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UniProtKB - P60201 (MYPR_HUMAN)

Entry version 175 (23 Feb 2022)
Sequence version 2 (23 Jan 2007)
Previous versions | rss
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Protein

Myelin proteolipid protein

Gene

PLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P60201

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P60201

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLP1
Synonyms:PLP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9086, PLP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300401, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P60201

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123560

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 9Cytoplasmic1 Publication8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 36Helical; Name=1CuratedAdd BLAST27
Topological domaini37 – 63Extracellular1 PublicationAdd BLAST27
Transmembranei64 – 88Helical; Name=2CuratedAdd BLAST25
Topological domaini89 – 151Cytoplasmic1 PublicationAdd BLAST63
Transmembranei152 – 177Helical; Name=3CuratedAdd BLAST26
Topological domaini178 – 233Extracellular1 PublicationAdd BLAST56
Transmembranei234 – 260Helical; Name=4CuratedAdd BLAST27
Topological domaini261 – 277Cytoplasmic1 PublicationAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 1 (HLD1)30 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn X-linked recessive disorder of the central nervous system in which myelin is not formed properly. Clinically characterized by nystagmus, spastic quadriplegia, ataxia, and developmental delay.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00454615P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar.1
Natural variantiVAR_01501431L → P in HLD1. 1 Publication1
Natural variantiVAR_01501532F → L in HLD1. 1 Publication1
Natural variantiVAR_01501632F → V in HLD1. 1 Publication1
Natural variantiVAR_04690633C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255EnsemblClinVar.1
Natural variantiVAR_04690735C → R in HLD1. 1 Publication1
Natural variantiVAR_01501735C → Y in HLD1. 1 Publication1
Natural variantiVAR_01501839A → T in HLD1. 2 Publications1
Natural variantiVAR_00454743T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar.1
Natural variantiVAR_01501946L → P in HLD1. 2 Publications1
Natural variantiVAR_01502046L → R in HLD1. 1 Publication1
Natural variantiVAR_04690850Y → C in HLD1. 1 Publication1
Natural variantiVAR_01502151F → S in HLD1. 1 Publication1
Natural variantiVAR_01502260Y → C in HLD1. 1 Publication1
Natural variantiVAR_00454874G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar.1
Natural variantiVAR_04690976A → P in HLD1. 1 Publication1
Natural variantiVAR_015023116T → K in HLD1. 1 Publication1
Natural variantiVAR_004550117 – 165Missing in HLD1. Add BLAST49
Natural variantiVAR_015025148H → Y in HLD1 and SPG2. 2 Publications1
Natural variantiVAR_015026151K → N in HLD1. 1 Publication1
Natural variantiVAR_004552156T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar.1
Natural variantiVAR_046911162V → E in HLD1. 1 Publication1
Natural variantiVAR_004553163W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar.1
Natural variantiVAR_004554166V → E in HLD1. 1 Publication1
Natural variantiVAR_015028169C → R in HLD1. 1 Publication1
Natural variantiVAR_046912170S → P in HLD1. 1 Publication1
Natural variantiVAR_015030172V → A in HLD1. 1 Publication1
Natural variantiVAR_046913173P → S in HLD1. 1 Publication1
Natural variantiVAR_015031175Y → C in HLD1. 1 Publication1
Natural variantiVAR_015032181W → C in HLD1. 2 Publications1
Natural variantiVAR_004555182T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar.1
Natural variantiVAR_015033183T → N in HLD1. 1 Publication1
Natural variantiVAR_015034203D → E in HLD1. 2 Publications1
Natural variantiVAR_015035203D → G in HLD1. 1 Publication1
Natural variantiVAR_004557203D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_015036203D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_007956203D → V in HLD1. 1 Publication1
Natural variantiVAR_015037205R → G in HLD1. 1 Publication1
Natural variantiVAR_015038207Y → C in HLD1. 1 Publication1
Natural variantiVAR_015039209V → D in HLD1. 2 Publications1
Natural variantiVAR_015040210L → H in HLD1. 1 Publication1
Natural variantiVAR_015041211P → L in HLD1. 2 Publications1
Natural variantiVAR_015042212W → R in HLD1. 2 Publications1
Natural variantiVAR_015043216P → A in HLD1. 1 Publication1
Natural variantiVAR_004558216P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar.1
Natural variantiVAR_004559217G → S in HLD1. 2 Publications1
Natural variantiVAR_004560219V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar.1
Natural variantiVAR_015044220C → Y in HLD1. 1 Publication1
Natural variantiVAR_004561221G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar.1
Natural variantiVAR_004562224L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar.1
Natural variantiVAR_046915225L → P in HLD1. 1 Publication1
Natural variantiVAR_015047228C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar.1
Natural variantiVAR_015048234Q → P in HLD1. 1 Publication1
Natural variantiVAR_046916239L → P in HLD1. 1 Publication1
Natural variantiVAR_015049242A → P in HLD1. 2 Publications1
Natural variantiVAR_046917243A → E in HLD1. 1 Publication1
Natural variantiVAR_046918243A → V in HLD1. 1 Publication1
Natural variantiVAR_046919246G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar.1
Natural variantiVAR_015050246G → E in HLD1. 1 Publication1
Natural variantiVAR_046920247A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar.1
Natural variantiVAR_015051248A → E in HLD1. 1 Publication1
Natural variantiVAR_004565249A → P in HLD1. 1 Publication1
Natural variantiVAR_015052253S → F in HLD1. 1 Publication1
Spastic paraplegia 2, X-linked (SPG2)10 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07066730A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication1
Natural variantiVAR_015024130H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar.1
Natural variantiVAR_046910137R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar.1
Natural variantiVAR_004551140H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar.1
Natural variantiVAR_015025148H → Y in HLD1 and SPG2. 2 Publications1
Natural variantiVAR_015029170S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar.1
Natural variantiVAR_004556187I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar.1
Natural variantiVAR_046914216P → L in SPG2. 1 Publication1
Natural variantiVAR_015046226S → P in SPG2. 1 Publication1
Natural variantiVAR_004563237F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		5354

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PLP1

MalaCards human disease database

More...MalaCardsi		PLP1
MIMi312080, phenotype
312920, phenotype

Open Targets

More...OpenTargetsi		ENSG00000123560

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		599376, Hypomyelination of early myelinating structures
280234, Null syndrome
280229, Pelizaeus-Merzbacher disease in female carriers
280219, Pelizaeus-Merzbacher disease, classic form
280210, Pelizaeus-Merzbacher disease, connatal form
280224, Pelizaeus-Merzbacher disease, transitional form
99015, Spastic paraplegia type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33414

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P60201, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		41393531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001590052 – 277Myelin proteolipid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi6S-palmitoyl cysteineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi109S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Lipidationi139S-palmitoyl cysteineBy similarity1
Lipidationi141S-palmitoyl cysteineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi184 ↔ 228By similarity
Lipidationi199O-palmitoyl serineBy similarity1
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P60201

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P60201

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P60201

PeptideAtlas

More...PeptideAtlasi		P60201

PRoteomics IDEntifications database

More...PRIDEi		P60201

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		57188 [P60201-1]
57189 [P60201-2]

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P60201

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P60201, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P60201

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P60201

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P60201

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123560, Expressed in middle frontal gyrus and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P60201, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P60201, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123560, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P60201
With#Exp.IntAct
APP - isoform APP695 [P05067-4]5EBI-8653150,EBI-302641
BCL2L13 [Q9BXK5]3EBI-8653150,EBI-747430
CREB3L1 [Q96BA8]3EBI-8653150,EBI-6942903
PTPRN - isoform 3 [Q16849-3]3EBI-8653150,EBI-10200782
PLP1 - isoform 1 [P60201-1]
With#Exp.IntAct
itself2EBI-15668477,EBI-15668477
Isoform DM-20 [P60201-2]
With#Exp.IntAct
ADGRG3 [Q86Y34]3EBI-12188331,EBI-17979264
AQP10 [Q96PS8]3EBI-12188331,EBI-12820279
AQP6 [Q13520]3EBI-12188331,EBI-13059134
ARL13B [Q3SXY8]3EBI-12188331,EBI-11343438
BBS4 [Q96RK4]3EBI-12188331,EBI-1805814
BCL2L13 [Q9BXK5]6EBI-12188331,EBI-747430
BIK [Q13323]3EBI-12188331,EBI-700794
CALN1 [Q9BXU9]3EBI-12188331,EBI-12187137
CAPN2 [P17655]3EBI-12188331,EBI-1028956
CD40 [P25942]3EBI-12188331,EBI-525714
CD74 - isoform p35 [P04233-2]3EBI-12188331,EBI-12222807
CDIPT [O14735]3EBI-12188331,EBI-358858
CLDN2 [P57739]3EBI-12188331,EBI-751440
CLDN20 [P56880]3EBI-12188331,EBI-23801559
CLEC2D - isoform 2 [Q9UHP7-3]3EBI-12188331,EBI-11749983
CREB3 - isoform 1 [O43889-2]3EBI-12188331,EBI-625022
CREB3L1 [Q96BA8]16EBI-12188331,EBI-6942903
CYBC1 [Q9BQA9]3EBI-12188331,EBI-2680384
DCT [P40126]3EBI-12188331,EBI-18640065
DYSF - isoform 13 [O75923-13]3EBI-12188331,EBI-19949386
EDA2R [Q9HAV5]3EBI-12188331,EBI-526033
ELOVL4 [Q9GZR5]3EBI-12188331,EBI-18535450
ERGIC3 [Q9Y282]3EBI-12188331,EBI-781551
FAM209A [Q5JX71]3EBI-12188331,EBI-18304435
FCRL2 - isoform 2 [Q96LA5-2]3EBI-12188331,EBI-17263163
FFAR2 [O15552]3EBI-12188331,EBI-2833872
FNDC9 [Q8TBE3]3EBI-12188331,EBI-12142257
GAST [P01350]3EBI-12188331,EBI-3436637
GPR42 [O15529]3EBI-12188331,EBI-18076404
GPR61 [Q9BZJ8]3EBI-12188331,EBI-12808020
HAS3 - isoform 2 [O00219-2]3EBI-12188331,EBI-17186025
IER3IP1 [Q9Y5U9]3EBI-12188331,EBI-725665
IFITM3 [Q01628]3EBI-12188331,EBI-7932862
JAGN1 [Q8N5M9]3EBI-12188331,EBI-10266796
JPH1 [Q9HDC5]3EBI-12188331,EBI-465137
KLHL36 - isoform 2 [Q8N4N3-2]3EBI-12188331,EBI-10973851
KLRC1 [P26715]3EBI-12188331,EBI-9018187
LEPROTL1 [O95214]3EBI-12188331,EBI-750776
LEUTX [A8MZ59]3EBI-12188331,EBI-17490413
LHFPL5 [Q8TAF8]3EBI-12188331,EBI-2820517
MFF - isoform 5 [Q9GZY8-5]3EBI-12188331,EBI-11956541
MGST3 [O14880]3EBI-12188331,EBI-724754
MS4A3 [Q96HJ5]3EBI-12188331,EBI-12806656
MS4A4A [Q96JQ5]5EBI-12188331,EBI-12820341
MTIF3 [Q9H2K0]3EBI-12188331,EBI-3923617
MUC1 - isoform Y-LSP [P15941-11]3EBI-12188331,EBI-17263240
MYADM [Q96S97]3EBI-12188331,EBI-13301517
NRG1 - isoform 10 [Q02297-10]3EBI-12188331,EBI-12842334
PER1 [O15534]3EBI-12188331,EBI-2557276
PI16 [Q6UXB8]3EBI-12188331,EBI-12810028
PIGP [P57054]3EBI-12188331,EBI-17630288
PTPRN - isoform 3 [Q16849-3]9EBI-12188331,EBI-10200782
RBBP4 [Q09028]3EBI-12188331,EBI-620823
RELL2 [Q8NC24]3EBI-12188331,EBI-10269209
RMDN3 [Q96TC7]3EBI-12188331,EBI-1056589
RNF24 - isoform 2 [Q9Y225-2]3EBI-12188331,EBI-13044680
SKAP1 - isoform 2 [Q86WV1-2]3EBI-12188331,EBI-11995314
SLC10A6 [Q3KNW5]3EBI-12188331,EBI-18159983
SLC18A1 - isoform 3 [P54219-3]3EBI-12188331,EBI-17595455
SLC1A5 [Q15758]3EBI-12188331,EBI-356576
SLC26A6 - isoform 3 [Q9BXS9-3]3EBI-12188331,EBI-12814225
SLC35E2A [P0CK97]3EBI-12188331,EBI-18054851
SLC35E3 [Q7Z769]3EBI-12188331,EBI-13389236
SLC41A3 [Q96GZ6]3EBI-12188331,EBI-7225508
SMIM3 [Q9BZL3]4EBI-12188331,EBI-741850
SPNS3 - isoform 2 [Q6ZMD2-2]3EBI-12188331,EBI-17848320
STX1A [Q16623]3EBI-12188331,EBI-712466
STX4 [Q12846]3EBI-12188331,EBI-744942
SUSD3 [Q96L08]3EBI-12188331,EBI-18194029
TEX35 - isoform 2 [Q5T0J7-2]3EBI-12188331,EBI-12833746
TMEM106C [Q9BVX2]3EBI-12188331,EBI-2821497
TMEM14B [Q9NUH8]3EBI-12188331,EBI-8638294
TMEM182 [Q6ZP80]3EBI-12188331,EBI-10255122
TMEM242 [Q9NWH2]3EBI-12188331,EBI-10315004
TMEM243 [Q9BU79]3EBI-12188331,EBI-12887458
TMEM254 [Q8TBM7]3EBI-12188331,EBI-11956809
TMEM45B [Q96B21]3EBI-12188331,EBI-3923061
TMEM52B [Q4KMG9]3EBI-12188331,EBI-18178701
TMEM97 [Q5BJF2]3EBI-12188331,EBI-12111910
TMPRSS2 - isoform 2 [O15393-2]3EBI-12188331,EBI-12345267
UPK2 [O00526]3EBI-12188331,EBI-10179682
VAT1 [Q99536]3EBI-12188331,EBI-2514883

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111368, 105 interactors

Protein interaction database and analysis system

More...IntActi		P60201, 103 interactors

Molecular INTeraction database

More...MINTi		P60201

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000481006

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P60201, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P60201

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4800, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000006915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_064167_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P60201

Identification of Orthologs from Complete Genome Data

More...OMAi		TCRTIDV

Database of Orthologous Groups

More...OrthoDBi		712239at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P60201

TreeFam database of animal gene trees

More...TreeFami		TF315162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001614, Myelin_PLP
IPR018237, Myelin_PLP_CS

The PANTHER Classification System

More...PANTHERi		PTHR11683, PTHR11683, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01275, Myelin_PLP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00214, MYELINPLP

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00002, PLP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00575, MYELIN_PLP_1, 1 hit
PS01004, MYELIN_PLP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY 
        60         70         80         90        100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI 
       110        120        130        140        150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD 
       160        170        180        190        200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL 
       210        220        230        240        250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT 
       260        270 
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1B1G2B1B1G2_HUMAN
Myelin proteolipid protein
PLP1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G1B1B1G1_HUMAN
Myelin proteolipid protein
PLP1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G4B1B1G4_HUMAN
Myelin proteolipid protein
PLP1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G3B1B1G3_HUMAN
Myelin proteolipid protein
PLP1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G6B1B1G6_HUMAN
Myelin proteolipid protein
PLP1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60350 differs from that shown. The submitted sequence only contains the last exon but the authors annotated a CDS including all exons of that gene.Curated
The sequence AAD13880 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140H → T in AAA60117 (PubMed:15489334).Curated1
Sequence conflicti185Q → D in AAA59565 (PubMed:2479017).Curated1
Sequence conflicti213N → I in AAA59565 (PubMed:2479017).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00454615P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar.1
Natural variantiVAR_07066730A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication1
Natural variantiVAR_01501431L → P in HLD1. 1 Publication1
Natural variantiVAR_01501532F → L in HLD1. 1 Publication1
Natural variantiVAR_01501632F → V in HLD1. 1 Publication1
Natural variantiVAR_04690633C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255EnsemblClinVar.1
Natural variantiVAR_04690735C → R in HLD1. 1 Publication1
Natural variantiVAR_01501735C → Y in HLD1. 1 Publication1
Natural variantiVAR_01501839A → T in HLD1. 2 Publications1
Natural variantiVAR_00454743T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar.1
Natural variantiVAR_01501946L → P in HLD1. 2 Publications1
Natural variantiVAR_01502046L → R in HLD1. 1 Publication1
Natural variantiVAR_04690850Y → C in HLD1. 1 Publication1
Natural variantiVAR_01502151F → S in HLD1. 1 Publication1
Natural variantiVAR_01502260Y → C in HLD1. 1 Publication1
Natural variantiVAR_00454874G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar.1
Natural variantiVAR_04690976A → P in HLD1. 1 Publication1
Natural variantiVAR_015023116T → K in HLD1. 1 Publication1
Natural variantiVAR_004550117 – 165Missing in HLD1. Add BLAST49
Natural variantiVAR_015024130H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar.1
Natural variantiVAR_046910137R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar.1
Natural variantiVAR_004551140H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar.1
Natural variantiVAR_015025148H → Y in HLD1 and SPG2. 2 Publications1
Natural variantiVAR_015026151K → N in HLD1. 1 Publication1
Natural variantiVAR_004552156T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar.1
Natural variantiVAR_046911162V → E in HLD1. 1 Publication1
Natural variantiVAR_004553163W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar.1
Natural variantiVAR_004554166V → E in HLD1. 1 Publication1
Natural variantiVAR_015027166V → G Probable disease-associated variant found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication1
Natural variantiVAR_015028169C → R in HLD1. 1 Publication1
Natural variantiVAR_015029170S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar.1
Natural variantiVAR_046912170S → P in HLD1. 1 Publication1
Natural variantiVAR_015030172V → A in HLD1. 1 Publication1
Natural variantiVAR_046913173P → S in HLD1. 1 Publication1
Natural variantiVAR_015031175Y → C in HLD1. 1 Publication1
Natural variantiVAR_015032181W → C in HLD1. 2 Publications1
Natural variantiVAR_004555182T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar.1
Natural variantiVAR_015033183T → N in HLD1. 1 Publication1
Natural variantiVAR_004556187I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar.1
Natural variantiVAR_015034203D → E in HLD1. 2 Publications1
Natural variantiVAR_015035203D → G in HLD1. 1 Publication1
Natural variantiVAR_004557203D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_015036203D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_007956203D → V in HLD1. 1 Publication1
Natural variantiVAR_015037205R → G in HLD1. 1 Publication1
Natural variantiVAR_015038207Y → C in HLD1. 1 Publication1
Natural variantiVAR_015039209V → D in HLD1. 2 Publications1
Natural variantiVAR_015040210L → H in HLD1. 1 Publication1
Natural variantiVAR_015041211P → L in HLD1. 2 Publications1
Natural variantiVAR_015042212W → R in HLD1. 2 Publications1
Natural variantiVAR_015043216P → A in HLD1. 1 Publication1
Natural variantiVAR_046914216P → L in SPG2. 1 Publication1
Natural variantiVAR_004558216P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar.1
Natural variantiVAR_004559217G → S in HLD1. 2 Publications1
Natural variantiVAR_004560219V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar.1
Natural variantiVAR_015044220C → Y in HLD1. 1 Publication1
Natural variantiVAR_004561221G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar.1
Natural variantiVAR_015045224L → I Probable disease-associated variant found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication1
Natural variantiVAR_004562224L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar.1
Natural variantiVAR_046915225L → P in HLD1. 1 Publication1
Natural variantiVAR_015046226S → P in SPG2. 1 Publication1
Natural variantiVAR_015047228C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar.1
Natural variantiVAR_015048234Q → P in HLD1. 1 Publication1
Natural variantiVAR_004563237F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar.1
Natural variantiVAR_046916239L → P in HLD1. 1 Publication1
Natural variantiVAR_015049242A → P in HLD1. 2 Publications1
Natural variantiVAR_046917243A → E in HLD1. 1 Publication1
Natural variantiVAR_046918243A → V in HLD1. 1 Publication1
Natural variantiVAR_046919246G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar.1
Natural variantiVAR_015050246G → E in HLD1. 1 Publication1
Natural variantiVAR_046920247A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar.1
Natural variantiVAR_015051248A → E in HLD1. 1 Publication1
Natural variantiVAR_004565249A → P in HLD1. 1 Publication1
Natural variantiVAR_015052253S → F in HLD1. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003325117 – 151Missing in isoform DM-20. 3 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M15032 M15031 Genomic DNA Translation: AAA60350.1 Sequence problems.
AJ006976 Genomic DNA Translation: CAA07364.1
M54927 mRNA Translation: AAA59565.1
M17085 mRNA Translation: AAA60118.1
M27110 mRNA Translation: AAA60117.1
CR536542 mRNA Translation: CAG38779.1
Z73964 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54690.1
BC002665 mRNA Translation: AAH02665.1
BC095452 mRNA Translation: AAH95452.1
D13320 Genomic DNA Translation: BAA02577.1
S55837 Genomic DNA Translation: AAD13880.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14513.1 [P60201-1]
CCDS14514.1 [P60201-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A26665, MPHUPL

NCBI Reference Sequences

More...RefSeqi		NP_000524.3, NM_000533.4 [P60201-1]
NP_001122306.1, NM_001128834.2 [P60201-1]
NP_001291933.1, NM_001305004.1
NP_955772.1, NM_199478.2 [P60201-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000612423; ENSP00000481006; ENSG00000123560
ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2]
ENST00000621218; ENSP00000484450; ENSG00000123560

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5354

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000621218.5; ENSP00000484450.1; NM_000533.5; NP_000524.3

UCSC genome browser

More...UCSCi		uc033epn.2, human [P60201-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15032 M15031 Genomic DNA Translation: AAA60350.1 Sequence problems.
AJ006976 Genomic DNA Translation: CAA07364.1
M54927 mRNA Translation: AAA59565.1
M17085 mRNA Translation: AAA60118.1
M27110 mRNA Translation: AAA60117.1
CR536542 mRNA Translation: CAG38779.1
Z73964 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54690.1
BC002665 mRNA Translation: AAH02665.1
BC095452 mRNA Translation: AAH95452.1
D13320 Genomic DNA Translation: BAA02577.1
S55837 Genomic DNA Translation: AAD13880.1 Sequence problems.
CCDSiCCDS14513.1 [P60201-1]
CCDS14514.1 [P60201-2]
PIRiA26665, MPHUPL
RefSeqiNP_000524.3, NM_000533.4 [P60201-1]
NP_001122306.1, NM_001128834.2 [P60201-1]
NP_001291933.1, NM_001305004.1
NP_955772.1, NM_199478.2 [P60201-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60C45-53[»]
SMRiP60201
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111368, 105 interactors
IntActiP60201, 103 interactors
MINTiP60201
STRINGi9606.ENSP00000481006

PTM databases

GlyGeniP60201, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP60201
PhosphoSitePlusiP60201
SwissPalmiP60201

Genetic variation databases

BioMutaiPLP1
DMDMi41393531

2D gel databases

UCD-2DPAGEiP60201

Proteomic databases

jPOSTiP60201
MassIVEiP60201
PaxDbiP60201
PeptideAtlasiP60201
PRIDEiP60201
ProteomicsDBi57188 [P60201-1]
57189 [P60201-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		582, 312 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		5354

Genome annotation databases

EnsembliENST00000612423; ENSP00000481006; ENSG00000123560
ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2]
ENST00000621218; ENSP00000484450; ENSG00000123560
GeneIDi5354
KEGGihsa:5354
MANE-SelectiENST00000621218.5; ENSP00000484450.1; NM_000533.5; NP_000524.3
UCSCiuc033epn.2, human [P60201-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5354
DisGeNETi5354

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLP1
GeneReviewsiPLP1
HGNCiHGNC:9086, PLP1
HPAiENSG00000123560, Tissue enriched (brain)
MalaCardsiPLP1
MIMi300401, gene
312080, phenotype
312920, phenotype
neXtProtiNX_P60201
OpenTargetsiENSG00000123560
Orphaneti599376, Hypomyelination of early myelinating structures
280234, Null syndrome
280229, Pelizaeus-Merzbacher disease in female carriers
280219, Pelizaeus-Merzbacher disease, classic form
280210, Pelizaeus-Merzbacher disease, connatal form
280224, Pelizaeus-Merzbacher disease, transitional form
99015, Spastic paraplegia type 2
PharmGKBiPA33414
VEuPathDBiHostDB:ENSG00000123560

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4800, Eukaryota
GeneTreeiENSGT00390000006915
HOGENOMiCLU_064167_2_1_1
InParanoidiP60201
OMAiTCRTIDV
OrthoDBi712239at2759
PhylomeDBiP60201
TreeFamiTF315162

Enzyme and pathway databases

PathwayCommonsiP60201
SignaLinkiP60201

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5354, 11 hits in 666 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Proteolipid_protein_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5354
PharosiP60201, Tbio

Protein Ontology

More...PROi		PR:P60201
RNActiP60201, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123560, Expressed in middle frontal gyrus and 228 other tissues
ExpressionAtlasiP60201, baseline and differential
GenevisibleiP60201, HS

Family and domain databases

InterProiView protein in InterPro
IPR001614, Myelin_PLP
IPR018237, Myelin_PLP_CS
PANTHERiPTHR11683, PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275, Myelin_PLP, 1 hit
PRINTSiPR00214, MYELINPLP
SMARTiView protein in SMART
SM00002, PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575, MYELIN_PLP_1, 1 hit
PS01004, MYELIN_PLP_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYPR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60201
Secondary accession number(s): P04400
, P06905, Q502Y1, Q6FHZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: February 23, 2022
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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