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Entry version 134 (26 Feb 2020)
Sequence version 3 (05 Dec 2018)
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Protein

Keratin-associated protein 10-7

Gene

KRTAP10-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-7
Alternative name(s):
High sulfur keratin-associated protein 10.7
Keratin-associated protein 10.7
Keratin-associated protein 18-7
Keratin-associated protein 18.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-7
Synonyms:KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22970 KRTAP10-7

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60409

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000272804

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134976547

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P60409 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP10-7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852151 – 370Keratin-associated protein 10-7Add BLAST370

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P60409

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60409

PeptideAtlas

More...
PeptideAtlasi
P60409

PRoteomics IDEntifications database

More...
PRIDEi
P60409

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60409

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60409

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000272804 Expressed in skin of leg and 9 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10172290,EBI-10172290
B0FTY23EBI-10172290,EBI-10175366
Q53FW83EBI-10172290,EBI-10242473
Q5BKY63EBI-10172290,EBI-10243533
Q5XG853EBI-10172290,EBI-10248413
Q9H6F03EBI-10172290,EBI-10307481
Q8WTP83EBI-10172290,EBI-8637627
P433533EBI-10172290,EBI-2558314
Q96IX93EBI-10172290,EBI-744859
Q9BXS53EBI-10172290,EBI-541426
P299723EBI-10172290,EBI-745213
Q5T6863EBI-10172290,EBI-8640233
Q9UBV73EBI-10172290,EBI-10319970
Q8TBE03EBI-10172290,EBI-742750
A8KA134EBI-10172290,EBI-10174813
A8K5713EBI-10172290,EBI-10174327
P412233EBI-10172290,EBI-3904603
Q138955EBI-10172290,EBI-358049
Q0VDD73EBI-10172290,EBI-741210
Q9H7E93EBI-10172290,EBI-715389
Q9Y2V23EBI-10172290,EBI-718719
Q7Z7H33EBI-10172290,EBI-10258233
Q147813EBI-10172290,EBI-745934
Q8N7153EBI-10172290,EBI-740814
Q8TAB73EBI-10172290,EBI-10271580
P519593EBI-10172290,EBI-3905829
Q96GN53EBI-10172290,EBI-5278764
Q9UKJ53EBI-10172290,EBI-741528
Q9H2X03EBI-10172290,EBI-947551
P075103EBI-10172290,EBI-9008836
P497593EBI-10172290,EBI-473775
Q9HAZ13EBI-10172290,EBI-633400
P276583EBI-10172290,EBI-747133
Q9UGL93EBI-10172290,EBI-713677
Q02930-34EBI-10172290,EBI-10192698
Q9HCP03EBI-10172290,EBI-1383814
P783683EBI-10172290,EBI-748380
Q9NSA33EBI-10172290,EBI-747082
Q998953EBI-10172290,EBI-10295404
Q9GZP93EBI-10172290,EBI-7962814
Q6P1583EBI-10172290,EBI-1051531
Q9NQL93EBI-10172290,EBI-9679045
O754613EBI-10172290,EBI-749694
H3BUJ73EBI-10172290,EBI-10178160
Q084263EBI-10172290,EBI-2339219
Q9H5Z63EBI-10172290,EBI-741626
Q3B8203EBI-10172290,EBI-719941
Q08E933EBI-10172290,EBI-2602739
Q5TZK33EBI-10172290,EBI-10247271
Q5HYJ33EBI-10172290,EBI-751192
O953633EBI-10172290,EBI-2513774
Q9H0R83EBI-10172290,EBI-746969
P605203EBI-10172290,EBI-720116
P550403EBI-10172290,EBI-744104
P432203EBI-10172290,EBI-7466542
Q9Y2233EBI-10172290,EBI-4291090
Q0D2H93EBI-10172290,EBI-10181276
P287993EBI-10172290,EBI-747754
P092113EBI-10172290,EBI-353467
Q96NT33EBI-10172290,EBI-8293751
P020083EBI-10172290,EBI-719843
Q030143EBI-10172290,EBI-747421
P372353EBI-10172290,EBI-749311
O755063EBI-10172290,EBI-748664
Q9H2F33EBI-10172290,EBI-3918847
Q969P03EBI-10172290,EBI-8293590
Q8WYH83EBI-10172290,EBI-488533
Q928353EBI-10172290,EBI-1380477
Q8NA543EBI-10172290,EBI-10220600
Q2WGJ63EBI-10172290,EBI-6426443
P359003EBI-10172290,EBI-742094
P783853EBI-10172290,EBI-10221390
P603703EBI-10172290,EBI-10172150
P604103EBI-10172290,EBI-10171774
P604113EBI-10172290,EBI-10172052
P599903EBI-10172290,EBI-10210845
Q9BYR53EBI-10172290,EBI-10172511
Q6L8G93EBI-10172290,EBI-10250562
P263715EBI-10172290,EBI-3958099
Q9BYQ43EBI-10172290,EBI-1044640
Q5T7P33EBI-10172290,EBI-10245913
Q5TA793EBI-10172290,EBI-10246607
Q5T5B03EBI-10172290,EBI-10245456
Q5TA783EBI-10172290,EBI-10246358
Q7Z4I7-53EBI-10172290,EBI-10257651
Q5T6M23EBI-10172290,EBI-10245897
P025453EBI-10172290,EBI-351935
P257913EBI-10172290,EBI-739696
O754273EBI-10172290,EBI-718707
O603363EBI-10172290,EBI-947402
B1AHB03EBI-10172290,EBI-10175425
Q138753EBI-10172290,EBI-10230628
Q9NV563EBI-10172290,EBI-399076
Q9BW113EBI-10172290,EBI-741574
P50539-33EBI-10172290,EBI-10211940
P412273EBI-10172290,EBI-747693
Q8IW453EBI-10172290,EBI-8650724
Q926923EBI-10172290,EBI-718419
Q9NQS33EBI-10172290,EBI-2826725
Q9UGY13EBI-10172290,EBI-716098
Q7Z3S93EBI-10172290,EBI-945833
P481463EBI-10172290,EBI-10210114
Q9NQX53EBI-10172290,EBI-748927
Q9Y5Y23EBI-10172290,EBI-1048886
Q7Z4173EBI-10172290,EBI-1210753
Q150773EBI-10172290,EBI-10235794
Q9H1Q73EBI-10172290,EBI-748452
Q928243EBI-10172290,EBI-751290
Q145543EBI-10172290,EBI-953879
Q96HC43EBI-10172290,EBI-751267
P178583EBI-10172290,EBI-487243
Q135263EBI-10172290,EBI-714158
Q9UGP5-23EBI-10172290,EBI-10320765
Q03181-23EBI-10172290,EBI-10223258
O437413EBI-10172290,EBI-1053424
Q1LZN13EBI-10172290,EBI-10239098
Q9NZ813EBI-10172290,EBI-740924
P412223EBI-10172290,EBI-948821
P43115-123EBI-10172290,EBI-10234038
Q8WUK03EBI-10172290,EBI-7199479
P151513EBI-10172290,EBI-3919694
Q8N4F73EBI-10172290,EBI-10265447
Q9H9Y23EBI-10172290,EBI-9996007
P629133EBI-10172290,EBI-354380
Q969Q03EBI-10172290,EBI-2877705
P628573EBI-10172290,EBI-353027
Q6P0873EBI-10172290,EBI-5458784
Q6UXX93EBI-10172290,EBI-8481036
Q86UN23EBI-10172290,EBI-10258951
P570603EBI-10172290,EBI-724442
Q9BWG63EBI-10172290,EBI-748391
O005603EBI-10172290,EBI-727004
Q9NUL53EBI-10172290,EBI-10313866
Q9UHI73EBI-10172290,EBI-1759386
Q6ZT893EBI-10172290,EBI-10255185
Q9NP913EBI-10172290,EBI-10311198
Q9NRQ53EBI-10172290,EBI-8640191
P499013EBI-10172290,EBI-750494
Q96E403EBI-10172290,EBI-722584
Q6RVD63EBI-10172290,EBI-8635958
Q9UQ903EBI-10172290,EBI-717201
O436093EBI-10172290,EBI-3866665
Q9Y2D83EBI-10172290,EBI-2212028
O757163EBI-10172290,EBI-749295
O434633EBI-10172290,EBI-349968
Q155603EBI-10172290,EBI-710310
Q8N8B73EBI-10172290,EBI-954696
Q7L2K03EBI-10172290,EBI-8465456
Q9NVV93EBI-10172290,EBI-741515
Q8TBB03EBI-10172290,EBI-3925505
Q081173EBI-10172290,EBI-717810
Q96EY43EBI-10172290,EBI-1045338
Q9HCN33EBI-10172290,EBI-10310808
Q4VB563EBI-10172290,EBI-10241829
Q63HR23EBI-10172290,EBI-949753
O146563EBI-10172290,EBI-524257
Q9NSU2-13EBI-10172290,EBI-16746122
Q8IWZ53EBI-10172290,EBI-5235829
O753863EBI-10172290,EBI-5357290
Q86UY03EBI-10172290,EBI-2825190
Q064183EBI-10172290,EBI-3951628
P558513EBI-10172290,EBI-2842077
Q9UBK93EBI-10172290,EBI-357355
Q9UEU03EBI-10172290,EBI-723716
Q96HA83EBI-10172290,EBI-741158
O960143EBI-10172290,EBI-8058160
O431673EBI-10172290,EBI-744471
Q96C004EBI-10172290,EBI-395708
Q68DK2-53EBI-10172290,EBI-8656416
Q8IZC73EBI-10172290,EBI-5278328
Q159733EBI-10172290,EBI-2555767
P527363EBI-10172290,EBI-2687350
Q12901-23EBI-10172290,EBI-10227379
Q53Z403EBI-10172290,EBI-10186058
Q149293EBI-10172290,EBI-10234472
Q9Y4733EBI-10172290,EBI-3438881
Q9UJW83EBI-10172290,EBI-10322527
Q9BSG1-23EBI-10172290,EBI-10297542
P170243EBI-10172290,EBI-717634
Q9UK113EBI-10172290,EBI-10322867
P15622-33EBI-10172290,EBI-10177272
P170313EBI-10172290,EBI-2841331
Q145845EBI-10172290,EBI-7115319
P170413EBI-10172290,EBI-1965483
A2RRD83EBI-10172290,EBI-10173019
Q86UD43EBI-10172290,EBI-7233259
Q9Y3M93EBI-10172290,EBI-714987
P518143EBI-10172290,EBI-2681830
Q8TAU33EBI-10172290,EBI-740727
Q8TF453EBI-10172290,EBI-3446851
Q96HQ03EBI-10172290,EBI-10288482
Q6IV723EBI-10172290,EBI-10250516
Q8N7K03EBI-10172290,EBI-10267553
Q8NDP43EBI-10172290,EBI-747580
Q9ULM23EBI-10172290,EBI-1105370
Q08ER83EBI-10172290,EBI-10226133
Q8NEP93EBI-10172290,EBI-10270752
Q8TBZ83EBI-10172290,EBI-10273713
Q7Z3I73EBI-10172290,EBI-10172590
Q3MI943EBI-10172290,EBI-10241108
Q9P0T43EBI-10172290,EBI-745520
Q96SQ53EBI-10172290,EBI-6427977
Q96I273EBI-10172290,EBI-4395587
Q9BS343EBI-10172290,EBI-745276
Q8N5083EBI-10172290,EBI-10265733
Q96C283EBI-10172290,EBI-748111
Q96MU63EBI-10172290,EBI-10291463
Q3KQV33EBI-10172290,EBI-10240849
Q147U13EBI-10172290,EBI-10234020
O432573EBI-10172290,EBI-347522
Q166703EBI-10172290,EBI-3920053

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132126, 218 interactors

Protein interaction database and analysis system

More...
IntActi
P60409, 210 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000476821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60409 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 4515
Repeati46 – 5025
Repeati67 – 7135
Repeati89 – 9345
Repeati99 – 10355
Repeati109 – 11365
Repeati114 – 11875
Repeati119 – 12385
Repeati135 – 13995
Repeati145 – 149105
Repeati155 – 159115
Repeati160 – 164125
Repeati172 – 176135
Repeati186 – 190145
Repeati208 – 212155
Repeati218 – 222165
Repeati228 – 232175
Repeati233 – 237185
Repeati238 – 242195
Repeati250 – 254205
Repeati255 – 259215
Repeati265 – 269225
Repeati270 – 274235
Repeati275 – 279245
Repeati287 – 291255
Repeati297 – 301265
Repeati302 – 306275
Repeati321 – 325285
Repeati339 – 343295
Repeati359 – 363305

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 36330 X 5 AA repeats of C-C-X(3)Add BLAST328

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBCF Eukaryota
ENOG4111398 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_062832_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60409

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAQACQT

Database of Orthologous Groups

More...
OrthoDBi
1629708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60409

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

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PANTHERi
PTHR23262 PTHR23262, 4 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60409-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA
60 70 80 90 100
PCLSLVCTPV SYVSSPCCRV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC
110 120 130 140 150
ASSPCQQACC VPVCCKTVCC KPVYCVPVCS GDSSCCQQSS CQSACCTSSP
160 170 180 190 200
CQQACCVPIC CKPVCSGISS SCCQQSSCVS CVSSPCCQAV CEPSPCQSGC
210 220 230 240 250
ISSCTPSCCQ QSSCKPACCT SSPCQQACCV PVCCKPVCCV PTCSDDSGSC
260 270 280 290 300
CQPACCTSSQ SQQGCCVPVC CKPVCCVPVC SGASTSCCQQ SSCQPACCTT
310 320 330 340 350
SCCRPSSSVS LLCRPVCRPA CCVPVPSCCA PTSSCQASCC RPASCVSLLC
360 370
RPACSRPACC GPTSTQKSSC
Length:370
Mass (Da):37,372
Last modified:December 5, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7D44544DEC05BCB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047852111V → M. Corresponds to variant dbSNP:rs944419Ensembl.1
Natural variantiVAR_060051124Y → C. Corresponds to variant dbSNP:rs233308Ensembl.1
Natural variantiVAR_047853215K → Q. Corresponds to variant dbSNP:rs363877Ensembl.1
Natural variantiVAR_047854285T → S. Corresponds to variant dbSNP:rs446817Ensembl.1
Natural variantiVAR_047855320A → T. Corresponds to variant dbSNP:rs369720Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB076354 mRNA Translation: BAD01541.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09413.1
BC119643 mRNA Translation: AAI19644.1
AJ566385 mRNA Translation: CAD97465.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS74803.1

NCBI Reference Sequences

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RefSeqi
NP_941962.1, NM_198689.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000609664; ENSP00000476821; ENSG00000272804

Database of genes from NCBI RefSeq genomes

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GeneIDi
386675

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:386675

UCSC genome browser

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UCSCi
uc032qbr.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076354 mRNA Translation: BAD01541.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09413.1
BC119643 mRNA Translation: AAI19644.1
AJ566385 mRNA Translation: CAD97465.1
CCDSiCCDS74803.1
RefSeqiNP_941962.1, NM_198689.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi132126, 218 interactors
IntActiP60409, 210 interactors
STRINGi9606.ENSP00000476821

PTM databases

iPTMnetiP60409
PhosphoSitePlusiP60409

Polymorphism and mutation databases

BioMutaiKRTAP10-7
DMDMi116242611

Proteomic databases

MassIVEiP60409
PaxDbiP60409
PeptideAtlasiP60409
PRIDEiP60409

Genome annotation databases

EnsembliENST00000609664; ENSP00000476821; ENSG00000272804
GeneIDi386675
KEGGihsa:386675
UCSCiuc032qbr.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
386675

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP10-7
HGNCiHGNC:22970 KRTAP10-7
neXtProtiNX_P60409
OpenTargetsiENSG00000272804
PharmGKBiPA134976547

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410JBCF Eukaryota
ENOG4111398 LUCA
GeneTreeiENSGT00940000163845
HOGENOMiCLU_062832_0_0_1
InParanoidiP60409
OMAiCAQACQT
OrthoDBi1629708at2759
PhylomeDBiP60409

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
386675
PharosiP60409 Tdark

Protein Ontology

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PROi
PR:P60409
RNActiP60409 protein

Gene expression databases

BgeeiENSG00000272804 Expressed in skin of leg and 9 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 4 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR107_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60409
Secondary accession number(s): Q0VDJ8, Q70LJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 5, 2018
Last modified: February 26, 2020
This is version 134 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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