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Protein

Myelin proteolipid protein

Gene

PLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • structural constituent of myelin sheath Source: GO_Central
  • structural molecule activity Source: ProtInc

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin proteolipid protein
Short name:
PLP
Alternative name(s):
Lipophilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLP1
Synonyms:PLP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000123560.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9086 PLP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300401 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60201

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 9Cytoplasmic1 Publication8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 36Helical; Name=1CuratedAdd BLAST27
Topological domaini37 – 63Extracellular1 PublicationAdd BLAST27
Transmembranei64 – 88Helical; Name=2CuratedAdd BLAST25
Topological domaini89 – 151Cytoplasmic1 PublicationAdd BLAST63
Transmembranei152 – 177Helical; Name=3CuratedAdd BLAST26
Topological domaini178 – 233Extracellular1 PublicationAdd BLAST56
Transmembranei234 – 260Helical; Name=4CuratedAdd BLAST27
Topological domaini261 – 277Cytoplasmic1 PublicationAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 1 (HLD1)30 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA X-linked recessive disorder of the central nervous system in which myelin is not formed properly. Clinically characterized by nystagmus, spastic quadriplegia, ataxia, and developmental delay.
See also OMIM:312080
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00454615P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar.1
Natural variantiVAR_01501431L → P in HLD1. 1 Publication1
Natural variantiVAR_01501532F → L in HLD1. 1 Publication1
Natural variantiVAR_01501632F → V in HLD1. 1 Publication1
Natural variantiVAR_04690633C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255Ensembl.1
Natural variantiVAR_04690735C → R in HLD1. 1 Publication1
Natural variantiVAR_01501735C → Y in HLD1. 1 Publication1
Natural variantiVAR_01501839A → T in HLD1. 2 Publications1
Natural variantiVAR_00454743T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar.1
Natural variantiVAR_01501946L → P in HLD1. 2 Publications1
Natural variantiVAR_01502046L → R in HLD1. 1 Publication1
Natural variantiVAR_04690850Y → C in HLD1. 1 Publication1
Natural variantiVAR_01502151F → S in HLD1. 1 Publication1
Natural variantiVAR_01502260Y → C in HLD1. 1 Publication1
Natural variantiVAR_00454874G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar.1
Natural variantiVAR_04690976A → P in HLD1. 1 Publication1
Natural variantiVAR_015023116T → K in HLD1. 1 Publication1
Natural variantiVAR_004550117 – 165Missing in HLD1. Add BLAST49
Natural variantiVAR_015026151K → N in HLD1. 1 Publication1
Natural variantiVAR_004552156T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar.1
Natural variantiVAR_046911162V → E in HLD1. 1 Publication1
Natural variantiVAR_004553163W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar.1
Natural variantiVAR_004554166V → E in HLD1. 1 Publication1
Natural variantiVAR_015028169C → R in HLD1. 1 Publication1
Natural variantiVAR_046912170S → P in HLD1. 1 Publication1
Natural variantiVAR_015030172V → A in HLD1. 1 Publication1
Natural variantiVAR_046913173P → S in HLD1. 1 Publication1
Natural variantiVAR_015031175Y → C in HLD1. 1 Publication1
Natural variantiVAR_015032181W → C in HLD1. 2 Publications1
Natural variantiVAR_004555182T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar.1
Natural variantiVAR_015033183T → N in HLD1. 1 Publication1
Natural variantiVAR_015034203D → E in HLD1. 2 Publications1
Natural variantiVAR_015035203D → G in HLD1. 1 Publication1
Natural variantiVAR_004557203D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_015036203D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_007956203D → V in HLD1. 1 Publication1
Natural variantiVAR_015037205R → G in HLD1. 1 Publication1
Natural variantiVAR_015038207Y → C in HLD1. 1 Publication1
Natural variantiVAR_015039209V → D in HLD1. 2 Publications1
Natural variantiVAR_015040210L → H in HLD1. 1 Publication1
Natural variantiVAR_015041211P → L in HLD1. 2 Publications1
Natural variantiVAR_015042212W → R in HLD1. 2 Publications1
Natural variantiVAR_015043216P → A in HLD1. 1 Publication1
Natural variantiVAR_004558216P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar.1
Natural variantiVAR_004559217G → S in HLD1. 2 Publications1
Natural variantiVAR_004560219V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar.1
Natural variantiVAR_015044220C → Y in HLD1. 1 Publication1
Natural variantiVAR_004561221G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar.1
Natural variantiVAR_004562224L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar.1
Natural variantiVAR_046915225L → P in HLD1. 1 Publication1
Natural variantiVAR_015047228C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar.1
Natural variantiVAR_015048234Q → P in HLD1. 1 Publication1
Natural variantiVAR_046916239L → P in HLD1. 1 Publication1
Natural variantiVAR_015049242A → P in HLD1. 2 Publications1
Natural variantiVAR_046917243A → E in HLD1. 1 Publication1
Natural variantiVAR_046918243A → V in HLD1. 1 Publication1
Natural variantiVAR_046919246G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar.1
Natural variantiVAR_015050246G → E in HLD1. 1 Publication1
Natural variantiVAR_046920247A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar.1
Natural variantiVAR_015051248A → E in HLD1. 1 Publication1
Natural variantiVAR_004565249A → P in HLD1. 1 Publication1
Natural variantiVAR_015052253S → F in HLD1. 1 Publication1
Spastic paraplegia 2, X-linked (SPG2)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy.
See also OMIM:312920
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07066730A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication1
Natural variantiVAR_015024130H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar.1
Natural variantiVAR_046910137R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar.1
Natural variantiVAR_004551140H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar.1
Natural variantiVAR_015029170S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar.1
Natural variantiVAR_004556187I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar.1
Natural variantiVAR_046914216P → L in SPG2. 1 Publication1
Natural variantiVAR_015046226S → P in SPG2. 1 Publication1
Natural variantiVAR_004563237F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
5354

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PLP1

MalaCards human disease database

More...
MalaCardsi
PLP1
MIMi312080 phenotype
312920 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000123560

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
280234 Null syndrome
280229 Pelizaeus-Merzbacher disease in female carriers
280219 Pelizaeus-Merzbacher disease, classic form
280210 Pelizaeus-Merzbacher disease, connatal form
280224 Pelizaeus-Merzbacher disease, transitional form
99015 Spastic paraplegia type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33414

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41393531

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001590052 – 277Myelin proteolipid proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi6S-palmitoyl cysteineBy similarity1
Lipidationi7S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi109S-palmitoyl cysteineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Modified residuei116PhosphothreonineBy similarity1
Modified residuei118PhosphothreonineBy similarity1
Lipidationi139S-palmitoyl cysteineBy similarity1
Lipidationi141S-palmitoyl cysteineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi184 ↔ 228By similarity
Lipidationi199O-palmitoyl serineBy similarity1
Disulfide bondi201 ↔ 220By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P60201

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P60201

PeptideAtlas

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PeptideAtlasi
P60201

PRoteomics IDEntifications database

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PRIDEi
P60201

ProteomicsDB human proteome resource

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ProteomicsDBi
57188
57189 [P60201-2]

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P60201

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P60201

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60201

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P60201

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000123560 Expressed in 214 organ(s), highest expression level in middle frontal gyrus

CleanEx database of gene expression profiles

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CleanExi
HS_PLP1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P60201 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P60201 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004128

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111368, 22 interactors

Protein interaction database and analysis system

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IntActi
P60201, 64 interactors

Molecular INTeraction database

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MINTi
P60201

STRING: functional protein association networks

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STRINGi
9606.ENSP00000305152

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P60201

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P60201

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4800 Eukaryota
ENOG4110EPW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006915

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231338

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000096

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P60201

KEGG Orthology (KO)

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KOi
K17271

Identification of Orthologs from Complete Genome Data

More...
OMAi
YCIVLLA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0IM5

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60201

TreeFam database of animal gene trees

More...
TreeFami
TF315162

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11683 PTHR11683, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01275 Myelin_PLP, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00214 MYELINPLP

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00002 PLP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
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MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY
60 70 80 90 100
FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI
110 120 130 140 150
FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD
160 170 180 190 200
KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL
210 220 230 240 250
CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT
260 270
LVSLLTFMIA ATYNFAVLKL MGRGTKF
Length:277
Mass (Da):30,077
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C2BC973C3061C38
GO
Isoform DM-20 (identifier: P60201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-151: Missing.

Show »
Length:242
Mass (Da):26,274
Checksum:i90DEFE60148DC659
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1B1G3B1B1G3_HUMAN
Myelin proteolipid protein
PLP1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G4B1B1G4_HUMAN
Myelin proteolipid protein
PLP1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G6B1B1G6_HUMAN
Myelin proteolipid protein
PLP1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G1B1B1G1_HUMAN
Myelin proteolipid protein
PLP1
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1B1G2B1B1G2_HUMAN
Myelin proteolipid protein
PLP1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA60350 differs from that shown. The submitted sequence only contains the last exon but the authors annotated a CDS including all exons of that gene.Curated
The sequence AAD13880 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti140H → T in AAA60117 (PubMed:15489334).Curated1
Sequence conflicti185Q → D in AAA59565 (PubMed:2479017).Curated1
Sequence conflicti213N → I in AAA59565 (PubMed:2479017).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00454615P → L in HLD1. 1 PublicationCorresponds to variant dbSNP:rs11543022EnsemblClinVar.1
Natural variantiVAR_07066730A → P in SPG2; partially retained in the endoplasmic reticulum; does not induce unfolded protein response. 1 Publication1
Natural variantiVAR_01501431L → P in HLD1. 1 Publication1
Natural variantiVAR_01501532F → L in HLD1. 1 Publication1
Natural variantiVAR_01501632F → V in HLD1. 1 Publication1
Natural variantiVAR_04690633C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs1064794255Ensembl.1
Natural variantiVAR_04690735C → R in HLD1. 1 Publication1
Natural variantiVAR_01501735C → Y in HLD1. 1 Publication1
Natural variantiVAR_01501839A → T in HLD1. 2 Publications1
Natural variantiVAR_00454743T → I in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630289EnsemblClinVar.1
Natural variantiVAR_01501946L → P in HLD1. 2 Publications1
Natural variantiVAR_01502046L → R in HLD1. 1 Publication1
Natural variantiVAR_04690850Y → C in HLD1. 1 Publication1
Natural variantiVAR_01502151F → S in HLD1. 1 Publication1
Natural variantiVAR_01502260Y → C in HLD1. 1 Publication1
Natural variantiVAR_00454874G → R in HLD1. 3 PublicationsCorresponds to variant dbSNP:rs132630285EnsemblClinVar.1
Natural variantiVAR_04690976A → P in HLD1. 1 Publication1
Natural variantiVAR_015023116T → K in HLD1. 1 Publication1
Natural variantiVAR_004550117 – 165Missing in HLD1. Add BLAST49
Natural variantiVAR_015024130H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs878853076EnsemblClinVar.1
Natural variantiVAR_046910137R → W in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630295EnsemblClinVar.1
Natural variantiVAR_004551140H → Y in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630287EnsemblClinVar.1
Natural variantiVAR_015025148H → Y in HLD1 and SPG2. 2 Publications1
Natural variantiVAR_015026151K → N in HLD1. 1 Publication1
Natural variantiVAR_004552156T → I in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630280EnsemblClinVar.1
Natural variantiVAR_046911162V → E in HLD1. 1 Publication1
Natural variantiVAR_004553163W → R in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630279EnsemblClinVar.1
Natural variantiVAR_004554166V → E in HLD1. 1 Publication1
Natural variantiVAR_015027166V → G Probable disease-associated mutation found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication1
Natural variantiVAR_015028169C → R in HLD1. 1 Publication1
Natural variantiVAR_015029170S → F in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630294EnsemblClinVar.1
Natural variantiVAR_046912170S → P in HLD1. 1 Publication1
Natural variantiVAR_015030172V → A in HLD1. 1 Publication1
Natural variantiVAR_046913173P → S in HLD1. 1 Publication1
Natural variantiVAR_015031175Y → C in HLD1. 1 Publication1
Natural variantiVAR_015032181W → C in HLD1. 2 Publications1
Natural variantiVAR_004555182T → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630282EnsemblClinVar.1
Natural variantiVAR_015033183T → N in HLD1. 1 Publication1
Natural variantiVAR_004556187I → T in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630288EnsemblClinVar.1
Natural variantiVAR_015034203D → E in HLD1. 2 Publications1
Natural variantiVAR_015035203D → G in HLD1. 1 Publication1
Natural variantiVAR_004557203D → H in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_015036203D → N in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630284EnsemblClinVar.1
Natural variantiVAR_007956203D → V in HLD1. 1 Publication1
Natural variantiVAR_015037205R → G in HLD1. 1 Publication1
Natural variantiVAR_015038207Y → C in HLD1. 1 Publication1
Natural variantiVAR_015039209V → D in HLD1. 2 Publications1
Natural variantiVAR_015040210L → H in HLD1. 1 Publication1
Natural variantiVAR_015041211P → L in HLD1. 2 Publications1
Natural variantiVAR_015042212W → R in HLD1. 2 Publications1
Natural variantiVAR_015043216P → A in HLD1. 1 Publication1
Natural variantiVAR_046914216P → L in SPG2. 1 Publication1
Natural variantiVAR_004558216P → S in HLD1. 2 PublicationsCorresponds to variant dbSNP:rs132630278EnsemblClinVar.1
Natural variantiVAR_004559217G → S in HLD1. 2 Publications1
Natural variantiVAR_004560219V → F in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630281EnsemblClinVar.1
Natural variantiVAR_015044220C → Y in HLD1. 1 Publication1
Natural variantiVAR_004561221G → C in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630286EnsemblClinVar.1
Natural variantiVAR_015045224L → I Probable disease-associated mutation found in Pelizaeus-Merzbacher disease/X-linked spastic paraplegia. 1 Publication1
Natural variantiVAR_004562224L → P in HLD1. 1 PublicationCorresponds to variant dbSNP:rs132630283EnsemblClinVar.1
Natural variantiVAR_046915225L → P in HLD1. 1 Publication1
Natural variantiVAR_015046226S → P in SPG2. 1 Publication1
Natural variantiVAR_015047228C → Y in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123466EnsemblClinVar.1
Natural variantiVAR_015048234Q → P in HLD1. 1 Publication1
Natural variantiVAR_004563237F → S in SPG2. 1 PublicationCorresponds to variant dbSNP:rs132630291EnsemblClinVar.1
Natural variantiVAR_046916239L → P in HLD1. 1 Publication1
Natural variantiVAR_015049242A → P in HLD1. 2 Publications1
Natural variantiVAR_046917243A → E in HLD1. 1 Publication1
Natural variantiVAR_046918243A → V in HLD1. 1 Publication1
Natural variantiVAR_046919246G → A in HLD1. 1 PublicationCorresponds to variant dbSNP:rs398123467EnsemblClinVar.1
Natural variantiVAR_015050246G → E in HLD1. 1 Publication1
Natural variantiVAR_046920247A → T in HLD1. 1 PublicationCorresponds to variant dbSNP:rs886043504EnsemblClinVar.1
Natural variantiVAR_015051248A → E in HLD1. 1 Publication1
Natural variantiVAR_004565249A → P in HLD1. 1 Publication1
Natural variantiVAR_015052253S → F in HLD1. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003325117 – 151Missing in isoform DM-20. 3 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15032
, M15026, M15027, M15028, M15029, M15031 Genomic DNA Translation: AAA60350.1 Sequence problems.
AJ006976 Genomic DNA Translation: CAA07364.1
M54927 mRNA Translation: AAA59565.1
M17085 mRNA Translation: AAA60118.1
M27110 mRNA Translation: AAA60117.1
CR536542 mRNA Translation: CAG38779.1
Z73964 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54690.1
BC002665 mRNA Translation: AAH02665.1
BC095452 mRNA Translation: AAH95452.1
D13320 Genomic DNA Translation: BAA02577.1
S55837 Genomic DNA Translation: AAD13880.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14513.1 [P60201-1]
CCDS14514.1 [P60201-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A26665 MPHUPL

NCBI Reference Sequences

More...
RefSeqi
NP_000524.3, NM_000533.4 [P60201-1]
NP_001122306.1, NM_001128834.2 [P60201-1]
NP_001291933.1, NM_001305004.1
NP_955772.1, NM_199478.2 [P60201-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1787

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000612423; ENSP00000481006; ENSG00000123560 [P60201-1]
ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2]
ENST00000621218; ENSP00000484450; ENSG00000123560 [P60201-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5354

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5354

UCSC genome browser

More...
UCSCi
uc033epn.2 human [P60201-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15032
, M15026, M15027, M15028, M15029, M15031 Genomic DNA Translation: AAA60350.1 Sequence problems.
AJ006976 Genomic DNA Translation: CAA07364.1
M54927 mRNA Translation: AAA59565.1
M17085 mRNA Translation: AAA60118.1
M27110 mRNA Translation: AAA60117.1
CR536542 mRNA Translation: CAG38779.1
Z73964 Genomic DNA No translation available.
CH471190 Genomic DNA Translation: EAW54690.1
BC002665 mRNA Translation: AAH02665.1
BC095452 mRNA Translation: AAH95452.1
D13320 Genomic DNA Translation: BAA02577.1
S55837 Genomic DNA Translation: AAD13880.1 Sequence problems.
CCDSiCCDS14513.1 [P60201-1]
CCDS14514.1 [P60201-2]
PIRiA26665 MPHUPL
RefSeqiNP_000524.3, NM_000533.4 [P60201-1]
NP_001122306.1, NM_001128834.2 [P60201-1]
NP_001291933.1, NM_001305004.1
NP_955772.1, NM_199478.2 [P60201-2]
UniGeneiHs.1787

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XPGX-ray2.60C45-53[»]
ProteinModelPortaliP60201
SMRiP60201
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111368, 22 interactors
IntActiP60201, 64 interactors
MINTiP60201
STRINGi9606.ENSP00000305152

PTM databases

iPTMnetiP60201
PhosphoSitePlusiP60201
SwissPalmiP60201

Polymorphism and mutation databases

BioMutaiPLP1
DMDMi41393531

2D gel databases

UCD-2DPAGEiP60201

Proteomic databases

EPDiP60201
PaxDbiP60201
PeptideAtlasiP60201
PRIDEiP60201
ProteomicsDBi57188
57189 [P60201-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5354
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612423; ENSP00000481006; ENSG00000123560 [P60201-1]
ENST00000619236; ENSP00000477619; ENSG00000123560 [P60201-2]
ENST00000621218; ENSP00000484450; ENSG00000123560 [P60201-1]
GeneIDi5354
KEGGihsa:5354
UCSCiuc033epn.2 human [P60201-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5354
DisGeNETi5354
EuPathDBiHostDB:ENSG00000123560.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLP1
GeneReviewsiPLP1
HGNCiHGNC:9086 PLP1
HPAiHPA004128
MalaCardsiPLP1
MIMi300401 gene
312080 phenotype
312920 phenotype
neXtProtiNX_P60201
OpenTargetsiENSG00000123560
Orphaneti280234 Null syndrome
280229 Pelizaeus-Merzbacher disease in female carriers
280219 Pelizaeus-Merzbacher disease, classic form
280210 Pelizaeus-Merzbacher disease, connatal form
280224 Pelizaeus-Merzbacher disease, transitional form
99015 Spastic paraplegia type 2
PharmGKBiPA33414

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP60201
KOiK17271
OMAiYCIVLLA
OrthoDBiEOG091G0IM5
PhylomeDBiP60201
TreeFamiTF315162

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLP1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Proteolipid_protein_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5354

Protein Ontology

More...
PROi
PR:P60201

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123560 Expressed in 214 organ(s), highest expression level in middle frontal gyrus
CleanExiHS_PLP1
ExpressionAtlasiP60201 baseline and differential
GenevisibleiP60201 HS

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYPR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60201
Secondary accession number(s): P04400
, P06905, Q502Y1, Q6FHZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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