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Entry version 59 (05 Dec 2018)
Sequence version 2 (22 Nov 2017)
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Protein

Beta-mammal toxin Css4

Gene
N/A
Organism
Centruroides suffusus (Durango bark scorpion)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on mammals.3 Publications

Caution

Authors of PubMed:21329715 cite the nucleotide sequence HQ262493 as coding for Css8 (AC P0DL83), but the sequence corresponds to Css4. For this reason, the corresponding cross-reference is indicated in this entry.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei43May interact with the receptor site1 Publication1
Sitei46May interact with the receptor site1 Publication1
Sitei47May interact with the receptor site1 Publication1
Sitei51May interact with the receptor site1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-mammal toxin Css4
Alternative name(s):
Css IV2 Publications
Short name:
CssIVCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCentruroides suffusus (Durango bark scorpion)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6880 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the lethal dose (LD), paralytic dose (PD), effect dose (ED) or lethal concentration (LC) of a protein toxin.<p><a href='/help/toxic_dose' target='_top'>More...</a></p>Toxic dosei

LD50 is 0.12 µg/kg in mouse by intracerebroventricular injection and LD50 is 115 µg/kg in mouse by subcutaneous injection.1 Publication
LD(100) is 3 µg/kg by intracranial injection into mice.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi26N → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi27S → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi28Y → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi32K → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi34E → A: Induces a marked shift in the voltage dependence of activation of Drosophila DmNav1 (para) channels and a contraction paralysis in blowfly larvae. However, it retains its high affinity for rat brain neuronal membranes and is highly active on the SCN2A (Nav1.2) channel. 2 Publications1
Mutagenesisi34E → Q or R: Has little effect on the binding affinity to rat sodium channels. 2 Publications1
Mutagenesisi36F → A: 11.2-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi36F → W: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi37K → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi38L → A: 157-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi38L → I: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi40D → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi41N → A: 649-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi42D → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi43Y → A: 886-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi43Y → W: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi45L → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi46R → A: 30.8-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi46R → I: 39-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi46R → Q: 14-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi47E → A: 648-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi47E → L: 45-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi47E → Q: 394-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi47E → R: 962-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi49R → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi50Q → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi51Q → A: 10.8-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi51Q → W: 35.8-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi54K → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi59Y → A: 1451-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi61Y → A: 1533-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi63F → A: 831-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi68T → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi71Y → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi72E → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi73Q → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi75V → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi76V → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi77W → A: 87-fold decrease in binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi80P → G: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi81N → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi83T → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1
Mutagenesisi85N → A: Has little effect on the binding affinity to rat sodium channels. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 181 PublicationAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000006677819 – 85Beta-mammal toxin Css41 PublicationAdd BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 84PROSITE-ProRule annotation
Disulfide bondi35 ↔ 60PROSITE-ProRule annotation
Disulfide bondi44 ↔ 65PROSITE-ProRule annotation
Disulfide bondi48 ↔ 67PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85Asparagine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60266

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P60266

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 85LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00285 SCORPNTOXIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00505 Knot1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57095 SSF57095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51863 LCN_CSAB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P60266-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSLLMITAC LALVGTVWAK EGYLVNSYTG CKFECFKLGD NDYCLRECRQ
60 70 80
QYGKGSGGYC YAFGCWCTHL YEQAVVWPLP NKTCNGK
Length:87
Mass (Da):9,785
Last modified:November 22, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AD30B6651C0C238
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 7601.6 Da from positions 20 - 85. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ262493 mRNA Translation: ADY17425.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ262493 mRNA Translation: ADY17425.1

3D structure databases

ProteinModelPortaliP60266
SMRiP60266
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCX4_CENSU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60266
Secondary accession number(s): F1CGT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 22, 2017
Last modified: December 5, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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