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UniProtKB - P60329 (KR124_HUMAN)

Entry version 121 (02 Dec 2020)
Sequence version 1 (02 Feb 2004)
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Protein

Keratin-associated protein 12-4

Gene

KRTAP12-4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P60329

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 12-4
Alternative name(s):
High sulfur keratin-associated protein 12.4
Keratin-associated protein 12.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP12-4
Synonyms:KAP12.4, KRTAP12.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000212933.1

Human Gene Nomenclature Database

More...HGNCi		HGNC:20532, KRTAP12-4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P60329

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134932676

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P60329, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRTAP12-4

Domain mapping of disease mutations (DMDM)

More...DMDMi		41688566

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851991 – 112Keratin-associated protein 12-4Add BLAST112

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P60329

PRoteomics IDEntifications database

More...PRIDEi		P60329

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57195

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000212933, Expressed in stomach and 11 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000212933, Group enriched (skin, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P60329
With#Exp.IntAct
AQP1 [P29972]3EBI-10176396,EBI-745213
ATXN1 [P54253]3EBI-10176396,EBI-930964
ATXN2L - isoform 9 [Q8WWM7-9]3EBI-10176396,EBI-12053753
CH25H [O95992]3EBI-10176396,EBI-12820943
CYSRT1 [A8MQ03]3EBI-10176396,EBI-3867333
FBXO34 [Q9NWN3]4EBI-10176396,EBI-719816
HMGB4 [Q8WW32]3EBI-10176396,EBI-10277297
HOXA1 [P49639]10EBI-10176396,EBI-740785
IQUB [Q8NA54]6EBI-10176396,EBI-10220600
KRTAP11-1 [Q8IUC1]4EBI-10176396,EBI-1052037
KRTAP12-2 [P59991]3EBI-10176396,EBI-10176379
KRTAP19-2 [Q3LHN2]3EBI-10176396,EBI-12196745
KRTAP19-5 [Q3LI72]3EBI-10176396,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-10176396,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-10176396,EBI-10241353
KRTAP2-4 [Q9BYR9]3EBI-10176396,EBI-14065470
KRTAP3-3 [Q9BYR6]3EBI-10176396,EBI-3957694
KRTAP6-2 [Q3LI66]3EBI-10176396,EBI-11962084
KRTAP8-1 [Q8IUC2]3EBI-10176396,EBI-10261141
LASP1 - isoform 2 [Q14847-2]3EBI-10176396,EBI-9088686
LCE1A [Q5T7P2]3EBI-10176396,EBI-11962058
LCE1C [Q5T751]3EBI-10176396,EBI-12224199
LCE1E [Q5T753]3EBI-10176396,EBI-11955335
LCE1F [Q5T754]3EBI-10176396,EBI-11958008
LCE2A [Q5TA79]3EBI-10176396,EBI-10246607
LCE2C [Q5TA81]3EBI-10176396,EBI-11973993
LCE3A [Q5TA76]3EBI-10176396,EBI-9394625
LCE4A [Q5TA78]3EBI-10176396,EBI-10246358
LCE5A [Q5TCM9]3EBI-10176396,EBI-11955689
MEOX2 [P50222]3EBI-10176396,EBI-748397
MEOX2 [Q6FHY5]3EBI-10176396,EBI-16439278
NOTCH2NLA [Q7Z3S9]3EBI-10176396,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-10176396,EBI-22310682
NR4A3 [Q92570]3EBI-10176396,EBI-13644623
OLIG2 [Q13516]3EBI-10176396,EBI-3914525
OTX1 [P32242]6EBI-10176396,EBI-740446
PIH1D2 [Q8WWB5]6EBI-10176396,EBI-10232538
POU4F2 [Q12837]3EBI-10176396,EBI-17236143
RBPMS - isoform C [Q93062-3]3EBI-10176396,EBI-740343
RERE [Q9P2R6]3EBI-10176396,EBI-948076
SMCP [P49901]3EBI-10176396,EBI-750494
TEKT5 [Q96M29]3EBI-10176396,EBI-10239812
TEX37 [Q96LM6]3EBI-10176396,EBI-743976
TRIP13 [Q15645]3EBI-10176396,EBI-358993
VENTX [O95231]4EBI-10176396,EBI-10191303

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		132135, 49 interactors

Protein interaction database and analysis system

More...IntActi		P60329, 46 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000375476

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P60329, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati10 – 1415
Repeati20 – 2425
Repeati25 – 2935
Repeati35 – 3945
Repeati41 – 4555
Repeati46 – 5065
Repeati56 – 6075
Repeati61 – 6585
Repeati66 – 7095
Repeati71 – 75105
Repeati76 – 80115
Repeati81 – 85125
Repeati86 – 90135
Repeati91 – 95145
Repeati96 – 100155

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 10015 X 5 AA approximate repeatsAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 12 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4726, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00960000187213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_138013_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P60329

Identification of Orthologs from Complete Genome Data

More...OMAi		PSTCYPP

Database of Orthologous Groups

More...OrthoDBi		1616617at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P60329

TreeFam database of animal gene trees

More...TreeFami		TF339135

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHTSHSSGC PMACPGSPCC VPSTCYPPEG YGTSCCCSAP CVALLCRPLC 
        60         70         80         90        100
GVSTCCQPAC CVPSPCQVAC CVPVSCKPVL CVASFCPTSG CCQPFCPTLV 
       110 
YRPVTWSTPT GC
Length:112
Mass (Da):11,433
Last modified:February 2, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05DC36FA889EB98A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB076360 mRNA Translation: BAD01547.1
AL773602 Genomic DNA No translation available.
BC125198 mRNA Translation: AAI25199.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42963.1

NCBI Reference Sequences

More...RefSeqi		NP_941971.1, NM_198698.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000391618; ENSP00000375476; ENSG00000212933

Database of genes from NCBI RefSeq genomes

More...GeneIDi		386684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:386684

UCSC genome browser

More...UCSCi		uc002zfs.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076360 mRNA Translation: BAD01547.1
AL773602 Genomic DNA No translation available.
BC125198 mRNA Translation: AAI25199.1
CCDSiCCDS42963.1
RefSeqiNP_941971.1, NM_198698.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132135, 49 interactors
IntActiP60329, 46 interactors
STRINGi9606.ENSP00000375476

Polymorphism and mutation databases

BioMutaiKRTAP12-4
DMDMi41688566

Proteomic databases

PaxDbiP60329
PRIDEiP60329
ProteomicsDBi57195

Genome annotation databases

EnsembliENST00000391618; ENSP00000375476; ENSG00000212933
GeneIDi386684
KEGGihsa:386684
UCSCiuc002zfs.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		386684
EuPathDBiHostDB:ENSG00000212933.1

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRTAP12-4
HGNCiHGNC:20532, KRTAP12-4
HPAiENSG00000212933, Group enriched (skin, testis)
neXtProtiNX_P60329
PharmGKBiPA134932676

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00960000187213
HOGENOMiCLU_138013_0_0_1
InParanoidiP60329
OMAiPSTCYPP
OrthoDBi1616617at2759
PhylomeDBiP60329
TreeFamiTF339135

Enzyme and pathway databases

PathwayCommonsiP60329
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		386684, 116 hits in 836 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		386684
PharosiP60329, Tdark

Protein Ontology

More...PROi		PR:P60329
RNActiP60329, protein

Gene expression databases

BgeeiENSG00000212933, Expressed in stomach and 11 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR124_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60329
Secondary accession number(s): Q08AF5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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