UniProtKB - P60335 (PCBP1_MOUSE)
Protein
Poly(rC)-binding protein 1
Gene
Pcbp1
Organism
Mus musculus (Mouse)
Status
Functioni
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.By similarity
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA binding Source: MGI
- RNA binding Source: MGI
- sequence-specific single stranded DNA binding Source: MGI
- single-stranded DNA binding Source: MGI
- translation activator activity Source: MGI
GO - Biological processi
- mRNA processing Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of gene expression Source: GO_Central
- regulation of RNA metabolic process Source: GO_Central
- viral RNA genome replication Source: MGI
Keywordsi
Molecular function | DNA-binding, Ribonucleoprotein, RNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Names & Taxonomyi
Protein namesi | Recommended name: Poly(rC)-binding protein 1Alternative name(s): Alpha-CP1 Heterogeneous nuclear ribonucleoprotein E1 Short name: hnRNP E1 |
Gene namesi | Name:Pcbp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1345635, Pcbp1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- cytoplasmic ribonucleoprotein granule Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050088 | 1 – 356 | Poly(rC)-binding protein 1Add BLAST | 356 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Cross-linki | 115 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 173 | PhosphoserineCombined sources | 1 | |
Modified residuei | 189 | PhosphoserineCombined sources | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 246 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 273 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P60335 |
jPOSTi | P60335 |
MaxQBi | P60335 |
PaxDbi | P60335 |
PeptideAtlasi | P60335 |
PRIDEi | P60335 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128904 P60335 |
PTM databases
iPTMneti | P60335 |
PhosphoSitePlusi | P60335 |
SwissPalmi | P60335 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000051695, Expressed in metanephric ureteric bud and 306 other tissues |
Genevisiblei | P60335, MM |
Interactioni
Binary interactionsi
P60335
With | #Exp. | IntAct |
---|---|---|
Hdac9 [Q99N13] | 6 | EBI-309059,EBI-645361 |
Protein-protein interaction databases
BioGRIDi | 204835, 50 interactors |
IntActi | P60335, 18 interactors |
MINTi | P60335 |
STRINGi | 10090.ENSMUSP00000054863 |
Miscellaneous databases
RNActi | P60335, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 75 | KH 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 97 – 162 | KH 2PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 279 – 343 | KH 3PROSITE-ProRule annotationAdd BLAST | 65 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2190, Eukaryota |
GeneTreei | ENSGT00940000161582 |
HOGENOMi | CLU_022670_0_1_1 |
InParanoidi | P60335 |
OMAi | TLTKLHQ |
OrthoDBi | 954970at2759 |
PhylomeDBi | P60335 |
TreeFami | TF318292 |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
i Sequence
Sequence statusi: Complete.
P60335-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDAGVTESGL NVTLTIRLLM HGKEVGSIIG KKGESVKRIR EESGARINIS
60 70 80 90 100
EGNCPERIIT LTGPTNAIFK AFAMIIDKLE EDINSSMTNS TAASRPPVTL
110 120 130 140 150
RLVVPATQCG SLIGKGGCKI KEIRESTGAQ VQVAGDMLPN STERAITIAG
160 170 180 190 200
VPQSVTECVK QICLVMLETL SQSPQGRVMT IPYQPMPASS PVICAGGQDR
210 220 230 240 250
CSDAAGYPHA THDLEGPPLD AYSIQGQHTI SPLDLAKLNQ VARQQSHFAM
260 270 280 290 300
MHGGTGFAGI DSSSPEVKGY WASLDASTQT THELTIPNNL IGCIIGRQGA
310 320 330 340 350
NINEIRQMSG AQIKIANPVE GSSGRQVTIT GSAASISLAQ YLINARLSSE
KGMGCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF139894 mRNA Translation: AAD51920.1 AF139895 Genomic DNA Translation: AAD51921.1 BC069915 mRNA Translation: AAH69915.1 BC004793 mRNA Translation: AAH04793.1 |
CCDSi | CCDS20314.1 |
RefSeqi | NP_035995.1, NM_011865.3 |
Genome annotation databases
Ensembli | ENSMUST00000053015; ENSMUSP00000054863; ENSMUSG00000051695 |
GeneIDi | 23983 |
KEGGi | mmu:23983 |
UCSCi | uc009csc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF139894 mRNA Translation: AAD51920.1 AF139895 Genomic DNA Translation: AAD51921.1 BC069915 mRNA Translation: AAH69915.1 BC004793 mRNA Translation: AAH04793.1 |
CCDSi | CCDS20314.1 |
RefSeqi | NP_035995.1, NM_011865.3 |
3D structure databases
SMRi | P60335 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204835, 50 interactors |
IntActi | P60335, 18 interactors |
MINTi | P60335 |
STRINGi | 10090.ENSMUSP00000054863 |
PTM databases
iPTMneti | P60335 |
PhosphoSitePlusi | P60335 |
SwissPalmi | P60335 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00128904 P60335 |
Proteomic databases
EPDi | P60335 |
jPOSTi | P60335 |
MaxQBi | P60335 |
PaxDbi | P60335 |
PeptideAtlasi | P60335 |
PRIDEi | P60335 |
Protocols and materials databases
Antibodypediai | 16295, 421 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000053015; ENSMUSP00000054863; ENSMUSG00000051695 |
GeneIDi | 23983 |
KEGGi | mmu:23983 |
UCSCi | uc009csc.1, mouse |
Organism-specific databases
CTDi | 5093 |
MGIi | MGI:1345635, Pcbp1 |
Phylogenomic databases
eggNOGi | KOG2190, Eukaryota |
GeneTreei | ENSGT00940000161582 |
HOGENOMi | CLU_022670_0_1_1 |
InParanoidi | P60335 |
OMAi | TLTKLHQ |
OrthoDBi | 954970at2759 |
PhylomeDBi | P60335 |
TreeFami | TF318292 |
Enzyme and pathway databases
Reactomei | R-MMU-72163, mRNA Splicing - Major Pathway R-MMU-72203, Processing of Capped Intron-Containing Pre-mRNA |
Miscellaneous databases
BioGRID-ORCSi | 23983, 6 hits in 13 CRISPR screens |
ChiTaRSi | Pcbp1, mouse |
PROi | PR:P60335 |
RNActi | P60335, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000051695, Expressed in metanephric ureteric bud and 306 other tissues |
Genevisiblei | P60335, MM |
Family and domain databases
Gene3Di | 3.30.1370.10, 3 hits |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf |
Pfami | View protein in Pfam PF00013, KH_1, 3 hits |
SMARTi | View protein in SMART SM00322, KH, 3 hits |
SUPFAMi | SSF54791, SSF54791, 3 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCBP1_MOUSE | |
Accessioni | P60335Primary (citable) accession number: P60335 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | February 16, 2004 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot