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Entry version 129 (17 Jun 2020)
Sequence version 2 (20 Apr 2010)
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Protein

Keratin-associated protein 10-9

Gene

KRTAP10-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567 Keratinization

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P60411 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-9
Alternative name(s):
High sulfur keratin-associated protein 10.9
Keratin-associated protein 10.9
Keratin-associated protein 18-9
Keratin-associated protein 18.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-9
Synonyms:KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000221837.5

Human Gene Nomenclature Database

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HGNCi
HGNC:22971 KRTAP10-9

neXtProt; the human protein knowledge platform

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neXtProti
NX_P60411

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134873081

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P60411 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRTAP10-9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852171 – 292Keratin-associated protein 10-9Add BLAST292

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P60411

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P60411

PeptideAtlas

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PeptideAtlasi
P60411

PRoteomics IDEntifications database

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PRIDEi
P60411

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
57205 [P60411-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60411

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P60411

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000221837 Expressed in heart and 11 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P60411 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000221837 Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60411
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]8EBI-10172052,EBI-10173507
ALDH3B1 [P43353]3EBI-10172052,EBI-2558314
ALPI [P09923]3EBI-10172052,EBI-1052631
ANKS1A [Q49AR9]3EBI-10172052,EBI-11954519
ARFGAP1 [Q8N6T3]3EBI-10172052,EBI-716933
ATXN7L1 [Q9ULK2]3EBI-10172052,EBI-310660
AVPI1 [Q5T686]3EBI-10172052,EBI-8640233
BCL6B [A8KA13]3EBI-10172052,EBI-10174813
BMP7 [P18075]3EBI-10172052,EBI-1035195
C10orf62 [Q5T681]3EBI-10172052,EBI-744052
C11orf87 [Q6NUJ2]3EBI-10172052,EBI-6660291
C19orf57 [Q0VDD7]4EBI-10172052,EBI-741210
C22orf39 [Q6P5X5]3EBI-10172052,EBI-7317823
C5orf60 - isoform 4 [A6NFR6-4]3EBI-10172052,EBI-10173955
CATIP [Q7Z7H3]3EBI-10172052,EBI-10258233
CATSPER1 [Q8NEC5]11EBI-10172052,EBI-744545
CBX2 [Q14781]3EBI-10172052,EBI-745934
CCDC26 [Q8TAB7]3EBI-10172052,EBI-10271580
CD300LG [Q6UXG3]3EBI-10172052,EBI-10254587
CDKL3 [Q8IVW4]3EBI-10172052,EBI-3919850
CHIC2 [Q9UKJ5]3EBI-10172052,EBI-741528
CHRD [Q9H2X0]3EBI-10172052,EBI-947551
CHRNG [P07510]4EBI-10172052,EBI-9008836
CHRNG - isoform 2 [P07510-2]6EBI-10172052,EBI-11979451
CKS1B [P61024]3EBI-10172052,EBI-456371
CLK4 [Q9HAZ1]3EBI-10172052,EBI-633400
CNNM3 [Q8NE01]6EBI-10172052,EBI-741032
CNNM3 - isoform 3 [Q8NE01-3]3EBI-10172052,EBI-10269984
CRCT1 [Q9UGL9]8EBI-10172052,EBI-713677
CREB5 - isoform 3 [Q02930-3]8EBI-10172052,EBI-10192698
CST9L [Q9H4G1]3EBI-10172052,EBI-3923092
CYSRT1 [A8MQ03]3EBI-10172052,EBI-3867333
DHRS1 [Q96LJ7]3EBI-10172052,EBI-746300
DHX57 [Q6P158]6EBI-10172052,EBI-1051531
DMRT3 [Q9NQL9]6EBI-10172052,EBI-9679045
DOCK2 [Q92608]3EBI-10172052,EBI-448771
EIF4E2 [O60573]3EBI-10172052,EBI-398610
EZH2 - isoform 2 [Q15910-2]3EBI-10172052,EBI-10699473
FAM124B [Q9H5Z6]3EBI-10172052,EBI-741626
FAM161A [Q3B820]3EBI-10172052,EBI-719941
FAM74A6 [Q5TZK3]3EBI-10172052,EBI-10247271
FAM76B [Q5HYJ3]3EBI-10172052,EBI-751192
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-10172052,EBI-11956087
FARS2 [O95363]6EBI-10172052,EBI-2513774
FBXW5 [Q969U6]3EBI-10172052,EBI-741068
GABARAPL1 [Q9H0R8]3EBI-10172052,EBI-746969
GABARAPL2 [P60520]3EBI-10172052,EBI-720116
GATA2 [P23769]3EBI-10172052,EBI-2806671
GLP1R [P43220]3EBI-10172052,EBI-7466542
GLRX3 [O76003]8EBI-10172052,EBI-374781
GNE [Q9Y223]3EBI-10172052,EBI-4291090
GPATCH2L [Q9NWQ4]3EBI-10172052,EBI-5666657
GSTP1 [P09211]3EBI-10172052,EBI-353467
GUCD1 - isoform 2 [Q96NT3-2]3EBI-10172052,EBI-11978177
HBG2 [D9YZU9]3EBI-10172052,EBI-10176884
HBZ [P02008]3EBI-10172052,EBI-719843
HCK [P08631]3EBI-10172052,EBI-346340
HCK - isoform 2 [P08631-2]3EBI-10172052,EBI-9834454
HES6 [Q96HZ4]3EBI-10172052,EBI-7469266
HOXA1 [P49639]8EBI-10172052,EBI-740785
HOXB9 [P17482]3EBI-10172052,EBI-745290
HOXC8 [P31273]3EBI-10172052,EBI-1752118
HPCAL1 [P37235]6EBI-10172052,EBI-749311
HSBP1 [O75506]3EBI-10172052,EBI-748664
HSD3B7 [Q9H2F3]3EBI-10172052,EBI-3918847
IGSF8 [Q969P0]3EBI-10172052,EBI-8293590
INPP5D [Q92835]3EBI-10172052,EBI-1380477
IQUB [Q8NA54]3EBI-10172052,EBI-10220600
ITGB4 - isoform Beta-4A [P16144-2]5EBI-10172052,EBI-11051601
ITGB5 [L7RT22]3EBI-10172052,EBI-10178729
ITGB5 [P18084]3EBI-10172052,EBI-1223434
KAT5 [Q92993]3EBI-10172052,EBI-399080
KIAA0040 [A0A384DVV8]3EBI-10172052,EBI-20764875
KLHL38 [Q2WGJ6]3EBI-10172052,EBI-6426443
KRT20 [P35900]3EBI-10172052,EBI-742094
KRT83 [P78385]3EBI-10172052,EBI-10221390
KRTAP1-1 [Q07627]3EBI-10172052,EBI-11959885
KRTAP10-7 [P60409]6EBI-10172052,EBI-10172290
KRTAP10-8 [P60410]6EBI-10172052,EBI-10171774
KRTAP12-1 [P59990]6EBI-10172052,EBI-10210845
KRTAP12-3 [P60328]3EBI-10172052,EBI-11953334
KRTAP26-1 [Q6PEX3]3EBI-10172052,EBI-3957672
KRTAP4-11 [Q9BYQ6]6EBI-10172052,EBI-10302392
KRTAP4-12 [Q9BQ66]6EBI-10172052,EBI-739863
KRTAP4-2 [Q9BYR5]5EBI-10172052,EBI-10172511
KRTAP5-11 [Q6L8G4]3EBI-10172052,EBI-11993296
KRTAP5-6 [Q6L8G9]3EBI-10172052,EBI-10250562
KRTAP5-9 [P26371]6EBI-10172052,EBI-3958099
KRTAP9-2 [Q9BYQ4]9EBI-10172052,EBI-1044640
KRTAP9-3 [Q9BYQ3]6EBI-10172052,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-10172052,EBI-10185730
LCE1A [Q5T7P2]3EBI-10172052,EBI-11962058
LCE1B [Q5T7P3]12EBI-10172052,EBI-10245913
LCE1D [Q5T752]5EBI-10172052,EBI-11741311
LCE1E [Q5T753]3EBI-10172052,EBI-11955335
LCE1F [Q5T754]5EBI-10172052,EBI-11958008
LCE2A [Q5TA79]6EBI-10172052,EBI-10246607
LCE2B [O14633]3EBI-10172052,EBI-11478468
LCE2C [Q5TA81]5EBI-10172052,EBI-11973993
LCE2D [Q5TA82]6EBI-10172052,EBI-10246750
LCE3A [Q5TA76]5EBI-10172052,EBI-9394625
LCE3B [Q5TA77]3EBI-10172052,EBI-11974495
LCE3C [Q5T5A8]10EBI-10172052,EBI-10245291
LCE3D [Q9BYE3]3EBI-10172052,EBI-6658837
LCE3E [Q5T5B0]7EBI-10172052,EBI-10245456
LCE4A [Q5TA78]6EBI-10172052,EBI-10246358
LCE5A [Q5TCM9]4EBI-10172052,EBI-11955689
LUZP4 [Q9P127]3EBI-10172052,EBI-10198848
MAB21L3 [Q8N8X9]3EBI-10172052,EBI-10268010
MAPKBP1 [O60336]3EBI-10172052,EBI-947402
MAZ - isoform 2 [P56270-2]3EBI-10172052,EBI-12068586
MED30 [Q96HR3]3EBI-10172052,EBI-394659
MEOX2 [P50222]4EBI-10172052,EBI-748397
MEOX2 [Q6FHY5]3EBI-10172052,EBI-16439278
MOBP [Q13875]6EBI-10172052,EBI-10230628
MOBP - isoform 3 [Q13875-3]3EBI-10172052,EBI-12013470
MT1DP [A1L3X4]3EBI-10172052,EBI-10172129
MXI1 - isoform 3 [P50539-3]3EBI-10172052,EBI-10211940
MYPOP [Q86VE0]3EBI-10172052,EBI-2858213
NAXD [Q8IW45]3EBI-10172052,EBI-8650724
NECTIN3 [Q9NQS3]3EBI-10172052,EBI-2826725
NKD1 [Q969G9]3EBI-10172052,EBI-1538217
NOTCH2NLA [Q7Z3S9]3EBI-10172052,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-10172052,EBI-22310682
NPBWR2 [P48146]3EBI-10172052,EBI-10210114
NPDC1 [Q9NQX5]6EBI-10172052,EBI-748927
NPPB [P16860]3EBI-10172052,EBI-747044
NR1D2 [Q6NSM0]4EBI-10172052,EBI-10250949
NUFIP2 [Q7Z417]8EBI-10172052,EBI-1210753
OTX1 [P32242]9EBI-10172052,EBI-740446
PCSK5 - isoform PC6A [Q92824-2]3EBI-10172052,EBI-11956269
PDE9A - isoform PDE9A2 [O76083-2]3EBI-10172052,EBI-11524542
PDGFRB [P09619]3EBI-10172052,EBI-641237
PGAP2 [Q9UHJ9]3EBI-10172052,EBI-10321427
PIGS [Q96S52]3EBI-10172052,EBI-2908273
PIN1 [Q13526]3EBI-10172052,EBI-714158
PLSCR1 [O15162]3EBI-10172052,EBI-740019
POU4F2 [Q12837]6EBI-10172052,EBI-17236143
PRKAA2 [P54646]3EBI-10172052,EBI-1383852
PRKAB2 [O43741]6EBI-10172052,EBI-1053424
PRPF31 [Q8WWY3]6EBI-10172052,EBI-1567797
PTGER3 - isoform 12 [P43115-12]3EBI-10172052,EBI-10234038
PTPMT1 [Q8WUK0]3EBI-10172052,EBI-7199479
PVR [P15151]3EBI-10172052,EBI-3919694
RASD1 [Q9Y272]3EBI-10172052,EBI-740818
RHNO1 [Q9BSD3]3EBI-10172052,EBI-9658624
RSPO2 [Q6UXX9]3EBI-10172052,EBI-8481036
SCARB1 [Q8WTV0]3EBI-10172052,EBI-78657
SCNM1 [Q9BWG6]3EBI-10172052,EBI-748391
SEMA3B - isoform 2 [Q13214-2]3EBI-10172052,EBI-11017428
SHFL [Q9NUL5]3EBI-10172052,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-10172052,EBI-11955083
SLC23A1 [Q9UHI7]3EBI-10172052,EBI-1759386
SLC6A20 [Q9NP91]3EBI-10172052,EBI-10311198
SMARCE1 [Q969G3]3EBI-10172052,EBI-455078
SMCP [P49901]8EBI-10172052,EBI-750494
SPACA9 [Q96E40]3EBI-10172052,EBI-722584
SPATA8 [Q6RVD6]3EBI-10172052,EBI-8635958
SPG7 [Q9UQ90]3EBI-10172052,EBI-717201
SPRY1 [O43609]6EBI-10172052,EBI-3866665
SPRY2 [O43597]3EBI-10172052,EBI-742487
STK16 [O75716]3EBI-10172052,EBI-749295
TBC1D23 [Q9NUY8]3EBI-10172052,EBI-2853126
TBC1D23 - isoform 2 [Q9NUY8-2]3EBI-10172052,EBI-10314276
TEDC2 [Q7L2K0]3EBI-10172052,EBI-8465456
TGOLN2 [O43493]3EBI-10172052,EBI-1752146
THAP10 [Q9P2Z0]3EBI-10172052,EBI-745404
TLE5 [Q08117]3EBI-10172052,EBI-717810
TNFRSF6B [O95407]3EBI-10172052,EBI-524171
TNP2 [Q05952]3EBI-10172052,EBI-12039775
TNP2 [Q4VB56]3EBI-10172052,EBI-10241829
TRIM41 [Q8WV44]5EBI-10172052,EBI-725997
TRIM42 [Q8IWZ5]6EBI-10172052,EBI-5235829
TXNDC5 [Q86UY0]3EBI-10172052,EBI-2825190
TYMSOS [Q8TAI1]3EBI-10172052,EBI-742060
TYRO3 [Q06418]3EBI-10172052,EBI-3951628
UTP23 [Q9BRU9]3EBI-10172052,EBI-5457544
VGLL3 - isoform 2 [A8MV65-2]3EBI-10172052,EBI-11957216
WNT11 [O96014]3EBI-10172052,EBI-8058160
WT1-AS [Q06250]3EBI-10172052,EBI-10223946
XCL2 [Q9UBD3]3EBI-10172052,EBI-10319095
YIPF3 [Q9GZM5]3EBI-10172052,EBI-743787
YY1 [P25490]3EBI-10172052,EBI-765538
ZBTB24 [O43167]3EBI-10172052,EBI-744471
ZBTB9 [Q96C00]6EBI-10172052,EBI-395708
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-10172052,EBI-8656416
ZNF124 [Q15973]6EBI-10172052,EBI-2555767
ZNF155 - isoform 2 [Q12901-2]3EBI-10172052,EBI-10227379
ZNF165 [P49910]3EBI-10172052,EBI-741694
ZNF20 [P17024]3EBI-10172052,EBI-717634
ZNF251 [Q9BRH9]3EBI-10172052,EBI-7254491
ZNF264 [Q14C61]3EBI-10172052,EBI-2826570
ZNF275 [Q9NSD4]3EBI-10172052,EBI-17263125
ZNF286A [Q9HBT8]3EBI-10172052,EBI-10754950
ZNF317 - isoform 4 [Q96PQ6-4]3EBI-10172052,EBI-10292528
ZNF319 [Q9P2F9]3EBI-10172052,EBI-11993110
ZNF417 [Q8TAU3]3EBI-10172052,EBI-740727
ZNF433 [Q8N7K0]3EBI-10172052,EBI-10267553
ZNF439 [Q8NDP4]3EBI-10172052,EBI-747580
ZNF440 [Q8IYI8]6EBI-10172052,EBI-726439
ZNF473 [Q8WTR7]3EBI-10172052,EBI-751409
ZNF497 [Q6ZNH5]3EBI-10172052,EBI-10486136
ZNF524 [Q96C55]3EBI-10172052,EBI-10283126
ZNF564 [Q8TBZ8]3EBI-10172052,EBI-10273713
ZNF572 [Q7Z3I7]6EBI-10172052,EBI-10172590
ZNF578 [Q3MI94]3EBI-10172052,EBI-10241108
ZNF581 [Q9P0T4]3EBI-10172052,EBI-745520
ZNF587 [Q96SQ5]6EBI-10172052,EBI-6427977
ZNF599 [Q96NL3]3EBI-10172052,EBI-8653994
ZNF625 [Q96I27]3EBI-10172052,EBI-4395587
ZNF688 [A0A0S2Z5X4]3EBI-10172052,EBI-16429014
ZNF696 [Q9H7X3]3EBI-10172052,EBI-11090299
ZNF697 [Q8N508]3EBI-10172052,EBI-10265733
ZNF699 [Q32M78]3EBI-10172052,EBI-10217363
ZNF764 [Q96H86]3EBI-10172052,EBI-745775
ZNF774 [Q6NX45]6EBI-10172052,EBI-10251462
ZNF777 [Q9ULD5]3EBI-10172052,EBI-11975599
ZNF792 [Q3KQV3]6EBI-10172052,EBI-10240849
ZNF80 [P51504]3EBI-10172052,EBI-12013828
ZNF837 [Q96EG3]3EBI-10172052,EBI-11962574
ZNF844 [Q08AG5]3EBI-10172052,EBI-10225757
ZNF860 [A6NHJ4]3EBI-10172052,EBI-17263060
ZSCAN21 [Q9Y5A6]3EBI-10172052,EBI-10281938
ZSCAN26 [Q16670]3EBI-10172052,EBI-3920053
A8K9323EBI-10172052,EBI-10174671
Q5XG853EBI-10172052,EBI-10248413
Q9H6F03EBI-10172052,EBI-10307481
Q9NWL93EBI-10172052,EBI-10315054

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132127, 167 interactors
132129, 15 interactors

Protein interaction database and analysis system

More...
IntActi
P60411, 221 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381009

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60411 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 3015
Repeati31 – 3525
Repeati36 – 4035
Repeati57 – 6145
Repeati79 – 8355
Repeati99 – 10365
Repeati104 – 10875
Repeati109 – 11385
Repeati114 – 11895
Repeati120 – 124105
Repeati130 – 134115
Repeati140 – 144125
Repeati145 – 149135
Repeati150 – 154145
Repeati162 – 166155
Repeati172 – 176165
Repeati182 – 186175
Repeati187 – 191185
Repeati192 – 196195
Repeati197 – 201205
Repeati209 – 213215
Repeati219 – 223225
Repeati224 – 228235
Repeati243 – 247245
Repeati250 – 254255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 25425 X 5 AA repeats of C-C-X(3)Add BLAST229

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JNRG Eukaryota
ENOG41116YF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164049

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60411

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQPACCA

Database of Orthologous Groups

More...
OrthoDBi
1622331at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60411

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P60411-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASTMSIRS SAYSDSWQVD DCPESCCEPP CCATSCCAPA PCLTLVCTPV
60 70 80 90 100
SRVSSPCCQV TCEPSPCQSG CTSSCTPSCC QQSSCQPAYC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC VPVCCGASSC CQQSSYQPAC CASSSCQPAC CVPVCCKPVC
160 170 180 190 200
CAPTCSEDSY SCCQQSSCQP ACCTSSPCQQ SYCVPVCCKP VCCKPICCVP
210 220 230 240 250
VCSGASSLCC QQSGCQPACC TTSCCRPSSS VSLLCRPVCR PACCVPVSSC
260 270 280 290
CAPTSSRQPS YCRQASCVSL LCRPVCSRPA CYSFSSGQKS SC
Length:292
Mass (Da):30,037
Last modified:April 20, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE61D891212803B98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT19A0A087WT19_HUMAN
Keratin-associated protein 10-9
KRTAP10-9
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti102P → PVCCKT in EAX09409 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017739182Y → C1 PublicationCorresponds to variant dbSNP:rs8127342Ensembl.1
Natural variantiVAR_060052257R → C2 PublicationsCorresponds to variant dbSNP:rs9980129Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB076356 mRNA Translation: BAD01543.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09409.1
CH471079 Genomic DNA Translation: EAX09411.1
BC131613 mRNA Translation: AAI31614.1
AJ566386 mRNA Translation: CAD97466.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42961.1 [P60411-1]

NCBI Reference Sequences

More...
RefSeqi
NP_941963.2, NM_198690.2 [P60411-1]
NP_941965.2, NM_198692.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000397911; ENSP00000381009; ENSG00000221837 [P60411-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
386676
386678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:386676
hsa:386678

UCSC genome browser

More...
UCSCi
uc002zfp.5 human [P60411-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076356 mRNA Translation: BAD01543.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09409.1
CH471079 Genomic DNA Translation: EAX09411.1
BC131613 mRNA Translation: AAI31614.1
AJ566386 mRNA Translation: CAD97466.1
CCDSiCCDS42961.1 [P60411-1]
RefSeqiNP_941963.2, NM_198690.2 [P60411-1]
NP_941965.2, NM_198692.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132127, 167 interactors
132129, 15 interactors
IntActiP60411, 221 interactors
STRINGi9606.ENSP00000381009

Protein family/group databases

MoonDBiP60411 Predicted

PTM databases

iPTMnetiP60411
PhosphoSitePlusiP60411

Polymorphism and mutation databases

BioMutaiKRTAP10-9
DMDMi294862449

Proteomic databases

MassIVEiP60411
PaxDbiP60411
PeptideAtlasiP60411
PRIDEiP60411
ProteomicsDBi57205 [P60411-1]

Genome annotation databases

EnsembliENST00000397911; ENSP00000381009; ENSG00000221837 [P60411-1]
GeneIDi386676
386678
KEGGihsa:386676
hsa:386678
UCSCiuc002zfp.5 human [P60411-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
386676
386678
EuPathDBiHostDB:ENSG00000221837.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP10-9
HGNCiHGNC:22971 KRTAP10-9
HPAiENSG00000221837 Tissue enriched (skin)
neXtProtiNX_P60411
PharmGKBiPA134873081

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JNRG Eukaryota
ENOG41116YF LUCA
GeneTreeiENSGT00940000164049
InParanoidiP60411
OMAiYQPACCA
OrthoDBi1622331at2759
PhylomeDBiP60411
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
386676 104 hits in 785 CRISPR screens
386678 10 hits in 774 CRISPR screens
PharosiP60411 Tdark

Protein Ontology

More...
PROi
PR:P60411
RNActiP60411 protein

Gene expression databases

BgeeiENSG00000221837 Expressed in heart and 11 other tissues
ExpressionAtlasiP60411 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 4 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR109_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60411
Secondary accession number(s): A2RRG1, A6NIR9, Q70LJ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: April 20, 2010
Last modified: June 17, 2020
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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