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Protein

Keratin-associated protein 10-8

Gene

KRTAP10-8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-8
Alternative name(s):
High sulfur keratin-associated protein 10.8
Keratin-associated protein 10.8
Keratin-associated protein 18-8
Keratin-associated protein 18.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-8
Synonyms:KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187766.1

Human Gene Nomenclature Database

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HGNCi
HGNC:20525 KRTAP10-8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60410

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000187766

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134968895

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP10-8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242612

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852161 – 259Keratin-associated protein 10-8Add BLAST259

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60410

PeptideAtlas

More...
PeptideAtlasi
P60410

PRoteomics IDEntifications database

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PRIDEi
P60410

ProteomicsDB human proteome resource

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ProteomicsDBi
57204

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60410

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60410

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187766 Expressed in 7 organ(s), highest expression level in skin of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_KRTAP10-8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10171774,EBI-10171774
Q5BKY65EBI-10171774,EBI-10243533
Q5XG853EBI-10171774,EBI-10248413
Q6ZVW33EBI-10171774,EBI-10255586
Q9NWL93EBI-10171774,EBI-10315054
ADAMTSL3P829875EBI-10171774,EBI-10221726
ADAMTSL4Q6UY14-35EBI-10171774,EBI-10173507
AENQ8WTP83EBI-10171774,EBI-8637627
AESQ081173EBI-10171774,EBI-717810
ALDH3B1P433535EBI-10171774,EBI-2558314
ALPIP099233EBI-10171774,EBI-1052631
AMMECR1Q9Y4X03EBI-10171774,EBI-8583355
AMMECR1Q9Y4X0-33EBI-10171774,EBI-12823597
ApoL6B3KTP43EBI-10171774,EBI-10175904
ASPSCR1Q9BZE93EBI-10171774,EBI-1993677
ATG9AQ7Z3C63EBI-10171774,EBI-727146
BEX2Q9BXY85EBI-10171774,EBI-745073
BMP7A8K5713EBI-10171774,EBI-10174327
C11orf87Q6NUJ25EBI-10171774,EBI-6660291
CARHSP1Q9Y2V25EBI-10171774,EBI-718719
CATSPER1Q8NEC59EBI-10171774,EBI-744545
CCDC26Q8TAB75EBI-10171774,EBI-10271580
CCNJLF6RF563EBI-10171774,EBI-10177725
CHIC2Q9UKJ55EBI-10171774,EBI-741528
CHRDQ9H2X05EBI-10171774,EBI-947551
CHRNGP075103EBI-10171774,EBI-9008836
CHRNGP07510-25EBI-10171774,EBI-11979451
CLK4Q9HAZ13EBI-10171774,EBI-633400
CNNM3Q8NE015EBI-10171774,EBI-741032
COL8A1P276585EBI-10171774,EBI-747133
CRCT1Q9UGL95EBI-10171774,EBI-713677
CREB5Q02930-39EBI-10171774,EBI-10192698
CYSRT1A8MQ034EBI-10171774,EBI-3867333
DCXO436023EBI-10171774,EBI-8646694
DDX55Q8NHQ93EBI-10171774,EBI-5459844
DDX6P261965EBI-10171774,EBI-351257
DERL2Q9GZP93EBI-10171774,EBI-7962814
DHRS1Q96LJ75EBI-10171774,EBI-746300
DHX57Q6P1585EBI-10171774,EBI-1051531
DMRT3Q9NQL95EBI-10171774,EBI-9679045
DOCK2Q926085EBI-10171774,EBI-448771
EIF4E2O605733EBI-10171774,EBI-398610
FAHP169303EBI-10171774,EBI-4397076
FAM27E3Q08E935EBI-10171774,EBI-2602739
FAM74A6Q5TZK35EBI-10171774,EBI-10247271
FAM76BQ5HYJ33EBI-10171774,EBI-751192
FBXW5Q969U65EBI-10171774,EBI-741068
FOXB1Q998533EBI-10171774,EBI-3916225
GFOD1Q9NXC23EBI-10171774,EBI-8799578
GLP1RP432203EBI-10171774,EBI-7466542
GLRX3O760037EBI-10171774,EBI-374781
GLYATQ6IB773EBI-10171774,EBI-715463
GNAI2P048993EBI-10171774,EBI-353997
GNEQ9Y2233EBI-10171774,EBI-4291090
GOLGA8DPQ0D2H95EBI-10171774,EBI-10181276
HEL-S-90nV9HWJ53EBI-10171774,EBI-10330335
HHEXQ030145EBI-10171774,EBI-747421
HOXA1P496397EBI-10171774,EBI-740785
HPCAL1P372355EBI-10171774,EBI-749311
HSD3B7Q9H2F35EBI-10171774,EBI-3918847
HSPD1P108093EBI-10171774,EBI-352528
IGSF8Q969P05EBI-10171774,EBI-8293590
ITGB5L7RT223EBI-10171774,EBI-10178729
JOSD1Q150405EBI-10171774,EBI-2510602
KLHL38Q2WGJ65EBI-10171774,EBI-6426443
KRT20P359005EBI-10171774,EBI-742094
KRT83P783853EBI-10171774,EBI-10221390
KRTAP10-7P604093EBI-10171774,EBI-10172290
KRTAP10-9P604115EBI-10171774,EBI-10172052
KRTAP12-1P599905EBI-10171774,EBI-10210845
KRTAP12-2P599913EBI-10171774,EBI-10176379
KRTAP4-11Q9BYQ67EBI-10171774,EBI-10302392
KRTAP4-12Q9BQ665EBI-10171774,EBI-739863
KRTAP4-2Q9BYR57EBI-10171774,EBI-10172511
KRTAP4-7Q9BYR03EBI-10171774,EBI-10302547
KRTAP5-6Q6L8G95EBI-10171774,EBI-10250562
KRTAP5-9P263717EBI-10171774,EBI-3958099
KRTAP9-2Q9BYQ47EBI-10171774,EBI-1044640
KRTAP9-3Q9BYQ34EBI-10171774,EBI-1043191
KRTAP9-4Q9BYQ23EBI-10171774,EBI-10185730
KRTAP9-8Q9BYQ04EBI-10171774,EBI-11958364
LCE1AQ5T7P24EBI-10171774,EBI-11962058
LCE1BQ5T7P37EBI-10171774,EBI-10245913
LCE1DQ5T7524EBI-10171774,EBI-11741311
LCE1EQ5T7534EBI-10171774,EBI-11955335
LCE1FQ5T7544EBI-10171774,EBI-11958008
LCE2AQ5TA797EBI-10171774,EBI-10246607
LCE2BO146334EBI-10171774,EBI-11478468
LCE2CQ5TA814EBI-10171774,EBI-11973993
LCE2DQ5TA825EBI-10171774,EBI-10246750
LCE3AQ5TA764EBI-10171774,EBI-9394625
LCE3CQ5T5A85EBI-10171774,EBI-10245291
LCE3DQ9BYE34EBI-10171774,EBI-6658837
LCE3EQ5T5B07EBI-10171774,EBI-10245456
LCE4AQ5TA787EBI-10171774,EBI-10246358
LOC200261Q17RD93EBI-10171774,EBI-10239007
LRCH4O754273EBI-10171774,EBI-718707
LUZP4Q9P1273EBI-10171774,EBI-10198848
LYVE1Q9Y5Y73EBI-10171774,EBI-10329546
MAPKBP1O603365EBI-10171774,EBI-947402
MATN3O152323EBI-10171774,EBI-6262458
MEOX2P502223EBI-10171774,EBI-748397
MLLT6Q6P2C63EBI-10171774,EBI-5773143
MOBPQ138753EBI-10171774,EBI-10230628
MOBPQ13875-33EBI-10171774,EBI-12013470
MTA1Q133303EBI-10171774,EBI-714236
MXI1P50539-35EBI-10171774,EBI-10211940
NAB2Q157423EBI-10171774,EBI-8641936
NAXDQ8IW455EBI-10171774,EBI-8650724
NECTIN3Q9NQS33EBI-10171774,EBI-2826725
NOTCH2NLAQ7Z3S95EBI-10171774,EBI-945833
NUFIP2Q7Z4177EBI-10171774,EBI-1210753
OTX1P322429EBI-10171774,EBI-740446
P2RX7C6KE323EBI-10171774,EBI-10176325
PCED1AQ9H1Q73EBI-10171774,EBI-748452
PCSK5Q928243EBI-10171774,EBI-751290
PCSK5Q92824-24EBI-10171774,EBI-11956269
PDE9AO760833EBI-10171774,EBI-742764
PIGSQ96S523EBI-10171774,EBI-2908273
PKD2Q135633EBI-10171774,EBI-7813714
PRKAB2O437415EBI-10171774,EBI-1053424
PRPF31Q8WWY38EBI-10171774,EBI-1567797
PRR13Q9NZ815EBI-10171774,EBI-740924
PTGER3P43115-123EBI-10171774,EBI-10234038
PTPMT1Q8WUK05EBI-10171774,EBI-7199479
PTPRHQ9HD433EBI-10171774,EBI-1267176
PVRP151515EBI-10171774,EBI-3919694
R3HDM2Q9Y2K5-23EBI-10171774,EBI-10326419
RPS28P628573EBI-10171774,EBI-353027
RTN4RL1Q86UN23EBI-10171774,EBI-10258951
RYDENQ9NUL53EBI-10171774,EBI-10313866
SCNM1Q9BWG65EBI-10171774,EBI-748391
SLC22A23A1A5C73EBI-10171774,EBI-10171756
SLC23A1Q9UHI73EBI-10171774,EBI-1759386
SLC25A10Q9UBX33EBI-10171774,EBI-750394
SLC6A20Q9NP915EBI-10171774,EBI-10311198
SMCPP499017EBI-10171774,EBI-750494
SMOC1Q9H4F83EBI-10171774,EBI-2801103
SPACA9Q96E403EBI-10171774,EBI-722584
SPRY1O436095EBI-10171774,EBI-3866665
SPRY2O435973EBI-10171774,EBI-742487
STK16O757165EBI-10171774,EBI-749295
SUSD6Q925375EBI-10171774,EBI-2866213
TBC1D23Q9NUY83EBI-10171774,EBI-2853126
THAP10Q9P2Z03EBI-10171774,EBI-745404
THAP7Q9BT495EBI-10171774,EBI-741350
TMEM150AQ86TG13EBI-10171774,EBI-2799342
TNIP3Q96KP63EBI-10171774,EBI-2509913
TNP2Q4VB563EBI-10171774,EBI-10241829
TNS2Q63HR23EBI-10171774,EBI-949753
TXNDC5Q86UY05EBI-10171774,EBI-2825190
TYMSOSQ8TAI15EBI-10171774,EBI-742060
TYRO3Q064183EBI-10171774,EBI-3951628
UTP23Q9BRU95EBI-10171774,EBI-5457544
UXTQ9UBK95EBI-10171774,EBI-357355
VPS11Q9H2705EBI-10171774,EBI-373380
WIF1Q9Y5W55EBI-10171774,EBI-3922719
WT1P195443EBI-10171774,EBI-2320534
WT1-ASQ062505EBI-10171774,EBI-10223946
YIPF3Q9GZM53EBI-10171774,EBI-743787
ZBTB24O431675EBI-10171774,EBI-744471
ZFABQ9Y2605EBI-10171774,EBI-750052
ZFYVE21Q9BQ243EBI-10171774,EBI-2849569
ZNF124Q159735EBI-10171774,EBI-2555767
ZNF138P52744-23EBI-10171774,EBI-10213071
ZNF20P170243EBI-10171774,EBI-717634
ZNF32P170413EBI-10171774,EBI-1965483
ZNF417Q8TAU35EBI-10171774,EBI-740727
ZNF439Q8NDP45EBI-10171774,EBI-747580
ZNF473Q8WTR75EBI-10171774,EBI-751409
ZNF572Q7Z3I78EBI-10171774,EBI-10172590
ZNF578Q3MI943EBI-10171774,EBI-10241108
ZNF587Q96SQ55EBI-10171774,EBI-6427977
ZNF697Q8N5083EBI-10171774,EBI-10265733
ZSCAN21Q9Y5A65EBI-10171774,EBI-10281938

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132132, 164 interactors

Protein interaction database and analysis system

More...
IntActi
P60410, 386 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000335565

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60410

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati50 – 5415
Repeati60 – 6425
Repeati65 – 6935
Repeati98 – 10245
Repeati108 – 11255
Repeati118 – 12265
Repeati123 – 12775
Repeati133 – 13785
Repeati145 – 14995
Repeati155 – 159105
Repeati165 – 169115
Repeati170 – 174125
Repeati175 – 179135
Repeati187 – 191145
Repeati197 – 201155
Repeati202 – 206165
Repeati221 – 225175
Repeati228 – 232185
Repeati239 – 243195

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 24319 X 5 AA repeats of C-C-X(3)Add BLAST218

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBGI Eukaryota
ENOG41118FU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163258

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234031

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108072

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60410

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEPRSCA

Database of Orthologous Groups

More...
OrthoDBi
1583483at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60410

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494 KAP
IPR007951 KRTAP_PMG

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 1 hit
PF05287 PMG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60410-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADACCTRTY VIAASTMSVC SSDVGHVSRV SSPSTCTGSS WQVDNCQESC
60 70 80 90 100
CEPRSCASSC CTPSCCAPAP CLALVCAPVS CEPSPCQSGC TDSCTPSCCQ
110 120 130 140 150
QSSCQPACCT SSPCQQACCV PVCCKSNCCK PVCCVSICSG ASSPCCQQSS
160 170 180 190 200
CQSACCTFSP CQQACCVPIC CKPICCVPVC SGASSLCCQK SSCQPACCTT
210 220 230 240 250
SCCRPSSSVS LLCRPVCRPA CCVPVPSCCV PASSCQPSCC HPASCLSFLC

RPACSRLAC
Length:259
Mass (Da):26,299
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i180307276CAB4607
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02823426H → R2 PublicationsCorresponds to variant dbSNP:rs411254Ensembl.1
Natural variantiVAR_03656064S → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036561159S → F in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs763238933Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB076355 mRNA Translation: BAD01542.1
AL773602 Genomic DNA No translation available.
BC127016 mRNA Translation: AAI27017.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13713.1

NCBI Reference Sequences

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RefSeqi
NP_941968.2, NM_198695.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.528021

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000334662; ENSP00000335565; ENSG00000187766

Database of genes from NCBI RefSeq genomes

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GeneIDi
386681

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:386681

UCSC genome browser

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UCSCi
uc002zfo.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076355 mRNA Translation: BAD01542.1
AL773602 Genomic DNA No translation available.
BC127016 mRNA Translation: AAI27017.1
CCDSiCCDS13713.1
RefSeqiNP_941968.2, NM_198695.2
UniGeneiHs.528021

3D structure databases

ProteinModelPortaliP60410
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132132, 164 interactors
IntActiP60410, 386 interactors
STRINGi9606.ENSP00000335565

PTM databases

iPTMnetiP60410
PhosphoSitePlusiP60410

Polymorphism and mutation databases

BioMutaiKRTAP10-8
DMDMi116242612

Proteomic databases

PaxDbiP60410
PeptideAtlasiP60410
PRIDEiP60410
ProteomicsDBi57204

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334662; ENSP00000335565; ENSG00000187766
GeneIDi386681
KEGGihsa:386681
UCSCiuc002zfo.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
386681
EuPathDBiHostDB:ENSG00000187766.1

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP10-8

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0040851
HGNCiHGNC:20525 KRTAP10-8
neXtProtiNX_P60410
OpenTargetsiENSG00000187766
PharmGKBiPA134968895

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JBGI Eukaryota
ENOG41118FU LUCA
GeneTreeiENSGT00940000163258
HOGENOMiHOG000234031
HOVERGENiHBG108072
InParanoidiP60410
OMAiCEPRSCA
OrthoDBi1583483at2759
PhylomeDBiP60410
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
386681

Protein Ontology

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PROi
PR:P60410

Gene expression databases

BgeeiENSG00000187766 Expressed in 7 organ(s), highest expression level in skin of leg
CleanExiHS_KRTAP10-8

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
IPR007951 KRTAP_PMG
PANTHERiPTHR23262 PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 1 hit
PF05287 PMG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR108_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60410
Secondary accession number(s): A0JNW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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