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Protein

Ubiquitin-conjugating enzyme E2 G2

Gene

UBE2G2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).2 Publications

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Glycyl thioester intermediate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP60604
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 G2 (EC:2.3.2.231 Publication)
Alternative name(s):
E2 ubiquitin-conjugating enzyme G2
Ubiquitin carrier protein G2
Ubiquitin-protein ligase G2
Gene namesi
Name:UBE2G2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000184787.18
HGNCiHGNC:12483 UBE2G2
MIMi603124 gene
neXtProtiNX_P60604

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184787
PharmGKBiPA37132

Polymorphism and mutation databases

BioMutaiUBE2G2
DMDMi45593583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000824832 – 165Ubiquitin-conjugating enzyme E2 G2Add BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP60604
MaxQBiP60604
PaxDbiP60604
PeptideAtlasiP60604
PRIDEiP60604
ProteomicsDBi57218
TopDownProteomicsiP60604-1 [P60604-1]

PTM databases

iPTMnetiP60604
PhosphoSitePlusiP60604
SwissPalmiP60604

Expressioni

Gene expression databases

BgeeiENSG00000184787 Expressed in 234 organ(s), highest expression level in tendon
CleanExiHS_UBE2G2
ExpressionAtlasiP60604 baseline and differential
GenevisibleiP60604 HS

Organism-specific databases

HPAiHPA003332

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AMFRQ9UKV519EBI-1051028,EBI-1046367

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113175, 55 interactors
DIPiDIP-50750N
IntActiP60604, 31 interactors
MINTiP60604
STRINGi9606.ENSP00000338348

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60604
SMRiP60604
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60604

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0426 Eukaryota
ENOG410Y0NU LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiP60604
KOiK04555
OMAiDYPLSPF
OrthoDBiEOG091G0O9F
PhylomeDBiP60604
TreeFamiTF101118

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60604-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE
60 70 80 90 100
FGVFPAILSF PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP
110 120 130 140 150
MGYESSAERW SPVQSVEKIL LSVVSMLAEP NDESGANVDA SKMWRDDREQ
160
FYKIAKQIVQ KSLGL
Length:165
Mass (Da):18,566
Last modified:March 15, 2004 - v1
Checksum:i74DEC732A79575E3
GO
Isoform 2 (identifier: P60604-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:137
Mass (Da):15,614
Checksum:iFA95FDC41C3FCAD4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WDB1F8WDB1_HUMAN
Ubiquitin-conjugating enzyme E2 G2
UBE2G2
99Annotation score:
F8WCB9F8WCB9_HUMAN
Ubiquitin-conjugating enzyme E2 G2
UBE2G2
48Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12E → V in AAC32312 (PubMed:9693041).Curated1
Sequence conflicti101 – 107MGYESSA → HGLREQP in AAC32312 (PubMed:9693041).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462601 – 28Missing in isoform 2. CuratedAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032456 mRNA Translation: AAC32312.1
BT006914 mRNA Translation: AAP35560.1
AK290629 mRNA Translation: BAF83318.1
AL163300 Genomic DNA Translation: CAB90551.1
CH471079 Genomic DNA Translation: EAX09395.1
CH471079 Genomic DNA Translation: EAX09397.1
CH471079 Genomic DNA Translation: EAX09398.1
CH471079 Genomic DNA Translation: EAX09399.1
BC001738 mRNA Translation: AAH01738.1
BC008351 mRNA Translation: AAH08351.1
BC011569 mRNA Translation: AAH11569.1
CCDSiCCDS13714.1 [P60604-1]
CCDS33586.1 [P60604-2]
RefSeqiNP_001189418.1, NM_001202489.1
NP_003334.2, NM_003343.5 [P60604-1]
NP_872630.1, NM_182688.2 [P60604-2]
XP_016883958.1, XM_017028469.1
UniGeneiHs.529420
Hs.701398

Genome annotation databases

EnsembliENST00000330942; ENSP00000331384; ENSG00000184787 [P60604-2]
ENST00000345496; ENSP00000338348; ENSG00000184787 [P60604-1]
GeneIDi7327
KEGGihsa:7327
UCSCiuc002zfx.4 human [P60604-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032456 mRNA Translation: AAC32312.1
BT006914 mRNA Translation: AAP35560.1
AK290629 mRNA Translation: BAF83318.1
AL163300 Genomic DNA Translation: CAB90551.1
CH471079 Genomic DNA Translation: EAX09395.1
CH471079 Genomic DNA Translation: EAX09397.1
CH471079 Genomic DNA Translation: EAX09398.1
CH471079 Genomic DNA Translation: EAX09399.1
BC001738 mRNA Translation: AAH01738.1
BC008351 mRNA Translation: AAH08351.1
BC011569 mRNA Translation: AAH11569.1
CCDSiCCDS13714.1 [P60604-1]
CCDS33586.1 [P60604-2]
RefSeqiNP_001189418.1, NM_001202489.1
NP_003334.2, NM_003343.5 [P60604-1]
NP_872630.1, NM_182688.2 [P60604-2]
XP_016883958.1, XM_017028469.1
UniGeneiHs.529420
Hs.701398

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CYXX-ray2.56A/B/C1-165[»]
2KLYNMR-A1-165[»]
2LXPNMR-A2-165[»]
3H8KX-ray1.80A2-165[»]
4LADX-ray2.30A1-165[»]
ProteinModelPortaliP60604
SMRiP60604
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113175, 55 interactors
DIPiDIP-50750N
IntActiP60604, 31 interactors
MINTiP60604
STRINGi9606.ENSP00000338348

PTM databases

iPTMnetiP60604
PhosphoSitePlusiP60604
SwissPalmiP60604

Polymorphism and mutation databases

BioMutaiUBE2G2
DMDMi45593583

Proteomic databases

EPDiP60604
MaxQBiP60604
PaxDbiP60604
PeptideAtlasiP60604
PRIDEiP60604
ProteomicsDBi57218
TopDownProteomicsiP60604-1 [P60604-1]

Protocols and materials databases

DNASUi7327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330942; ENSP00000331384; ENSG00000184787 [P60604-2]
ENST00000345496; ENSP00000338348; ENSG00000184787 [P60604-1]
GeneIDi7327
KEGGihsa:7327
UCSCiuc002zfx.4 human [P60604-1]

Organism-specific databases

CTDi7327
EuPathDBiHostDB:ENSG00000184787.18
GeneCardsiUBE2G2
HGNCiHGNC:12483 UBE2G2
HPAiHPA003332
MIMi603124 gene
neXtProtiNX_P60604
OpenTargetsiENSG00000184787
PharmGKBiPA37132
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0426 Eukaryota
ENOG410Y0NU LUCA
GeneTreeiENSGT00730000110436
HOGENOMiHOG000233454
HOVERGENiHBG063308
InParanoidiP60604
KOiK04555
OMAiDYPLSPF
OrthoDBiEOG091G0O9F
PhylomeDBiP60604
TreeFamiTF101118

Enzyme and pathway databases

UniPathwayi
UPA00143

BRENDAi2.3.2.B6 2681
ReactomeiR-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiP60604

Miscellaneous databases

ChiTaRSiUBE2G2 human
EvolutionaryTraceiP60604
GeneWikiiUBE2G2
GenomeRNAii7327
PROiPR:P60604
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184787 Expressed in 234 organ(s), highest expression level in tendon
CleanExiHS_UBE2G2
ExpressionAtlasiP60604 baseline and differential
GenevisibleiP60604 HS

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUB2G2_HUMAN
AccessioniPrimary (citable) accession number: P60604
Secondary accession number(s): A6NMQ7
, A8K3L4, D3DSL7, P56554
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 7, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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