UniProtKB - P60329 (KR124_HUMAN)
Protein
Keratin-associated protein 12-4
Gene
KRTAP12-4
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Biological processi
- keratinization Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | P60329 |
Reactomei | R-HSA-6805567, Keratinization |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 12-4Alternative name(s): High sulfur keratin-associated protein 12.4 Keratin-associated protein 12.4 |
Gene namesi | Name:KRTAP12-4 Synonyms:KAP12.4, KRTAP12.4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000212933.1 |
HGNCi | HGNC:20532, KRTAP12-4 |
neXtProti | NX_P60329 |
Subcellular locationi
Cytoskeleton
- intermediate filament Source: UniProtKB-KW
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
PharmGKBi | PA134932676 |
Miscellaneous databases
Pharosi | P60329, Tdark |
Polymorphism and mutation databases
BioMutai | KRTAP12-4 |
DMDMi | 41688566 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185199 | 1 – 112 | Keratin-associated protein 12-4Add BLAST | 112 |
Proteomic databases
PaxDbi | P60329 |
PRIDEi | P60329 |
ProteomicsDBi | 57195 |
Expressioni
Tissue specificityi
Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications
Gene expression databases
Bgeei | ENSG00000212933, Expressed in stomach and 11 other tissues |
Organism-specific databases
HPAi | ENSG00000212933, Group enriched (skin, testis) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
Hide detailsP60329
Protein-protein interaction databases
BioGRIDi | 132135, 49 interactors |
IntActi | P60329, 46 interactors |
STRINGi | 9606.ENSP00000375476 |
Miscellaneous databases
RNActi | P60329, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 10 – 14 | 1 | 5 | |
Repeati | 20 – 24 | 2 | 5 | |
Repeati | 25 – 29 | 3 | 5 | |
Repeati | 35 – 39 | 4 | 5 | |
Repeati | 41 – 45 | 5 | 5 | |
Repeati | 46 – 50 | 6 | 5 | |
Repeati | 56 – 60 | 7 | 5 | |
Repeati | 61 – 65 | 8 | 5 | |
Repeati | 66 – 70 | 9 | 5 | |
Repeati | 71 – 75 | 10 | 5 | |
Repeati | 76 – 80 | 11 | 5 | |
Repeati | 81 – 85 | 12 | 5 | |
Repeati | 86 – 90 | 13 | 5 | |
Repeati | 91 – 95 | 14 | 5 | |
Repeati | 96 – 100 | 15 | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 10 – 100 | 15 X 5 AA approximate repeatsAdd BLAST | 91 |
Sequence similaritiesi
Belongs to the KRTAP type 12 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00960000187213 |
HOGENOMi | CLU_138013_0_0_1 |
InParanoidi | P60329 |
OMAi | PSTCYPP |
OrthoDBi | 1616617at2759 |
PhylomeDBi | P60329 |
TreeFami | TF339135 |
i Sequence
Sequence statusi: Complete.
P60329-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCHTSHSSGC PMACPGSPCC VPSTCYPPEG YGTSCCCSAP CVALLCRPLC
60 70 80 90 100
GVSTCCQPAC CVPSPCQVAC CVPVSCKPVL CVASFCPTSG CCQPFCPTLV
110
YRPVTWSTPT GC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076360 mRNA Translation: BAD01547.1 AL773602 Genomic DNA No translation available. BC125198 mRNA Translation: AAI25199.1 |
CCDSi | CCDS42963.1 |
RefSeqi | NP_941971.1, NM_198698.1 |
Genome annotation databases
Ensembli | ENST00000391618; ENSP00000375476; ENSG00000212933 |
GeneIDi | 386684 |
KEGGi | hsa:386684 |
UCSCi | uc002zfs.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB076360 mRNA Translation: BAD01547.1 AL773602 Genomic DNA No translation available. BC125198 mRNA Translation: AAI25199.1 |
CCDSi | CCDS42963.1 |
RefSeqi | NP_941971.1, NM_198698.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132135, 49 interactors |
IntActi | P60329, 46 interactors |
STRINGi | 9606.ENSP00000375476 |
Polymorphism and mutation databases
BioMutai | KRTAP12-4 |
DMDMi | 41688566 |
Proteomic databases
PaxDbi | P60329 |
PRIDEi | P60329 |
ProteomicsDBi | 57195 |
Genome annotation databases
Ensembli | ENST00000391618; ENSP00000375476; ENSG00000212933 |
GeneIDi | 386684 |
KEGGi | hsa:386684 |
UCSCi | uc002zfs.1, human |
Organism-specific databases
CTDi | 386684 |
EuPathDBi | HostDB:ENSG00000212933.1 |
GeneCardsi | KRTAP12-4 |
HGNCi | HGNC:20532, KRTAP12-4 |
HPAi | ENSG00000212933, Group enriched (skin, testis) |
neXtProti | NX_P60329 |
PharmGKBi | PA134932676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00960000187213 |
HOGENOMi | CLU_138013_0_0_1 |
InParanoidi | P60329 |
OMAi | PSTCYPP |
OrthoDBi | 1616617at2759 |
PhylomeDBi | P60329 |
TreeFami | TF339135 |
Enzyme and pathway databases
PathwayCommonsi | P60329 |
Reactomei | R-HSA-6805567, Keratinization |
Miscellaneous databases
BioGRID-ORCSi | 386684, 116 hits in 836 CRISPR screens |
GenomeRNAii | 386684 |
Pharosi | P60329, Tdark |
PROi | PR:P60329 |
RNActi | P60329, protein |
Gene expression databases
Bgeei | ENSG00000212933, Expressed in stomach and 11 other tissues |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KR124_HUMAN | |
Accessioni | P60329Primary (citable) accession number: P60329 Secondary accession number(s): Q08AF5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 2, 2004 |
Last sequence update: | February 2, 2004 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM