UniProtKB - P60566 (FIXA_ECOLI)
Protein
Protein FixA
Gene
fixA
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for anaerobic carnitine reduction. May bring reductant to CaiA.1 Publication
: carnitine metabolism Pathwayi
This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.
GO - Molecular functioni
- electron transfer activity Source: InterPro
GO - Biological processi
- carnitine catabolic process Source: EcoCyc
- carnitine metabolic process Source: EcoliWiki
Keywordsi
Biological process | Electron transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11562-MONOMER |
UniPathwayi | UPA00117 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FixA |
Gene namesi | Name:fixA Synonyms:yaaQ Ordered Locus Names:b0041, JW0040 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000167892 | 1 – 256 | Protein FixAAdd BLAST | 256 |
Proteomic databases
PaxDbi | P60566 |
PRIDEi | P60566 |
Interactioni
Subunit structurei
Heterodimer of FixA and FixB.
CuratedBinary interactionsi
P60566
With | #Exp. | IntAct |
---|---|---|
ybhF [P0A9U1] | 3 | EBI-1113126,EBI-547696 |
Protein-protein interaction databases
BioGRIDi | 4262207, 10 interactors 851643, 3 interactors |
IntActi | P60566, 8 interactors |
STRINGi | 511145.b0041 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ETF beta-subunit/FixA family.Curated
Phylogenomic databases
eggNOGi | COG2086, Bacteria |
HOGENOMi | CLU_060196_2_2_6 |
InParanoidi | P60566 |
PhylomeDBi | P60566 |
Family and domain databases
CDDi | cd01714, ETF_beta, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_01055, FixA, 1 hit |
InterProi | View protein in InterPro IPR000049, ET-Flavoprotein_bsu_CS IPR014730, ETF_a/b_N IPR012255, ETF_b IPR033948, ETF_beta_N IPR023463, FixA IPR014729, Rossmann-like_a/b/a_fold |
PANTHERi | PTHR21294, PTHR21294, 1 hit |
Pfami | View protein in Pfam PF01012, ETF, 1 hit |
PIRSFi | PIRSF000090, Beta-ETF, 1 hit |
SMARTi | View protein in SMART SM00893, ETF, 1 hit |
PROSITEi | View protein in PROSITE PS01065, ETF_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
P60566-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIITCYKCV PDEQDIAVNN ADGSLDFSKA DAKISQYDLN AIEAACQLKQ
60 70 80 90 100
QAAEAQVTAL SVGGKALTNA KGRKDVLSRG PDELIVVIDD QFEQALPQQT
110 120 130 140 150
ASALAAAAQK AGFDLILCGD GSSDLYAQQV GLLVGEILNI PAVNGVSKII
160 170 180 190 200
SLTADTLTVE RELEDETETL SIPLPAVVAV STDINSPQIP SMKAILGAAK
210 220 230 240 250
KPVQVWSAAD IGFNAEAAWS EQQVAAPKQR ERQRIVIEGD GEEQIAAFAE
NLRKVI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 216 – 217 | EA → VD in CAA50797 (PubMed:7473063).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71977 Genomic DNA Translation: CAA50797.1 U00096 Genomic DNA Translation: AAC73152.2 AP009048 Genomic DNA Translation: BAB96610.2 |
PIRi | A64725 |
RefSeqi | NP_414583.2, NC_000913.3 WP_000692204.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73152; AAC73152; b0041 BAB96610; BAB96610; BAB96610 |
GeneIDi | 947316 |
KEGGi | ecj:JW0040 eco:b0041 |
PATRICi | fig|1411691.4.peg.2242 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X71977 Genomic DNA Translation: CAA50797.1 U00096 Genomic DNA Translation: AAC73152.2 AP009048 Genomic DNA Translation: BAB96610.2 |
PIRi | A64725 |
RefSeqi | NP_414583.2, NC_000913.3 WP_000692204.1, NZ_STEB01000010.1 |
3D structure databases
SMRi | P60566 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262207, 10 interactors 851643, 3 interactors |
IntActi | P60566, 8 interactors |
STRINGi | 511145.b0041 |
Proteomic databases
PaxDbi | P60566 |
PRIDEi | P60566 |
Genome annotation databases
EnsemblBacteriai | AAC73152; AAC73152; b0041 BAB96610; BAB96610; BAB96610 |
GeneIDi | 947316 |
KEGGi | ecj:JW0040 eco:b0041 |
PATRICi | fig|1411691.4.peg.2242 |
Organism-specific databases
EchoBASEi | EB1523 |
Phylogenomic databases
eggNOGi | COG2086, Bacteria |
HOGENOMi | CLU_060196_2_2_6 |
InParanoidi | P60566 |
PhylomeDBi | P60566 |
Enzyme and pathway databases
UniPathwayi | UPA00117 |
BioCyci | EcoCyc:EG11562-MONOMER |
Miscellaneous databases
PROi | PR:P60566 |
Family and domain databases
CDDi | cd01714, ETF_beta, 1 hit |
Gene3Di | 3.40.50.620, 1 hit |
HAMAPi | MF_01055, FixA, 1 hit |
InterProi | View protein in InterPro IPR000049, ET-Flavoprotein_bsu_CS IPR014730, ETF_a/b_N IPR012255, ETF_b IPR033948, ETF_beta_N IPR023463, FixA IPR014729, Rossmann-like_a/b/a_fold |
PANTHERi | PTHR21294, PTHR21294, 1 hit |
Pfami | View protein in Pfam PF01012, ETF, 1 hit |
PIRSFi | PIRSF000090, Beta-ETF, 1 hit |
SMARTi | View protein in SMART SM00893, ETF, 1 hit |
PROSITEi | View protein in PROSITE PS01065, ETF_BETA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIXA_ECOLI | |
Accessioni | P60566Primary (citable) accession number: P60566 Secondary accession number(s): P31573 Q8XA29 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | March 15, 2004 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families