Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U21 glycoprotein

Gene

U21

Organism
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds to MHC class I molecules in the endoplasmic reticulum and targets them from the Golgi directly to the lysosomes. Once in the lysosomes both proteins are degraded. In consequence, surface class I molecules are down-regulated and infected cells are masked for immune recognition by cytotoxic T lymphocytes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
U21 glycoprotein
Gene namesi
Name:U21
OrganismiHuman herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus)
Taxonomic identifieri57278 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeRoseolovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009246 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 362LumenalSequence analysisAdd BLAST362
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 430CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001163571 – 430U21 glycoproteinAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi293N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Family & Domainsi

Domaini

The ER-lumenal domain associates with class I MHC molecules and is responsible for lysosomal sorting.By similarity

Sequence similaritiesi

Belongs to the herpesviridae U21 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000A3

Family and domain databases

InterProiView protein in InterPro
IPR020177 Herpes_glycoprotein_U21
ProDomiView protein in ProDom or Entries sharing at least one domain
PD025160 Herpes_glycoprotein_U21, 1 hit

Sequencei

Sequence statusi: Complete.

P60505-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTILLFCVP VIYGELYPDF CPLAVVDFDV NATVDDLLLF DISLSKQCSD
60 70 80 90 100
DKIRHSAVAA MTDNAFFFGN SETQIETDFG KYLAFNCYQV FSTLNHFLFK
110 120 130 140 150
NFKKTKGLMK RYDKLCLDVE SYIHIQIICS PFKSFIRLRR MNETGISPRI
160 170 180 190 200
LETTFYLQNK RNSTWVAIKN YLGEDDPFTY RIWHTLTHAK NFLINSCEND
210 220 230 240 250
FNQLFFWQRK YLSLAKTFEA TFKQGFNPMI EQRNEQRYRT NNIDCSFSKF
260 270 280 290 300
RQNGVKVAVC KYTGWGVSGF GSLEVLQKIK SPFGEEWKRV GFNSTGAFTP
310 320 330 340 350
LYGSDVLWGL IFLRVEMTTY VCTCTNKNTG TQIQVTLPDV DLDLLDSEKT
360 370 380 390 400
SSNVFVDMLC YTLIAILFLA FVTAVVLLGV SCLDGVQKVL TWPLQHIQKE
410 420 430
PVSEKIINLT NLMFGQEPLP KKESLKQQCL
Length:430
Mass (Da):49,571
Last modified:March 1, 2004 - v1
Checksum:iBCCCAF674543AF94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43400 Genomic DNA Translation: AAC54683.1
PIRiT41923
RefSeqiYP_073761.1, NC_001716.2

Genome annotation databases

GeneIDi3289479
KEGGivg:3289479

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43400 Genomic DNA Translation: AAC54683.1
PIRiT41923
RefSeqiYP_073761.1, NC_001716.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3289479
KEGGivg:3289479

Phylogenomic databases

OrthoDBiVOG090000A3

Family and domain databases

InterProiView protein in InterPro
IPR020177 Herpes_glycoprotein_U21
ProDomiView protein in ProDom or Entries sharing at least one domain
PD025160 Herpes_glycoprotein_U21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiU21_HHV7J
AccessioniPrimary (citable) accession number: P60505
Secondary accession number(s): Q69503
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: November 7, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again