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Entry version 139 (02 Dec 2020)
Sequence version 3 (05 Dec 2018)
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Protein

Keratin-associated protein 10-7

Gene

KRTAP10-7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P60409

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-7
Alternative name(s):
High sulfur keratin-associated protein 10.7
Keratin-associated protein 10.7
Keratin-associated protein 18-7
Keratin-associated protein 18.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-7
Synonyms:KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000272804.2

Human Gene Nomenclature Database

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HGNCi
HGNC:22970, KRTAP10-7

neXtProt; the human protein knowledge platform

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neXtProti
NX_P60409

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000272804

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134976547

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P60409, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KRTAP10-7

Domain mapping of disease mutations (DMDM)

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DMDMi
116242611

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852151 – 370Keratin-associated protein 10-7Add BLAST370

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P60409

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P60409

PeptideAtlas

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PeptideAtlasi
P60409

PRoteomics IDEntifications database

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PRIDEi
P60409

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60409

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60409

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000272804, Expressed in skin of leg and 10 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000272804, Not detected

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60409
With#Exp.IntAct
AEN [Q8WTP8]3EBI-10172290,EBI-8637627
ALDH3B1 [P43353]3EBI-10172290,EBI-2558314
ANKRD36BP1 [Q96IX9]3EBI-10172290,EBI-744859
AP1M1 [Q9BXS5]6EBI-10172290,EBI-541426
AQP1 [P29972]3EBI-10172290,EBI-745213
AVPI1 [Q5T686]3EBI-10172290,EBI-8640233
B4GALT7 [Q9UBV7]3EBI-10172290,EBI-10319970
BAHD1 [Q8TBE0]3EBI-10172290,EBI-742750
BCL6B [A8KA13]4EBI-10172290,EBI-10174813
BMP7 [A8K571]3EBI-10172290,EBI-10174327
BUD31 [P41223]6EBI-10172290,EBI-3904603
BYSL [Q13895]5EBI-10172290,EBI-358049
C19orf57 [Q0VDD7]3EBI-10172290,EBI-741210
C8orf33 [Q9H7E9]3EBI-10172290,EBI-715389
CARHSP1 [Q9Y2V2]3EBI-10172290,EBI-718719
CATIP [Q7Z7H3]3EBI-10172290,EBI-10258233
CBX2 [Q14781]3EBI-10172290,EBI-745934
CCDC185 [Q8N715]3EBI-10172290,EBI-740814
CCDC26 [Q8TAB7]3EBI-10172290,EBI-10271580
CCNG1 [P51959]3EBI-10172290,EBI-3905829
CDCA7L [Q96GN5]3EBI-10172290,EBI-5278764
CHIC2 [Q9UKJ5]3EBI-10172290,EBI-741528
CHRD [Q9H2X0]6EBI-10172290,EBI-947551
CHRNG [P07510]4EBI-10172290,EBI-9008836
CLK1 [P49759]3EBI-10172290,EBI-473775
CLK1 - isoform 3 [P49759-3]3EBI-10172290,EBI-11981867
CLK4 [Q9HAZ1]6EBI-10172290,EBI-633400
CNNM3 [Q8NE01]5EBI-10172290,EBI-741032
COL8A1 [P27658]3EBI-10172290,EBI-747133
CRCT1 [Q9UGL9]6EBI-10172290,EBI-713677
CREB5 - isoform 3 [Q02930-3]4EBI-10172290,EBI-10192698
CRY2 [Q49AN0]3EBI-10172290,EBI-2212355
CSNK1G1 [Q9HCP0]3EBI-10172290,EBI-1383814
CSNK1G2 [P78368]3EBI-10172290,EBI-748380
CTNNBIP1 [Q9NSA3]3EBI-10172290,EBI-747082
CTRC [Q99895]3EBI-10172290,EBI-10295404
CYSRT1 [A8MQ03]3EBI-10172290,EBI-3867333
DERL2 [Q9GZP9]3EBI-10172290,EBI-7962814
DHX57 [Q6P158]6EBI-10172290,EBI-1051531
DMRT3 [Q9NQL9]3EBI-10172290,EBI-9679045
DOCK2 [Q92608]5EBI-10172290,EBI-448771
E2F6 [O75461]3EBI-10172290,EBI-749694
E4F1 [H3BUJ7]3EBI-10172290,EBI-10178160
EHHADH [Q08426]3EBI-10172290,EBI-2339219
FADS6 [Q8N9I5]3EBI-10172290,EBI-3943864
FAM124B [Q9H5Z6]3EBI-10172290,EBI-741626
FAM161A [Q3B820]3EBI-10172290,EBI-719941
FAM27E3 [Q08E93]3EBI-10172290,EBI-2602739
FAM74A6 [Q5TZK3]3EBI-10172290,EBI-10247271
FAM76B [Q5HYJ3]3EBI-10172290,EBI-751192
FARS2 [O95363]6EBI-10172290,EBI-2513774
GABARAPL1 [Q9H0R8]3EBI-10172290,EBI-746969
GABARAPL2 [P60520]6EBI-10172290,EBI-720116
GEM [P55040]6EBI-10172290,EBI-744104
GLP1R [P43220]3EBI-10172290,EBI-7466542
GNE [Q9Y223]3EBI-10172290,EBI-4291090
GNE - isoform 2 [Q9Y223-2]3EBI-10172290,EBI-11975289
GOLGA8DP [Q0D2H9]3EBI-10172290,EBI-10181276
GRN [P28799]3EBI-10172290,EBI-747754
GSTP1 [P09211]6EBI-10172290,EBI-353467
GUCD1 [Q96NT3]3EBI-10172290,EBI-8293751
HBZ [P02008]3EBI-10172290,EBI-719843
HCK - isoform 2 [P08631-2]3EBI-10172290,EBI-9834454
HHEX [Q03014]3EBI-10172290,EBI-747421
HOXA1 [P49639]5EBI-10172290,EBI-740785
HOXC8 [P31273]3EBI-10172290,EBI-1752118
HPCAL1 [P37235]3EBI-10172290,EBI-749311
HSBP1 [O75506]3EBI-10172290,EBI-748664
HSD3B7 [Q9H2F3]3EBI-10172290,EBI-3918847
IGSF8 [Q969P0]6EBI-10172290,EBI-8293590
ING5 [Q8WYH8]3EBI-10172290,EBI-488533
INPP5D [Q92835]3EBI-10172290,EBI-1380477
IQUB [Q8NA54]3EBI-10172290,EBI-10220600
ITGB4 - isoform Beta-4A [P16144-2]3EBI-10172290,EBI-11051601
ITGB5 [P18084]3EBI-10172290,EBI-1223434
KLHL38 [Q2WGJ6]6EBI-10172290,EBI-6426443
KRT20 [P35900]3EBI-10172290,EBI-742094
KRT83 [P78385]3EBI-10172290,EBI-10221390
KRTAP10-5 [P60370]3EBI-10172290,EBI-10172150
itself3EBI-10172290,EBI-10172290
KRTAP10-8 [P60410]6EBI-10172290,EBI-10171774
KRTAP10-9 [P60411]6EBI-10172290,EBI-10172052
KRTAP12-1 [P59990]6EBI-10172290,EBI-10210845
KRTAP12-3 [P60328]3EBI-10172290,EBI-11953334
KRTAP26-1 [Q6PEX3]3EBI-10172290,EBI-3957672
KRTAP4-2 [Q9BYR5]3EBI-10172290,EBI-10172511
KRTAP4-5 [Q9BYR2]3EBI-10172290,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-10172290,EBI-11993296
KRTAP5-2 [Q701N4]3EBI-10172290,EBI-11958178
KRTAP5-6 [Q6L8G9]6EBI-10172290,EBI-10250562
KRTAP5-9 [P26371]5EBI-10172290,EBI-3958099
KRTAP9-2 [Q9BYQ4]6EBI-10172290,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-10172290,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-10172290,EBI-11958364
LCE1A [Q5T7P2]3EBI-10172290,EBI-11962058
LCE1B [Q5T7P3]9EBI-10172290,EBI-10245913
LCE1D [Q5T752]3EBI-10172290,EBI-11741311
LCE1F [Q5T754]5EBI-10172290,EBI-11958008
LCE2A [Q5TA79]3EBI-10172290,EBI-10246607
LCE2B [O14633]5EBI-10172290,EBI-11478468
LCE2C [Q5TA81]5EBI-10172290,EBI-11973993
LCE3A [Q5TA76]3EBI-10172290,EBI-9394625
LCE3B [Q5TA77]3EBI-10172290,EBI-11974495
LCE3C [Q5T5A8]3EBI-10172290,EBI-10245291
LCE3D [Q9BYE3]5EBI-10172290,EBI-6658837
LCE3E [Q5T5B0]8EBI-10172290,EBI-10245456
LCE4A [Q5TA78]8EBI-10172290,EBI-10246358
LCE5A [Q5TCM9]3EBI-10172290,EBI-11955689
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-10172290,EBI-10257651
LINC00242 [Q5T6M2]3EBI-10172290,EBI-10245897
LMNA [P02545]3EBI-10172290,EBI-351935
LMO2 [P25791]3EBI-10172290,EBI-739696
LRCH4 [O75427]3EBI-10172290,EBI-718707
MAPKBP1 [O60336]6EBI-10172290,EBI-947402
MCM5 [B1AHB0]3EBI-10172290,EBI-10175425
MCRS1 [Q96EZ8]3EBI-10172290,EBI-348259
MOBP [Q13875]3EBI-10172290,EBI-10230628
MOBP - isoform 3 [Q13875-3]3EBI-10172290,EBI-12013470
MRGBP [Q9NV56]6EBI-10172290,EBI-399076
MXD3 [Q9BW11]3EBI-10172290,EBI-741574
MXI1 - isoform 3 [P50539-3]3EBI-10172290,EBI-10211940
MYPOP [Q86VE0]3EBI-10172290,EBI-2858213
NAA10 [P41227]3EBI-10172290,EBI-747693
NAXD [Q8IW45]6EBI-10172290,EBI-8650724
NECTIN2 [Q92692]3EBI-10172290,EBI-718419
NECTIN3 [Q9NQS3]3EBI-10172290,EBI-2826725
NKD1 [Q969G9]5EBI-10172290,EBI-1538217
NOL12 [Q9UGY1]3EBI-10172290,EBI-716098
NOTCH2NLA [Q7Z3S9]3EBI-10172290,EBI-945833
NPBWR2 [P48146]3EBI-10172290,EBI-10210114
NPDC1 [Q9NQX5]6EBI-10172290,EBI-748927
NTAQ1 [Q96HA8]3EBI-10172290,EBI-741158
NUBP2 [Q9Y5Y2]3EBI-10172290,EBI-1048886
NUFIP2 [Q7Z417]6EBI-10172290,EBI-1210753
OTX1 [P32242]5EBI-10172290,EBI-740446
P2RY6 [Q15077]3EBI-10172290,EBI-10235794
PCED1A [Q9H1Q7]3EBI-10172290,EBI-748452
PCSK5 [Q92824]3EBI-10172290,EBI-751290
PDE9A - isoform PDE9A2 [O76083-2]3EBI-10172290,EBI-11524542
PDIA5 [Q14554]3EBI-10172290,EBI-953879
PDLIM5 [Q96HC4]3EBI-10172290,EBI-751267
PFKL [P17858]3EBI-10172290,EBI-487243
PGAP6 [Q9HCN3]3EBI-10172290,EBI-10310808
PHLDA1 [A2BDE7]3EBI-10172290,EBI-14084211
PIN1 [Q13526]6EBI-10172290,EBI-714158
POLL - isoform 2 [Q9UGP5-2]3EBI-10172290,EBI-10320765
PPARD - isoform 2 [Q03181-2]3EBI-10172290,EBI-10223258
PRKAB2 [O43741]8EBI-10172290,EBI-1053424
PRM2 [P04554]3EBI-10172290,EBI-9681663
PRM2 [Q1LZN1]3EBI-10172290,EBI-10239098
PRR13 [Q9NZ81]3EBI-10172290,EBI-740924
PRR35 [P0CG20]3EBI-10172290,EBI-11986293
PTGDS [P41222]3EBI-10172290,EBI-948821
PTGER3 - isoform 12 [P43115-12]3EBI-10172290,EBI-10234038
PTPMT1 [Q8WUK0]6EBI-10172290,EBI-7199479
PVR [P15151]3EBI-10172290,EBI-3919694
R3HDM2 [Q9Y2K5]3EBI-10172290,EBI-948428
RNF175 [Q8N4F7]3EBI-10172290,EBI-10265447
RPF1 [Q9H9Y2]4EBI-10172290,EBI-9996007
RPL11 [P62913]3EBI-10172290,EBI-354380
RPL36AL [Q969Q0]3EBI-10172290,EBI-2877705
RPS28 [P62857]3EBI-10172290,EBI-353027
RPUSD3 [Q6P087]3EBI-10172290,EBI-5458784
RSPO2 [Q6UXX9]3EBI-10172290,EBI-8481036
RSPO2 - isoform 2 [Q6UXX9-2]3EBI-10172290,EBI-12009390
RTN4RL1 [Q86UN2]3EBI-10172290,EBI-10258951
RWDD2B [P57060]3EBI-10172290,EBI-724442
SCNM1 [Q9BWG6]3EBI-10172290,EBI-748391
SDCBP [O00560]3EBI-10172290,EBI-727004
SHFL [Q9NUL5]3EBI-10172290,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-10172290,EBI-11955083
SLC23A1 [Q9UHI7]3EBI-10172290,EBI-1759386
SLC25A48 [Q6ZT89]3EBI-10172290,EBI-10255185
SLC6A20 [Q9NP91]3EBI-10172290,EBI-10311198
SMCO4 [Q9NRQ5]3EBI-10172290,EBI-8640191
SMCP [P49901]6EBI-10172290,EBI-750494
SPACA9 [Q96E40]3EBI-10172290,EBI-722584
SPATA24 - isoform 2 [Q86W54-2]3EBI-10172290,EBI-12041693
SPATA8 [Q6RVD6]3EBI-10172290,EBI-8635958
SPG7 [Q9UQ90]3EBI-10172290,EBI-717201
SPRY1 [O43609]6EBI-10172290,EBI-3866665
SSX2IP [Q9Y2D8]3EBI-10172290,EBI-2212028
STK16 [O75716]3EBI-10172290,EBI-749295
SUV39H1 [O43463]6EBI-10172290,EBI-349968
TCEA2 [Q15560]3EBI-10172290,EBI-710310
TCEANC [Q8N8B7]3EBI-10172290,EBI-954696
TEDC2 [Q7L2K0]3EBI-10172290,EBI-8465456
TFAP2D [Q7Z6R9]5EBI-10172290,EBI-11952651
THAP1 [Q9NVV9]3EBI-10172290,EBI-741515
THAP6 [Q8TBB0]3EBI-10172290,EBI-3925505
TLE5 [Q08117]3EBI-10172290,EBI-717810
TLE5 - isoform 2 [Q08117-2]3EBI-10172290,EBI-11741437
TMA16 [Q96EY4]3EBI-10172290,EBI-1045338
TNP2 [Q4VB56]3EBI-10172290,EBI-10241829
TNS2 [Q63HR2]3EBI-10172290,EBI-949753
TOR1A [O14656]3EBI-10172290,EBI-524257
TREX1 - isoform 1 [Q9NSU2-1]3EBI-10172290,EBI-16746122
TRIM42 [Q8IWZ5]3EBI-10172290,EBI-5235829
TTPA [P49638]3EBI-10172290,EBI-10210710
TULP3 [O75386]3EBI-10172290,EBI-5357290
TXNDC5 [Q86UY0]3EBI-10172290,EBI-2825190
TYRO3 [Q06418]3EBI-10172290,EBI-3951628
UCP2 [P55851]3EBI-10172290,EBI-2842077
UXT [Q9UBK9]3EBI-10172290,EBI-357355
VASN [Q6EMK4]3EBI-10172290,EBI-10249550
VGLL3 - isoform 2 [A8MV65-2]3EBI-10172290,EBI-11957216
VTI1B [Q9UEU0]3EBI-10172290,EBI-723716
WNT11 [O96014]3EBI-10172290,EBI-8058160
WT1 - isoform 6 [P19544-6]3EBI-10172290,EBI-11745701
ZBTB24 [O43167]3EBI-10172290,EBI-744471
ZBTB48 [P10074]3EBI-10172290,EBI-744864
ZBTB9 [Q96C00]7EBI-10172290,EBI-395708
ZFP41 [Q8N8Y5]3EBI-10172290,EBI-12224489
ZFYVE26 - isoform 5 [Q68DK2-5]6EBI-10172290,EBI-8656416
ZIM2 [Q9NZV7]3EBI-10172290,EBI-11962760
ZNF101 [Q8IZC7]6EBI-10172290,EBI-5278328
ZNF124 [Q15973]3EBI-10172290,EBI-2555767
ZNF133 [P52736]3EBI-10172290,EBI-2687350
ZNF138 [P52744]3EBI-10172290,EBI-10746567
ZNF155 - isoform 2 [Q12901-2]3EBI-10172290,EBI-10227379
ZNF165 [Q53Z40]3EBI-10172290,EBI-10186058
ZNF169 [Q14929]3EBI-10172290,EBI-10234472
ZNF175 [Q9Y473]3EBI-10172290,EBI-3438881
ZNF180 [Q9UJW8]3EBI-10172290,EBI-10322527
ZNF2 - isoform 2 [Q9BSG1-2]3EBI-10172290,EBI-10297542
ZNF20 [P17024]3EBI-10172290,EBI-717634
ZNF223 [Q9UK11]4EBI-10172290,EBI-10322867
ZNF250 - isoform 3 [P15622-3]3EBI-10172290,EBI-10177272
ZNF256 [Q9Y2P7]3EBI-10172290,EBI-12223065
ZNF26 [P17031]3EBI-10172290,EBI-2841331
ZNF260 [Q3ZCT1]3EBI-10172290,EBI-10241410
ZNF264 [O43296]3EBI-10172290,EBI-4395808
ZNF266 [Q14584]5EBI-10172290,EBI-7115319
ZNF32 [P17041]3EBI-10172290,EBI-1965483
ZNF320 [A2RRD8]3EBI-10172290,EBI-10173019
ZNF329 [Q86UD4]3EBI-10172290,EBI-7233259
ZNF337 [Q9Y3M9]3EBI-10172290,EBI-714987
ZNF408 [Q9H9D4]3EBI-10172290,EBI-347633
ZNF41 [P51814]3EBI-10172290,EBI-2681830
ZNF414 [Q96IQ9]3EBI-10172290,EBI-744257
ZNF417 [Q8TAU3]6EBI-10172290,EBI-740727
ZNF418 [Q8TF45]3EBI-10172290,EBI-3446851
ZNF419 [Q96HQ0]3EBI-10172290,EBI-10288482
ZNF420 [Q8TAQ5]3EBI-10172290,EBI-3923307
ZNF425 [Q6IV72]3EBI-10172290,EBI-10250516
ZNF433 [Q8N7K0]3EBI-10172290,EBI-10267553
ZNF439 [Q8NDP4]3EBI-10172290,EBI-747580
ZNF440 [Q8IYI8]3EBI-10172290,EBI-726439
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-10172290,EBI-12010736
ZNF490 [Q9ULM2]6EBI-10172290,EBI-1105370
ZNF491 [Q8N8L2]5EBI-10172290,EBI-12019860
ZNF524 [Q96C55]3EBI-10172290,EBI-10283126
ZNF543 [Q08ER8]3EBI-10172290,EBI-10226133
ZNF555 [Q8NEP9]3EBI-10172290,EBI-10270752
ZNF564 [Q8TBZ8]6EBI-10172290,EBI-10273713
ZNF572 [Q7Z3I7]3EBI-10172290,EBI-10172590
ZNF575 [Q86XF7]3EBI-10172290,EBI-14069183
ZNF578 [Q3MI94]3EBI-10172290,EBI-10241108
ZNF578 [Q96N58]3EBI-10172290,EBI-11955189
ZNF580 [Q9UK33]3EBI-10172290,EBI-746277
ZNF581 [Q9P0T4]6EBI-10172290,EBI-745520
ZNF587 [Q96SQ5]6EBI-10172290,EBI-6427977
ZNF625 [Q96I27]3EBI-10172290,EBI-4395587
ZNF667 [Q5HYK9]3EBI-10172290,EBI-7115499
ZNF670 [Q9BS34]3EBI-10172290,EBI-745276
ZNF696 [Q9H7X3]5EBI-10172290,EBI-11090299
ZNF697 [Q8N508]3EBI-10172290,EBI-10265733
ZNF707 [Q96C28]3EBI-10172290,EBI-748111
ZNF764 [Q96H86]3EBI-10172290,EBI-745775
ZNF774 [Q6NX45]3EBI-10172290,EBI-10251462
ZNF778 [Q96MU6]3EBI-10172290,EBI-10291463
ZNF786 [Q8N393]3EBI-10172290,EBI-10265203
ZNF792 [Q3KQV3]3EBI-10172290,EBI-10240849
ZNF837 [Q96EG3]3EBI-10172290,EBI-11962574
ZNF844 [Q08AG5]3EBI-10172290,EBI-10225757
ZNF846 [Q147U1]3EBI-10172290,EBI-10234020
ZNHIT1 [O43257]3EBI-10172290,EBI-347522
ZSCAN10 [Q96SZ4]3EBI-10172290,EBI-14934888
ZSCAN21 [Q9Y5A6]3EBI-10172290,EBI-10281938
ZSCAN26 [Q16670]7EBI-10172290,EBI-3920053
B0FTY23EBI-10172290,EBI-10175366
Q53FW83EBI-10172290,EBI-10242473
Q5BKY63EBI-10172290,EBI-10243533
Q5XG853EBI-10172290,EBI-10248413
Q9H6F03EBI-10172290,EBI-10307481

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132126, 283 interactors

Protein interaction database and analysis system

More...
IntActi
P60409, 278 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000476821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60409, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 4515
Repeati46 – 5025
Repeati67 – 7135
Repeati89 – 9345
Repeati99 – 10355
Repeati109 – 11365
Repeati114 – 11875
Repeati119 – 12385
Repeati135 – 13995
Repeati145 – 149105
Repeati155 – 159115
Repeati160 – 164125
Repeati172 – 176135
Repeati186 – 190145
Repeati208 – 212155
Repeati218 – 222165
Repeati228 – 232175
Repeati233 – 237185
Repeati238 – 242195
Repeati250 – 254205
Repeati255 – 259215
Repeati265 – 269225
Repeati270 – 274235
Repeati275 – 279245
Repeati287 – 291255
Repeati297 – 301265
Repeati302 – 306275
Repeati321 – 325285
Repeati339 – 343295
Repeati359 – 363305

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni36 – 36330 X 5 AA repeats of C-C-X(3)Add BLAST328

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163845

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_062832_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60409

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQESSCV

Database of Orthologous Groups

More...
OrthoDBi
1629708at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60409

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60409-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASTMSVCS SDLSYGSRVC LPGSCDSCSD SWQVDDCPES CCEPPCCAPA
60 70 80 90 100
PCLSLVCTPV SYVSSPCCRV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC
110 120 130 140 150
ASSPCQQACC VPVCCKTVCC KPVYCVPVCS GDSSCCQQSS CQSACCTSSP
160 170 180 190 200
CQQACCVPIC CKPVCSGISS SCCQQSSCVS CVSSPCCQAV CEPSPCQSGC
210 220 230 240 250
ISSCTPSCCQ QSSCKPACCT SSPCQQACCV PVCCKPVCCV PTCSDDSGSC
260 270 280 290 300
CQPACCTSSQ SQQGCCVPVC CKPVCCVPVC SGASTSCCQQ SSCQPACCTT
310 320 330 340 350
SCCRPSSSVS LLCRPVCRPA CCVPVPSCCA PTSSCQASCC RPASCVSLLC
360 370
RPACSRPACC GPTSTQKSSC
Length:370
Mass (Da):37,372
Last modified:December 5, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7D44544DEC05BCB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047852111V → M. Corresponds to variant dbSNP:rs944419Ensembl.1
Natural variantiVAR_060051124Y → C. Corresponds to variant dbSNP:rs233308Ensembl.1
Natural variantiVAR_047853215K → Q. Corresponds to variant dbSNP:rs363877Ensembl.1
Natural variantiVAR_047854285T → S. Corresponds to variant dbSNP:rs446817Ensembl.1
Natural variantiVAR_047855320A → T. Corresponds to variant dbSNP:rs369720Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB076354 mRNA Translation: BAD01541.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09413.1
BC119643 mRNA Translation: AAI19644.1
AJ566385 mRNA Translation: CAD97465.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74803.1

NCBI Reference Sequences

More...
RefSeqi
NP_941962.1, NM_198689.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000609664; ENSP00000476821; ENSG00000272804

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
386675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:386675

UCSC genome browser

More...
UCSCi
uc032qbr.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076354 mRNA Translation: BAD01541.1
AL773602 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09413.1
BC119643 mRNA Translation: AAI19644.1
AJ566385 mRNA Translation: CAD97465.1
CCDSiCCDS74803.1
RefSeqiNP_941962.1, NM_198689.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132126, 283 interactors
IntActiP60409, 278 interactors
STRINGi9606.ENSP00000476821

PTM databases

iPTMnetiP60409
PhosphoSitePlusiP60409

Polymorphism and mutation databases

BioMutaiKRTAP10-7
DMDMi116242611

Proteomic databases

MassIVEiP60409
PaxDbiP60409
PeptideAtlasiP60409
PRIDEiP60409

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
76638, 2 antibodies

Genome annotation databases

EnsembliENST00000609664; ENSP00000476821; ENSG00000272804
GeneIDi386675
KEGGihsa:386675
UCSCiuc032qbr.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
386675
EuPathDBiHostDB:ENSG00000272804.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP10-7
HGNCiHGNC:22970, KRTAP10-7
HPAiENSG00000272804, Not detected
neXtProtiNX_P60409
OpenTargetsiENSG00000272804
PharmGKBiPA134976547

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00940000163845
HOGENOMiCLU_062832_0_0_1
InParanoidiP60409
OMAiCQESSCV
OrthoDBi1629708at2759
PhylomeDBiP60409

Enzyme and pathway databases

PathwayCommonsiP60409
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
386675, 1 hit in 94 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
386675
PharosiP60409, Tdark

Protein Ontology

More...
PROi
PR:P60409
RNActiP60409, protein

Gene expression databases

BgeeiENSG00000272804, Expressed in skin of leg and 10 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 4 hits
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR107_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60409
Secondary accession number(s): Q0VDJ8, Q70LJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 5, 2018
Last modified: December 2, 2020
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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