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Protein

tRNA pseudouridine synthase D

Gene

truD

Organism
Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(13) = tRNA pseudouridine(13).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82NucleophileUniRule annotation1

GO - Molecular functioni

  • pseudouridine synthase activity Source: GO_Central
  • RNA binding Source: InterPro
  • tRNA pseudouridine synthase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processtRNA processing

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-563-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase DUniRule annotation (EC:5.4.99.27UniRule annotation)
Alternative name(s):
tRNA pseudouridine(13) synthaseUniRule annotation
tRNA pseudouridylate synthase DUniRule annotation
tRNA-uridine isomerase DUniRule annotation
Gene namesi
Name:truDUniRule annotation
Ordered Locus Names:GSU0520
OrganismiGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
Taxonomic identifieri243231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000000577 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001524991 – 408tRNA pseudouridine synthase DAdd BLAST408

Interactioni

Protein-protein interaction databases

STRINGi243231.GSU0520

Structurei

3D structure databases

ProteinModelPortaliP60347
SMRiP60347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 367TRUDUniRule annotationAdd BLAST211

Sequence similaritiesi

Belongs to the pseudouridine synthase TruD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
InParanoidiP60347
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit

Sequencei

Sequence statusi: Complete.

P60347-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARDEHDSRY LTAELPGTGG LFKETPEDFL VEEISLYLPC GEGEHTYAVI
60 70 80 90 100
EKRGITTLEA IRRLCRATGA PERDTGYAGM KDARGITRQT VSLPRVTPAE
110 120 130 140 150
VMGLNIPGIR ILSADRHRNK LRLGHLAGNR FRLRLRETVP DAADRARAIL
160 170 180 190 200
DVLARRGVPN RFGEQRYGIQ GNSHLVGRAM LAGDWRGAVD LLMGDPAKVE
210 220 230 240 250
GERWRAAIEA YRQGDLAGSL SLFPGHCRTE RDVLQRLAKR PDDFERAVHG
260 270 280 290 300
VHPRLKKLYL SACQSALFDR VLETRLQTID HVMEGDLAWK HDNGACFLVT
310 320 330 340 350
DAKAEAPRAE RFEISPTGPL FGCRMTSPEG EPAALEKSIL DAAGLTPAAF
360 370 380 390 400
NLAGGLRMEG ERRPLRVPLE GPELSCEEED LVLRFSLPRG SYATAVLREV

MKRPGNGA
Length:408
Mass (Da):45,099
Last modified:February 16, 2004 - v1
Checksum:i04BE7A4013CEB7C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR33851.1
RefSeqiNP_951578.1, NC_002939.5
WP_010941188.1, NC_002939.5

Genome annotation databases

EnsemblBacteriaiAAR33851; AAR33851; GSU0520
GeneIDi2686060
KEGGigsu:GSU0520
PATRICifig|243231.5.peg.521

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017180 Genomic DNA Translation: AAR33851.1
RefSeqiNP_951578.1, NC_002939.5
WP_010941188.1, NC_002939.5

3D structure databases

ProteinModelPortaliP60347
SMRiP60347
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243231.GSU0520

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAR33851; AAR33851; GSU0520
GeneIDi2686060
KEGGigsu:GSU0520
PATRICifig|243231.5.peg.521

Phylogenomic databases

eggNOGiENOG4106NZV Bacteria
COG0585 LUCA
HOGENOMiHOG000224848
InParanoidiP60347
KOiK06176
OMAiLWLWVEK
OrthoDBiPOG091H03KK

Enzyme and pathway databases

BioCyciGSUL243231:G1G0I-563-MONOMER

Family and domain databases

HAMAPiMF_01082 TruD, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001656 PsdUridine_synth_TruD
IPR020119 PsdUridine_synth_TruD_CS
IPR011760 PsdUridine_synth_TruD_insert
PANTHERiPTHR13326 PTHR13326, 1 hit
PfamiView protein in Pfam
PF01142 TruD, 1 hit
PIRSFiPIRSF037016 Pseudouridin_synth_euk_prd, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00094 tRNA_TruD_broad, 1 hit
PROSITEiView protein in PROSITE
PS50984 TRUD, 1 hit
PS01268 UPF0024, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRUD_GEOSL
AccessioniPrimary (citable) accession number: P60347
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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