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Protein

Alpha-conotoxin GID

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin reversibly blocks alpha-3-beta-2/CHRNA3-CHRNB2 (IC50=3.1-5.1 nM), alpha-7/CHRNA7 (IC50=4.5-5.1 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC50=128.6-390 nM) nAChRs.4 Publications

Miscellaneous

The mutant [V62N] (V18N) shows a very important selectivity for alpha-4-beta-2/CHRNA4-CHRNB2 over alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.1 Publication
This toxin does not inhibit neuronal alpha-3-beta-4/CHRNA3-CHRNB4 and alpha-4-beta-4/CHRNA4-CHRNB4 nAChR, and muscle alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRND nAChR.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei47Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR2 Publications1
Sitei53Key residue for activity on alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR1 Publication1
Sitei54Important for determining subtype selectivity1 Publication1
Sitei56Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR2 Publications1
Sitei57Important for determining subtype selectivity1 Publication1
Sitei58Key residue for activity on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-conotoxin GID1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiConus geographus (Geography cone) (Nubecula geographus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6491 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServer: Cone snail toxin database

More...
ConoServeri
98 GID

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi45 – 48Missing : No change or small decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-7/CHRNA7 nAChRs, 4.4-fold decrease in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR. 1 Publication4
Mutagenesisi45 – 47IRD → A: 3.4-fold and 9.6-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication3
Mutagenesisi45 – 47Missing : 19.7-fold and 22.9-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with A-48. 1 Publication3
Mutagenesisi45 – 47Missing : 2.5-fold and 18-fold decrease in inhibitory potency on of alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication3
Mutagenesisi45 – 46IR → A: 2.8-fold and 5.8-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication2
Mutagenesisi45 – 46Missing : 2.5-fold decrease in inhibitory potency on alpha-7/CHRNA7 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication2
Mutagenesisi45I → A: No change in inhibitory potency on alpha-7/CHRNA7, 4.6-fold decrease or small increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 (depending on experiments), 2-fold decrease or no change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR (depending on experiments); when associated with lack of gamma-carboxyglutamation at Glu-48. 2 Publications1
Mutagenesisi46R → A: 2.5-fold decrease in inhibitory potency on alpha-7/CHRNA7, very important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 2 Publications1
Mutagenesisi46R → K: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi47D → A: 8.3-fold decrease in inhibitory potency on alpha-7/CHRNA7, important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 2 Publications1
Mutagenesisi47D → N: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi48E → A: No change in inhibitory potency on alpha-7/CHRNA7, no change or small increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and small increase in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 19.7-fold decrease in inhibitory potency on alpha-7/CHRNA7, 22.9-fold decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with 45-I--D-47 DEL. 2 Publications1
Mutagenesisi48E → Q: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi51S → A: 2.5-fold and 3.3-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, and 1.4-fold increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi52N → A: Important decrease in inhibitory potency on alpha-7/CHRNA7 nAChR, no change in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi53P → A: 17.7-fold and 50-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi54A → Q: Loss of inhibitory potency on all receptors tested (alpha-4-beta-2/CHRNA4-CHRNB2, alpha-7/CHRNA7, and alpha-3-beta-2/CHRNA3-CHRNB2); when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi54A → S: No change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi54A → T: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi54A → V: >10-fold increase in selectivity on alpha-4-beta-2/CHRNA4-CHRNB2 over alpha-7/CHRNA7; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi56R → A: 3.2-fold decrease in inhibitory potency on alpha3-beta-2/CHRNA3-CHRNB2, 13.2-fold decrease in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2, and 10.7-fold decrease in inhibitory potency on alpha-7/CHRNA7 nAChRs. 9.6-fold decrease in inhibitory potency on alpha-7/CHRNA7, 3.1-fold decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 2 Publications1
Mutagenesisi57V → A: 2.2-fold decrease in inhibitory potency on alpha-7/CHRNA7 nAChR, 5.7-fold increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and no change in activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → F: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and very important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → I: 2-3-fold decrease in inhibitory activity on alpha-4-beta-2/CHRNA4-CHRNB2 and alpha-7/CHRNA7, and 10-fold increase in inhibitory activity on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → I: No change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → L or W: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → S: No change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and small increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → T: No change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and no change in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi57V → Y: 40-fold increase in selectivity on alpha-4-beta-2/CHRNA4-CHRNB2 over alpha-7/CHRNA7; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi58N → A: 10.1-fold decrease in inhibitory potency on alpha-7/CHRNA7 nAChR, 2.6-fold increase in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi59N → A: No change in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi59N → H: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and very important decrease in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi59N → K: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi60P → A: 2.5-fold and 4-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, respectively, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi61H → A: No change in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and 4.7-fold decrease in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi62V → A: 1.5-fold and 12-fold decrease in inhibitory potency on alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR, and complete loss of activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi62V → N: Small increase in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1
Mutagenesisi62V → Y or Q: Loss in inhibitory potency on alpha-4-beta-2/CHRNA4-CHRNB2 and loss in inhibitory potency on alpha-3-beta-2/CHRNA3-CHRNB2; when associated with lack of gamma-carboxyglutamation at Glu-48. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000043992922 – 441 PublicationAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000004445945 – 63Alpha-conotoxin GID1 PublicationAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei484-carboxyglutamate1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi49 ↔ 551 PublicationImported
Disulfide bondi50 ↔ 631 PublicationImported
Modified residuei604-hydroxyproline1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Gamma-carboxyglutamation of Glu-48 seems to be not important for nAChR inhibition, since synthetic peptides without this modification do not show change in inhibition of alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR and show a 2.3-fold increase in inhibition of alpha-4-beta-2/CHRNA4-CHRNB2 nAChR.1 Publication
Hydroxylation of Pro-60 seems to be important for nAChR inhibition, since synthetic peptides without this modification show a small decrease in inhibition of alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR and a very important decrease in inhibition of alpha-4-beta-2/CHRNA4-CHRNB2 nAChR.1 Publication
An amidation of Cys-63 increases potency against alpha-7/CHRNA7 (2.6-fold) and alpha-3-beta-2/CHRNA3-CHRNB2 (2-fold) nAChR. On the other hand, the peptide has no more activity on alpha-4-beta-2/CHRNA4-CHRNB2 nAChR with an amidated Cys-63.1 Publication

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom duct.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MTQNMR-A45-63[»]
5UG3NMR-A45-63[»]
5UG5NMR-A45-63[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P60274

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P60274

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni45 – 48N-terminal tail important for activity on alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 nAChR3 Publications4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cysteine framework is I (CC-C-C). Alpha4/7 pattern.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF07365 Toxin_8, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P60274-1 [UniParc]FASTAAdd to basket
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MGMRMMFTVF LLVVLAATIV SFTSDRASDG RNVAAKAFHR IGRTIRDECC
60
SNPACRVNNP HVCRRR
Length:66
Mass (Da):7,428
Last modified:May 10, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA366397F42F3A876
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 2184.9 Da from positions 45 - 63. 1 Publication

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB910812 mRNA Translation: BAO65580.1
AB910893 mRNA Translation: BAO65661.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB910812 mRNA Translation: BAO65580.1
AB910893 mRNA Translation: BAO65661.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MTQNMR-A45-63[»]
5UG3NMR-A45-63[»]
5UG5NMR-A45-63[»]
SMRiP60274
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri98 GID

Miscellaneous databases

EvolutionaryTraceiP60274

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCA1D_CONGE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60274
Secondary accession number(s): X5IH33
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: May 10, 2017
Last modified: September 12, 2018
This is version 65 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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