UniProtKB - P60208 (KA153_ANDMA)
Protein
Potassium channel toxin alpha-KTx 15.3
Gene
N/A
Organism
Androctonus mauritanicus mauritanicus (Scorpion)
Status
Functioni
Blocker of A-type voltage-gated potassium channels of striated neurons (PubMed:12473099). Has been shown to block ERG1/Kv11.1/KCNH2 potassium channels (IC50=7.9 µM) (PubMed:18687312). In adult rat brain, it binds to sites in the striatum, and cerebellum. It shares the same target in rat brain than AaTX1 (AC Q867F4) and BmTX3 (AC Q8I0L5).2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 6 | Hot spot residue in hERG blocking currents1 Publication | 1 | |
Sitei | 18 | Hot spot basic residue in hERG blocking currents1 Publication | 1 | |
Sitei | 19 | Hot spot basic residue in hERG blocking currents1 Publication | 1 | |
Sitei | 27 | Basic residue of the functional dyadBy similarity | 1 | |
Sitei | 36 | Aromatic residue of the functional dyadBy similarity | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 15.3CuratedAlternative name(s): Toxin AmmTX31 Publication |
Organismi | Androctonus mauritanicus mauritanicus (Scorpion) |
Taxonomic identifieri | 6860 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus › |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 6 | K → V: Increase in hERG blocking activity with activity close to BmTx3 activity (IC(50)=3.2 uM). 1 Publication | 1 | |
Mutagenesisi | 18 | R → A: Loss of hERG blocking activity. 1 Publication | 1 | |
Mutagenesisi | 19 | K → A: Loss of hERG blocking activity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000044895 | 1 – 37 | Potassium channel toxin alpha-KTx 15.31 PublicationAdd BLAST | 37 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 8 ↔ 28 | By similarity | ||
Disulfide bondi | 13 ↔ 33 | By similarity | ||
Disulfide bondi | 17 ↔ 35 | By similarity |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Structurei
3D structure databases
ProteinModelPortali | P60208 |
SMRi | P60208 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.Curated
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Similar proteinsi
Cross-referencesi
3D structure databases
ProteinModelPortali | P60208 |
SMRi | P60208 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 3.30.30.10, 1 hit |
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR001947 Scorpion_toxinS_K_inh |
Pfami | View protein in Pfam PF00451 Toxin_2, 1 hit |
ProDomi | View protein in ProDom or Entries sharing at least one domain PD003586 Scorpion_toxinS, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
PROSITEi | View protein in PROSITE PS01138 SCORP_SHORT_TOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KA153_ANDMA | |
Accessioni | P60208Primary (citable) accession number: P60208 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2004 |
Last sequence update: | January 16, 2004 | |
Last modified: | November 22, 2017 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families