UniProtKB - P60201 (MYPR_HUMAN)
Myelin proteolipid protein
PLP1
Functioni
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein-containing complex binding Source: Ensembl
- structural constituent of myelin sheath Source: GO_Central
- structural molecule activity Source: ProtInc
GO - Biological processi
- AMPA selective glutamate receptor signaling pathway Source: Ensembl
- astrocyte development Source: Ensembl
- axon development Source: GO_Central
- axon ensheathment Source: ProtInc
- central nervous system myelination Source: GO_Central
- chemical synaptic transmission Source: ProtInc
- inflammatory response Source: Ensembl
- long-chain fatty acid biosynthetic process Source: Ensembl
- neuron projection development Source: GO_Central
- positive regulation of calcium ion transmembrane transport Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- substantia nigra development Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P60201 |
SignaLinki | P60201 |
Names & Taxonomyi
Protein namesi | Recommended name: Myelin proteolipid proteinShort name: PLP Alternative name(s): Lipophilin |
Gene namesi | Name:PLP1 Synonyms:PLP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9086, PLP1 |
MIMi | 300401, gene |
neXtProti | NX_P60201 |
VEuPathDBi | HostDB:ENSG00000123560 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
- Myelin membrane By similarity
Note: Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.By similarity
Plasma Membrane
- integrin alphav-beta3 complex Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- myelin sheath Source: GO_Central
- synapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 9 | Cytoplasmic1 Publication | 8 | |
Transmembranei | 10 – 36 | Helical; Name=1CuratedAdd BLAST | 27 | |
Topological domaini | 37 – 63 | Extracellular1 PublicationAdd BLAST | 27 | |
Transmembranei | 64 – 88 | Helical; Name=2CuratedAdd BLAST | 25 | |
Topological domaini | 89 – 151 | Cytoplasmic1 PublicationAdd BLAST | 63 | |
Transmembranei | 152 – 177 | Helical; Name=3CuratedAdd BLAST | 26 | |
Topological domaini | 178 – 233 | Extracellular1 PublicationAdd BLAST | 56 | |
Transmembranei | 234 – 260 | Helical; Name=4CuratedAdd BLAST | 27 | |
Topological domaini | 261 – 277 | Cytoplasmic1 PublicationAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Leukodystrophy, hypomyelinating, 1 (HLD1)30 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004546 | 15 | P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar. | 1 | |
Natural variantiVAR_015014 | 31 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015015 | 32 | F → L in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015016 | 32 | F → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046906 | 33 | C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255EnsemblClinVar. | 1 | |
Natural variantiVAR_046907 | 35 | C → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015017 | 35 | C → Y in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015018 | 39 | A → T in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004547 | 43 | T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar. | 1 | |
Natural variantiVAR_015019 | 46 | L → P in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015020 | 46 | L → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046908 | 50 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015021 | 51 | F → S in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015022 | 60 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004548 | 74 | G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar. | 1 | |
Natural variantiVAR_046909 | 76 | A → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015023 | 116 | T → K in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004550 | 117 – 165 | Missing in HLD1. Add BLAST | 49 | |
Natural variantiVAR_015025 | 148 | H → Y in HLD1 and SPG2. 2 Publications | 1 | |
Natural variantiVAR_015026 | 151 | K → N in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004552 | 156 | T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar. | 1 | |
Natural variantiVAR_046911 | 162 | V → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004553 | 163 | W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar. | 1 | |
Natural variantiVAR_004554 | 166 | V → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015028 | 169 | C → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046912 | 170 | S → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015030 | 172 | V → A in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046913 | 173 | P → S in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015031 | 175 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015032 | 181 | W → C in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004555 | 182 | T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar. | 1 | |
Natural variantiVAR_015033 | 183 | T → N in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015034 | 203 | D → E in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015035 | 203 | D → G in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004557 | 203 | D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar. | 1 | |
Natural variantiVAR_015036 | 203 | D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar. | 1 | |
Natural variantiVAR_007956 | 203 | D → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015037 | 205 | R → G in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015038 | 207 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015039 | 209 | V → D in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015040 | 210 | L → H in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015041 | 211 | P → L in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015042 | 212 | W → R in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015043 | 216 | P → A in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004558 | 216 | P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar. | 1 | |
Natural variantiVAR_004559 | 217 | G → S in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004560 | 219 | V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar. | 1 | |
Natural variantiVAR_015044 | 220 | C → Y in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004561 | 221 | G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar. | 1 | |
Natural variantiVAR_004562 | 224 | L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar. | 1 | |
Natural variantiVAR_046915 | 225 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015047 | 228 | C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar. | 1 | |
Natural variantiVAR_015048 | 234 | Q → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046916 | 239 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015049 | 242 | A → P in HLD1. 2 Publications | 1 | |
Natural variantiVAR_046917 | 243 | A → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046918 | 243 | A → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046919 | 246 | G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar. | 1 | |
Natural variantiVAR_015050 | 246 | G → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046920 | 247 | A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar. | 1 | |
Natural variantiVAR_015051 | 248 | A → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004565 | 249 | A → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015052 | 253 | S → F in HLD1. 1 Publication | 1 |
Spastic paraplegia 2, X-linked (SPG2)10 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070667 | 30 | A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication | 1 | |
Natural variantiVAR_015024 | 130 | H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar. | 1 | |
Natural variantiVAR_046910 | 137 | R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar. | 1 | |
Natural variantiVAR_004551 | 140 | H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar. | 1 | |
Natural variantiVAR_015025 | 148 | H → Y in HLD1 and SPG2. 2 Publications | 1 | |
Natural variantiVAR_015029 | 170 | S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar. | 1 | |
Natural variantiVAR_004556 | 187 | I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar. | 1 | |
Natural variantiVAR_046914 | 216 | P → L in SPG2. 1 Publication | 1 | |
Natural variantiVAR_015046 | 226 | S → P in SPG2. 1 Publication | 1 | |
Natural variantiVAR_004563 | 237 | F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Hereditary spastic paraplegia, Leukodystrophy, NeurodegenerationOrganism-specific databases
DisGeNETi | 5354 |
GeneReviewsi | PLP1 |
MalaCardsi | PLP1 |
MIMi | 312080, phenotype 312920, phenotype |
OpenTargetsi | ENSG00000123560 |
Orphaneti | 599376, Hypomyelination of early myelinating structures 280234, Null syndrome 280229, Pelizaeus-Merzbacher disease in female carriers 280219, Pelizaeus-Merzbacher disease, classic form 280210, Pelizaeus-Merzbacher disease, connatal form 280224, Pelizaeus-Merzbacher disease, transitional form 99015, Spastic paraplegia type 2 |
PharmGKBi | PA33414 |
Miscellaneous databases
Pharosi | P60201, Tbio |
Genetic variation databases
BioMutai | PLP1 |
DMDMi | 41393531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000159005 | 2 – 277 | Myelin proteolipid proteinAdd BLAST | 276 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 6 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 7 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 10 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 109 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 114 | PhosphoserineBy similarity | 1 | |
Modified residuei | 116 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 118 | PhosphothreonineBy similarity | 1 | |
Lipidationi | 139 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 141 | S-palmitoyl cysteineBy similarity | 1 | |
Disulfide bondi | 184 ↔ 228 | By similarity | ||
Lipidationi | 199 | O-palmitoyl serineBy similarity | 1 | |
Disulfide bondi | 201 ↔ 220 | By similarity |
Keywords - PTMi
Disulfide bond, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P60201 |
MassIVEi | P60201 |
PaxDbi | P60201 |
PeptideAtlasi | P60201 |
PRIDEi | P60201 |
ProteomicsDBi | 57188 [P60201-1] 57189 [P60201-2] |
2D gel databases
UCD-2DPAGEi | P60201 |
PTM databases
GlyGeni | P60201, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P60201 |
PhosphoSitePlusi | P60201 |
SwissPalmi | P60201 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123560, Expressed in middle frontal gyrus and 228 other tissues |
ExpressionAtlasi | P60201, baseline and differential |
Genevisiblei | P60201, HS |
Organism-specific databases
HPAi | ENSG00000123560, Tissue enriched (brain) |
Interactioni
Binary interactionsi
P60201
PLP1 - isoform 1 [P60201-1]
With | #Exp. | IntAct |
---|---|---|
itself | 2 | EBI-15668477,EBI-15668477 |
Isoform DM-20 [P60201-2]
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 111368, 105 interactors |
IntActi | P60201, 103 interactors |
MINTi | P60201 |
STRINGi | 9606.ENSP00000481006 |
Miscellaneous databases
RNActi | P60201, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4800, Eukaryota |
GeneTreei | ENSGT00390000006915 |
HOGENOMi | CLU_064167_2_1_1 |
InParanoidi | P60201 |
OMAi | TCRTIDV |
OrthoDBi | 712239at2759 |
PhylomeDBi | P60201 |
TreeFami | TF315162 |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
The sequence of this isoform differs from the canonical sequence as follows:
117-151: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1B1G2 | B1B1G2_HUMAN | Myelin proteolipid protein | PLP1 | 111 | Annotation score: | ||
B1B1G1 | B1B1G1_HUMAN | Myelin proteolipid protein | PLP1 | 100 | Annotation score: | ||
B1B1G4 | B1B1G4_HUMAN | Myelin proteolipid protein | PLP1 | 127 | Annotation score: | ||
B1B1G3 | B1B1G3_HUMAN | Myelin proteolipid protein | PLP1 | 122 | Annotation score: | ||
B1B1G6 | B1B1G6_HUMAN | Myelin proteolipid protein | PLP1 | 136 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 140 | H → T in AAA60117 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 185 | Q → D in AAA59565 (PubMed:2479017).Curated | 1 | |
Sequence conflicti | 213 | N → I in AAA59565 (PubMed:2479017).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004546 | 15 | P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar. | 1 | |
Natural variantiVAR_070667 | 30 | A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication | 1 | |
Natural variantiVAR_015014 | 31 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015015 | 32 | F → L in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015016 | 32 | F → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046906 | 33 | C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255EnsemblClinVar. | 1 | |
Natural variantiVAR_046907 | 35 | C → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015017 | 35 | C → Y in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015018 | 39 | A → T in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004547 | 43 | T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar. | 1 | |
Natural variantiVAR_015019 | 46 | L → P in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015020 | 46 | L → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046908 | 50 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015021 | 51 | F → S in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015022 | 60 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004548 | 74 | G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar. | 1 | |
Natural variantiVAR_046909 | 76 | A → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015023 | 116 | T → K in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004550 | 117 – 165 | Missing in HLD1. Add BLAST | 49 | |
Natural variantiVAR_015024 | 130 | H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar. | 1 | |
Natural variantiVAR_046910 | 137 | R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar. | 1 | |
Natural variantiVAR_004551 | 140 | H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar. | 1 | |
Natural variantiVAR_015025 | 148 | H → Y in HLD1 and SPG2. 2 Publications | 1 | |
Natural variantiVAR_015026 | 151 | K → N in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004552 | 156 | T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar. | 1 | |
Natural variantiVAR_046911 | 162 | V → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004553 | 163 | W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar. | 1 | |
Natural variantiVAR_004554 | 166 | V → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015027 | 166 | V → G Probable disease-associated variant found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication | 1 | |
Natural variantiVAR_015028 | 169 | C → R in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015029 | 170 | S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar. | 1 | |
Natural variantiVAR_046912 | 170 | S → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015030 | 172 | V → A in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046913 | 173 | P → S in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015031 | 175 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015032 | 181 | W → C in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004555 | 182 | T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar. | 1 | |
Natural variantiVAR_015033 | 183 | T → N in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004556 | 187 | I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar. | 1 | |
Natural variantiVAR_015034 | 203 | D → E in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015035 | 203 | D → G in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004557 | 203 | D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar. | 1 | |
Natural variantiVAR_015036 | 203 | D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar. | 1 | |
Natural variantiVAR_007956 | 203 | D → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015037 | 205 | R → G in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015038 | 207 | Y → C in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015039 | 209 | V → D in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015040 | 210 | L → H in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015041 | 211 | P → L in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015042 | 212 | W → R in HLD1. 2 Publications | 1 | |
Natural variantiVAR_015043 | 216 | P → A in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046914 | 216 | P → L in SPG2. 1 Publication | 1 | |
Natural variantiVAR_004558 | 216 | P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar. | 1 | |
Natural variantiVAR_004559 | 217 | G → S in HLD1. 2 Publications | 1 | |
Natural variantiVAR_004560 | 219 | V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar. | 1 | |
Natural variantiVAR_015044 | 220 | C → Y in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004561 | 221 | G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar. | 1 | |
Natural variantiVAR_015045 | 224 | L → I Probable disease-associated variant found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication | 1 | |
Natural variantiVAR_004562 | 224 | L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar. | 1 | |
Natural variantiVAR_046915 | 225 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015046 | 226 | S → P in SPG2. 1 Publication | 1 | |
Natural variantiVAR_015047 | 228 | C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar. | 1 | |
Natural variantiVAR_015048 | 234 | Q → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004563 | 237 | F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar. | 1 | |
Natural variantiVAR_046916 | 239 | L → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015049 | 242 | A → P in HLD1. 2 Publications | 1 | |
Natural variantiVAR_046917 | 243 | A → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046918 | 243 | A → V in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046919 | 246 | G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar. | 1 | |
Natural variantiVAR_015050 | 246 | G → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_046920 | 247 | A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar. | 1 | |
Natural variantiVAR_015051 | 248 | A → E in HLD1. 1 Publication | 1 | |
Natural variantiVAR_004565 | 249 | A → P in HLD1. 1 Publication | 1 | |
Natural variantiVAR_015052 | 253 | S → F in HLD1. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003325 | 117 – 151 | Missing in isoform DM-20. 3 PublicationsAdd BLAST | 35 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15032 , M15026, M15027, M15028, M15029, M15031 Genomic DNA Translation: AAA60350.1 Sequence problems. AJ006976 Genomic DNA Translation: CAA07364.1 M54927 mRNA Translation: AAA59565.1 M17085 mRNA Translation: AAA60118.1 M27110 mRNA Translation: AAA60117.1 CR536542 mRNA Translation: CAG38779.1 Z73964 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54690.1 BC002665 mRNA Translation: AAH02665.1 BC095452 mRNA Translation: AAH95452.1 D13320 Genomic DNA Translation: BAA02577.1 S55837 Genomic DNA Translation: AAD13880.1 Sequence problems. |
CCDSi | CCDS14513.1 [P60201-1] CCDS14514.1 [P60201-2] |
PIRi | A26665, MPHUPL |
RefSeqi | NP_000524.3, NM_000533.4 [P60201-1] NP_001122306.1, NM_001128834.2 [P60201-1] NP_001291933.1, NM_001305004.1 NP_955772.1, NM_199478.2 [P60201-2] |
Genome annotation databases
Ensembli | ENST00000612423; ENSP00000481006; ENSG00000123560 ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2] ENST00000621218; ENSP00000484450; ENSG00000123560 |
GeneIDi | 5354 |
KEGGi | hsa:5354 |
MANE-Selecti | ENST00000621218.5; ENSP00000484450.1; NM_000533.5; NP_000524.3 |
UCSCi | uc033epn.2, human [P60201-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15032 , M15026, M15027, M15028, M15029, M15031 Genomic DNA Translation: AAA60350.1 Sequence problems. AJ006976 Genomic DNA Translation: CAA07364.1 M54927 mRNA Translation: AAA59565.1 M17085 mRNA Translation: AAA60118.1 M27110 mRNA Translation: AAA60117.1 CR536542 mRNA Translation: CAG38779.1 Z73964 Genomic DNA No translation available. CH471190 Genomic DNA Translation: EAW54690.1 BC002665 mRNA Translation: AAH02665.1 BC095452 mRNA Translation: AAH95452.1 D13320 Genomic DNA Translation: BAA02577.1 S55837 Genomic DNA Translation: AAD13880.1 Sequence problems. |
CCDSi | CCDS14513.1 [P60201-1] CCDS14514.1 [P60201-2] |
PIRi | A26665, MPHUPL |
RefSeqi | NP_000524.3, NM_000533.4 [P60201-1] NP_001122306.1, NM_001128834.2 [P60201-1] NP_001291933.1, NM_001305004.1 NP_955772.1, NM_199478.2 [P60201-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2XPG | X-ray | 2.60 | C | 45-53 | [»] | |
SMRi | P60201 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111368, 105 interactors |
IntActi | P60201, 103 interactors |
MINTi | P60201 |
STRINGi | 9606.ENSP00000481006 |
PTM databases
GlyGeni | P60201, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P60201 |
PhosphoSitePlusi | P60201 |
SwissPalmi | P60201 |
Genetic variation databases
BioMutai | PLP1 |
DMDMi | 41393531 |
2D gel databases
UCD-2DPAGEi | P60201 |
Proteomic databases
jPOSTi | P60201 |
MassIVEi | P60201 |
PaxDbi | P60201 |
PeptideAtlasi | P60201 |
PRIDEi | P60201 |
ProteomicsDBi | 57188 [P60201-1] 57189 [P60201-2] |
Protocols and materials databases
Antibodypediai | 582, 312 antibodies from 30 providers |
DNASUi | 5354 |
Genome annotation databases
Ensembli | ENST00000612423; ENSP00000481006; ENSG00000123560 ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2] ENST00000621218; ENSP00000484450; ENSG00000123560 |
GeneIDi | 5354 |
KEGGi | hsa:5354 |
MANE-Selecti | ENST00000621218.5; ENSP00000484450.1; NM_000533.5; NP_000524.3 |
UCSCi | uc033epn.2, human [P60201-1] |
Organism-specific databases
CTDi | 5354 |
DisGeNETi | 5354 |
GeneCardsi | PLP1 |
GeneReviewsi | PLP1 |
HGNCi | HGNC:9086, PLP1 |
HPAi | ENSG00000123560, Tissue enriched (brain) |
MalaCardsi | PLP1 |
MIMi | 300401, gene 312080, phenotype 312920, phenotype |
neXtProti | NX_P60201 |
OpenTargetsi | ENSG00000123560 |
Orphaneti | 599376, Hypomyelination of early myelinating structures 280234, Null syndrome 280229, Pelizaeus-Merzbacher disease in female carriers 280219, Pelizaeus-Merzbacher disease, classic form 280210, Pelizaeus-Merzbacher disease, connatal form 280224, Pelizaeus-Merzbacher disease, transitional form 99015, Spastic paraplegia type 2 |
PharmGKBi | PA33414 |
VEuPathDBi | HostDB:ENSG00000123560 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4800, Eukaryota |
GeneTreei | ENSGT00390000006915 |
HOGENOMi | CLU_064167_2_1_1 |
InParanoidi | P60201 |
OMAi | TCRTIDV |
OrthoDBi | 712239at2759 |
PhylomeDBi | P60201 |
TreeFami | TF315162 |
Enzyme and pathway databases
PathwayCommonsi | P60201 |
SignaLinki | P60201 |
Miscellaneous databases
BioGRID-ORCSi | 5354, 11 hits in 666 CRISPR screens |
ChiTaRSi | PLP1, human |
GeneWikii | Proteolipid_protein_1 |
GenomeRNAii | 5354 |
Pharosi | P60201, Tbio |
PROi | PR:P60201 |
RNActi | P60201, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123560, Expressed in middle frontal gyrus and 228 other tissues |
ExpressionAtlasi | P60201, baseline and differential |
Genevisiblei | P60201, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001614, Myelin_PLP IPR018237, Myelin_PLP_CS |
PANTHERi | PTHR11683, PTHR11683, 1 hit |
Pfami | View protein in Pfam PF01275, Myelin_PLP, 1 hit |
PRINTSi | PR00214, MYELINPLP |
SMARTi | View protein in SMART SM00002, PLP, 1 hit |
PROSITEi | View protein in PROSITE PS00575, MYELIN_PLP_1, 1 hit PS01004, MYELIN_PLP_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYPR_HUMAN | |
Accessioni | P60201Primary (citable) accession number: P60201 Secondary accession number(s): P04400 Q6FHZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families