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Protein

U2-hexatoxin-Hi1a

Gene
N/A
Organism
Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits sodium channels (Nav) of insects.By similarity

Miscellaneous

Exists in two forms, due to cis-trans isomerization at Pro-75.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
U2-hexatoxin-Hi1aCurated
Short name:
U2-HXTX-Hi1aCurated
Alternative name(s):
Toxin AcTx-Hi:OB42191 Publication
OrganismiHadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)
Taxonomic identifieri153481 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeHadronyche

Organism-specific databases

ArachnoServeriAS000390 U2-hexatoxin-Hi1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000044442224 – 451 PublicationAdd BLAST22
PeptideiPRO_000004496646 – 83U2-hexatoxin-Hi1a1 PublicationAdd BLAST38

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 631 PublicationImported
Disulfide bondi54 ↔ 681 PublicationImported
Disulfide bondi62 ↔ 781 PublicationImported
Disulfide bondi70 ↔ 761 PublicationImported

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP60272
SMRiP60272
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP60272

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication

Sequence similaritiesi

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR016328 Beta/delta-agatoxin_fam
PROSITEiView protein in PROSITE
PS60015 MU_AGATOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P60272-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNTTFLVLN VMLLVSVALF CAADPEMEKS SFAEILDTGN PEQERKCLAE
60 70 80
AADCSPWSGD SCCKPYLCSC IFFYPCSCRP KGW
Length:83
Mass (Da):9,241
Last modified:June 20, 2018 - v2
Checksum:iFFCC80427B5CC0D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HACE01000038 mRNA Translation: CDZ18822.1
HACE01000101 mRNA Translation: CDZ18885.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HACE01000038 mRNA Translation: CDZ18822.1
HACE01000101 mRNA Translation: CDZ18885.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KQHNMR-A46-83[»]
1KQINMR-A46-83[»]
ProteinModelPortaliP60272
SMRiP60272
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000390 U2-hexatoxin-Hi1a

Miscellaneous databases

EvolutionaryTraceiP60272

Family and domain databases

InterProiView protein in InterPro
IPR016328 Beta/delta-agatoxin_fam
PROSITEiView protein in PROSITE
PS60015 MU_AGATOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXMO_HADIN
AccessioniPrimary (citable) accession number: P60272
Secondary accession number(s): A0A1D0BPQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 20, 2018
Last modified: September 12, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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