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Protein

50S ribosomal protein L2

Gene

rplB

Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial (By similarity). Makes several contacts with the 16S rRNA (forming bridge B7b) in the 70S ribosome.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciTTHE300852:G1GKC-1695-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2
Gene namesi
Name:rplB
Ordered Locus Names:TTHA1689
OrganismiThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Taxonomic identifieri300852 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000000532 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001296412 – 27650S ribosomal protein L2Add BLAST275

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome, contacting the 16S rRNA. May also make transient contacts with protein S6 during translation in the 70S ribosome.

Protein-protein interaction databases

STRINGi300852.TTHA1689

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 15Combined sources5
Turni22 – 24Combined sources3
Beta strandi32 – 35Combined sources4
Beta strandi43 – 51Combined sources9
Helixi69 – 72Combined sources4
Beta strandi77 – 83Combined sources7
Beta strandi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi102 – 106Combined sources5
Beta strandi130 – 132Combined sources3
Helixi133 – 135Combined sources3
Beta strandi141 – 145Combined sources5
Beta strandi153 – 156Combined sources4
Beta strandi163 – 169Combined sources7
Beta strandi172 – 176Combined sources5
Beta strandi182 – 186Combined sources5
Beta strandi189 – 194Combined sources6
Helixi199 – 203Combined sources5
Turni209 – 216Combined sources8
Turni228 – 230Combined sources3
Beta strandi243 – 245Combined sources3
Turni265 – 268Combined sources4

3D structure databases

ProteinModelPortaliP60405
SMRiP60405
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60405

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CFD Bacteria
COG0090 LUCA
HOGENOMiHOG000232982
KOiK02886
OMAiHGYIKGV
PhylomeDBiP60405

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_B Ribosomal_L2_B, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR005880 Ribosomal_L2_bac/org-type
IPR022669 Ribosomal_L2_C
IPR022671 Ribosomal_L2_CS
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR01171 rplB_bact, 1 hit
PROSITEiView protein in PROSITE
PS00467 RIBOSOMAL_L2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKKFKPYT PSRRFMTVAD FSEITKTEPE KSLVKPLKKT GGRNNQGRIT
60 70 80 90 100
VRFRGGGHKR LYRIIDFKRW DKVGIPAKVA AIEYDPNRSA RIALLHYVDG
110 120 130 140 150
EKRYIIAPDG LQVGQQVVAG PDAPIQVGNA LPLRFIPVGT VVHAVELEPK
160 170 180 190 200
KGAKLARAAG TSAQIQGREG DYVILRLPSG ELRKVHGECY ATVGAVGNAD
210 220 230 240 250
HKNIVLGKAG RSRWLGRRPH VRGAAMNPVD HPHGGGEGRA PRGRPPASPW
260 270
GWQTKGLKTR KRRKPSSRFI IARRKK
Length:276
Mass (Da):30,468
Last modified:January 23, 2007 - v3
Checksum:i7CF40C2BD586349B
GO

Mass spectrometryi

Molecular mass is 30337 Da from positions 2 - 276. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP008226 Genomic DNA Translation: BAD71512.1
RefSeqiWP_011173712.1, NC_006461.1
YP_144955.1, NC_006461.1

Genome annotation databases

EnsemblBacteriaiBAD71512; BAD71512; BAD71512
GeneIDi3168720
KEGGittj:TTHA1689
PATRICifig|300852.9.peg.1659

Similar proteinsi

Entry informationi

Entry nameiRL2_THET8
AccessioniPrimary (citable) accession number: P60405
Secondary accession number(s): Q5SHP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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