin 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBungarus multicinctus (Many-banded krait)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeBungarinaeBungarus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the lethal dose (LD), paralytic dose (PD), effect dose (ED) or lethal concentration (LC) of a protein toxin.<p><a href='/help/toxic_dose' target='_top'>More...</a></p>Toxic dosei

LD50 is 0.3 mg/kg by subcutaneous injection.

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 212 PublicationsAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003540622 – 95Alpha-bungarotoxin isoform A31Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 44
Disulfide bondi37 ↔ 65
Disulfide bondi50 ↔ 54
Disulfide bondi69 ↔ 80
Disulfide bondi81 ↔ 86

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.Curated

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer in solution, homodimer in crystal state.5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Chrna7Q059414EBI-7516391,EBI-79422From Rattus norvegicus.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P60615, 5 interactors

Molecular INTeraction database

More...
MINTi
P60615

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P60615

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ABTNMR-A22-95[»]
1BXPNMR-A22-95[»]
1HAANMR-A22-95[»]
1HAJNMR-A22-95[»]
1HC9X-ray1.80B22-95[»]
1HOYNMR-A22-95[»]
1IDGNMR-A22-95[»]
1IDHNMR-A22-95[»]
1IDINMR-A22-95[»]
1IDLNMR-A22-95[»]
1IK8NMR-A22-95[»]
1IKCNMR-A22-95[»]
1JBDNMR-A22-95[»]
1KC4NMR-A22-95[»]
1KFHNMR-A22-95[»]
1KL8NMR-A22-95[»]
1L4WNMR-A22-95[»]
1LJZNMR-A22-95[»]
1LK1model-C/F22-95[»]
1RGJNMR-A22-95[»]
2ABXX-ray2.50A/B22-95[»]
2BTXNMR-A22-95[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60615

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P60615

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P60615

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006553

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00206 snake_toxin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00087 Toxin_TOLIP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P60615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTLVV VTIVCLDLGY TIVCHTTATS PISAVTCPPG ENLCYRKMWC
60 70 80 90
DAFCSSRGKV VELGCAATCP SKKPYEEVTC CSTDKCNPHP KQRPG
Length:95
Mass (Da):10,285
Last modified:March 15, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i589B26743ABBA5E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48M → V in AAC83985 (PubMed:9837992).Curated1
Sequence conflicti53F → S in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti56S → N in AAC83986 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83982 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83983 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83984 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83985 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83986 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83987 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83988 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83989 (PubMed:9837992).Curated1
Sequence conflicti68T → P in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti70P → S in AAC83987 (PubMed:9837992).Curated1
Sequence conflicti72K → E in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti72K → E in AAC83997 (PubMed:9837992).Curated1
Sequence conflicti73K → R in AAC83988 (PubMed:9837992).Curated1
Sequence conflicti79T → S in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti79T → S in AAC83997 (PubMed:9837992).Curated1
Sequence conflicti85K → Q in AAC83990 (PubMed:9837992).Curated1
Sequence conflicti87N → H in AAC83990 (PubMed:9837992).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF056400 mRNA Translation: AAC83981.1
AF056401 Genomic DNA Translation: AAC83982.1
AF056402 mRNA Translation: AAC83983.1
AF056403 mRNA Translation: AAC83984.1
AF056404 mRNA Translation: AAC83985.1
AF056405 mRNA Translation: AAC83986.1
AF056406 mRNA Translation: AAC83987.1
AF056407 mRNA Translation: AAC83988.1
AF056408 mRNA Translation: AAC83989.1
AF056409 mRNA Translation: AAC83990.1
AF056410 mRNA Translation: AAC83991.1
AF056411 mRNA Translation: AAC83992.1
AF056412 mRNA Translation: AAC83993.1
AF056413 mRNA Translation: AAC83994.1
AF056415 mRNA Translation: AAC83996.1
AF056416 mRNA Translation: AAC83997.1
Y17694 Genomic DNA Translation: CAB51844.1
Y17058 mRNA Translation: CAB51842.1
X91990 mRNA Translation: CAA63045.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31519 N2KF1U

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056400 mRNA Translation: AAC83981.1
AF056401 Genomic DNA Translation: AAC83982.1
AF056402 mRNA Translation: AAC83983.1
AF056403 mRNA Translation: AAC83984.1
AF056404 mRNA Translation: AAC83985.1
AF056405 mRNA Translation: AAC83986.1
AF056406 mRNA Translation: AAC83987.1
AF056407 mRNA Translation: AAC83988.1
AF056408 mRNA Translation: AAC83989.1
AF056409 mRNA Translation: AAC83990.1
AF056410 mRNA Translation: AAC83991.1
AF056411 mRNA Translation: AAC83992.1
AF056412 mRNA Translation: AAC83993.1
AF056413 mRNA Translation: AAC83994.1
AF056415 mRNA Translation: AAC83996.1
AF056416 mRNA Translation: AAC83997.1
Y17694 Genomic DNA Translation: CAB51844.1
Y17058 mRNA Translation: CAB51842.1
X91990 mRNA Translation: CAA63045.1
PIRiA31519 N2KF1U

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ABTNMR-A22-95[»]
1BXPNMR-A22-95[»]
1HAANMR-A22-95[»]
1HAJNMR-A22-95[»]
1HC9X-ray1.80B22-95[»]
1HOYNMR-A22-95[»]
1IDGNMR-A22-95[»]
1IDHNMR-A22-95[»]
1IDINMR-A22-95[»]
1IDLNMR-A22-95[»]
1IK8NMR-A22-95[»]
1IKCNMR-A22-95[»]
1JBDNMR-A22-95[»]
1KC4NMR-A22-95[»]
1KFHNMR-A22-95[»]
1KL8NMR-A22-95[»]
1L4WNMR-A22-95[»]
1LJZNMR-A22-95[»]
1LK1model-C/F22-95[»]
1RGJNMR-A22-95[»]
2ABXX-ray2.50A/B22-95[»]
2BTXNMR-A22-95[»]
ProteinModelPortaliP60615
SMRiP60615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60615, 5 interactors
MINTiP60615

Chemistry databases

BindingDBiP60615

Protein family/group databases

TCDBi1.C.74.1.2 the snake cytotoxin (sct) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Miscellaneous databases

EvolutionaryTraceiP60615

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei3L21A_BUNMU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60615
Secondary accession number(s): P01378
, Q9PRI6, Q9YGD1, Q9YI06, Q9YI07, Q9YI09, Q9YI10, Q9YI11, Q9YI12, Q9YI13
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 15, 2004
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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