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Entry version 115 (07 Oct 2020)
Sequence version 2 (18 May 2010)
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Protein

Keratin-associated protein 12-3

Gene

KRTAP12-3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P60328

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567, Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 12-3
Alternative name(s):
High sulfur keratin-associated protein 12.3
Keratin-associated protein 12.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP12-3
Synonyms:KAP12.3, KRTAP12.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205439.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20531, KRTAP12-3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000205439

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134986807

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P60328, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP12-3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434553

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001851981 – 96Keratin-associated protein 12-3Add BLAST96

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P60328

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P60328

PeptideAtlas

More...
PeptideAtlasi
P60328

PRoteomics IDEntifications database

More...
PRIDEi
P60328

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
57194

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205439, Expressed in heart and 21 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205439, Group enriched (blood, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60328
With#Exp.IntAct
ADAMTSL3 [P82987]3EBI-11953334,EBI-10221726
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11953334,EBI-10173507
AGXT [P21549]3EBI-11953334,EBI-727098
ALDH3B1 [P43353]3EBI-11953334,EBI-2558314
BCL6B [A8KA13]3EBI-11953334,EBI-10174813
BMP7 [P18075]3EBI-11953334,EBI-1035195
C11orf87 [Q6NUJ2]3EBI-11953334,EBI-6660291
C22orf39 [Q6P5X5]3EBI-11953334,EBI-7317823
CARD10 [Q9BWT7]3EBI-11953334,EBI-3866279
CATSPER1 [Q8NEC5]3EBI-11953334,EBI-744545
CBX2 - isoform 2 [Q14781-2]3EBI-11953334,EBI-11974585
CELF5 [Q8N6W0]3EBI-11953334,EBI-12139335
CHIC2 [Q9UKJ5]3EBI-11953334,EBI-741528
CHRD [Q9H2X0]3EBI-11953334,EBI-947551
CHRNG - isoform 2 [P07510-2]3EBI-11953334,EBI-11979451
CNNM3 [Q8NE01]3EBI-11953334,EBI-741032
COL8A1 [P27658]3EBI-11953334,EBI-747133
CRCT1 [Q9UGL9]3EBI-11953334,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-11953334,EBI-10192698
CYSRT1 [A8MQ03]3EBI-11953334,EBI-3867333
DALRD3 - isoform 2 [Q5D0E6-2]3EBI-11953334,EBI-9090939
DHRS1 [Q96LJ7]3EBI-11953334,EBI-746300
DHX57 [Q6P158]3EBI-11953334,EBI-1051531
DNAL4 [O96015]3EBI-11953334,EBI-742362
DOCK2 [Q92608]3EBI-11953334,EBI-448771
FASLG [P48023]3EBI-11953334,EBI-495538
FBXW5 [Q969U6]3EBI-11953334,EBI-741068
GLRX3 [O76003]3EBI-11953334,EBI-374781
GNE - isoform 2 [Q9Y223-2]3EBI-11953334,EBI-11975289
GTF3C5 [Q9Y5Q8]3EBI-11953334,EBI-1045409
HOXA1 [P49639]6EBI-11953334,EBI-740785
ITGB4 - isoform Beta-4A [P16144-2]3EBI-11953334,EBI-11051601
JOSD1 [Q15040]3EBI-11953334,EBI-2510602
KPRP [Q5T749]6EBI-11953334,EBI-10981970
KRT20 [P35900]3EBI-11953334,EBI-742094
KRTAP1-1 [Q07627]3EBI-11953334,EBI-11959885
KRTAP10-7 [P60409]3EBI-11953334,EBI-10172290
KRTAP10-8 [P60410]3EBI-11953334,EBI-10171774
KRTAP10-9 [P60411]3EBI-11953334,EBI-10172052
KRTAP11-1 [Q8IUC1]3EBI-11953334,EBI-1052037
KRTAP12-1 [P59990]6EBI-11953334,EBI-10210845
itself3EBI-11953334,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-11953334,EBI-11953846
KRTAP13-3 [Q3SY46]3EBI-11953334,EBI-10241252
KRTAP19-7 [Q3SYF9]3EBI-11953334,EBI-10241353
KRTAP3-3 [Q9BYR6]3EBI-11953334,EBI-3957694
KRTAP4-2 [Q9BYR5]3EBI-11953334,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-11953334,EBI-11958132
KRTAP5-6 [Q6L8G9]3EBI-11953334,EBI-10250562
KRTAP5-9 [P26371]3EBI-11953334,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-11953334,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-11953334,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-11953334,EBI-1044640
LCE1A [Q5T7P2]6EBI-11953334,EBI-11962058
LCE1B [Q5T7P3]4EBI-11953334,EBI-10245913
LCE1C [Q5T751]3EBI-11953334,EBI-12224199
LCE1E [Q5T753]3EBI-11953334,EBI-11955335
LCE1F [Q5T754]7EBI-11953334,EBI-11958008
LCE2A [Q5TA79]3EBI-11953334,EBI-10246607
LCE2B [O14633]6EBI-11953334,EBI-11478468
LCE2C [Q5TA81]3EBI-11953334,EBI-11973993
LCE2D [Q5TA82]3EBI-11953334,EBI-10246750
LCE3A [Q5TA76]6EBI-11953334,EBI-9394625
LCE3C [Q5T5A8]6EBI-11953334,EBI-10245291
LCE3D [Q9BYE3]3EBI-11953334,EBI-6658837
LCE3E [Q5T5B0]3EBI-11953334,EBI-10245456
LCE4A [Q5TA78]6EBI-11953334,EBI-10246358
LCE5A [Q5TCM9]3EBI-11953334,EBI-11955689
LIF [P15018]3EBI-11953334,EBI-1037189
LMNTD2 [Q8IXW0]3EBI-11953334,EBI-12028858
LNX1 [Q8TBB1]3EBI-11953334,EBI-739832
LYVE1 [Q9Y5Y7]3EBI-11953334,EBI-10329546
MAPKBP1 [O60336]3EBI-11953334,EBI-947402
MEOX2 [Q6FHY5]3EBI-11953334,EBI-16439278
MISP [Q8IVT2]3EBI-11953334,EBI-2555085
MOBP - isoform 3 [Q13875-3]3EBI-11953334,EBI-12013470
NKD1 [Q969G9]3EBI-11953334,EBI-1538217
NMU [P48645]3EBI-11953334,EBI-10210351
NOTCH2NLC [P0DPK4]3EBI-11953334,EBI-22310682
NPDC1 [Q9NQX5]3EBI-11953334,EBI-748927
NR1D2 [Q6NSM0]6EBI-11953334,EBI-10250949
NR4A3 [Q92570]3EBI-11953334,EBI-13644623
NUFIP2 [Q7Z417]3EBI-11953334,EBI-1210753
OTX1 [P32242]3EBI-11953334,EBI-740446
OXER1 [Q8TDS5]3EBI-11953334,EBI-12813389
P2RX4 [Q99571]3EBI-11953334,EBI-2828248
P2RY6 [Q15077]3EBI-11953334,EBI-10235794
P3H3 - isoform 2 [Q8IVL6-2]3EBI-11953334,EBI-12149899
P4HB [P07237]3EBI-11953334,EBI-395883
PDE9A - isoform PDE9A2 [O76083-2]3EBI-11953334,EBI-11524542
PDGFRB [P09619]3EBI-11953334,EBI-641237
PGAP6 [Q9HCN3]3EBI-11953334,EBI-10310808
PHLDA1 [A2BDE7]3EBI-11953334,EBI-14084211
POU4F2 [Q12837]3EBI-11953334,EBI-17236143
PTGDS [P41222]3EBI-11953334,EBI-948821
PTPMT1 [Q8WUK0]3EBI-11953334,EBI-7199479
R3HDM2 [Q9Y2K5]3EBI-11953334,EBI-948428
RSPO2 - isoform 2 [Q6UXX9-2]3EBI-11953334,EBI-12009390
SELENOM [Q8WWX9]3EBI-11953334,EBI-10277687
SHFL - isoform 4 [Q9NUL5-4]3EBI-11953334,EBI-11955083
SLC13A5 [Q86YT5]3EBI-11953334,EBI-12002412
SLC15A2 [Q16348]3EBI-11953334,EBI-12806032
SLC23A1 - isoform 3 [Q9UHI7-3]3EBI-11953334,EBI-11998660
SPATA3 [A0A024R4B0]3EBI-11953334,EBI-14123856
SPRY1 [O43609]3EBI-11953334,EBI-3866665
TCEA2 [Q15560]3EBI-11953334,EBI-710310
TCEANC - isoform 2 [Q8N8B7-2]3EBI-11953334,EBI-11955057
TFAP2D [Q7Z6R9]3EBI-11953334,EBI-11952651
TNP2 [Q05952]3EBI-11953334,EBI-12039775
TNS2 [Q63HR2]3EBI-11953334,EBI-949753
TTPA [P49638]3EBI-11953334,EBI-10210710
UTP23 [Q9BRU9]3EBI-11953334,EBI-5457544
UXT [Q9UBK9]4EBI-11953334,EBI-357355
VASN [Q6EMK4]6EBI-11953334,EBI-10249550
VGLL3 - isoform 2 [A8MV65-2]3EBI-11953334,EBI-11957216
VSTM4 [Q8IW00]3EBI-11953334,EBI-4311759
WDR25 - isoform 2 [Q64LD2-2]3EBI-11953334,EBI-12032042
WNT11 [O96014]3EBI-11953334,EBI-8058160
YY1 [P25490]3EBI-11953334,EBI-765538
ZDHHC1 [Q8WTX9]3EBI-11953334,EBI-2818796
ZNF101 [Q8IZC7]3EBI-11953334,EBI-5278328
ZNF124 [Q15973]3EBI-11953334,EBI-2555767
ZNF138 [P52744]3EBI-11953334,EBI-10746567
ZNF20 [P17024]3EBI-11953334,EBI-717634
ZNF408 [Q9H9D4]3EBI-11953334,EBI-347633
ZNF417 [Q8TAU3]3EBI-11953334,EBI-740727
ZNF439 [Q8NDP4]3EBI-11953334,EBI-747580
ZNF440 [Q8IYI8]3EBI-11953334,EBI-726439
ZNF467 [Q7Z7K2]3EBI-11953334,EBI-11986485
ZNF490 [Q9ULM2]3EBI-11953334,EBI-1105370
ZNF491 [Q8N8L2]3EBI-11953334,EBI-12019860
ZNF497 [Q6ZNH5]3EBI-11953334,EBI-10486136
ZNF578 [Q96N58]3EBI-11953334,EBI-11955189
ZNF587 [Q96SQ5]3EBI-11953334,EBI-6427977
ZNF648 [Q5T619]3EBI-11953334,EBI-11985915
ZNF696 [Q9H7X3]3EBI-11953334,EBI-11090299
ZNF80 [P51504]3EBI-11953334,EBI-12013828
ZNF835 [Q9Y2P0]3EBI-11953334,EBI-5667516
ZNF837 [Q96EG3]3EBI-11953334,EBI-11962574
ZSCAN21 [Q9Y5A6]3EBI-11953334,EBI-10281938

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132134, 143 interactors

Protein interaction database and analysis system

More...
IntActi
P60328, 139 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381005

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P60328, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati10 – 1415
Repeati15 – 1925
Repeati24 – 2835
Repeati30 – 3445
Repeati35 – 3955
Repeati45 – 4965
Repeati50 – 5475
Repeati55 – 5985
Repeati60 – 6495
Repeati70 – 74105
Repeati75 – 79115
Repeati80 – 84125
Repeati85 – 89135
Repeati90 – 94145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 9414 X 5 AA approximate repeatsAdd BLAST85

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 12 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163527

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_138013_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60328

Database of Orthologous Groups

More...
OrthoDBi
1616617at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60328

TreeFam database of animal gene trees

More...
TreeFami
TF339135

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494, KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262, PTHR23262, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13885, Keratin_B2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P60328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCHTSCSPAC QPTCCIHSPC QASCYVPVSC QSSVCMPVSC TRIVCVAPSC
60 70 80 90
QPSVCVPVSC RPIIYVTPSC QSSGCCQPPC TTALCRPISC STPSCC
Length:96
Mass (Da):9,947
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D870B11E34F111C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01759217H → R1 PublicationCorresponds to variant dbSNP:rs9306111Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB076361 mRNA Translation: BAD01548.1
AL773602 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS42964.1

NCBI Reference Sequences

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RefSeqi
NP_941970.2, NM_198697.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397907; ENSP00000381005; ENSG00000205439

Database of genes from NCBI RefSeq genomes

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GeneIDi
386683

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:386683

UCSC genome browser

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UCSCi
uc002zft.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076361 mRNA Translation: BAD01548.1
AL773602 Genomic DNA No translation available.
CCDSiCCDS42964.1
RefSeqiNP_941970.2, NM_198697.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132134, 143 interactors
IntActiP60328, 139 interactors
STRINGi9606.ENSP00000381005

Polymorphism and mutation databases

BioMutaiKRTAP12-3
DMDMi296434553

Proteomic databases

MassIVEiP60328
PaxDbiP60328
PeptideAtlasiP60328
PRIDEiP60328
ProteomicsDBi57194

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
386683

Genome annotation databases

EnsembliENST00000397907; ENSP00000381005; ENSG00000205439
GeneIDi386683
KEGGihsa:386683
UCSCiuc002zft.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
386683
EuPathDBiHostDB:ENSG00000205439.9

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP12-3
HGNCiHGNC:20531, KRTAP12-3
HPAiENSG00000205439, Group enriched (blood, skin)
neXtProtiNX_P60328
OpenTargetsiENSG00000205439
PharmGKBiPA134986807

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4726, Eukaryota
GeneTreeiENSGT00940000163527
HOGENOMiCLU_138013_1_0_1
InParanoidiP60328
OrthoDBi1616617at2759
PhylomeDBiP60328
TreeFamiTF339135

Enzyme and pathway databases

PathwayCommonsiP60328
ReactomeiR-HSA-6805567, Keratinization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
386683, 1 hit in 843 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
386683
PharosiP60328, Tdark

Protein Ontology

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PROi
PR:P60328
RNActiP60328, protein

Gene expression databases

BgeeiENSG00000205439, Expressed in heart and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002494, KAP
PANTHERiPTHR23262, PTHR23262, 1 hit
PfamiView protein in Pfam
PF13885, Keratin_B2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKR123_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60328
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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