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Protein

Triosephosphate isomerase

Gene

TPI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase, Triosephosphate isomerase (TPI1), Triosephosphate isomerase, Triosephosphate isomerase (TPI1), Triosephosphate isomerase, Triosephosphate isomerase (HEL-S-49), Triosephosphate isomerase (TPI1), Triosephosphate isomerase (tpiA), Triosephosphate isomerase (tpiA), Triosephosphate isomerase (TPI1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei49Substrate1
Binding sitei51Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei133Electrophile1
Active sitei203Proton acceptor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • triose-phosphate isomerase activity Source: Reactome
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS03441-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
5.3.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P60174

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00109;UER00189

UPA00138

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
P60174

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPI1
Synonyms:TPI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000111669.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12009 TPI1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190450 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P60174

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Triosephosphate isomerase deficiency (TPID)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy.
See also OMIM:615512
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00753479C → Y in TPID. 1 PublicationCorresponds to variant dbSNP:rs121964848EnsemblClinVar.1
Natural variantiVAR_007535110G → A in TPID. 1 Publication1
Natural variantiVAR_007536142E → D in TPID; the enzyme becomes thermolabile. 5 PublicationsCorresponds to variant dbSNP:rs121964845EnsemblClinVar.1
Natural variantiVAR_007538192V → M in TPID. 1 PublicationCorresponds to variant dbSNP:rs188138723Ensembl.1
Natural variantiVAR_007539208I → V in TPID. 1 PublicationCorresponds to variant dbSNP:rs121964849EnsemblClinVar.1
Natural variantiVAR_007540269V → M in TPID. 1 Publication1
Natural variantiVAR_007541278F → L in TPID; Hungary; thermolabile. 1 PublicationCorresponds to variant dbSNP:rs121964847EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
7167

MalaCards human disease database

More...
MalaCardsi
TPI1
MIMi615512 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111669

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
868 Triose phosphate-isomerase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36689

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4880

Drug and drug target database

More...
DrugBanki
DB03379 2-Carboxyethylphosphonic Acid
DB03900 2-Methyl-2-Propanol
DB02726 2-Phosphoglycolic Acid
DB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid
DB07387 3-(BUTYLSULPHONYL)-PROPANOIC ACID
DB04510 3-Phosphoglyceric Acid
DB03135 [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
DB03314 Fluorotryptophane
DB01695 N-Hydroxy-4-Phosphono-Butanamide
DB03026 Phosphoglycolohydroxamic Acid

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
353526311

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000901131 – 286Triosephosphate isomeraseAdd BLAST286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51N6-acetyllysineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei105Nitrated tyrosineBy similarity1
Modified residuei117PhosphoserineCombined sources1
Modified residuei143PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei186N6-succinyllysineBy similarity1
Modified residuei193N6-acetyllysine; alternateBy similarity1
Modified residuei193N6-succinyllysine; alternateBy similarity1
Modified residuei196PhosphoserineBy similarity1
Modified residuei210PhosphothreonineBy similarity1
Modified residuei231N6-acetyllysine; alternateCombined sources1
Modified residuei231N6-methyllysine; alternateCombined sources1
Modified residuei231N6-succinyllysine; alternateBy similarity1
Modified residuei235PhosphoserineBy similarity1
Modified residuei246Nitrated tyrosineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei251PhosphothreonineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei275N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The initiator methionine for isoform 2 is removed.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Nitration, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P60174

MaxQB - The MaxQuant DataBase

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MaxQBi
P60174

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P60174

PeptideAtlas

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PeptideAtlasi
P60174

PRoteomics IDEntifications database

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PRIDEi
P60174

ProteomicsDB human proteome resource

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ProteomicsDBi
57186
57187 [P60174-1]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P60174-1 [P60174-1]
P60174-3 [P60174-3]
P60174-4 [P60174-4]

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P60174

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00797687
P60174

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P60174

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P60174

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P60174

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P60174

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P60174

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000111669 Expressed in 227 organ(s), highest expression level in right frontal lobe

CleanEx database of gene expression profiles

More...
CleanExi
HS_TPI1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P60174 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P60174 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050924
HPA053568

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113020, 100 interactors

Protein interaction database and analysis system

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IntActi
P60174, 28 interactors

Molecular INTeraction database

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MINTi
P60174

STRING: functional protein association networks

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STRINGi
9606.ENSP00000229270

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P60174

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1286
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P60174

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P60174

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P60174

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the triosephosphate isomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1643 Eukaryota
COG0149 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000226413

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002599

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P60174

KEGG Orthology (KO)

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KOi
K01803

Identification of Orthologs from Complete Genome Data

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OMAi
LCVGEGL

Database of Orthologous Groups

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OrthoDBi
EOG091G0LEZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P60174

TreeFam database of animal gene trees

More...
TreeFami
TF300829

Family and domain databases

Conserved Domains Database

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CDDi
cd00311 TIM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.20.70, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00147_B TIM_B, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR21139 PTHR21139, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00121 TIM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51351 SSF51351, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00419 tim, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P60174-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEDGEEAEF HFAALYISGQ WPRLRADTDL QRLGSSAMAP SRKFFVGGNW
60 70 80 90 100
KMNGRKQSLG ELIGTLNAAK VPADTEVVCA PPTAYIDFAR QKLDPKIAVA
110 120 130 140 150
AQNCYKVTNG AFTGEISPGM IKDCGATWVV LGHSERRHVF GESDELIGQK
160 170 180 190 200
VAHALAEGLG VIACIGEKLD EREAGITEKV VFEQTKVIAD NVKDWSKVVL
210 220 230 240 250
AYEPVWAIGT GKTATPQQAQ EVHEKLRGWL KSNVSDAVAQ STRIIYGGSV
260 270 280
TGATCKELAS QPDVDGFLVG GASLKPEFVD IINAKQ
Length:286
Mass (Da):30,791
Last modified:October 19, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6C2157706AE97F8
GO
Isoform 2 (identifier: P60174-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Show »
Length:249
Mass (Da):26,669
Checksum:i73844175635F858E
GO
Isoform 4 (identifier: P60174-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Note: Produced by alternative splicing.
Show »
Length:167
Mass (Da):17,958
Checksum:i1E9ADB034A513E18
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQF3U3KQF3_HUMAN
Triosephosphate isomerase
TPI1
98Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPZ0U3KPZ0_HUMAN
Triosephosphate isomerase
TPI1
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPS5U3KPS5_HUMAN
Triosephosphate isomerase
TPI1
38Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB51316 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB59511 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH07086 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH07812 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH09329 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH11611 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH15100 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH17917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH70129 differs from that shown. Sequence differs at the C-terminus.Curated
The sequence AAH70129 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAN86636 differs from that shown. Reason: Frameshift at position 23.Curated
The sequence BAG36090 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA49379 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23 – 26RLRA → TAR in AAB59511 (PubMed:2579079).Curated4
Sequence conflicti36Missing in AAB59511 (PubMed:2579079).Curated1
Sequence conflicti36Missing in AAN86636 (PubMed:16541075).Curated1
Sequence conflicti57 – 58QS → KN AA sequence (PubMed:6434534).Curated2
Sequence conflicti64G → S AA sequence (PubMed:6434534).Curated1
Sequence conflicti67 – 68NA → QG AA sequence (PubMed:6434534).Curated2
Sequence conflicti80 – 81AP → IG AA sequence (PubMed:6434534).Curated2
Sequence conflicti95P → Q AA sequence (PubMed:6434534).Curated1
Sequence conflicti192V → A in AAH17917 (PubMed:15489334).Curated1
Sequence conflicti204P → N AA sequence (PubMed:6434534).Curated1
Sequence conflicti281I → L AA sequence (PubMed:6434534).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00753479C → Y in TPID. 1 PublicationCorresponds to variant dbSNP:rs121964848EnsemblClinVar.1
Natural variantiVAR_007535110G → A in TPID. 1 Publication1
Natural variantiVAR_007536142E → D in TPID; the enzyme becomes thermolabile. 5 PublicationsCorresponds to variant dbSNP:rs121964845EnsemblClinVar.1
Natural variantiVAR_007537160G → R in Manchester; thermolabile. 1 PublicationCorresponds to variant dbSNP:rs121964846EnsemblClinVar.1
Natural variantiVAR_007538192V → M in TPID. 1 PublicationCorresponds to variant dbSNP:rs188138723Ensembl.1
Natural variantiVAR_007539208I → V in TPID. 1 PublicationCorresponds to variant dbSNP:rs121964849EnsemblClinVar.1
Natural variantiVAR_007540269V → M in TPID. 1 Publication1
Natural variantiVAR_007541278F → L in TPID; Hungary; thermolabile. 1 PublicationCorresponds to variant dbSNP:rs121964847EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0453101 – 119Missing in isoform 4. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_0418951 – 37Missing in isoform 2. CuratedAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M10036 mRNA Translation: AAB59511.1 Different initiation.
X69723 Genomic DNA Translation: CAA49379.1 Different initiation.
AK298809 mRNA Translation: BAH12874.1
U47924 Genomic DNA Translation: AAB51316.1 Different initiation.
CH471116 Genomic DNA Translation: EAW88722.1
CH471116 Genomic DNA Translation: EAW88723.1
J04603 Genomic DNA Translation: AAN86636.1 Frameshift.
BC007086 mRNA Translation: AAH07086.1 Different initiation.
BC007812 mRNA Translation: AAH07812.1 Different initiation.
BC009329 mRNA Translation: AAH09329.1 Different initiation.
BC011611 mRNA Translation: AAH11611.1 Different initiation.
BC015100 mRNA Translation: AAH15100.1 Different initiation.
BC017165 mRNA Translation: AAH17165.1
BC017917 mRNA Translation: AAH17917.1 Different initiation.
BC070129 mRNA Translation: AAH70129.1 Sequence problems.
AK313282 mRNA Translation: BAG36090.1 Different initiation.
CR541702 mRNA Translation: CAG46503.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53740.1 [P60174-3]
CCDS58206.1 [P60174-4]
CCDS8566.1 [P60174-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S29743 ISHUT

NCBI Reference Sequences

More...
RefSeqi
NP_000356.1, NM_000365.5 [P60174-1]
NP_001152759.1, NM_001159287.1 [P60174-3]
NP_001244955.1, NM_001258026.1 [P60174-4]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.524219

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229270; ENSP00000229270; ENSG00000111669 [P60174-3]
ENST00000396705; ENSP00000379933; ENSG00000111669 [P60174-1]
ENST00000488464; ENSP00000475620; ENSG00000111669 [P60174-4]
ENST00000535434; ENSP00000443599; ENSG00000111669 [P60174-4]
ENST00000613953; ENSP00000484435; ENSG00000111669 [P60174-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7167

UCSC genome browser

More...
UCSCi
uc001qrk.5 human [P60174-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Triosephosphate isomerase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10036 mRNA Translation: AAB59511.1 Different initiation.
X69723 Genomic DNA Translation: CAA49379.1 Different initiation.
AK298809 mRNA Translation: BAH12874.1
U47924 Genomic DNA Translation: AAB51316.1 Different initiation.
CH471116 Genomic DNA Translation: EAW88722.1
CH471116 Genomic DNA Translation: EAW88723.1
J04603 Genomic DNA Translation: AAN86636.1 Frameshift.
BC007086 mRNA Translation: AAH07086.1 Different initiation.
BC007812 mRNA Translation: AAH07812.1 Different initiation.
BC009329 mRNA Translation: AAH09329.1 Different initiation.
BC011611 mRNA Translation: AAH11611.1 Different initiation.
BC015100 mRNA Translation: AAH15100.1 Different initiation.
BC017165 mRNA Translation: AAH17165.1
BC017917 mRNA Translation: AAH17917.1 Different initiation.
BC070129 mRNA Translation: AAH70129.1 Sequence problems.
AK313282 mRNA Translation: BAG36090.1 Different initiation.
CR541702 mRNA Translation: CAG46503.1
CCDSiCCDS53740.1 [P60174-3]
CCDS58206.1 [P60174-4]
CCDS8566.1 [P60174-1]
PIRiS29743 ISHUT
RefSeqiNP_000356.1, NM_000365.5 [P60174-1]
NP_001152759.1, NM_001159287.1 [P60174-3]
NP_001244955.1, NM_001258026.1 [P60174-4]
UniGeneiHs.524219

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HTIX-ray2.80A/B39-286[»]
1KLGX-ray2.40C60-74[»]
1KLUX-ray1.93C60-74[»]
1WYIX-ray2.20A/B39-286[»]
2IAMX-ray2.80P60-74[»]
2IANX-ray2.80C/H/M/R60-74[»]
2JK2X-ray1.70A/B39-286[»]
2VOMX-ray1.85A/B/C/D39-286[»]
4BR1X-ray1.90A/B41-286[»]
4E41X-ray2.60C/H60-74[»]
4POCX-ray1.60A/B38-286[»]
4PODX-ray1.99A/B38-286[»]
4UNKX-ray2.00A/B39-286[»]
4UNLX-ray1.50A/B39-286[»]
4ZVJX-ray1.70A/B38-286[»]
6C2GX-ray2.30A/B/C/D38-286[»]
6D43X-ray2.04A/B41-286[»]
ProteinModelPortaliP60174
SMRiP60174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113020, 100 interactors
IntActiP60174, 28 interactors
MINTiP60174
STRINGi9606.ENSP00000229270

Chemistry databases

BindingDBiP60174
ChEMBLiCHEMBL4880
DrugBankiDB03379 2-Carboxyethylphosphonic Acid
DB03900 2-Methyl-2-Propanol
DB02726 2-Phosphoglycolic Acid
DB03132 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid
DB07387 3-(BUTYLSULPHONYL)-PROPANOIC ACID
DB04510 3-Phosphoglyceric Acid
DB03135 [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid
DB03314 Fluorotryptophane
DB01695 N-Hydroxy-4-Phosphono-Butanamide
DB03026 Phosphoglycolohydroxamic Acid

Protein family/group databases

MoonProtiP60174

PTM databases

iPTMnetiP60174
PhosphoSitePlusiP60174
SwissPalmiP60174

Polymorphism and mutation databases

BioMutaiTPI1
DMDMi353526311

2D gel databases

DOSAC-COBS-2DPAGEiP60174
REPRODUCTION-2DPAGEiIPI00797687
P60174
SWISS-2DPAGEiP60174
UCD-2DPAGEiP60174

Proteomic databases

EPDiP60174
MaxQBiP60174
PaxDbiP60174
PeptideAtlasiP60174
PRIDEiP60174
ProteomicsDBi57186
57187 [P60174-1]
TopDownProteomicsiP60174-1 [P60174-1]
P60174-3 [P60174-3]
P60174-4 [P60174-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7167
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229270; ENSP00000229270; ENSG00000111669 [P60174-3]
ENST00000396705; ENSP00000379933; ENSG00000111669 [P60174-1]
ENST00000488464; ENSP00000475620; ENSG00000111669 [P60174-4]
ENST00000535434; ENSP00000443599; ENSG00000111669 [P60174-4]
ENST00000613953; ENSP00000484435; ENSG00000111669 [P60174-3]
GeneIDi7167
KEGGihsa:7167
UCSCiuc001qrk.5 human [P60174-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7167
DisGeNETi7167
EuPathDBiHostDB:ENSG00000111669.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPI1
HGNCiHGNC:12009 TPI1
HPAiHPA050924
HPA053568
MalaCardsiTPI1
MIMi190450 gene
615512 phenotype
neXtProtiNX_P60174
OpenTargetsiENSG00000111669
Orphaneti868 Triose phosphate-isomerase deficiency
PharmGKBiPA36689

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1643 Eukaryota
COG0149 LUCA
GeneTreeiENSGT00390000013354
HOGENOMiHOG000226413
HOVERGENiHBG002599
InParanoidiP60174
KOiK01803
OMAiLCVGEGL
OrthoDBiEOG091G0LEZ
PhylomeDBiP60174
TreeFamiTF300829

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00189

UPA00138

BioCyciMetaCyc:HS03441-MONOMER
BRENDAi5.3.1.1 2681
ReactomeiR-HSA-70171 Glycolysis
R-HSA-70263 Gluconeogenesis
SABIO-RKiP60174

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TPI1 human
EvolutionaryTraceiP60174

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TPI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7167

Protein Ontology

More...
PROi
PR:P60174

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111669 Expressed in 227 organ(s), highest expression level in right frontal lobe
CleanExiHS_TPI1
ExpressionAtlasiP60174 baseline and differential
GenevisibleiP60174 HS

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPIS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P60174
Secondary accession number(s): B7Z5D8
, D3DUS9, P00938, Q6FHP9, Q6IS07, Q8WWD0, Q96AG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 19, 2011
Last modified: December 5, 2018
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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