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Protein

Keratin-associated protein 10-9

Gene

KRTAP10-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567 Keratinization

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P60411 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-9
Alternative name(s):
High sulfur keratin-associated protein 10.9
Keratin-associated protein 10.9
Keratin-associated protein 18-9
Keratin-associated protein 18.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-9
Synonyms:KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000221837.5

Human Gene Nomenclature Database

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HGNCi
HGNC:22971 KRTAP10-9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60411

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134873081

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP10-9

Domain mapping of disease mutations (DMDM)

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DMDMi
294862449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852171 – 292Keratin-associated protein 10-9Add BLAST292

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P60411

PeptideAtlas

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PeptideAtlasi
P60411

PRoteomics IDEntifications database

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PRIDEi
P60411

ProteomicsDB human proteome resource

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ProteomicsDBi
57205

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P60411

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P60411

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000221837 Expressed in 12 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_KRTAP10-9

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P60411 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-10172052,EBI-10174671
Q5XG853EBI-10172052,EBI-10248413
Q9H6F03EBI-10172052,EBI-10307481
Q9NWL93EBI-10172052,EBI-10315054
ADAMTSL4Q6UY14-35EBI-10172052,EBI-10173507
AESQ081173EBI-10172052,EBI-717810
ALDH3B1P433533EBI-10172052,EBI-2558314
ALPIP099233EBI-10172052,EBI-1052631
ARFGAP1Q8N6T33EBI-10172052,EBI-716933
ATXN7L1Q9ULK23EBI-10172052,EBI-310660
AVPI1Q5T6863EBI-10172052,EBI-8640233
BCL6BA8KA133EBI-10172052,EBI-10174813
C10orf62Q5T6813EBI-10172052,EBI-744052
C11orf87Q6NUJ23EBI-10172052,EBI-6660291
C19orf57Q0VDD73EBI-10172052,EBI-741210
C5orf60A6NFR6-43EBI-10172052,EBI-10173955
CATIPQ7Z7H33EBI-10172052,EBI-10258233
CATSPER1Q8NEC59EBI-10172052,EBI-744545
CBX2Q147813EBI-10172052,EBI-745934
CCDC26Q8TAB73EBI-10172052,EBI-10271580
CD300LGQ6UXG33EBI-10172052,EBI-10254587
CDKL3Q8IVW43EBI-10172052,EBI-3919850
CHIC2Q9UKJ53EBI-10172052,EBI-741528
CHRDQ9H2X03EBI-10172052,EBI-947551
CHRNGP075103EBI-10172052,EBI-9008836
CHRNGP07510-25EBI-10172052,EBI-11979451
CKS1BP610243EBI-10172052,EBI-456371
CLK4Q9HAZ13EBI-10172052,EBI-633400
CNNM3Q8NE015EBI-10172052,EBI-741032
CNNM3Q8NE01-33EBI-10172052,EBI-10269984
CRCT1Q9UGL97EBI-10172052,EBI-713677
CREB5Q02930-37EBI-10172052,EBI-10192698
CST9LQ9H4G13EBI-10172052,EBI-3923092
DHX57Q6P1585EBI-10172052,EBI-1051531
DMRT3Q9NQL95EBI-10172052,EBI-9679045
DOCK2Q926083EBI-10172052,EBI-448771
EIF4E2O605733EBI-10172052,EBI-398610
FAM124BQ9H5Z63EBI-10172052,EBI-741626
FAM161AQ3B8203EBI-10172052,EBI-719941
FAM74A6Q5TZK33EBI-10172052,EBI-10247271
FAM76BQ5HYJ33EBI-10172052,EBI-751192
FARS2O953635EBI-10172052,EBI-2513774
GABARAPL1Q9H0R83EBI-10172052,EBI-746969
GABARAPL2P605203EBI-10172052,EBI-720116
GATA2P237693EBI-10172052,EBI-2806671
GLP1RP432203EBI-10172052,EBI-7466542
GLRX3O760035EBI-10172052,EBI-374781
GNEQ9Y2233EBI-10172052,EBI-4291090
GPATCH2LQ9NWQ43EBI-10172052,EBI-5666657
GSTP1P092113EBI-10172052,EBI-353467
HBG2D9YZU93EBI-10172052,EBI-10176884
HBZP020083EBI-10172052,EBI-719843
HCKP086313EBI-10172052,EBI-346340
HOXA1P496397EBI-10172052,EBI-740785
HOXB9P174823EBI-10172052,EBI-745290
HPCAL1P372355EBI-10172052,EBI-749311
HSD3B7Q9H2F33EBI-10172052,EBI-3918847
IGSF8Q969P03EBI-10172052,EBI-8293590
INPP5DQ928353EBI-10172052,EBI-1380477
IQUBQ8NA543EBI-10172052,EBI-10220600
ITGB5L7RT223EBI-10172052,EBI-10178729
KAT5Q929933EBI-10172052,EBI-399080
KLHL38Q2WGJ63EBI-10172052,EBI-6426443
KRT20P359003EBI-10172052,EBI-742094
KRT83P783853EBI-10172052,EBI-10221390
KRTAP10-7P604093EBI-10172052,EBI-10172290
KRTAP10-8P604105EBI-10172052,EBI-10171774
KRTAP12-1P599905EBI-10172052,EBI-10210845
KRTAP26-1Q6PEX33EBI-10172052,EBI-3957672
KRTAP4-11Q9BYQ65EBI-10172052,EBI-10302392
KRTAP4-12Q9BQ665EBI-10172052,EBI-739863
KRTAP4-2Q9BYR55EBI-10172052,EBI-10172511
KRTAP5-6Q6L8G93EBI-10172052,EBI-10250562
KRTAP5-9P263715EBI-10172052,EBI-3958099
KRTAP9-2Q9BYQ48EBI-10172052,EBI-1044640
KRTAP9-3Q9BYQ34EBI-10172052,EBI-1043191
KRTAP9-4Q9BYQ23EBI-10172052,EBI-10185730
LCE1BQ5T7P37EBI-10172052,EBI-10245913
LCE1DQ5T7524EBI-10172052,EBI-11741311
LCE1EQ5T7534EBI-10172052,EBI-11955335
LCE2AQ5TA795EBI-10172052,EBI-10246607
LCE2CQ5TA814EBI-10172052,EBI-11973993
LCE2DQ5TA825EBI-10172052,EBI-10246750
LCE3BQ5TA774EBI-10172052,EBI-11974495
LCE3CQ5T5A85EBI-10172052,EBI-10245291
LCE3EQ5T5B06EBI-10172052,EBI-10245456
LCE4AQ5TA785EBI-10172052,EBI-10246358
LUZP4Q9P1275EBI-10172052,EBI-10198848
MAB21L3Q8N8X93EBI-10172052,EBI-10268010
MAPKBP1O603363EBI-10172052,EBI-947402
MED30Q96HR33EBI-10172052,EBI-394659
MEOX2P502224EBI-10172052,EBI-748397
MOBPQ138756EBI-10172052,EBI-10230628
MOBPQ13875-33EBI-10172052,EBI-12013470
MT1DPA1L3X43EBI-10172052,EBI-10172129
MXI1P50539-33EBI-10172052,EBI-10211940
NAXDQ8IW453EBI-10172052,EBI-8650724
NECTIN3Q9NQS33EBI-10172052,EBI-2826725
NOTCH2NLAQ7Z3S95EBI-10172052,EBI-945833
NPBWR2P481463EBI-10172052,EBI-10210114
NPDC1Q9NQX55EBI-10172052,EBI-748927
NPPBP168603EBI-10172052,EBI-747044
NR1D2Q6NSM04EBI-10172052,EBI-10250949
NUFIP2Q7Z4175EBI-10172052,EBI-1210753
OTX1P3224210EBI-10172052,EBI-740446
PGAP2Q9UHJ93EBI-10172052,EBI-10321427
PIN1Q135263EBI-10172052,EBI-714158
PLSCR1O151623EBI-10172052,EBI-740019
POU4F2Q128374EBI-10172052,EBI-17236143
PRKAB2O437415EBI-10172052,EBI-1053424
PRPF31Q8WWY36EBI-10172052,EBI-1567797
PTGER3P43115-123EBI-10172052,EBI-10234038
PVRP151513EBI-10172052,EBI-3919694
RHNO1Q9BSD33EBI-10172052,EBI-9658624
RSPO2Q6UXX93EBI-10172052,EBI-8481036
RYDENQ9NUL53EBI-10172052,EBI-10313866
SCARB1Q8WTV03EBI-10172052,EBI-78657
SCNM1Q9BWG63EBI-10172052,EBI-748391
SLC23A1Q9UHI73EBI-10172052,EBI-1759386
SLC6A20Q9NP913EBI-10172052,EBI-10311198
SMARCE1Q969G33EBI-10172052,EBI-455078
SMCPP499017EBI-10172052,EBI-750494
SPACA9Q96E403EBI-10172052,EBI-722584
SPATA8Q6RVD63EBI-10172052,EBI-8635958
SPG7Q9UQ903EBI-10172052,EBI-717201
SPRY1O436095EBI-10172052,EBI-3866665
SPRY2O435973EBI-10172052,EBI-742487
STK16O757163EBI-10172052,EBI-749295
TBC1D23Q9NUY83EBI-10172052,EBI-2853126
TBC1D23Q9NUY8-23EBI-10172052,EBI-10314276
TEDC2Q7L2K03EBI-10172052,EBI-8465456
TGOLN2O434933EBI-10172052,EBI-1752146
THAP10Q9P2Z03EBI-10172052,EBI-745404
TNFRSF6BO954073EBI-10172052,EBI-524171
TNP2Q4VB563EBI-10172052,EBI-10241829
TRIM41Q8WV445EBI-10172052,EBI-725997
TRIM42Q8IWZ56EBI-10172052,EBI-5235829
TXNDC5Q86UY05EBI-10172052,EBI-2825190
TYMSOSQ8TAI13EBI-10172052,EBI-742060
TYRO3Q064183EBI-10172052,EBI-3951628
UTP23Q9BRU93EBI-10172052,EBI-5457544
WNT11O960143EBI-10172052,EBI-8058160
WT1-ASQ062503EBI-10172052,EBI-10223946
XCL2Q9UBD33EBI-10172052,EBI-10319095
ZBTB24O431673EBI-10172052,EBI-744471
ZBTB9Q96C005EBI-10172052,EBI-395708
ZFYVE26Q68DK2-53EBI-10172052,EBI-8656416
ZNF124Q159735EBI-10172052,EBI-2555767
ZNF155Q12901-23EBI-10172052,EBI-10227379
ZNF20P170243EBI-10172052,EBI-717634
ZNF264Q14C613EBI-10172052,EBI-2826570
ZNF317Q96PQ6-43EBI-10172052,EBI-10292528
ZNF417Q8TAU33EBI-10172052,EBI-740727
ZNF439Q8NDP43EBI-10172052,EBI-747580
ZNF440Q8IYI85EBI-10172052,EBI-726439
ZNF473Q8WTR73EBI-10172052,EBI-751409
ZNF564Q8TBZ83EBI-10172052,EBI-10273713
ZNF572Q7Z3I76EBI-10172052,EBI-10172590
ZNF578Q3MI943EBI-10172052,EBI-10241108
ZNF581Q9P0T43EBI-10172052,EBI-745520
ZNF587Q96SQ55EBI-10172052,EBI-6427977
ZNF625Q96I273EBI-10172052,EBI-4395587
ZNF688A0A0S2Z5X43EBI-10172052,EBI-16429014
ZNF697Q8N5083EBI-10172052,EBI-10265733
ZNF699Q32M783EBI-10172052,EBI-10217363
ZNF774Q6NX454EBI-10172052,EBI-10251462
ZNF792Q3KQV35EBI-10172052,EBI-10240849
ZNF844Q08AG53EBI-10172052,EBI-10225757
ZSCAN21Q9Y5A63EBI-10172052,EBI-10281938
ZSCAN26Q166703EBI-10172052,EBI-3920053

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132127, 166 interactors
132129, 15 interactors

Protein interaction database and analysis system

More...
IntActi
P60411, 222 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381009

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60411

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 3015
Repeati31 – 3525
Repeati36 – 4035
Repeati57 – 6145
Repeati79 – 8355
Repeati99 – 10365
Repeati104 – 10875
Repeati109 – 11385
Repeati114 – 11895
Repeati120 – 124105
Repeati130 – 134115
Repeati140 – 144125
Repeati145 – 149135
Repeati150 – 154145
Repeati162 – 166155
Repeati172 – 176165
Repeati182 – 186175
Repeati187 – 191185
Repeati192 – 196195
Repeati197 – 201205
Repeati209 – 213215
Repeati219 – 223225
Repeati224 – 228235
Repeati243 – 247245
Repeati250 – 254255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 25425 X 5 AA repeats of C-C-X(3)Add BLAST229

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JNRG Eukaryota
ENOG41116YF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234031

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108072

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60411

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMPICCK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G17RC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60411

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P60411-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASTMSIRS SAYSDSWQVD DCPESCCEPP CCATSCCAPA PCLTLVCTPV
60 70 80 90 100
SRVSSPCCQV TCEPSPCQSG CTSSCTPSCC QQSSCQPAYC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCGASSC CQQSSYQPAC CASSSCQPAC CVPVCCKPVC
160 170 180 190 200
CAPTCSEDSY SCCQQSSCQP ACCTSSPCQQ SYCVPVCCKP VCCKPICCVP
210 220 230 240 250
VCSGASSLCC QQSGCQPACC TTSCCRPSSS VSLLCRPVCR PACCVPVSSC
260 270 280 290
CAPTSSRQPS YCRQASCVSL LCRPVCSRPA CYSFSSGQKS SC
Length:292
Mass (Da):30,037
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE61D891212803B98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT19A0A087WT19_HUMAN
Keratin-associated protein 10-9
KRTAP10-9
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102P → PVCCKT in EAX09409 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017739182Y → C1 PublicationCorresponds to variant dbSNP:rs8127342Ensembl.1
Natural variantiVAR_060052257R → C2 PublicationsCorresponds to variant dbSNP:rs9980129Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB076356 mRNA Translation: BAD01543.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09409.1
CH471079 Genomic DNA Translation: EAX09411.1
BC131613 mRNA Translation: AAI31614.1
AJ566386 mRNA Translation: CAD97466.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42961.1 [P60411-1]

NCBI Reference Sequences

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RefSeqi
NP_941963.2, NM_198690.2 [P60411-1]
NP_941965.2, NM_198692.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.474000
Hs.58076

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397911; ENSP00000381009; ENSG00000221837 [P60411-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
386676
386678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:386676
hsa:386678

UCSC genome browser

More...
UCSCi
uc002zfp.5 human [P60411-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076356 mRNA Translation: BAD01543.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09409.1
CH471079 Genomic DNA Translation: EAX09411.1
BC131613 mRNA Translation: AAI31614.1
AJ566386 mRNA Translation: CAD97466.1
CCDSiCCDS42961.1 [P60411-1]
RefSeqiNP_941963.2, NM_198690.2 [P60411-1]
NP_941965.2, NM_198692.2
UniGeneiHs.474000
Hs.58076

3D structure databases

ProteinModelPortaliP60411
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132127, 166 interactors
132129, 15 interactors
IntActiP60411, 222 interactors
STRINGi9606.ENSP00000381009

Protein family/group databases

MoonDBiP60411 Predicted

PTM databases

iPTMnetiP60411
PhosphoSitePlusiP60411

Polymorphism and mutation databases

BioMutaiKRTAP10-9
DMDMi294862449

Proteomic databases

PaxDbiP60411
PeptideAtlasiP60411
PRIDEiP60411
ProteomicsDBi57205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397911; ENSP00000381009; ENSG00000221837 [P60411-1]
GeneIDi386676
386678
KEGGihsa:386676
hsa:386678
UCSCiuc002zfp.5 human [P60411-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
386676
386678
EuPathDBiHostDB:ENSG00000221837.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP10-9

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0040852
HGNCiHGNC:22971 KRTAP10-9
neXtProtiNX_P60411
PharmGKBiPA134873081

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JNRG Eukaryota
ENOG41116YF LUCA
GeneTreeiENSGT00940000164049
HOGENOMiHOG000234031
HOVERGENiHBG108072
InParanoidiP60411
OMAiCMPICCK
OrthoDBiEOG091G17RC
PhylomeDBiP60411
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P60411

Gene expression databases

BgeeiENSG00000221837 Expressed in 12 organ(s), highest expression level in heart
CleanExiHS_KRTAP10-9
ExpressionAtlasiP60411 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 4 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR109_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60411
Secondary accession number(s): A2RRG1, A6NIR9, Q70LJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: April 20, 2010
Last modified: December 5, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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