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Entry version 126 (18 Sep 2019)
Sequence version 1 (15 Mar 2004)
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Protein

Reactive oxygen species modulator 1

Gene

ROMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Miscellaneous

Enforced expression in IMR-90 cells leads to increased levels of ROS and induces premature cell senescence and nuclear DNA damage.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.111.1.1 the reactive oxygen species modulator 1 (romo1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reactive oxygen species modulator 1
Short name:
ROS modulator 1
Alternative name(s):
Epididymis tissue protein Li 175
Glyrichin
Mitochondrial targeting GxxxG motif protein
Short name:
MTGM
Protein MGR2 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROMO1
Synonyms:C20orf52
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16185 ROMO1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 44HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140823

Open Targets

More...
OpenTargetsi
ENSG00000125995

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164725540

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ROMO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45593159

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794332 – 79Reactive oxygen species modulator 1Add BLAST78

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P60602

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P60602

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P60602

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P60602

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60602

PeptideAtlas

More...
PeptideAtlasi
P60602

PRoteomics IDEntifications database

More...
PRIDEi
P60602

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57216 [P60602-1]
57217 [P60602-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P60602-1 [P60602-1]

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P60602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression increases in senescent cells.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By the anticancer drug fluorouracil (5FU).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125995 Expressed in 200 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P60602 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA012782

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126718, 22 interactors

Protein interaction database and analysis system

More...
IntActi
P60602, 4 interactors

Molecular INTeraction database

More...
MINTi
P60602

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363191

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 60Sufficient for antibacterial activityAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MGR2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4096 Eukaryota
ENOG411279J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005315

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60602

Identification of Orthologs from Complete Genome Data

More...
OMAi
AMFGTFS

Database of Orthologous Groups

More...
OrthoDBi
1635599at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60602

TreeFam database of animal gene trees

More...
TreeFami
TF300273

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018450 Romo1/Mgr2

The PANTHER Classification System

More...
PANTHERi
PTHR28525 PTHR28525, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10247 Romo1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01378 Romo1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P60602-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR
60 70
ELMGGIGKTM MQSGGTFGTF MAIGMGIRC
Length:79
Mass (Da):8,183
Last modified:March 15, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD959C88C89EF80A
GO
Isoform 2 (identifier: P60602-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-79: RIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC → SSILVSSSGSECGVES

Note: Gene prediction based on EST data.
Show »
Length:59
Mass (Da):5,900
Checksum:i22C898C2946D76C7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01412728A → P. Corresponds to variant dbSNP:rs1044521Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03648644 – 79RIGMR…MGIRC → SSILVSSSGSECGVES in isoform 2. CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AM397244 mRNA Translation: CAL37002.1
AM397245 mRNA Translation: CAL37003.1
AM397246 mRNA Translation: CAL37004.1
GU727625 mRNA Translation: ADU87627.1
AL357374 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76168.1
CH471077 Genomic DNA Translation: EAW76169.1
BC008488 mRNA Translation: AAH08488.1
BC105281 mRNA Translation: AAI05282.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13264.1 [P60602-1]

NCBI Reference Sequences

More...
RefSeqi
NP_542786.1, NM_080748.2 [P60602-1]
XP_016883167.1, XM_017027678.1 [P60602-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336695; ENSP00000338293; ENSG00000125995 [P60602-1]
ENST00000374072; ENSP00000363185; ENSG00000125995 [P60602-2]
ENST00000374077; ENSP00000363190; ENSG00000125995 [P60602-1]
ENST00000374078; ENSP00000363191; ENSG00000125995 [P60602-1]
ENST00000397416; ENSP00000380561; ENSG00000125995 [P60602-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140823

UCSC genome browser

More...
UCSCi
uc002xdy.4 human [P60602-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM397244 mRNA Translation: CAL37002.1
AM397245 mRNA Translation: CAL37003.1
AM397246 mRNA Translation: CAL37004.1
GU727625 mRNA Translation: ADU87627.1
AL357374 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76168.1
CH471077 Genomic DNA Translation: EAW76169.1
BC008488 mRNA Translation: AAH08488.1
BC105281 mRNA Translation: AAI05282.1
CCDSiCCDS13264.1 [P60602-1]
RefSeqiNP_542786.1, NM_080748.2 [P60602-1]
XP_016883167.1, XM_017027678.1 [P60602-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126718, 22 interactors
IntActiP60602, 4 interactors
MINTiP60602
STRINGi9606.ENSP00000363191

Protein family/group databases

TCDBi1.A.111.1.1 the reactive oxygen species modulator 1 (romo1) family

PTM databases

SwissPalmiP60602

Polymorphism and mutation databases

BioMutaiROMO1
DMDMi45593159

Proteomic databases

EPDiP60602
jPOSTiP60602
MassIVEiP60602
MaxQBiP60602
PaxDbiP60602
PeptideAtlasiP60602
PRIDEiP60602
ProteomicsDBi57216 [P60602-1]
57217 [P60602-2]
TopDownProteomicsiP60602-1 [P60602-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
140823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336695; ENSP00000338293; ENSG00000125995 [P60602-1]
ENST00000374072; ENSP00000363185; ENSG00000125995 [P60602-2]
ENST00000374077; ENSP00000363190; ENSG00000125995 [P60602-1]
ENST00000374078; ENSP00000363191; ENSG00000125995 [P60602-1]
ENST00000397416; ENSP00000380561; ENSG00000125995 [P60602-1]
GeneIDi140823
KEGGihsa:140823
UCSCiuc002xdy.4 human [P60602-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140823
DisGeNETi140823

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ROMO1
HGNCiHGNC:16185 ROMO1
HPAiHPA012782
neXtProtiNX_P60602
OpenTargetsiENSG00000125995
PharmGKBiPA164725540

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4096 Eukaryota
ENOG411279J LUCA
GeneTreeiENSGT00390000005315
InParanoidiP60602
OMAiAMFGTFS
OrthoDBi1635599at2759
PhylomeDBiP60602
TreeFamiTF300273

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ROMO1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140823

Pharos

More...
Pharosi
P60602

Protein Ontology

More...
PROi
PR:P60602

Gene expression databases

BgeeiENSG00000125995 Expressed in 200 organ(s), highest expression level in quadriceps femoris
GenevisibleiP60602 HS

Family and domain databases

InterProiView protein in InterPro
IPR018450 Romo1/Mgr2
PANTHERiPTHR28525 PTHR28525, 1 hit
PfamiView protein in Pfam
PF10247 Romo1, 1 hit
SMARTiView protein in SMART
SM01378 Romo1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROMO1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60602
Secondary accession number(s): A7M872
, E1P5R9, E9KL28, Q3MHD5, Q5QP16, Q9CQ98, Q9H1N2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: September 18, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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