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Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
Gene namesi
Name:Plp1
Synonyms:Plp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:97623 Plp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 9CytoplasmicCurated8
Transmembranei10 – 36Helical; Name=1CuratedAdd BLAST27
Topological domaini37 – 63ExtracellularCuratedAdd BLAST27
Transmembranei64 – 88Helical; Name=2CuratedAdd BLAST25
Topological domaini89 – 151CytoplasmicCuratedAdd BLAST63
Transmembranei152 – 177Helical; Name=3CuratedAdd BLAST26
Topological domaini178 – 233ExtracellularCuratedAdd BLAST56
Transmembranei234 – 260Helical; Name=4CuratedAdd BLAST27
Topological domaini261 – 277CytoplasmicCuratedAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001590072 – 277Myelin proteolipid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi6S-palmitoyl cysteineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi109S-palmitoyl cysteineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Lipidationi139S-palmitoyl cysteineBy similarity1
Lipidationi141S-palmitoyl cysteineBy similarity1
Disulfide bondi184 ↔ 228By similarity
Lipidationi199O-palmitoyl serineBy similarity1
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP60202
PeptideAtlasiP60202
PRIDEiP60202

PTM databases

iPTMnetiP60202
PhosphoSitePlusiP60202
SwissPalmiP60202

Expressioni

Gene expression databases

BgeeiENSMUSG00000031425 Expressed in 285 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_PLP1
ExpressionAtlasiP60202 baseline and differential
GenevisibleiP60202 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202254, 5 interactors
CORUMiP60202
IntActiP60202, 4 interactors
MINTiP60202
STRINGi10090.ENSMUSP00000033800

Structurei

3D structure databases

ProteinModelPortaliP60202
SMRiP60202
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP60202
KOiK17271
OMAiYCIVLLA
OrthoDBiEOG091G0IM5
PhylomeDBiP60202
TreeFamiTF315162

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P60202-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60202-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70Y → C (PubMed:3466187).Curated1
Sequence conflicti70Y → C (PubMed:2441390).Curated1
Sequence conflicti126S → Y in AAA39955 (PubMed:3466187).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti187I → T in Rumpshaker. 1 Publication1
Natural varianti243A → V in Jimpy MSD. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009194117 – 151Missing in isoform DM-20. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA Translation: AAA39951.1
M15442 mRNA Translation: AAA39952.1 Sequence problems.
M15442 mRNA Translation: AAA39953.1
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA Translation: CAA30184.1
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA Translation: AAA39954.1
M14674 mRNA Translation: AAA39955.1
M16472 mRNA Translation: AAA39950.1
BC027010 mRNA Translation: AAH27010.1
X06375 Genomic DNA Translation: CAB40821.1
CCDSiCCDS30424.1 [P60202-1]
CCDS72436.1 [P60202-2]
PIRiS34792
RefSeqiNP_001277490.1, NM_001290561.1 [P60202-2]
NP_001277491.1, NM_001290562.1
NP_035253.1, NM_011123.3 [P60202-1]
XP_017173919.1, XM_017318430.1
XP_017173920.1, XM_017318431.1
XP_017173921.1, XM_017318432.1
UniGeneiMm.1268

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425 [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425 [P60202-2]
GeneIDi18823
KEGGimmu:18823
UCSCiuc009ujc.2 mouse [P60202-1]
uc009ujd.2 mouse [P60202-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA Translation: AAA39951.1
M15442 mRNA Translation: AAA39952.1 Sequence problems.
M15442 mRNA Translation: AAA39953.1
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA Translation: CAA30184.1
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA Translation: AAA39954.1
M14674 mRNA Translation: AAA39955.1
M16472 mRNA Translation: AAA39950.1
BC027010 mRNA Translation: AAH27010.1
X06375 Genomic DNA Translation: CAB40821.1
CCDSiCCDS30424.1 [P60202-1]
CCDS72436.1 [P60202-2]
PIRiS34792
RefSeqiNP_001277490.1, NM_001290561.1 [P60202-2]
NP_001277491.1, NM_001290562.1
NP_035253.1, NM_011123.3 [P60202-1]
XP_017173919.1, XM_017318430.1
XP_017173920.1, XM_017318431.1
XP_017173921.1, XM_017318432.1
UniGeneiMm.1268

3D structure databases

ProteinModelPortaliP60202
SMRiP60202
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202254, 5 interactors
CORUMiP60202
IntActiP60202, 4 interactors
MINTiP60202
STRINGi10090.ENSMUSP00000033800

PTM databases

iPTMnetiP60202
PhosphoSitePlusiP60202
SwissPalmiP60202

Proteomic databases

PaxDbiP60202
PeptideAtlasiP60202
PRIDEiP60202

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425 [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425 [P60202-2]
GeneIDi18823
KEGGimmu:18823
UCSCiuc009ujc.2 mouse [P60202-1]
uc009ujd.2 mouse [P60202-2]

Organism-specific databases

CTDi5354
MGIiMGI:97623 Plp1

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP60202
KOiK17271
OMAiYCIVLLA
OrthoDBiEOG091G0IM5
PhylomeDBiP60202
TreeFamiTF315162

Miscellaneous databases

ChiTaRSiPlp1 mouse
PROiPR:P60202
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031425 Expressed in 285 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_PLP1
ExpressionAtlasiP60202 baseline and differential
GenevisibleiP60202 MM

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYPR_MOUSE
AccessioniPrimary (citable) accession number: P60202
Secondary accession number(s): P04400, P06905, Q9WUS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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