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Protein

Alpha-bungarotoxin isoform A31

Gene
N/A
Organism
Bungarus multicinctus (Many-banded krait)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 µM).2 Publications

Caution

PubMed:9837992 indicates that a number of mRNA with sequence conflict(s) are produced by RNA editing. This seems not to be the case as discussed in PubMed:10497260.Curated

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Protein family/group databases

TCDBi1.C.74.1.2 the snake cytotoxin (sct) family

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-bungarotoxin isoform A31
Short name:
Alpha-BTX A31
Short name:
Alpha-Bgt(A31)
Short name:
BGTX A31
Alternative name(s):
Long neurotoxin 1
OrganismiBungarus multicinctus (Many-banded krait)
Taxonomic identifieri8616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeBungarinaeBungarus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.3 mg/kg by subcutaneous injection.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000003540622 – 95Alpha-bungarotoxin isoform A31Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 44
Disulfide bondi37 ↔ 65
Disulfide bondi50 ↔ 54
Disulfide bondi69 ↔ 80
Disulfide bondi81 ↔ 86

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Monomer in solution, homodimer in crystal state.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Chrna7Q059414EBI-7516391,EBI-79422From Rattus norvegicus.

Protein-protein interaction databases

IntActiP60615, 5 interactors
MINTiP60615

Chemistry databases

BindingDBiP60615

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60615
SMRiP60615
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60615

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60615-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTLVV VTIVCLDLGY TIVCHTTATS PISAVTCPPG ENLCYRKMWC
60 70 80 90
DAFCSSRGKV VELGCAATCP SKKPYEEVTC CSTDKCNPHP KQRPG
Length:95
Mass (Da):10,285
Last modified:March 15, 2004 - v1
Checksum:i589B26743ABBA5E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48M → V in AAC83985 (PubMed:9837992).Curated1
Sequence conflicti53F → S in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti56S → N in AAC83986 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83982 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83983 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83984 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83985 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83986 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83987 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83988 (PubMed:9837992).Curated1
Sequence conflicti57R → K in AAC83989 (PubMed:9837992).Curated1
Sequence conflicti68T → P in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti70P → S in AAC83987 (PubMed:9837992).Curated1
Sequence conflicti72K → E in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti72K → E in AAC83997 (PubMed:9837992).Curated1
Sequence conflicti73K → R in AAC83988 (PubMed:9837992).Curated1
Sequence conflicti79T → S in AAC83996 (PubMed:9837992).Curated1
Sequence conflicti79T → S in AAC83997 (PubMed:9837992).Curated1
Sequence conflicti85K → Q in AAC83990 (PubMed:9837992).Curated1
Sequence conflicti87N → H in AAC83990 (PubMed:9837992).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056400 mRNA Translation: AAC83981.1
AF056401 Genomic DNA Translation: AAC83982.1
AF056402 mRNA Translation: AAC83983.1
AF056403 mRNA Translation: AAC83984.1
AF056404 mRNA Translation: AAC83985.1
AF056405 mRNA Translation: AAC83986.1
AF056406 mRNA Translation: AAC83987.1
AF056407 mRNA Translation: AAC83988.1
AF056408 mRNA Translation: AAC83989.1
AF056409 mRNA Translation: AAC83990.1
AF056410 mRNA Translation: AAC83991.1
AF056411 mRNA Translation: AAC83992.1
AF056412 mRNA Translation: AAC83993.1
AF056413 mRNA Translation: AAC83994.1
AF056415 mRNA Translation: AAC83996.1
AF056416 mRNA Translation: AAC83997.1
Y17694 Genomic DNA Translation: CAB51844.1
Y17058 mRNA Translation: CAB51842.1
X91990 mRNA Translation: CAA63045.1
PIRiA31519 N2KF1U

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056400 mRNA Translation: AAC83981.1
AF056401 Genomic DNA Translation: AAC83982.1
AF056402 mRNA Translation: AAC83983.1
AF056403 mRNA Translation: AAC83984.1
AF056404 mRNA Translation: AAC83985.1
AF056405 mRNA Translation: AAC83986.1
AF056406 mRNA Translation: AAC83987.1
AF056407 mRNA Translation: AAC83988.1
AF056408 mRNA Translation: AAC83989.1
AF056409 mRNA Translation: AAC83990.1
AF056410 mRNA Translation: AAC83991.1
AF056411 mRNA Translation: AAC83992.1
AF056412 mRNA Translation: AAC83993.1
AF056413 mRNA Translation: AAC83994.1
AF056415 mRNA Translation: AAC83996.1
AF056416 mRNA Translation: AAC83997.1
Y17694 Genomic DNA Translation: CAB51844.1
Y17058 mRNA Translation: CAB51842.1
X91990 mRNA Translation: CAA63045.1
PIRiA31519 N2KF1U

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ABTNMR-A22-95[»]
1BXPNMR-A22-95[»]
1HAANMR-A22-95[»]
1HAJNMR-A22-95[»]
1HC9X-ray1.80B22-95[»]
1HOYNMR-A22-95[»]
1IDGNMR-A22-95[»]
1IDHNMR-A22-95[»]
1IDINMR-A22-95[»]
1IDLNMR-A22-95[»]
1IK8NMR-A22-95[»]
1IKCNMR-A22-95[»]
1JBDNMR-A22-95[»]
1KC4NMR-A22-95[»]
1KFHNMR-A22-95[»]
1KL8NMR-A22-95[»]
1L4WNMR-A22-95[»]
1LJZNMR-A22-95[»]
1LK1model-C/F22-95[»]
1RGJNMR-A22-95[»]
2ABXX-ray2.50A/B22-95[»]
2BTXNMR-A22-95[»]
ProteinModelPortaliP60615
SMRiP60615
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP60615, 5 interactors
MINTiP60615

Chemistry databases

BindingDBiP60615

Protein family/group databases

TCDBi1.C.74.1.2 the snake cytotoxin (sct) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Miscellaneous databases

EvolutionaryTraceiP60615

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3L21A_BUNMU
AccessioniPrimary (citable) accession number: P60615
Secondary accession number(s): P01378
, Q9PRI6, Q9YGD1, Q9YI06, Q9YI07, Q9YI09, Q9YI10, Q9YI11, Q9YI12, Q9YI13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 15, 2004
Last modified: February 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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