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Entry version 125 (10 Feb 2021)
Sequence version 2 (25 Nov 2008)
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Protein

Keratin-associated protein 10-5

Gene

KRTAP10-5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P60370

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-5
Alternative name(s):
High sulfur keratin-associated protein 10.5
Keratin-associated protein 10.5
Keratin-associated protein 18-5
Keratin-associated protein 18.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-5
Synonyms:KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22969, KRTAP10-5

neXtProt; the human protein knowledge platform

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neXtProti
NX_P60370

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000241123.1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134950015

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P60370, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP10-5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852131 – 271Keratin-associated protein 10-5Add BLAST271

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P60370

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60370

PeptideAtlas

More...
PeptideAtlasi
P60370

PRoteomics IDEntifications database

More...
PRIDEi
P60370

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57199

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241123, Expressed in skin of leg and 12 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241123, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60370
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]6EBI-10172150,EBI-10173507
AEN [Q8WTP8]3EBI-10172150,EBI-8637627
ALDH3B1 [P43353]3EBI-10172150,EBI-2558314
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-10172150,EBI-10187270
BCL6B [A8KA13]3EBI-10172150,EBI-10174813
BMP7 [A8K571]3EBI-10172150,EBI-10174327
BYSL [Q13895]5EBI-10172150,EBI-358049
C11orf87 [Q6NUJ2]3EBI-10172150,EBI-6660291
C17orf50 [Q8WW18]3EBI-10172150,EBI-12877892
CARD9 [Q9H257]3EBI-10172150,EBI-751319
CATSPER1 [Q8NEC5]3EBI-10172150,EBI-744545
CHRD [Q9H2X0]3EBI-10172150,EBI-947551
CNNM3 [Q8NE01]3EBI-10172150,EBI-741032
CREB5 - isoform 3 [Q02930-3]6EBI-10172150,EBI-10192698
CYSRT1 [A8MQ03]3EBI-10172150,EBI-3867333
DHX57 [Q6P158]3EBI-10172150,EBI-1051531
ECE1 [P42892]3EBI-10172150,EBI-2859983
EIF4E2 [O60573]3EBI-10172150,EBI-398610
ENKD1 [Q9H0I2]3EBI-10172150,EBI-744099
FAM74A6 [Q5TZK3]3EBI-10172150,EBI-10247271
FAM76B [Q5HYJ3]5EBI-10172150,EBI-751192
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-10172150,EBI-11956087
FARS2 [O95363]3EBI-10172150,EBI-2513774
FBXO34 [Q9NWN3]3EBI-10172150,EBI-719816
FCHO1 [A0A0C3SFZ9]3EBI-10172150,EBI-11977403
GATA1 [P15976]3EBI-10172150,EBI-3909284
GLRX3 [O76003]6EBI-10172150,EBI-374781
GNE [Q9Y223]3EBI-10172150,EBI-4291090
GOLGA8DP [Q0D2H9]3EBI-10172150,EBI-10181276
HHEX [Q03014]3EBI-10172150,EBI-747421
HOXA1 [P49639]6EBI-10172150,EBI-740785
HPCAL1 [P37235]3EBI-10172150,EBI-749311
itself3EBI-10172150,EBI-10172150
KRTAP10-6 [P60371]3EBI-10172150,EBI-12012928
KRTAP10-7 [P60409]3EBI-10172150,EBI-10172290
KRTAP10-8 [P60410]3EBI-10172150,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-10172150,EBI-1052037
KRTAP12-1 [P59990]3EBI-10172150,EBI-10210845
KRTAP12-2 [P59991]3EBI-10172150,EBI-10176379
KRTAP13-2 [Q52LG2]3EBI-10172150,EBI-11953846
KRTAP2-3 [P0C7H8]3EBI-10172150,EBI-10196781
KRTAP26-1 [Q6PEX3]3EBI-10172150,EBI-3957672
KRTAP3-2 [Q9BYR7]6EBI-10172150,EBI-751260
KRTAP4-12 [Q9BQ66]3EBI-10172150,EBI-739863
KRTAP4-2 [Q9BYR5]8EBI-10172150,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-10172150,EBI-11958132
KRTAP5-6 [Q6L8G9]3EBI-10172150,EBI-10250562
KRTAP5-9 [P26371]8EBI-10172150,EBI-3958099
KRTAP9-2 [Q9BYQ4]5EBI-10172150,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-10172150,EBI-1043191
KRTAP9-4 [Q9BYQ2]5EBI-10172150,EBI-10185730
KRTAP9-8 [Q9BYQ0]3EBI-10172150,EBI-11958364
LCE1B [Q5T7P3]10EBI-10172150,EBI-10245913
LCE1C [Q5T751]5EBI-10172150,EBI-12224199
LCE1D [Q5T752]3EBI-10172150,EBI-11741311
LCE1E [Q5T753]3EBI-10172150,EBI-11955335
LCE2A [Q5TA79]6EBI-10172150,EBI-10246607
LCE2C [Q5TA81]3EBI-10172150,EBI-11973993
LCE2D [Q5TA82]3EBI-10172150,EBI-10246750
LCE3B [Q5TA77]3EBI-10172150,EBI-11974495
LCE3C [Q5T5A8]7EBI-10172150,EBI-10245291
LCE3D [Q9BYE3]6EBI-10172150,EBI-6658837
LCE3E [Q5T5B0]8EBI-10172150,EBI-10245456
LCE4A [Q5TA78]3EBI-10172150,EBI-10246358
LCE5A [Q5TCM9]3EBI-10172150,EBI-11955689
LELP1 [Q5T871]3EBI-10172150,EBI-18115868
LIMS2 - isoform 5 [Q7Z4I7-5]3EBI-10172150,EBI-10257651
LUZP4 [Q9P127]3EBI-10172150,EBI-10198848
MEOX2 [P50222]3EBI-10172150,EBI-748397
MEOX2 [Q6FHY5]3EBI-10172150,EBI-16439278
MOBP [Q13875]3EBI-10172150,EBI-10230628
MT1DP [A1L3X4]3EBI-10172150,EBI-10172129
MXI1 - isoform 3 [P50539-3]3EBI-10172150,EBI-10211940
NAA10 [P41227]3EBI-10172150,EBI-747693
NECTIN2 [Q92692]3EBI-10172150,EBI-718419
NOTCH2NLA [Q7Z3S9]3EBI-10172150,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-10172150,EBI-22310682
NPDC1 [Q9NQX5]3EBI-10172150,EBI-748927
NR4A1 [P22736]3EBI-10172150,EBI-721550
NR4A3 [Q92570]5EBI-10172150,EBI-13644623
NTAQ1 [Q96HA8]3EBI-10172150,EBI-741158
NUFIP2 [Q7Z417]6EBI-10172150,EBI-1210753
OTX1 [P32242]6EBI-10172150,EBI-740446
POU4F2 [Q12837]3EBI-10172150,EBI-17236143
PRKAB2 [O43741]3EBI-10172150,EBI-1053424
PRKAG1 [P54619]3EBI-10172150,EBI-1181439
PRR13 [Q9NZ81]3EBI-10172150,EBI-740924
RBP3 [P10745]3EBI-10172150,EBI-12806054
SCNM1 [Q9BWG6]3EBI-10172150,EBI-748391
SHFL [Q9NUL5]3EBI-10172150,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-10172150,EBI-11955083
SLC23A1 [Q9UHI7]3EBI-10172150,EBI-1759386
SLC6A20 [Q9NP91]3EBI-10172150,EBI-10311198
SMCP [P49901]3EBI-10172150,EBI-750494
SPACA9 [Q96E40]3EBI-10172150,EBI-722584
SPRY1 [O43609]3EBI-10172150,EBI-3866665
SPRY2 [O43597]3EBI-10172150,EBI-742487
STK16 [O75716]3EBI-10172150,EBI-749295
THAP10 [Q9P2Z0]3EBI-10172150,EBI-745404
TNP2 [Q4VB56]3EBI-10172150,EBI-10241829
TNS2 [Q63HR2]3EBI-10172150,EBI-949753
TRIM42 [Q8IWZ5]3EBI-10172150,EBI-5235829
TRPV6 [Q9Y260]3EBI-10172150,EBI-750052
TULP3 [O75386]3EBI-10172150,EBI-5357290
TXNDC5 [Q86UY0]3EBI-10172150,EBI-2825190
TYMSOS [Q8TAI1]3EBI-10172150,EBI-742060
UTP23 [Q9BRU9]3EBI-10172150,EBI-5457544
WT1-AS [Q06250]3EBI-10172150,EBI-10223946
YY1 [P25490]3EBI-10172150,EBI-765538
ZBTB24 [O43167]3EBI-10172150,EBI-744471
ZBTB48 [P10074]3EBI-10172150,EBI-744864
ZFYVE21 [Q9BQ24]3EBI-10172150,EBI-2849569
ZNF124 [Q15973]3EBI-10172150,EBI-2555767
ZNF20 [P17024]3EBI-10172150,EBI-717634
ZNF264 [Q14C61]3EBI-10172150,EBI-2826570
ZNF273 [Q14593]3EBI-10172150,EBI-3922471
ZNF286A - isoform 2 [Q9HBT8-2]3EBI-10172150,EBI-10310244
ZNF32 [P17041]3EBI-10172150,EBI-1965483
ZNF320 [A2RRD8]3EBI-10172150,EBI-10173019
ZNF329 [Q86UD4]3EBI-10172150,EBI-7233259
ZNF34 [Q8IZ26]3EBI-10172150,EBI-10264496
ZNF417 [Q8TAU3]5EBI-10172150,EBI-740727
ZNF433 [Q8N7K0]3EBI-10172150,EBI-10267553
ZNF439 [Q8NDP4]3EBI-10172150,EBI-747580
ZNF440 [Q8IYI8]3EBI-10172150,EBI-726439
ZNF559 [Q9BR84]4EBI-10172150,EBI-746605
ZNF572 [Q7Z3I7]3EBI-10172150,EBI-10172590
ZNF578 [Q96N58]3EBI-10172150,EBI-11955189
ZNF587 [Q96SQ5]6EBI-10172150,EBI-6427977
ZNF670 [Q9BS34]3EBI-10172150,EBI-745276
ZNF679 [Q8IYX0]3EBI-10172150,EBI-745567
ZNF696 [Q9H7X3]3EBI-10172150,EBI-11090299
ZNF697 [Q8N508]3EBI-10172150,EBI-10265733
ZNF707 [Q96C28]3EBI-10172150,EBI-748111
ZNF785 [A8K8V0]3EBI-10172150,EBI-3925400
ZNF792 [Q3KQV3]3EBI-10172150,EBI-10240849
ZSCAN21 [Q9Y5A6]3EBI-10172150,EBI-10281938
ZSCAN26 [Q16670]3EBI-10172150,EBI-3920053
Q5BKY63EBI-10172150,EBI-10243533
Q5XG853EBI-10172150,EBI-10248413
Q9NWL93EBI-10172150,EBI-10315054

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P60370, 138 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383223

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60370, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 3015
Repeati51 – 5525
Repeati73 – 7735
Repeati78 – 8245
Repeati88 – 9255
Repeati93 – 9765
Repeati98 – 10275
Repeati110 – 11485
Repeati120 – 12495
Repeati130 – 134105
Repeati135 – 139115
Repeati140 – 144125
Repeati152 – 156135
Repeati162 – 166145
Repeati177 – 181155
Repeati187 – 191165
Repeati199 – 203175
Repeati209 – 213185
Repeati214 – 218195
Repeati233 – 237205
Repeati240 – 244215
Repeati251 – 255225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 25522 X 5 AA repeats of C-C-X(3)Add BLAST230

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_062832_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60370

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60370

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP
60 70 80 90 100
CCQAACEPSP CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL
110 120 130 140 150
PTCSKDSSSC CQQSSCQPTC CASSSCQQSC CVPVCCKPVC CVPTCSEDSS
160 170 180 190 200
SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP VCFKPICCVP VCSGASTSCC
210 220 230 240 250
QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC CAPASSYQAS
260 270
CCRPASCVSL LCRPACSRLA C
Length:271
Mass (Da):27,626
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20E32DB102D523ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0621134C → S. Corresponds to variant dbSNP:rs5017208Ensembl.1
Natural variantiVAR_01769620D → N1 PublicationCorresponds to variant dbSNP:rs2020221Ensembl.1
Natural variantiVAR_047505183F → C. Corresponds to variant dbSNP:rs380585Ensembl.1
Natural variantiVAR_017697235V → L1 PublicationCorresponds to variant dbSNP:rs464424Ensembl.1
Natural variantiVAR_047506247Y → C. Corresponds to variant dbSNP:rs7509970Ensembl.1
Natural variantiVAR_047507268R → P1 PublicationCorresponds to variant dbSNP:rs464391Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB076352 mRNA Translation: BAD01539.1
AL773602 Genomic DNA No translation available.
BC120949 mRNA Translation: AAI20950.1
BC120950 mRNA Translation: AAI20951.1
AJ566384 mRNA Translation: CAD97464.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42958.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000400372; ENSP00000383223; ENSG00000241123

UCSC genome browser

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UCSCi
uc002zfl.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076352 mRNA Translation: BAD01539.1
AL773602 Genomic DNA No translation available.
BC120949 mRNA Translation: AAI20950.1
BC120950 mRNA Translation: AAI20951.1
AJ566384 mRNA Translation: CAD97464.1
CCDSiCCDS42958.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiP60370, 138 interactors
STRINGi9606.ENSP00000383223

Genetic variation databases

BioMutaiKRTAP10-5
DMDMi215274018

Proteomic databases

MassIVEiP60370
PaxDbiP60370
PeptideAtlasiP60370
PRIDEiP60370
ProteomicsDBi57199

Genome annotation databases

EnsembliENST00000400372; ENSP00000383223; ENSG00000241123
UCSCiuc002zfl.2, human

Organism-specific databases

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP10-5
HGNCiHGNC:22969, KRTAP10-5
HPAiENSG00000241123, Tissue enriched (skin)
neXtProtiNX_P60370
PharmGKBiPA134950015
VEuPathDBiHostDB:ENSG00000241123.1

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
HOGENOMiCLU_062832_0_0_1
InParanoidiP60370
PhylomeDBiP60370
TreeFamiTF351356

Enzyme and pathway databases

PathwayCommonsiP60370
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

PharosiP60370, Tdark

Protein Ontology

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PROi
PR:P60370
RNActiP60370, protein

Gene expression databases

BgeeiENSG00000241123, Expressed in skin of leg and 12 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 3 hits
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR105_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60370
Secondary accession number(s): Q0VAR7, Q0VAR8, Q70LJ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: November 25, 2008
Last modified: February 10, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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