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UniProtKB - P60520 (GBRL2_HUMAN)

Entry version 157 (22 Apr 2020)
Sequence version 1 (01 Mar 2004)
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Protein

Gamma-aminobutyric acid receptor-associated protein-like 2

Gene

GABARAPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1632852 Macroautophagy
R-HSA-8854214 TBC/RABGAPs

SIGNOR Signaling Network Open Resource

More...SIGNORi		P60520

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		P60520 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein-like 2
Alternative name(s):
GABA(A) receptor-associated protein-like 2
Ganglioside expression factor 2
Short name:
GEF-2
General protein transport factor p16
Golgi-associated ATPase enhancer of 16 kDa
Short name:
GATE-16
MAP1 light chain 3-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GABARAPL2
Synonyms:FLC3A, GEF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13291 GABARAPL2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607452 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P60520

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi116G → A: Impairs localization at the autophagosomal membrane. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		11345

Open Targets

More...OpenTargetsi		ENSG00000034713

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28482

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P60520 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GABARAPL2

Domain mapping of disease mutations (DMDM)

More...DMDMi		44888808

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002123731 – 116Gamma-aminobutyric acid receptor-associated protein-like 2Add BLAST116
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000423070117Removed in mature form1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24N6-acetyllysineCombined sources1
Modified residuei39PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi116Phosphatidylethanolamine amidated glycine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.1 Publication
The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei116 – 117Cleavage; by ATG42

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P60520

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P60520

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P60520

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P60520

PeptideAtlas

More...PeptideAtlasi		P60520

PRoteomics IDEntifications database

More...PRIDEi		P60520

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57214

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P60520

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P60520

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P60520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000034713 Expressed in caudate nucleus and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P60520 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P60520 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000034713 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity).

Interacts with ATG3, ATG7, ATG13 and ULK1.

Interacts with TP53INP1 and TP53INP2.

Interacts with TBC1D25. Directly interacts with SQSTM1 and BNIP3.

Interacts with TECPR2 and PCM1.

Interacts with TBC1D5 (PubMed:22354992).

Interacts with TRIM5 (PubMed:25127057).

Interacts with MEFV and TRIM21 (PubMed:26347139).

Interacts with WDFY3 (PubMed:24668264).

By similarity17 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60520
With#Exp.IntAct
AGTRAP [Q6RW13]3EBI-720116,EBI-741181
AHNAK2 - isoform 2 [Q8IVF2-2]3EBI-720116,EBI-10217765
ANKFY1 [Q9P2R3]2EBI-720116,EBI-2513908
ARFGAP1 [Q8N6T3]3EBI-720116,EBI-716933
ARFGAP1 - isoform 2 [Q8N6T3-2]3EBI-720116,EBI-6288865
ATG13 [O75143]3EBI-720116,EBI-2798775
ATG16L1 [Q676U5]2EBI-720116,EBI-535909
ATG2A [Q2TAZ0]2EBI-720116,EBI-2514077
ATG3 [Q9NT62]5EBI-720116,EBI-988094
ATG4B [Q9Y4P1]10EBI-720116,EBI-712014
ATG7 [O95352]7EBI-720116,EBI-987834
BCL2L13 [Q9BXK5]4EBI-720116,EBI-747430
BNIP3L [O60238]3EBI-720116,EBI-849893
Bnip3l [Q9Z2F7] from Mus musculus.2EBI-720116,EBI-1774669
BSDC1 [Q9NW68]3EBI-720116,EBI-721848
CALCOCO1 [Q9P1Z2]3EBI-720116,EBI-749920
CALCOCO2 [Q13137]7EBI-720116,EBI-739580
CCDC155 [Q8N6L0]3EBI-720116,EBI-749265
DNAAF4 [Q8WXU2]2EBI-720116,EBI-2946907
DYNLL1 [P63167]3EBI-720116,EBI-349105
DYNLL2 [Q96FJ2]3EBI-720116,EBI-742371
EGFR [P00533]3EBI-720116,EBI-297353
FUNDC1 [Q8IVP5]4EBI-720116,EBI-3059266
FYCO1 [Q9BQS8]2EBI-720116,EBI-2869338
HADHA [P40939]4EBI-720116,EBI-356720
HAP1 [P54257]3EBI-720116,EBI-712814
INSYN1 [Q2T9L4]3EBI-720116,EBI-4311436
IPO5 [O00410]5EBI-720116,EBI-356424
KBTBD6 [Q86V97]2EBI-720116,EBI-2514778
KBTBD7 [Q8WVZ9]3EBI-720116,EBI-473695
KIAA1958 [Q8N8K9]7EBI-720116,EBI-10181113
KIF16B - isoform 5 [Q96L93-6]3EBI-720116,EBI-10988217
KRTAP10-7 [P60409]6EBI-720116,EBI-10172290
KRTAP10-9 [P60411]3EBI-720116,EBI-10172052
LZTR1 [Q8N653]3EBI-720116,EBI-2350056
MLX [Q9UH92]5EBI-720116,EBI-741109
MLX - isoform Beta [Q9UH92-3]3EBI-720116,EBI-8852072
NBR1 [Q14596]11EBI-720116,EBI-742698
NEDD4 [P46934]6EBI-720116,EBI-726944
NEDD4 - isoform 3 [P46934-3]3EBI-720116,EBI-11980721
NEK9 [Q8TD19]7EBI-720116,EBI-1044009
NIPSNAP2 [O75323]6EBI-720116,EBI-307133
NUDT15 [Q9NV35]3EBI-720116,EBI-3924801
OSBPL3 [Q9H4L5]3EBI-720116,EBI-1051317
PCM1 [Q15154]2EBI-720116,EBI-741421
RASSF1 [Q9NS23]2EBI-720116,EBI-367363
RASSF5 [Q8WWW0]2EBI-720116,EBI-367390
RCN2 [Q14257]6EBI-720116,EBI-356710
RETREG1 - isoform 1 [Q9H6L5-1]2EBI-720116,EBI-16159046
RETREG1 - isoform 2 [Q9H6L5-2]3EBI-720116,EBI-13382642
RETREG3 [Q86VR2]3EBI-720116,EBI-10192441
SCYL3 - isoform 2 [Q8IZE3-2]3EBI-720116,EBI-11959369
SIK2 [Q9H0K1]3EBI-720116,EBI-1181664
SQSTM1 [Q13501]19EBI-720116,EBI-307104
STBD1 [O95210]5EBI-720116,EBI-2947137
STK3 [Q13188]2EBI-720116,EBI-992580
STK4 [Q13043]2EBI-720116,EBI-367376
TAX1BP1 [Q86VP1]3EBI-720116,EBI-529518
TBC1D15 [Q8TC07]2EBI-720116,EBI-1048247
TBC1D25 [Q3MII6]4EBI-720116,EBI-11899977
TBC1D2B [Q9UPU7]3EBI-720116,EBI-2947180
TBC1D5 [B9A6K1]3EBI-720116,EBI-10217641
TBC1D5 [Q92609]5EBI-720116,EBI-742381
TBC1D9B - isoform 2 [Q66K14-2]3EBI-720116,EBI-10217736
TECPR2 [O15040]2EBI-720116,EBI-2946991
TEX264 [Q9Y6I9]3EBI-720116,EBI-10329860
TNIP1 [Q15025]6EBI-720116,EBI-357849
TP53INP1 [Q96A56]6EBI-720116,EBI-9986117
TRIM45 - isoform 2 [Q9H8W5-2]3EBI-720116,EBI-11993364
TSR2 [Q969E8]11EBI-720116,EBI-746981
UBA5 [Q9GZZ9]17EBI-720116,EBI-747805
ULK1 [O75385]3EBI-720116,EBI-908831
WDFY3 [Q8IZQ1]3EBI-720116,EBI-1569256
ZBTB2 [Q8N680]3EBI-720116,EBI-2515601
ZNF774 [Q6NX45]3EBI-720116,EBI-10251462

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116473, 106 interactors

Database of interacting proteins

More...DIPi		DIP-35051N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P60520

Protein interaction database and analysis system

More...IntActi		P60520, 534 interactors

Molecular INTeraction database

More...MINTi		P60520

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000037243

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P60520 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P60520

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22Interaction with beta-tubulinBy similarityAdd BLAST22
Regioni36 – 68Interaction with GABRG2Sequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1654 Eukaryota
ENOG4111JAT LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_119276_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P60520

KEGG Orthology (KO)

More...KOi		K08341

Identification of Orthologs from Complete Genome Data

More...OMAi		AAAMKWM

Database of Orthologous Groups

More...OrthoDBi		1508198at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P60520

TreeFam database of animal gene trees

More...TreeFami		TF312964

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004241 Atg8-like
IPR029071 Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR10969 PTHR10969, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02991 Atg8, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236 SSF54236, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P60520-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL 
        60         70         80         90        100
VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD 
       110 
EDGFLYVAYS GENTFGF
Length:117
Mass (Da):13,667
Last modified:March 1, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i17ACB540FD5B975B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQ50H3BQ50_HUMAN
Gamma-aminobutyric acid receptor-as...
GABARAPL2
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSM5H3BSM5_HUMAN
Gamma-aminobutyric acid receptor-as...
GABARAPL2
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU36H3BU36_HUMAN
GABA(A) receptor-associated protein...
GABARAPL2 hCG_21766
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29V → F in AAD27779 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04975651V → A. Corresponds to variant dbSNP:rs11556291Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB030710 mRNA Translation: BAB21548.1
AF087848 mRNA Translation: AAK20400.1
AJ010569 mRNA Translation: CAA09249.1
AF077046 mRNA Translation: AAD27779.1
CR542217 mRNA Translation: CAG47013.1
AK289788 mRNA Translation: BAF82477.1
CH471114 Genomic DNA Translation: EAW95630.1
BC005985 mRNA Translation: AAH05985.1
BC014594 mRNA Translation: AAH14594.1
BC029601 mRNA Translation: AAH29601.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10921.1

NCBI Reference Sequences

More...RefSeqi		NP_009216.1, NM_007285.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000037243; ENSP00000037243; ENSG00000034713

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11345

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11345

UCSC genome browser

More...UCSCi		uc002fen.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030710 mRNA Translation: BAB21548.1
AF087848 mRNA Translation: AAK20400.1
AJ010569 mRNA Translation: CAA09249.1
AF077046 mRNA Translation: AAD27779.1
CR542217 mRNA Translation: CAG47013.1
AK289788 mRNA Translation: BAF82477.1
CH471114 Genomic DNA Translation: EAW95630.1
BC005985 mRNA Translation: AAH05985.1
BC014594 mRNA Translation: AAH14594.1
BC029601 mRNA Translation: AAH29601.1
CCDSiCCDS10921.1
RefSeqiNP_009216.1, NM_007285.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CO7X-ray2.00A/B1-117[»]
SMRiP60520
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116473, 106 interactors
DIPiDIP-35051N
ELMiP60520
IntActiP60520, 534 interactors
MINTiP60520
STRINGi9606.ENSP00000037243

Protein family/group databases

MoonDBiP60520 Predicted

PTM databases

iPTMnetiP60520
PhosphoSitePlusiP60520

Polymorphism and mutation databases

BioMutaiGABARAPL2
DMDMi44888808

2D gel databases

UCD-2DPAGEiP60520

Proteomic databases

EPDiP60520
jPOSTiP60520
MassIVEiP60520
PaxDbiP60520
PeptideAtlasiP60520
PRIDEiP60520
ProteomicsDBi57214

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30328 541 antibodies

The DNASU plasmid repository

More...DNASUi		11345

Genome annotation databases

EnsembliENST00000037243; ENSP00000037243; ENSG00000034713
GeneIDi11345
KEGGihsa:11345
UCSCiuc002fen.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11345
DisGeNETi11345

GeneCards: human genes, protein and diseases

More...GeneCardsi		GABARAPL2
HGNCiHGNC:13291 GABARAPL2
HPAiENSG00000034713 Low tissue specificity
MIMi607452 gene
neXtProtiNX_P60520
OpenTargetsiENSG00000034713
PharmGKBiPA28482

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1654 Eukaryota
ENOG4111JAT LUCA
GeneTreeiENSGT00940000155010
HOGENOMiCLU_119276_0_1_1
InParanoidiP60520
KOiK08341
OMAiAAAMKWM
OrthoDBi1508198at2759
PhylomeDBiP60520
TreeFamiTF312964

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-8854214 TBC/RABGAPs
SIGNORiP60520

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GABARAPL2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GABARAPL2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11345
PharosiP60520 Tbio

Protein Ontology

More...PROi		PR:P60520
RNActiP60520 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000034713 Expressed in caudate nucleus and 237 other tissues
ExpressionAtlasiP60520 baseline and differential
GenevisibleiP60520 HS

Family and domain databases

InterProiView protein in InterPro
IPR004241 Atg8-like
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR10969 PTHR10969, 1 hit
PfamiView protein in Pfam
PF02991 Atg8, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGBRL2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60520
Secondary accession number(s): O08765
, Q6FG91, Q9DCP8, Q9UQF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 22, 2020
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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