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Protein

Interleukin-2

Gene

IL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P60568

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P60568

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
INN: Aldesleukin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109471.4

Human Gene Nomenclature Database

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HGNCi
HGNC:6001 IL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60568

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.1 Publication

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
3558

Open Targets

More...
OpenTargetsi
ENSG00000109471

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA195

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5880

Drug and drug target database

More...
DrugBanki
DB03455 (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid
DB04278 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide
DB05676 Apremilast
DB05299 keyhole limpet hemocyanin
DB00852 Pseudoephedrine
DB03957 SP2456
DB02555 SP4160
DB05304 WX-G250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45593462

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001548421 – 153Interleukin-2Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00005123O-linked (GalNAc...) threonine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 1252 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60568

PeptideAtlas

More...
PeptideAtlasi
P60568

PRoteomics IDEntifications database

More...
PRIDEi
P60568

ProteomicsDB human proteome resource

More...
ProteomicsDBi
57215

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
225
297
298
299
300

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60568

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60568

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P60568

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109471 Expressed in 45 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P60568 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P60568 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010310

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109773, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P60568

Database of interacting proteins

More...
DIPi
DIP-475N

Protein interaction database and analysis system

More...
IntActi
P60568, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226730

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P60568

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-226-153[»]
1ILNmodel-226-153[»]
1IRLNMR-A21-153[»]
1M47X-ray1.99A21-153[»]
1M48X-ray1.95A/B21-153[»]
1M49X-ray2.00A/B21-153[»]
1M4AX-ray2.18A21-153[»]
1M4BX-ray2.15A21-153[»]
1M4CX-ray2.40A/B21-153[»]
1NBPX-ray2.20A21-153[»]
1PW6X-ray2.60A/B21-153[»]
1PY2X-ray2.80A/B/C/D21-152[»]
1QVNX-ray2.70A/B/C/D21-152[»]
1Z92X-ray2.80A21-153[»]
2B5IX-ray2.30A21-153[»]
2ERJX-ray3.00D/H21-153[»]
3INKX-ray2.50C/D21-153[»]
3QAZX-ray3.80A/D/G/J/M/P/S/V/Y/b/e/h21-153[»]
3QB1X-ray3.10A/B/C/D/E/F/G/H21-153[»]
4NEJX-ray1.92A24-153[»]
4NEMX-ray1.93A24-153[»]
5LQBX-ray1.95A22-153[»]
5M5EX-ray2.30D8-153[»]
5UTZX-ray2.75A/D/E/I21-153[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60568

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P60568

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P60568

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J049 Eukaryota
ENOG41119SF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003555

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG007496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60568

KEGG Orthology (KO)

More...
KOi
K05429

Identification of Orthologs from Complete Genome Data

More...
OMAi
KWITFCQ

Database of Orthologous Groups

More...
OrthoDBi
309052at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60568

TreeFam database of animal gene trees

More...
TreeFami
TF338200

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS

The PANTHER Classification System

More...
PANTHERi
PTHR45426 PTHR45426, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00715 IL2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00265 INTERLEUKIN2

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00189 IL2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P60568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRMQLLSCI ALSLALVTNS APTSSSTKKT QLQLEHLLLD LQMILNGINN
60 70 80 90 100
YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL
110 120 130 140 150
RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS

TLT
Length:153
Mass (Da):17,628
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59E2F40F25860F84
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA59140 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00396721Missing in FT-IL2-A and FT-IL2-B. 1
Natural variantiVAR_00396822Missing in FT-IL2-B. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00695 Genomic DNA Translation: CAA25292.1
V00564 mRNA Translation: CAA23827.1
X01586 mRNA Translation: CAA25742.1
J00264 Genomic DNA Translation: AAD48509.1
K02056 Genomic DNA Translation: AAA98792.1
S77834 mRNA Translation: AAD14263.2
S82692 mRNA Translation: AAB46883.1
AF359939 Genomic DNA Translation: AAK26665.1
BC066255 mRNA Translation: AAH66255.1
BC066257 mRNA Translation: AAH66257.1
BC070338 mRNA Translation: AAH70338.1
M33199 Genomic DNA Translation: AAA59139.1
M13879 Genomic DNA Translation: AAA59141.1
M22005 Genomic DNA Translation: AAA59140.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3726.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A01849 ICHU2

NCBI Reference Sequences

More...
RefSeqi
NP_000577.2, NM_000586.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.89679

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000226730; ENSP00000226730; ENSG00000109471

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3558

Keywords - Coding sequence diversityi

Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-2 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00695 Genomic DNA Translation: CAA25292.1
V00564 mRNA Translation: CAA23827.1
X01586 mRNA Translation: CAA25742.1
J00264 Genomic DNA Translation: AAD48509.1
K02056 Genomic DNA Translation: AAA98792.1
S77834 mRNA Translation: AAD14263.2
S82692 mRNA Translation: AAB46883.1
AF359939 Genomic DNA Translation: AAK26665.1
BC066255 mRNA Translation: AAH66255.1
BC066257 mRNA Translation: AAH66257.1
BC070338 mRNA Translation: AAH70338.1
M33199 Genomic DNA Translation: AAA59139.1
M13879 Genomic DNA Translation: AAA59141.1
M22005 Genomic DNA Translation: AAA59140.1 Different initiation.
CCDSiCCDS3726.1
PIRiA01849 ICHU2
RefSeqiNP_000577.2, NM_000586.3
UniGeneiHs.89679

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-226-153[»]
1ILNmodel-226-153[»]
1IRLNMR-A21-153[»]
1M47X-ray1.99A21-153[»]
1M48X-ray1.95A/B21-153[»]
1M49X-ray2.00A/B21-153[»]
1M4AX-ray2.18A21-153[»]
1M4BX-ray2.15A21-153[»]
1M4CX-ray2.40A/B21-153[»]
1NBPX-ray2.20A21-153[»]
1PW6X-ray2.60A/B21-153[»]
1PY2X-ray2.80A/B/C/D21-152[»]
1QVNX-ray2.70A/B/C/D21-152[»]
1Z92X-ray2.80A21-153[»]
2B5IX-ray2.30A21-153[»]
2ERJX-ray3.00D/H21-153[»]
3INKX-ray2.50C/D21-153[»]
3QAZX-ray3.80A/D/G/J/M/P/S/V/Y/b/e/h21-153[»]
3QB1X-ray3.10A/B/C/D/E/F/G/H21-153[»]
4NEJX-ray1.92A24-153[»]
4NEMX-ray1.93A24-153[»]
5LQBX-ray1.95A22-153[»]
5M5EX-ray2.30D8-153[»]
5UTZX-ray2.75A/D/E/I21-153[»]
ProteinModelPortaliP60568
SMRiP60568
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109773, 2 interactors
CORUMiP60568
DIPiDIP-475N
IntActiP60568, 3 interactors
STRINGi9606.ENSP00000226730

Chemistry databases

BindingDBiP60568
ChEMBLiCHEMBL5880
DrugBankiDB03455 (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid
DB04278 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide
DB05676 Apremilast
DB05299 keyhole limpet hemocyanin
DB00852 Pseudoephedrine
DB03957 SP2456
DB02555 SP4160
DB05304 WX-G250

PTM databases

GlyConnecti225
297
298
299
300
iPTMnetiP60568
PhosphoSitePlusiP60568
UniCarbKBiP60568

Polymorphism and mutation databases

BioMutaiIL2
DMDMi45593462

Proteomic databases

PaxDbiP60568
PeptideAtlasiP60568
PRIDEiP60568
ProteomicsDBi57215

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3558
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226730; ENSP00000226730; ENSG00000109471
GeneIDi3558
KEGGihsa:3558

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3558
DisGeNETi3558
EuPathDBiHostDB:ENSG00000109471.4

GeneCards: human genes, protein and diseases

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GeneCardsi
IL2
HGNCiHGNC:6001 IL2
HPAiCAB010310
MIMi147680 gene
neXtProtiNX_P60568
OpenTargetsiENSG00000109471
PharmGKBiPA195

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOVERGENiHBG007496
InParanoidiP60568
KOiK05429
OMAiKWITFCQ
OrthoDBi309052at2759
PhylomeDBiP60568
TreeFamiTF338200

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SignaLinkiP60568
SIGNORiP60568

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IL2 human
EvolutionaryTraceiP60568

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3558

Protein Ontology

More...
PROi
PR:P60568

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109471 Expressed in 45 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_IL2
ExpressionAtlasiP60568 baseline and differential
GenevisibleiP60568 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60568
Secondary accession number(s): P01585
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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