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Protein

Protein transport protein Sec61 subunit beta

Gene

SEC61B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for protein translocation in the endoplasmic reticulum.

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • epidermal growth factor binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • posttranslational protein targeting to membrane, translocation Source: GO_Central
  • protein import into nucleus, translocation Source: UniProtKB
  • retrograde protein transport, ER to cytosol Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: GO_Central
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein Sec61 subunit beta
Gene namesi
Name:SEC61B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106803.9
HGNCiHGNC:16993 SEC61B
MIMi609214 gene
neXtProtiNX_P60468

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39C → S: Abolishes S-acylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000106803
PharmGKBiPA134888963

Polymorphism and mutation databases

BioMutaiSEC61B
DMDMi42560366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001572542 – 96Protein transport protein Sec61 subunit betaAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineCombined sources1
Modified residuei7Phosphoserine1 Publication1
Modified residuei9PhosphothreonineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Lipidationi39S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP60468
MaxQBiP60468
PaxDbiP60468
PeptideAtlasiP60468
PRIDEiP60468
ProteomicsDBi57208
TopDownProteomicsiP60468

PTM databases

iPTMnetiP60468
PhosphoSitePlusiP60468
SwissPalmiP60468

Expressioni

Gene expression databases

BgeeiENSG00000106803
CleanExiHS_SEC61B
ExpressionAtlasiP60468 baseline and differential
GenevisibleiP60468 HS

Organism-specific databases

HPAiHPA049407

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: GO_Central
  • epidermal growth factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116152, 50 interactors
CORUMiP60468
DIPiDIP-40997N
IntActiP60468, 51 interactors
MINTiP60468
STRINGi9606.ENSP00000223641

Structurei

3D structure databases

ProteinModelPortaliP60468
SMRiP60468
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC61-beta family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3457 Eukaryota
ENOG4111UAR LUCA
GeneTreeiENSGT00390000003561
HOGENOMiHOG000211109
HOVERGENiHBG061281
InParanoidiP60468
KOiK09481
OMAiNSGGMWR
OrthoDBiEOG091G17J4
PhylomeDBiP60468
TreeFamiTF313144

Family and domain databases

InterProiView protein in InterPro
IPR030671 Sec61-beta/Sbh
IPR016482 SecG/Sec61-beta/Sbh
PANTHERiPTHR13509 PTHR13509, 1 hit
PfamiView protein in Pfam
PF03911 Sec61_beta, 1 hit
PIRSFiPIRSF006398 Sec61_beta_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA
60 70 80 90
GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS
Length:96
Mass (Da):9,974
Last modified:January 23, 2007 - v2
Checksum:i5FAFF4197A62FA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25085 mRNA Translation: AAA19706.1
CR456883 mRNA Translation: CAG33164.1
AL137067 Genomic DNA No translation available.
BC001734 mRNA Translation: AAH01734.1
CCDSiCCDS6741.1
PIRiS42410
RefSeqiNP_006799.1, NM_006808.2
UniGeneiHs.191887

Genome annotation databases

EnsembliENST00000223641; ENSP00000223641; ENSG00000106803
GeneIDi10952
KEGGihsa:10952
UCSCiuc004azh.4 human

Similar proteinsi

Entry informationi

Entry nameiSC61B_HUMAN
AccessioniPrimary (citable) accession number: P60468
Secondary accession number(s): P38390, P38391, Q6IBC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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