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Protein

Myelin proteolipid protein

Gene

Plp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plp1
Synonyms:Plp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97623 Plp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 9CytoplasmicCurated8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 36Helical; Name=1CuratedAdd BLAST27
Topological domaini37 – 63ExtracellularCuratedAdd BLAST27
Transmembranei64 – 88Helical; Name=2CuratedAdd BLAST25
Topological domaini89 – 151CytoplasmicCuratedAdd BLAST63
Transmembranei152 – 177Helical; Name=3CuratedAdd BLAST26
Topological domaini178 – 233ExtracellularCuratedAdd BLAST56
Transmembranei234 – 260Helical; Name=4CuratedAdd BLAST27
Topological domaini261 – 277CytoplasmicCuratedAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).

Keywords - Diseasei

Disease mutation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001590072 – 277Myelin proteolipid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi6S-palmitoyl cysteineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi109S-palmitoyl cysteineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Lipidationi139S-palmitoyl cysteineBy similarity1
Lipidationi141S-palmitoyl cysteineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi184 ↔ 228By similarity
Lipidationi199O-palmitoyl serineBy similarity1
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60202

PeptideAtlas

More...
PeptideAtlasi
P60202

PRoteomics IDEntifications database

More...
PRIDEi
P60202

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P60202

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60202

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P60202

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031425 Expressed in 285 organ(s), highest expression level in ventral horn of spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
MM_PLP1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P60202 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P60202 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
202254, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P60202

Database of interacting proteins

More...
DIPi
DIP-46200N

Protein interaction database and analysis system

More...
IntActi
P60202, 4 interactors

Molecular INTeraction database

More...
MINTi
P60202

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033800

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60202

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P60202

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4800 Eukaryota
ENOG4110EPW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231338

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000096

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60202

KEGG Orthology (KO)

More...
KOi
K17271

Identification of Orthologs from Complete Genome Data

More...
OMAi
YCIVLLA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0IM5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60202

TreeFam database of animal gene trees

More...
TreeFami
TF315162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11683 PTHR11683, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01275 Myelin_PLP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00214 MYELINPLP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00002 PLP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P60202-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60202-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70Y → C (PubMed:3466187).Curated1
Sequence conflicti70Y → C (PubMed:2441390).Curated1
Sequence conflicti126S → Y in AAA39955 (PubMed:3466187).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti187I → T in Rumpshaker. 1 Publication1
Natural varianti243A → V in Jimpy MSD. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009194117 – 151Missing in isoform DM-20. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15442 mRNA Translation: AAA39951.1
M15442 mRNA Translation: AAA39952.1 Sequence problems.
M15442 mRNA Translation: AAA39953.1
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA Translation: CAA30184.1
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA Translation: AAA39954.1
M14674 mRNA Translation: AAA39955.1
M16472 mRNA Translation: AAA39950.1
BC027010 mRNA Translation: AAH27010.1
X06375 Genomic DNA Translation: CAB40821.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30424.1 [P60202-1]
CCDS72436.1 [P60202-2]

Protein sequence database of the Protein Information Resource

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PIRi
S34792

NCBI Reference Sequences

More...
RefSeqi
NP_001277490.1, NM_001290561.1 [P60202-2]
NP_001277491.1, NM_001290562.1
NP_035253.1, NM_011123.3 [P60202-1]
XP_017173919.1, XM_017318430.1
XP_017173920.1, XM_017318431.1
XP_017173921.1, XM_017318432.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.1268

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425 [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425 [P60202-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18823

UCSC genome browser

More...
UCSCi
uc009ujc.2 mouse [P60202-1]
uc009ujd.2 mouse [P60202-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15442 mRNA Translation: AAA39951.1
M15442 mRNA Translation: AAA39952.1 Sequence problems.
M15442 mRNA Translation: AAA39953.1
X07215
, X07216, X07217, X07218, X07219, X07220, X07221 Genomic DNA Translation: CAA30184.1
M37335
, M37329, M37330, M37331, M37332, M37333, M37334 Genomic DNA Translation: AAA39954.1
M14674 mRNA Translation: AAA39955.1
M16472 mRNA Translation: AAA39950.1
BC027010 mRNA Translation: AAH27010.1
X06375 Genomic DNA Translation: CAB40821.1
CCDSiCCDS30424.1 [P60202-1]
CCDS72436.1 [P60202-2]
PIRiS34792
RefSeqiNP_001277490.1, NM_001290561.1 [P60202-2]
NP_001277491.1, NM_001290562.1
NP_035253.1, NM_011123.3 [P60202-1]
XP_017173919.1, XM_017318430.1
XP_017173920.1, XM_017318431.1
XP_017173921.1, XM_017318432.1
UniGeneiMm.1268

3D structure databases

ProteinModelPortaliP60202
SMRiP60202
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202254, 5 interactors
CORUMiP60202
DIPiDIP-46200N
IntActiP60202, 4 interactors
MINTiP60202
STRINGi10090.ENSMUSP00000033800

PTM databases

iPTMnetiP60202
PhosphoSitePlusiP60202
SwissPalmiP60202

Proteomic databases

PaxDbiP60202
PeptideAtlasiP60202
PRIDEiP60202

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033800; ENSMUSP00000033800; ENSMUSG00000031425 [P60202-1]
ENSMUST00000113085; ENSMUSP00000108708; ENSMUSG00000031425 [P60202-2]
GeneIDi18823
KEGGimmu:18823
UCSCiuc009ujc.2 mouse [P60202-1]
uc009ujd.2 mouse [P60202-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5354
MGIiMGI:97623 Plp1

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP60202
KOiK17271
OMAiYCIVLLA
OrthoDBiEOG091G0IM5
PhylomeDBiP60202
TreeFamiTF315162

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plp1 mouse

Protein Ontology

More...
PROi
PR:P60202

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031425 Expressed in 285 organ(s), highest expression level in ventral horn of spinal cord
CleanExiMM_PLP1
ExpressionAtlasiP60202 baseline and differential
GenevisibleiP60202 MM

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYPR_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60202
Secondary accession number(s): P04400, P06905, Q9WUS9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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