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Entry version 123 (26 Feb 2020)
Sequence version 2 (25 Nov 2008)
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Protein

Keratin-associated protein 10-1

Gene

KRTAP10-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 10-1
Alternative name(s):
High sulfur keratin-associated protein 10.1
Keratin-associated protein 10.1
Keratin-associated protein 18-1
Keratin-associated protein 18.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP10-1
Synonyms:KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22966 KRTAP10-1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60331

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000215455

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884303

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P60331 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP10-1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274024

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001852091 – 282Keratin-associated protein 10-1Add BLAST282

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P60331

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60331

PeptideAtlas

More...
PeptideAtlasi
P60331

PRoteomics IDEntifications database

More...
PRIDEi
P60331

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57196

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000215455 Expressed in skin of leg and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
132128, 76 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000383226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60331 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati26 – 3015
Repeati31 – 3525
Repeati36 – 4035
Repeati57 – 6145
Repeati79 – 8355
Repeati89 – 9365
Repeati99 – 10375
Repeati104 – 10885
Repeati109 – 11395
Repeati121 – 125105
Repeati131 – 135115
Repeati141 – 145125
Repeati146 – 150135
Repeati163 – 167145
Repeati173 – 177155
Repeati183 – 187165
Repeati193 – 197175
Repeati198 – 202185
Repeati210 – 214195
Repeati220 – 224205
Repeati225 – 229215
Repeati244 – 248225
Repeati251 – 255235
Repeati262 – 266245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 26624 X 5 AA repeats of C-C-X(3)Add BLAST241

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 137Poly-Ser4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JH3R Eukaryota
ENOG4111BSI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158579

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_062832_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60331

Identification of Orthologs from Complete Genome Data

More...
OMAi
QSCCKPV

TreeFam database of animal gene trees

More...
TreeFami
TF351356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885 Keratin_B2_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60331-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASTMSVCS SACSDSWQVD ACPESCCEPH CCALSCCAPA PCLTLVCTPV
60 70 80 90 100
SRVSSPCCQA ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC
110 120 130 140 150
VPVCCKPVCC LPTCSKDSSS CCQQSSCQPT CCASSSSQQS CCVPVCCKPV
160 170 180 190 200
CYVPTCSEDS SSCCQQSSCH PACCTSSPCQ QACCVPVRCK PVCCKPICCV
210 220 230 240 250
PVCSGASTSC CQQSSCQPAC CTTSCCRPSS SVSLLCRPVC RPACCMPVSS
260 270 280
CCAPASSCQA SCCRPASCVS LLCRPACSRP AC
Length:282
Mass (Da):28,660
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3312B39453544BDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → T in AAI20960 (PubMed:15489334).Curated1
Sequence conflicti159D → S in BAD01534 (PubMed:15028290).Curated1
Sequence conflicti159D → S in AAI20960 (PubMed:15489334).Curated1
Sequence conflicti159D → S in AAI20961 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01760339P → L2 PublicationsCorresponds to variant dbSNP:rs233320Ensembl.1
Natural variantiVAR_047502101V → M2 PublicationsCorresponds to variant dbSNP:rs233319Ensembl.1
Natural variantiVAR_047503241R → Q1 PublicationCorresponds to variant dbSNP:rs233317Ensembl.1
Natural variantiVAR_047504280P → L1 PublicationCorresponds to variant dbSNP:rs233316Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB076347 mRNA Translation: BAD01534.1
AP001067 Genomic DNA No translation available.
BC120959 mRNA Translation: AAI20960.1
BC120960 mRNA Translation: AAI20961.1
AJ566380 mRNA Translation: CAD97461.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42954.1

NCBI Reference Sequences

More...
RefSeqi
NP_941964.2, NM_198691.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000400375; ENSP00000383226; ENSG00000215455

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
386677

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:386677

UCSC genome browser

More...
UCSCi
uc002zfh.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076347 mRNA Translation: BAD01534.1
AP001067 Genomic DNA No translation available.
BC120959 mRNA Translation: AAI20960.1
BC120960 mRNA Translation: AAI20961.1
AJ566380 mRNA Translation: CAD97461.1
CCDSiCCDS42954.1
RefSeqiNP_941964.2, NM_198691.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi132128, 76 interactors
STRINGi9606.ENSP00000383226

Polymorphism and mutation databases

BioMutaiKRTAP10-1
DMDMi215274024

Proteomic databases

MassIVEiP60331
PaxDbiP60331
PeptideAtlasiP60331
PRIDEiP60331
ProteomicsDBi57196

Genome annotation databases

EnsembliENST00000400375; ENSP00000383226; ENSG00000215455
GeneIDi386677
KEGGihsa:386677
UCSCiuc002zfh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
386677

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRTAP10-1
HGNCiHGNC:22966 KRTAP10-1
neXtProtiNX_P60331
OpenTargetsiENSG00000215455
PharmGKBiPA134884303

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JH3R Eukaryota
ENOG4111BSI LUCA
GeneTreeiENSGT00940000158579
HOGENOMiCLU_062832_0_0_1
InParanoidiP60331
OMAiQSCCKPV
TreeFamiTF351356

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
386677
PharosiP60331 Tdark

Protein Ontology

More...
PROi
PR:P60331
RNActiP60331 protein

Gene expression databases

BgeeiENSG00000215455 Expressed in skin of leg and 6 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 4 hits
PfamiView protein in Pfam
PF13885 Keratin_B2_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR101_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60331
Secondary accession number(s): Q0VAR0, Q0VAR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: November 25, 2008
Last modified: February 26, 2020
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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