UniProtKB - P60412 (KR10B_HUMAN)
Protein
Keratin-associated protein 10-11
Gene
KRTAP10-11
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Biological processi
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | P60412 |
Reactomei | R-HSA-6805567, Keratinization |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 10-11Alternative name(s): High sulfur keratin-associated protein 10.11 Keratin-associated protein 10.11 Keratin-associated protein 18-11 Keratin-associated protein 18.11 |
Gene namesi | Name:KRTAP10-11 Synonyms:KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20528, KRTAP10-11 |
neXtProti | NX_P60412 |
VEuPathDBi | HostDB:ENSG00000243489.4 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: InterPro
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000243489 |
PharmGKBi | PA134873081 |
Miscellaneous databases
Pharosi | P60412, Tdark |
Genetic variation databases
BioMutai | KRTAP10-11 |
DMDMi | 296439312 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185219 | 1 – 298 | Keratin-associated protein 10-11Add BLAST | 298 |
Proteomic databases
MassIVEi | P60412 |
PaxDbi | P60412 |
PeptideAtlasi | P60412 |
PRIDEi | P60412 |
ProteomicsDBi | 57206 |
Expressioni
Tissue specificityi
Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications
Gene expression databases
Bgeei | ENSG00000243489, Expressed in quadriceps femoris and 40 other tissues |
Genevisiblei | P60412, HS |
Organism-specific databases
HPAi | ENSG00000243489, Tissue enriched (skin) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Hide detailsP60412
Protein-protein interaction databases
BioGRIDi | 132129, 38 interactors |
IntActi | P60412, 38 interactors |
STRINGi | 9606.ENSP00000334197 |
Miscellaneous databases
RNActi | P60412, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 30 | 1 | 5 | |
Repeati | 36 – 40 | 2 | 5 | |
Repeati | 57 – 61 | 3 | 5 | |
Repeati | 79 – 83 | 4 | 5 | |
Repeati | 89 – 93 | 5 | 5 | |
Repeati | 99 – 103 | 6 | 5 | |
Repeati | 104 – 108 | 7 | 5 | |
Repeati | 109 – 113 | 8 | 5 | |
Repeati | 114 – 118 | 9 | 5 | |
Repeati | 119 – 123 | 10 | 5 | |
Repeati | 126 – 130 | 11 | 5 | |
Repeati | 136 – 140 | 12 | 5 | |
Repeati | 146 – 150 | 13 | 5 | |
Repeati | 151 – 155 | 14 | 5 | |
Repeati | 156 – 160 | 15 | 5 | |
Repeati | 168 – 172 | 16 | 5 | |
Repeati | 178 – 182 | 17 | 5 | |
Repeati | 188 – 192 | 18 | 5 | |
Repeati | 193 – 197 | 19 | 5 | |
Repeati | 203 – 207 | 20 | 5 | |
Repeati | 225 – 229 | 21 | 5 | |
Repeati | 230 – 234 | 22 | 5 | |
Repeati | 249 – 253 | 23 | 5 | |
Repeati | 256 – 260 | 24 | 5 | |
Repeati | 267 – 271 | 25 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 26 – 271 | 25 X 5 AA repeats of C-C-X(3)Add BLAST | 246 |
Sequence similaritiesi
Belongs to the KRTAP type 10 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00940000165026 |
InParanoidi | P60412 |
OMAi | SECAGNC |
OrthoDBi | 1622331at2759 |
PhylomeDBi | P60412 |
TreeFami | TF351356 |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 3 hits |
Pfami | View protein in Pfam PF13885, Keratin_B2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P60412-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASTMSVCS SAYSDSWQVD DCPESCCEPP CSAPSCCAPA PSLSLVCTPV
60 70 80 90 100
SCVSSPCCQA ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKTVCC KPVCCVPVCC GAASSCCRQS SCQPACCASS SCQPACCVPV
160 170 180 190 200
CCKPVCCVST CSEDSSSCCQ QSSCQPACCT SSSYQQACCV PVCCKTVYCK
210 220 230 240 250
PICCVPVCSR ASSSRCQQPS CQPACCTTSC CRPSSSVSLL CHPVCRSTCC
260 270 280 290
VPVSSCCAPT SSCQSSCCRP ASCVSLLCRP ASSRLACYSL CSGKKSSC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 213 | S → Y in BAD01546 (PubMed:15028290).Curated | 1 | |
Sequence conflicti | 269 | R → C in BAD01546 (PubMed:15028290).Curated | 1 | |
Sequence conflicti | 269 | R → C in AAI31612 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060056 | 130 | S → F. Corresponds to variant dbSNP:rs4818952Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076359 mRNA Translation: BAD01546.1 AL773602 Genomic DNA No translation available. BC131611 mRNA Translation: AAI31612.1 |
CCDSi | CCDS42962.1 |
RefSeqi | NP_941965.2, NM_198692.2 |
Genome annotation databases
Ensembli | ENST00000334670; ENSP00000334197; ENSG00000243489 |
GeneIDi | 386678 |
KEGGi | hsa:386678 |
UCSCi | uc002zfr.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076359 mRNA Translation: BAD01546.1 AL773602 Genomic DNA No translation available. BC131611 mRNA Translation: AAI31612.1 |
CCDSi | CCDS42962.1 |
RefSeqi | NP_941965.2, NM_198692.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132129, 38 interactors |
IntActi | P60412, 38 interactors |
STRINGi | 9606.ENSP00000334197 |
Genetic variation databases
BioMutai | KRTAP10-11 |
DMDMi | 296439312 |
Proteomic databases
MassIVEi | P60412 |
PaxDbi | P60412 |
PeptideAtlasi | P60412 |
PRIDEi | P60412 |
ProteomicsDBi | 57206 |
Genome annotation databases
Ensembli | ENST00000334670; ENSP00000334197; ENSG00000243489 |
GeneIDi | 386678 |
KEGGi | hsa:386678 |
UCSCi | uc002zfr.5, human |
Organism-specific databases
CTDi | 386678 |
GeneCardsi | KRTAP10-11 |
HGNCi | HGNC:20528, KRTAP10-11 |
HPAi | ENSG00000243489, Tissue enriched (skin) |
neXtProti | NX_P60412 |
OpenTargetsi | ENSG00000243489 |
PharmGKBi | PA134873081 |
VEuPathDBi | HostDB:ENSG00000243489.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00940000165026 |
InParanoidi | P60412 |
OMAi | SECAGNC |
OrthoDBi | 1622331at2759 |
PhylomeDBi | P60412 |
TreeFami | TF351356 |
Enzyme and pathway databases
PathwayCommonsi | P60412 |
Reactomei | R-HSA-6805567, Keratinization |
Miscellaneous databases
BioGRID-ORCSi | 386678, 11 hits in 841 CRISPR screens |
GenomeRNAii | 386678 |
Pharosi | P60412, Tdark |
PROi | PR:P60412 |
RNActi | P60412, protein |
Gene expression databases
Bgeei | ENSG00000243489, Expressed in quadriceps femoris and 40 other tissues |
Genevisiblei | P60412, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 3 hits |
Pfami | View protein in Pfam PF13885, Keratin_B2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KR10B_HUMAN | |
Accessioni | P60412Primary (citable) accession number: P60412 Secondary accession number(s): A2RRF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - SIMILARITY comments
Index of protein domains and families